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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13UniRule annotation1

GO - Molecular functioni

  • L-methionine:thioredoxin-disulfide S-oxidoreductase activity Source: MTBBASE
  • peptide-methionine (S)-S-oxide reductase activity Source: MTBBASE

GO - Biological processi

  • cellular protein modification process Source: UniProtKB-HAMAP
  • evasion or tolerance by symbiont of host-produced nitric oxide Source: Reactome
  • protein repair Source: InterPro
  • response to nitrosative stress Source: MTBBASE
  • response to oxidative stress Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4254-MONOMER.
ReactomeiR-HSA-1222538. Tolerance by Mtb to nitric oxide produced by macrophages.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Rv0137c
ORF Names:MTCI5.11c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0137c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001385601 – 182Peptide methionine sulfoxide reductase MsrAAdd BLAST182

Proteomic databases

PaxDbiP9WJM5.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0137c.

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 12Combined sources8
Helixi14 – 21Combined sources8
Beta strandi27 – 38Combined sources12
Beta strandi51 – 58Combined sources8
Turni60 – 62Combined sources3
Helixi65 – 75Combined sources11
Beta strandi87 – 89Combined sources3
Helixi90 – 92Combined sources3
Beta strandi94 – 100Combined sources7
Helixi101 – 117Combined sources17
Beta strandi120 – 122Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi134 – 136Combined sources3
Helixi139 – 141Combined sources3
Helixi144 – 147Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NWAX-ray1.50A1-182[»]
ProteinModelPortaliP9WJM5.
SMRiP9WJM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFB. Bacteria.
COG0225. LUCA.
KOiK07304.
OMAiPTDSKGQ.
PhylomeDBiP9WJM5.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WJM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNQKAILA GGCFWGLQDL IRNQPGVVST RVGYSGGNIP NATYRNHGTH
60 70 80 90 100
AEAVEIIFDP TVTDYRTLLE FFFQIHDPTT KDRQGNDRGT SYRSAIFYFD
110 120 130 140 150
EQQKRIALDT IADVEASGLW PGKVVTEVSP AGDFWEAEPE HQDYLQRYPN
160 170 180
GYTCHFVRPG WRLPRRTAES ALRASLSPEL GT
Length:182
Mass (Da):20,485
Last modified:April 16, 2014 - v1
Checksum:iB0A2847A699C2016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42862.1.
PIRiD70616.
RefSeqiNP_214651.1. NC_000962.3.
WP_003400942.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42862; CCP42862; Rv0137c.
GeneIDi886865.
KEGGimtu:Rv0137c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42862.1.
PIRiD70616.
RefSeqiNP_214651.1. NC_000962.3.
WP_003400942.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NWAX-ray1.50A1-182[»]
ProteinModelPortaliP9WJM5.
SMRiP9WJM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0137c.

Proteomic databases

PaxDbiP9WJM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42862; CCP42862; Rv0137c.
GeneIDi886865.
KEGGimtu:Rv0137c.

Organism-specific databases

TubercuListiRv0137c.

Phylogenomic databases

eggNOGiENOG4107RFB. Bacteria.
COG0225. LUCA.
KOiK07304.
OMAiPTDSKGQ.
PhylomeDBiP9WJM5.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4254-MONOMER.
ReactomeiR-HSA-1222538. Tolerance by Mtb to nitric oxide produced by macrophages.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_MYCTU
AccessioniPrimary (citable) accession number: P9WJM5
Secondary accession number(s): L0T5N9, P0A5L0, P96814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.