Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P9WHN4

- PUP_MYCTO

UniProt

P9WHN4 - PUP_MYCTO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Prokaryotic ubiquitin-like protein Pup

Gene

pup

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins By similarity.By similarity

Pathwayi

GO - Molecular functioni

  1. protein tag Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
  3. protein pupylation Source: UniProtKB-HAMAP
Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokaryotic ubiquitin-like protein Pup
Alternative name(s):
Bacterial ubiquitin-like modifier
Gene namesi
Name:pup
Ordered Locus Names:MT2171
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001020: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464Prokaryotic ubiquitin-like protein PupPRO_0000428154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Deamidated glutamineBy similarity

Post-translational modificationi

Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.By similarity

Interactioni

Subunit structurei

Strongly interacts with the proteasome-associated ATPase ARC (Mpa) through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WHN4.
SMRiP9WHN4. Positions 39-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 5838Mpa/ARC ATPase bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili23 – 5230Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

KOiK13570.

Family and domain databases

HAMAPiMF_02106. Pup.
InterProiIPR008515. Ubiquitin-like_Pup.
[Graphical view]
PfamiPF05639. Pup. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03687. pupylate_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WHN4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQEQTKRGG GGGDDDDIAG STAAGQERRE KLTEETDDLL DEIDDVLEEN
60
AEDFVRAYVQ KGGQ
Length:64
Mass (Da):6,944
Last modified:April 16, 2014 - v1
Checksum:i7D958B770D8766E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000516 Genomic DNA. Translation: AAK46454.1.
PIRiB70512.
RefSeqiNP_336640.1. NC_002755.2.

Genome annotation databases

GeneIDi924534.
KEGGimtc:MT2171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000516 Genomic DNA. Translation: AAK46454.1 .
PIRi B70512.
RefSeqi NP_336640.1. NC_002755.2.

3D structure databases

ProteinModelPortali P9WHN4.
SMRi P9WHN4. Positions 39-64.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 924534.
KEGGi mtc:MT2171.

Phylogenomic databases

KOi K13570.

Enzyme and pathway databases

UniPathwayi UPA00997 .

Family and domain databases

HAMAPi MF_02106. Pup.
InterProi IPR008515. Ubiquitin-like_Pup.
[Graphical view ]
Pfami PF05639. Pup. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03687. pupylate_cterm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 1551 / Oshkosh.

Entry informationi

Entry nameiPUP_MYCTO
AccessioniPrimary (citable) accession number: P9WHN4
Secondary accession number(s): B6DAC1
, L0TBK1, O33246, Q7D7I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 29, 2014
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3