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Protein

Chaperone protein HtpG

Gene

htpG

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone. Has ATPase activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to superoxide Source: MTBBASE
  • protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HtpGUniRule annotation
Alternative name(s):
Heat shock protein HtpGUniRule annotation
High temperature protein GUniRule annotation
Gene namesi
Name:htpGUniRule annotation
Ordered Locus Names:Rv2299c
ORF Names:MTCY339.11
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2299c.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular region Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Chaperone protein HtpGPRO_0000062996Add
BLAST

Proteomic databases

PaxDbiP9WMJ7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi83332.Rv2299c.

Structurei

3D structure databases

ProteinModelPortaliP9WMJ7.
SMRiP9WMJ7. Positions 6-643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 353353A; substrate-bindingUniRule annotationAdd
BLAST
Regioni354 – 567214BUniRule annotationAdd
BLAST
Regioni568 – 64780CUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 90 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJX. Bacteria.
COG0326. LUCA.
KOiK04079.
OMAiYLRFMRG.
PhylomeDBiP9WMJ7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WMJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHVEQLEF QAEARQLLDL MVHSVYSNKD AFLRELISNA SDALDKLRIE
60 70 80 90 100
ALRNKDLEVD TSDLHIEIDA DKAARTLTVR DNGIGMAREE VVDLIGTLAK
110 120 130 140 150
SGTAELRAQL REAKNAAASE ELIGQFGIGF YSSFMVADKV QLLTRKAGES
160 170 180 190 200
AATRWESSGE GTYTIESVED APQGTSVTLH LKPEDAEDDL HDYTSEWKIR
210 220 230 240 250
NLVKKYSDFI AWPIRMDVER RTPASQEEGG EGGEETVTIE TETLNSMKAL
260 270 280 290 300
WARPKEEVSE QEYKEFYKHV AHAWDDPLEI IAMKAEGTFE YQALLFIPSH
310 320 330 340 350
APFDLFDRDA HVGIQLYVKR VFIMGDCDQL MPEYLRFVKG VVDAQDMSLN
360 370 380 390 400
VSREILQQDR QIKAIRRRLT KKVLSTIKDV QSSRPEDYRT FWTQFGRVLK
410 420 430 440 450
EGLLSDIDNR ETLLGISSFV STYSEEEPTT LAEYVERMKD GQQQIFYATG
460 470 480 490 500
ETRQQLLKSP HLEAFKAKGY EVLLLTDPVD EVWVGMVPEF DGKPLQSVAK
510 520 530 540 550
GEVDLSSEED TSEAEREERQ KEFADLLTWL QETLSDHVKE VRLSTRLTES
560 570 580 590 600
PACLITDAFG MTPALARIYR ASGQEVPVGK RILELNPSHP LVTGLRQAHQ
610 620 630 640
DRADDAEKSL AETAELLYGT ALLAEGGALE DPARFAELLA ERLARTL
Length:647
Mass (Da):72,961
Last modified:April 16, 2014 - v1
Checksum:iFE2C7C6F2398D741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45081.1.
PIRiG70733.
RefSeqiNP_216815.1. NC_000962.3.
WP_003411855.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP45081; CCP45081; Rv2299c.
GeneIDi887501.
KEGGimtu:Rv2299c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45081.1.
PIRiG70733.
RefSeqiNP_216815.1. NC_000962.3.
WP_003411855.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WMJ7.
SMRiP9WMJ7. Positions 6-643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2299c.

Proteomic databases

PaxDbiP9WMJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45081; CCP45081; Rv2299c.
GeneIDi887501.
KEGGimtu:Rv2299c.

Organism-specific databases

TubercuListiRv2299c.

Phylogenomic databases

eggNOGiENOG4105CJX. Bacteria.
COG0326. LUCA.
KOiK04079.
OMAiYLRFMRG.
PhylomeDBiP9WMJ7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTPG_MYCTU
AccessioniPrimary (citable) accession number: P9WMJ7
Secondary accession number(s): L0TC38, P64411, Q50667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 11, 2016
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.