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P9WHN4

- PUP_MYCTO

UniProt

P9WHN4 - PUP_MYCTO

Protein

Prokaryotic ubiquitin-like protein Pup

Gene

pup

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. protein tag Source: UniProtKB-HAMAP

    GO - Biological processi

    1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
    2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
    3. protein pupylation Source: UniProtKB-HAMAP

    Enzyme and pathway databases

    UniPathwayiUPA00997.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prokaryotic ubiquitin-like protein Pup
    Alternative name(s):
    Bacterial ubiquitin-like modifier
    Gene namesi
    Name:pup
    Ordered Locus Names:MT2171
    OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
    Taxonomic identifieri83331 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001020: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6464Prokaryotic ubiquitin-like protein PupPRO_0000428154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641Deamidated glutamineBy similarity

    Post-translational modificationi

    Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.By similarity

    Interactioni

    Subunit structurei

    Strongly interacts with the proteasome-associated ATPase ARC (Mpa) through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP9WHN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 5838Mpa/ARC ATPase bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili23 – 5230Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    KOiK13570.

    Family and domain databases

    HAMAPiMF_02106. Pup.
    InterProiIPR008515. Ubiquitin-like_Pup.
    [Graphical view]
    PfamiPF05639. Pup. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03687. pupylate_cterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P9WHN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQEQTKRGG GGGDDDDIAG STAAGQERRE KLTEETDDLL DEIDDVLEEN   50
    AEDFVRAYVQ KGGQ 64
    Length:64
    Mass (Da):6,944
    Last modified:April 16, 2014 - v1
    Checksum:i7D958B770D8766E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK46454.1.
    PIRiB70512.
    RefSeqiNP_336640.1. NC_002755.2.

    Genome annotation databases

    GeneIDi924534.
    KEGGimtc:MT2171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK46454.1 .
    PIRi B70512.
    RefSeqi NP_336640.1. NC_002755.2.

    3D structure databases

    ProteinModelPortali P9WHN4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 924534.
    KEGGi mtc:MT2171.

    Phylogenomic databases

    KOi K13570.

    Enzyme and pathway databases

    UniPathwayi UPA00997 .

    Family and domain databases

    HAMAPi MF_02106. Pup.
    InterProi IPR008515. Ubiquitin-like_Pup.
    [Graphical view ]
    Pfami PF05639. Pup. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03687. pupylate_cterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 1551 / Oshkosh.

    Entry informationi

    Entry nameiPUP_MYCTO
    AccessioniPrimary (citable) accession number: P9WHN4
    Secondary accession number(s): B6DAC1
    , L0TBK1, O33246, Q7D7I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 6 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3