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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity).By similarity

GO - Molecular functioni

  • gated channel activity Source: MTBBASE
  • mechanically gated channel activity Source: MTBBASE
  • mechanically-gated ion channel activity Source: GO_Central

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transport Source: GO_Central
  • transmembrane transport Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channel
Gene namesi
Name:mscL
Ordered Locus Names:Rv0985c
ORF Names:MTV044.13c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0985c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicBy similarityAdd BLAST14
Transmembranei15 – 43HelicalBy similarityAdd BLAST29
Topological domaini44 – 68ExtracellularBy similarityAdd BLAST25
Transmembranei69 – 90HelicalBy similarityAdd BLAST22
Topological domaini91 – 151CytoplasmicBy similarityAdd BLAST61

GO - Cellular componenti

  • integral component of plasma membrane Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924521 – 151Large-conductance mechanosensitive channelAdd BLAST151

Proteomic databases

PaxDbiP9WJN5.

Interactioni

Subunit structurei

Homopentamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WJN5.
SMRiP9WJN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41080FJ. Bacteria.
COG1970. LUCA.
KOiK03282.
OMAiWVAFVNA.
PhylomeDBiP9WJN5.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
IPR029027. Single_a-helix.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WJN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKGFKEFLA RGNIVDLAVA VVIGTAFTAL VTKFTDSIIT PLINRIGVNA
60 70 80 90 100
QSDVGILRIG IGGGQTIDLN VLLSAAINFF LIAFAVYFLV VLPYNTLRKK
110 120 130 140 150
GEVEQPGDTQ VVLLTEIRDL LAQTNGDSPG RHGGRGTPSP TDGPRASTES

Q
Length:151
Mass (Da):16,023
Last modified:April 16, 2014 - v1
Checksum:iD682D3F2C1651E9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43735.1.
PIRiE70821.
RefSeqiNP_215500.1. NC_000962.3.
WP_003405128.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43735; CCP43735; Rv0985c.
GeneIDi885368.
KEGGimtu:Rv0985c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43735.1.
PIRiE70821.
RefSeqiNP_215500.1. NC_000962.3.
WP_003405128.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WJN5.
SMRiP9WJN5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP9WJN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43735; CCP43735; Rv0985c.
GeneIDi885368.
KEGGimtu:Rv0985c.

Organism-specific databases

TubercuListiRv0985c.

Phylogenomic databases

eggNOGiENOG41080FJ. Bacteria.
COG1970. LUCA.
KOiK03282.
OMAiWVAFVNA.
PhylomeDBiP9WJN5.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5142-MONOMER.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
IPR029027. Single_a-helix.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSCL_MYCTU
AccessioniPrimary (citable) accession number: P9WJN5
Secondary accession number(s): L0T5D5, O53898, P0A5K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.