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P9WJJ7

- NADC_MYCTU

UniProt

P9WJJ7 - NADC_MYCTU

Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

nadC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 6 (01 Oct 2014)
      Sequence version 1 (16 Apr 2014)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of quinolinic acid (QA).By similarity

    Catalytic activityi

    Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051Substrate1 Publication
    Binding sitei162 – 1621Substrate1 Publication
    Binding sitei172 – 1721Substrate1 Publication
    Binding sitei201 – 2011Substrate1 Publication
    Binding sitei222 – 2221Substrate1 Publication

    GO - Molecular functioni

    1. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00331.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
    Alternative name(s):
    Quinolinate phosphoribosyltransferase [decarboxylating]
    Short name:
    QAPRTase
    Gene namesi
    Name:nadC
    Ordered Locus Names:Rv1596
    ORF Names:MTCY336.08c
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv1596.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: MTBBASE
    2. plasma membrane Source: MTBBASE

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Nicotinate-nucleotide pyrophosphorylase [carboxylating]PRO_0000155946Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Hexamer formed by 3 homodimers.1 Publication

    Structurei

    Secondary structure

    1
    285
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2319
    Helixi29 – 346
    Beta strandi40 – 4910
    Helixi56 – 6712
    Beta strandi71 – 777
    Beta strandi89 – 968
    Helixi97 – 12731
    Turni128 – 1303
    Beta strandi134 – 1363
    Turni143 – 1453
    Helixi146 – 15510
    Beta strandi164 – 1718
    Helixi173 – 1797
    Helixi182 – 19211
    Beta strandi198 – 2047
    Helixi205 – 2117
    Helixi212 – 2143
    Beta strandi217 – 2237
    Helixi226 – 23914
    Beta strandi244 – 2507
    Turni253 – 2553
    Helixi256 – 2616
    Beta strandi265 – 2684
    Helixi270 – 2723
    Beta strandi274 – 2763
    Beta strandi281 – 2844

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QPNX-ray2.60A/B/C/D/E/F2-285[»]
    1QPOX-ray2.40A/B/C/D/E/F2-285[»]
    1QPQX-ray2.45A/B/C/D/E/F2-285[»]
    1QPRX-ray2.45A/B/C/D/E/F2-285[»]
    ProteinModelPortaliP9WJJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni138 – 1403Substrate binding
    Regioni248 – 2503Substrate binding
    Regioni269 – 2713Substrate binding

    Sequence similaritiesi

    Belongs to the NadC/ModD family.Curated

    Phylogenomic databases

    KOiK00767.
    PhylomeDBiP9WJJ7.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.90.1170.20. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR004393. NadC.
    IPR027277. NadC/ModD.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    IPR022412. Quinolinate_PRibosylTrfase_N.
    [Graphical view]
    PfamiPF01729. QRPTase_C. 1 hit.
    PF02749. QRPTase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006250. NadC_ModD. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR00078. nadC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P9WJJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSDWELAA ARAAIARGLD EDLRYGPDVT TLATVPASAT TTASLVTREA    50
    GVVAGLDVAL LTLNEVLGTN GYRVLDRVED GARVPPGEAL MTLEAQTRGL 100
    LTAERTMLNL VGHLSGIATA TAAWVDAVRG TKAKIRDTRK TLPGLRALQK 150
    YAVRTGGGVN HRLGLGDAAL IKDNHVAAAG SVVDALRAVR NAAPDLPCEV 200
    EVDSLEQLDA VLPEKPELIL LDNFAVWQTQ TAVQRRDSRA PTVMLESSGG 250
    LSLQTAATYA ETGVDYLAVG ALTHSVRVLD IGLDM 285
    Length:285
    Mass (Da):29,951
    Last modified:April 16, 2014 - v1
    Checksum:i45DE3335EC1C522F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP44360.1.
    PIRiF70543.
    RefSeqiNP_216112.1. NC_000962.3.
    YP_006514985.1. NC_018143.2.

    Genome annotation databases

    GeneIDi13316374.
    886281.
    KEGGimtu:Rv1596.
    mtv:RVBD_1596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP44360.1 .
    PIRi F70543.
    RefSeqi NP_216112.1. NC_000962.3.
    YP_006514985.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QPN X-ray 2.60 A/B/C/D/E/F 2-285 [» ]
    1QPO X-ray 2.40 A/B/C/D/E/F 2-285 [» ]
    1QPQ X-ray 2.45 A/B/C/D/E/F 2-285 [» ]
    1QPR X-ray 2.45 A/B/C/D/E/F 2-285 [» ]
    ProteinModelPortali P9WJJ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13316374.
    886281.
    KEGGi mtu:Rv1596.
    mtv:RVBD_1596.

    Organism-specific databases

    TubercuListi Rv1596.

    Phylogenomic databases

    KOi K00767.
    PhylomeDBi P9WJJ7.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00331 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.90.1170.20. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR004393. NadC.
    IPR027277. NadC/ModD.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    IPR022412. Quinolinate_PRibosylTrfase_N.
    [Graphical view ]
    Pfami PF01729. QRPTase_C. 1 hit.
    PF02749. QRPTase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006250. NadC_ModD. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR00078. nadC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.
    3. "Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential tb drug target."
      Sharma V., Grubmeyer C., Sacchettini J.C.
      Structure 6:1587-1599(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.
      Strain: ATCC 25618 / H37Rv.

    Entry informationi

    Entry nameiNADC_MYCTU
    AccessioniPrimary (citable) accession number: P9WJJ7
    Secondary accession number(s): L0T8R5, O06594
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3