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P9WJJ7

- NADC_MYCTU

UniProt

P9WJJ7 - NADC_MYCTU

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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene
nadC, Rv1596, MTCY336.08c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the catabolism of quinolinic acid (QA) By similarity.

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051Substrate
Binding sitei162 – 1621Substrate
Binding sitei172 – 1721Substrate
Binding sitei201 – 2011Substrate
Binding sitei222 – 2221Substrate

GO - Molecular functioni

  1. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00331.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Gene namesi
Name:nadC
Ordered Locus Names:Rv1596
ORF Names:MTCY336.08c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv1596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Nicotinate-nucleotide pyrophosphorylase [carboxylating]PRO_0000155946Add
BLAST

Interactioni

Subunit structurei

Homodimer. Hexamer formed by 3 homodimers.1 Publication

Structurei

Secondary structure

1
285
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2319
Helixi29 – 346
Beta strandi40 – 4910
Helixi56 – 6712
Beta strandi71 – 777
Beta strandi89 – 968
Helixi97 – 12731
Turni128 – 1303
Beta strandi134 – 1363
Turni143 – 1453
Helixi146 – 15510
Beta strandi164 – 1718
Helixi173 – 1797
Helixi182 – 19211
Beta strandi198 – 2047
Helixi205 – 2117
Helixi212 – 2143
Beta strandi217 – 2237
Helixi226 – 23914
Beta strandi244 – 2507
Turni253 – 2553
Helixi256 – 2616
Beta strandi265 – 2684
Helixi270 – 2723
Beta strandi274 – 2763
Beta strandi281 – 2844

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QPNX-ray2.60A/B/C/D/E/F2-285[»]
1QPOX-ray2.40A/B/C/D/E/F2-285[»]
1QPQX-ray2.45A/B/C/D/E/F2-285[»]
1QPRX-ray2.45A/B/C/D/E/F2-285[»]
ProteinModelPortaliP9WJJ7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1403Substrate binding
Regioni248 – 2503Substrate binding
Regioni269 – 2713Substrate binding

Sequence similaritiesi

Belongs to the NadC/ModD family.

Phylogenomic databases

KOiK00767.
PhylomeDBiP9WJJ7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WJJ7-1 [UniParc]FASTAAdd to Basket

« Hide

MGLSDWELAA ARAAIARGLD EDLRYGPDVT TLATVPASAT TTASLVTREA    50
GVVAGLDVAL LTLNEVLGTN GYRVLDRVED GARVPPGEAL MTLEAQTRGL 100
LTAERTMLNL VGHLSGIATA TAAWVDAVRG TKAKIRDTRK TLPGLRALQK 150
YAVRTGGGVN HRLGLGDAAL IKDNHVAAAG SVVDALRAVR NAAPDLPCEV 200
EVDSLEQLDA VLPEKPELIL LDNFAVWQTQ TAVQRRDSRA PTVMLESSGG 250
LSLQTAATYA ETGVDYLAVG ALTHSVRVLD IGLDM 285
Length:285
Mass (Da):29,951
Last modified:April 16, 2014 - v1
Checksum:i45DE3335EC1C522F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44360.1.
PIRiF70543.
RefSeqiNP_216112.1. NC_000962.3.
YP_006514985.1. NC_018143.2.

Genome annotation databases

GeneIDi13316374.
886281.
KEGGimtu:Rv1596.
mtv:RVBD_1596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP44360.1 .
PIRi F70543.
RefSeqi NP_216112.1. NC_000962.3.
YP_006514985.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QPN X-ray 2.60 A/B/C/D/E/F 2-285 [» ]
1QPO X-ray 2.40 A/B/C/D/E/F 2-285 [» ]
1QPQ X-ray 2.45 A/B/C/D/E/F 2-285 [» ]
1QPR X-ray 2.45 A/B/C/D/E/F 2-285 [» ]
ProteinModelPortali P9WJJ7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13316374.
886281.
KEGGi mtu:Rv1596.
mtv:RVBD_1596.

Organism-specific databases

TubercuListi Rv1596.

Phylogenomic databases

KOi K00767.
PhylomeDBi P9WJJ7.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00331 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view ]
Pfami PF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF006250. NadC_ModD. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR00078. nadC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.
  3. "Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential tb drug target."
    Sharma V., Grubmeyer C., Sacchettini J.C.
    Structure 6:1587-1599(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiNADC_MYCTU
AccessioniPrimary (citable) accession number: P9WJJ7
Secondary accession number(s): L0T8R5, O06594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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