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Protein

Transcriptional regulatory protein DevR (DosR)

Gene

devR

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi167 – 186H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein DevR (DosR)
Gene namesi
Name:devR
Synonyms:dosR
Ordered Locus Names:MT3219
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Host cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004273111 – 217Transcriptional regulatory protein DevR (DosR)Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei198Phosphothreonine; by PknHBy similarity1
Modified residuei205Phosphothreonine; by PknHBy similarity1

Post-translational modificationi

Phosphorylated on aspartate by both DevS (DosS) and DosT. Phosphorylated on threonine by PknH. Phosphorylation by PknH enhances DevR dimerization. Aspartate phosphorylation and threonine phosphorylation cooperatively enhance DevR binding to DNA (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

A member of the dormancy regulon. Moderately expressed under aerobic conditions, it is strongly induced in response to reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WMF8.
SMRiP9WMF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini143 – 208HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

KOiK07695.
OrthoDBiPOG091H05B9.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
cd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WMF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVFLVDDH EVVRRGLVDL LGADPELDVV GEAGSVAEAM ARVPAARPDV
60 70 80 90 100
AVLDVRLPDG NGIELCRDLL SRMPDLRCLI LTSYTSDEAM LDAILAGASG
110 120 130 140 150
YVVKDIKGME LARAVKDVGA GRSLLDNRAA AALMAKLRGA AEKQDPLSGL
160 170 180 190 200
TDQERTLLGL LSEGLTNKQI ADRMFLAEKT VKNYVSRLLA KLGMERRTQA
210
AVFATELKRS RPPGDGP
Length:217
Mass (Da):23,294
Last modified:April 16, 2014 - v1
Checksum:i1BA535C26CC4EB51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK47557.1.
PIRiF70645.
RefSeqiWP_003416369.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK47557; AAK47557; MT3219.
KEGGimtc:MT3219.
PATRICifig|83331.31.peg.3469.

Similar proteinsi

Entry informationi

Entry nameiDEVR_MYCTO
AccessioniPrimary (citable) accession number: P9WMF8
Secondary accession number(s): L0TBX9
, P95193, Q79CX8, Q7D625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome