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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
MTB-TRUB
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:Rv2793c
ORF Names:MTV002.58c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2793c

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001218721 – 298tRNA pseudouridine synthase BAdd BLAST298

Proteomic databases

PaxDbiP9WHP7
PRIDEiP9WHP7

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2793c

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi19 – 29Combined sources11
Beta strandi35 – 39Combined sources5
Beta strandi46 – 53Combined sources8
Helixi54 – 62Combined sources9
Turni63 – 65Combined sources3
Beta strandi68 – 76Combined sources9
Beta strandi78 – 80Combined sources3
Beta strandi89 – 92Combined sources4
Helixi100 – 109Combined sources10
Beta strandi112 – 114Combined sources3
Beta strandi148 – 161Combined sources14
Beta strandi164 – 174Combined sources11
Helixi179 – 189Combined sources11
Beta strandi194 – 204Combined sources11
Helixi209 – 211Combined sources3
Helixi215 – 220Combined sources6
Beta strandi225 – 227Combined sources3
Helixi228 – 235Combined sources8
Beta strandi236 – 240Combined sources5
Helixi243 – 250Combined sources8
Beta strandi264 – 267Combined sources4
Beta strandi273 – 280Combined sources8
Beta strandi283 – 290Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SGVX-ray1.90A/B1-298[»]
ProteinModelPortaliP9WHP7
SMRiP9WHP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T Bacteria
COG0130 LUCA
KOiK03177
OMAiVDCSKGT
PhylomeDBiP9WHP7

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01080 TruB_bact, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR015225 tRNA_psdUridine_synth_fam2_C
IPR014780 tRNA_psdUridine_synth_TruB
IPR032819 TruB_C
PANTHERiPTHR13767 PTHR13767, 1 hit
PfamiView protein in Pfam
PF09142 TruB_C, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00431 TruB, 1 hit

Sequencei

Sequence statusi: Complete.

P9WHP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGPGIVV IDKPAGMTSH DVVGRCRRIF ATRRVGHAGT LDPMATGVLV
60 70 80 90 100
IGIERATKIL GLLTAAPKSY AATIRLGQTT STEDAEGQVL QSVPAKHLTI
110 120 130 140 150
EAIDAAMERL RGEIRQVPSS VSAIKVGGRR AYRLARQGRS VQLEARPIRI
160 170 180 190 200
DRFELLAARR RDQLIDIDVE IDCSSGTYIR ALARDLGDAL GVGGHVTALR
210 220 230 240 250
RTRVGRFELD QARSLDDLAE RPALSLSLDE ACLLMFARRD LTAAEASAAA
260 270 280 290
NGRSLPAVGI DGVYAACDAD GRVIALLRDE GSRTRSVAVL RPATMHPG
Length:298
Mass (Da):31,820
Last modified:April 16, 2014 - v1
Checksum:i9F77797DC13B34C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45592.1
PIRiH70884
RefSeqiNP_217309.1, NC_000962.3
WP_003414147.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP45592; CCP45592; Rv2793c
GeneIDi888587
KEGGimtu:Rv2793c

Similar proteinsi

Entry informationi

Entry nameiTRUB_MYCTU
AccessioniPrimary (citable) accession number: P9WHP7
Secondary accession number(s): L0TDK3, O33335, P62190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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