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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateBy similarity1
Metal bindingi36Divalent metal cationBy similarity1
Active sitei38Proton acceptorBy similarity1
Metal bindingi38Divalent metal cationBy similarity1
Metal bindingi69Divalent metal cationBy similarity1
Binding sitei69SubstrateBy similarity1
Active sitei178Proton donorBy similarity1
Metal bindingi178Divalent metal cationBy similarity1
Binding sitei180Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:Rv1408
ORF Names:MTCY21B4.25
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1408.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715781 – 229Ribulose-phosphate 3-epimeraseAdd BLAST229

Proteomic databases

PaxDbiP9WI51.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1408.

Structurei

3D structure databases

ProteinModelPortaliP9WI51.
SMRiP9WI51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 148Substrate bindingBy similarity4
Regioni200 – 201Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
KOiK01783.
OMAiCHLMIED.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiView protein in Pfam
PF00834. Ribul_P_3_epim. 1 hit.
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiView protein in PROSITE
PS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WI51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSTGGPLI APSILAADFA RLADEAAAVN GADWLHVDVM DGHFVPNLTI
60 70 80 90 100
GLPVVESLLA VTDIPMDCHL MIDNPDRWAP PYAEAGAYNV TFHAEATDNP
110 120 130 140 150
VGVARDIRAA GAKAGISVKP GTPLEPYLDI LPHFDTLLVM SVEPGFGGQR
160 170 180 190 200
FIPEVLSKVR AVRKMVDAGE LTILVEIDGG INDDTIEQAA EAGVDCFVAG
210 220
SAVYGADDPA AAVAALRRQA GAASLHLSL
Length:229
Mass (Da):23,774
Last modified:April 16, 2014 - v1
Checksum:i5C2E39D098490302
GO

Sequence cautioni

The sequence CCP44167 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44167.1. Different initiation.
PIRiE70901.
RefSeqiNP_215924.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP44167; CCP44167; Rv1408.
GeneIDi886702.
KEGGimtu:Rv1408.
PATRICifig|83332.12.peg.1573.

Similar proteinsi

Entry informationi

Entry nameiRPE_MYCTU
AccessioniPrimary (citable) accession number: P9WI51
Secondary accession number(s): L0T6S4, P65760, P71676
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 5, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families