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Protein

NADH-quinone oxidoreductase subunit A

Gene

nuoA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit AUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit AUniRule annotation
NDH-1 subunit AUniRule annotation
NUO1UniRule annotation
Gene namesi
Name:nuoAUniRule annotation
Ordered Locus Names:Rv3145
ORF Names:MTCY03A2.13c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3145.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei100 – 120HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001178701 – 128NADH-quinone oxidoreductase subunit AAdd BLAST128

Keywords - PTMi

Quinone

Proteomic databases

PaxDbiP9WIW7.

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi83332.Rv3145.

Structurei

3D structure databases

ProteinModelPortaliP9WIW7.
SMRiP9WIW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KWU. Bacteria.
COG0838. LUCA.
KOiK00330.
OMAiAYEWRRG.
PhylomeDBiP9WIW7.

Family and domain databases

HAMAPiMF_01394. NDH1_NuoA. 1 hit.
InterProiView protein in InterPro
IPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiView protein in Pfam
PF00507. Oxidored_q4. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WIW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVYIPILVL AALAAAFAVV SVVIASLVGP SRFNRSKQAA YECGIEPAST
60 70 80 90 100
GARTSIGPGA ASGQRFPIKY YLTAMLFIVF DIEIVFLYPW AVSYDSLGTF
110 120
ALVEMAIFML TVFVAYAYVW RRGGLTWD
Length:128
Mass (Da):13,975
Last modified:April 16, 2014 - v1
Checksum:iDDF4FD3F77A8149A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45956.1.
PIRiB70647.
RefSeqiNP_217661.1. NC_000962.3.
WP_003416417.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP45956; CCP45956; Rv3145.
GeneIDi887397.
KEGGimtu:Rv3145.

Similar proteinsi

Entry informationi

Entry nameiNUOA_MYCTU
AccessioniPrimary (citable) accession number: P9WIW7
Secondary accession number(s): L0TDA2, P65563, P95181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 5, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families