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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
MTB-TRUB
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:Rv2793c
ORF Names:MTV002.58c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2793c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001218721 – 298tRNA pseudouridine synthase BAdd BLAST298

Proteomic databases

PaxDbiP9WHP7.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2793c.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi19 – 29Combined sources11
Beta strandi35 – 39Combined sources5
Beta strandi46 – 53Combined sources8
Helixi54 – 62Combined sources9
Turni63 – 65Combined sources3
Beta strandi68 – 76Combined sources9
Beta strandi78 – 80Combined sources3
Beta strandi89 – 92Combined sources4
Helixi100 – 109Combined sources10
Beta strandi112 – 114Combined sources3
Beta strandi148 – 161Combined sources14
Beta strandi164 – 174Combined sources11
Helixi179 – 189Combined sources11
Beta strandi194 – 204Combined sources11
Helixi209 – 211Combined sources3
Helixi215 – 220Combined sources6
Beta strandi225 – 227Combined sources3
Helixi228 – 235Combined sources8
Beta strandi236 – 240Combined sources5
Helixi243 – 250Combined sources8
Beta strandi264 – 267Combined sources4
Beta strandi273 – 280Combined sources8
Beta strandi283 – 290Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SGVX-ray1.90A/B1-298[»]
ProteinModelPortaliP9WHP7.
SMRiP9WHP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
KOiK03177.
OMAiKEYISEF.
PhylomeDBiP9WHP7.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR015947. PUA-like_domain.
IPR015225. tRNA_psdUridine_synth_fam2_C.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09142. TruB_C. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WHP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGPGIVV IDKPAGMTSH DVVGRCRRIF ATRRVGHAGT LDPMATGVLV
60 70 80 90 100
IGIERATKIL GLLTAAPKSY AATIRLGQTT STEDAEGQVL QSVPAKHLTI
110 120 130 140 150
EAIDAAMERL RGEIRQVPSS VSAIKVGGRR AYRLARQGRS VQLEARPIRI
160 170 180 190 200
DRFELLAARR RDQLIDIDVE IDCSSGTYIR ALARDLGDAL GVGGHVTALR
210 220 230 240 250
RTRVGRFELD QARSLDDLAE RPALSLSLDE ACLLMFARRD LTAAEASAAA
260 270 280 290
NGRSLPAVGI DGVYAACDAD GRVIALLRDE GSRTRSVAVL RPATMHPG
Length:298
Mass (Da):31,820
Last modified:April 16, 2014 - v1
Checksum:i9F77797DC13B34C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45592.1.
PIRiH70884.
RefSeqiNP_217309.1. NC_000962.3.
WP_003414147.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP45592; CCP45592; Rv2793c.
GeneIDi888587.
KEGGimtu:Rv2793c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45592.1.
PIRiH70884.
RefSeqiNP_217309.1. NC_000962.3.
WP_003414147.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SGVX-ray1.90A/B1-298[»]
ProteinModelPortaliP9WHP7.
SMRiP9WHP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2793c.

Proteomic databases

PaxDbiP9WHP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45592; CCP45592; Rv2793c.
GeneIDi888587.
KEGGimtu:Rv2793c.

Organism-specific databases

TubercuListiRv2793c.

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
KOiK03177.
OMAiKEYISEF.
PhylomeDBiP9WHP7.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7042-MONOMER.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR015947. PUA-like_domain.
IPR015225. tRNA_psdUridine_synth_fam2_C.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09142. TruB_C. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB_MYCTU
AccessioniPrimary (citable) accession number: P9WHP7
Secondary accession number(s): L0TDK3, O33335, P62190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.