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Protein

Uncharacterized HTH-type transcriptional regulator Rv0081

Gene

Rv0081

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 60H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized HTH-type transcriptional regulator Rv0081
Gene namesi
Ordered Locus Names:Rv0081
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0081.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE

Pathology & Biotechi

Biotechnological usei

This protein serves as an immunogenic antigen, inducing gamma-interferon responses in whole-blood cultures from M.tuberculosis-exposed adults in Uganda, The Gambia and South Africa, indicating this might be a good vaccine candidate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003926811 – 114Uncharacterized HTH-type transcriptional regulator Rv0081Add BLAST114

Proteomic databases

PaxDbiP9WMI7.

Expressioni

Inductioni

A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection.4 Publications

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0081.

Structurei

3D structure databases

ProteinModelPortaliP9WMI7.
SMRiP9WMI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 97HTH arsR-typePROSITE-ProRule annotationAdd BLAST96

Phylogenomic databases

eggNOGiENOG4105M9X. Bacteria.
COG0640. LUCA.
OMAiPLYQLKA.
PhylomeDBiP9WMI7.

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WMI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEPLYKLK AEFFKTLAHP ARIRILELLV ERDRSVGELL SSDVGLESSN
60 70 80 90 100
LSQQLGVLRR AGVVAARRDG NAMIYSIAAP DIAELLAVAR KVLARVLSDR
110
VAVLEDLRAG GSAT
Length:114
Mass (Da):12,356
Last modified:April 16, 2014 - v1
Checksum:iAF3C88714DCC1B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42806.1.
PIRiB70850.
RefSeqiNP_214595.1. NC_000962.3.
WP_003400657.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42806; CCP42806; Rv0081.
GeneIDi887012.
KEGGimtu:Rv0081.

Similar proteinsi

Entry informationi

Entry nameiY0081_MYCTU
AccessioniPrimary (citable) accession number: P9WMI7
Secondary accession number(s): L0T5M3, O53626, Q7DAH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: January 31, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names