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Protein

Putative NAD(P)H nitroreductase acg

Gene

acg

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

FMNCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316FMNSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 32FMNSequence analysis5

GO - Molecular functioni

GO - Biological processi

  • response to host immune response Source: MTBBASE
  • response to hypoxia Source: MTBBASE

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative NAD(P)H nitroreductase acg (EC:1.-.-.-)
Gene namesi
Name:acg
Ordered Locus Names:Rv2032
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2032

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003926261 – 331Putative NAD(P)H nitroreductase acgAdd BLAST331

Proteomic databases

PaxDbiP9WIZ9
PRIDEiP9WIZ9

Expressioni

Inductioni

A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection. Induced in C57BL/6 mouse lungs 3 weeks after low dose aerosol infection with H37Rv bacteria.4 Publications

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2032

Structurei

3D structure databases

ProteinModelPortaliP9WIZ9
SMRiP9WIZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Phylogenomic databases

eggNOGiENOG4108DYU Bacteria
ENOG410ZYU8 LUCA
OMAiDWWTAPF
PhylomeDBiP9WIZ9

Family and domain databases

Gene3Di3.40.109.10, 2 hits
InterProiView protein in InterPro
IPR000415 Nitroreductase-like
SUPFAMiSSF55469 SSF55469, 2 hits

Sequencei

Sequence statusi: Complete.

P9WIZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDTMVTTDV IKSAVQLACR APSLHNSQPW RWIAEDHTVA LFLDKDRVLY
60 70 80 90 100
ATDHSGREAL LGCGAVLDHF RVAMAAAGTT ANVERFPNPN DPLHLASIDF
110 120 130 140 150
SPADFVTEGH RLRADAILLR RTDRLPFAEP PDWDLVESQL RTTVTADTVR
160 170 180 190 200
IDVIADDMRP ELAAASKLTE SLRLYDSSYH AELFWWTGAF ETSEGIPHSS
210 220 230 240 250
LVSAAESDRV TFGRDFPVVA NTDRRPEFGH DRSKVLVLST YDNERASLLR
260 270 280 290 300
CGEMLSAVLL DATMAGLATC TLTHITELHA SRDLVAALIG QPATPQALVR
310 320 330
VGLAPEMEEP PPATPRRPID EVFHVRAKDH R
Length:331
Mass (Da):36,559
Last modified:April 16, 2014 - v1
Checksum:i8FF2A825CE90C6EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44805.1
PIRiG70942
RefSeqiNP_216548.1, NC_000962.3
WP_003410193.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP44805; CCP44805; Rv2032
GeneIDi887582
KEGGimtu:Rv2032

Similar proteinsi

Entry informationi

Entry nameiACG_MYCTU
AccessioniPrimary (citable) accession number: P9WIZ9
Secondary accession number(s): L0TB56, O53476, Q7D7L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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