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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Substrate; shared with dimeric partnerBy similarity1
Binding sitei152SubstrateBy similarity1
Binding sitei176SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:Rv1379
ORF Names:MTCY02B12.13
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1379.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830461 – 193Bifunctional protein PyrRAdd BLAST193

Proteomic databases

PaxDbiP9WHK3.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1379.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 17Combined sources5
Helixi19 – 36Combined sources18
Turni37 – 40Combined sources4
Beta strandi50 – 54Combined sources5
Helixi58 – 74Combined sources17
Beta strandi79 – 82Combined sources4
Helixi86 – 88Combined sources3
Beta strandi114 – 125Combined sources12
Helixi126 – 138Combined sources13
Beta strandi142 – 151Combined sources10
Beta strandi156 – 159Combined sources4
Beta strandi162 – 167Combined sources6
Beta strandi175 – 179Combined sources5
Helixi181 – 184Combined sources4
Beta strandi188 – 192Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W30X-ray1.90A/B1-193[»]
5IAOX-ray2.60A/B/C/D/E/F1-193[»]
ProteinModelPortaliP9WHK3.
SMRiP9WHK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 58Substrate-bindingBy similarity2
Regioni119 – 127Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi115 – 127PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
KOiK02825.
OMAiLMDMGRP.
PhylomeDBiP9WHK3.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAGDAAIG RESRELMSAA DVGRTISRIA HQIIEKTALD DPVGPDAPRV
60 70 80 90 100
VLLGIPTRGV TLANRLAGNI TEYSGIHVGH GALDITLYRD DLMIKPPRPL
110 120 130 140 150
ASTSIPAGGI DDALVILVDD VLYSGRSVRS ALDALRDVGR PRAVQLAVLV
160 170 180 190
DRGHRELPLR ADYVGKNVPT SRSESVHVRL REHDGRDGVV ISR
Length:193
Mass (Da):20,627
Last modified:April 16, 2014 - v1
Checksum:i07A499B7D4E66159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44138.1.
PIRiH70958.
RefSeqiNP_215895.1. NC_000962.3.
WP_003407196.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44138; CCP44138; Rv1379.
GeneIDi886769.
KEGGimtu:Rv1379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44138.1.
PIRiH70958.
RefSeqiNP_215895.1. NC_000962.3.
WP_003407196.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W30X-ray1.90A/B1-193[»]
5IAOX-ray2.60A/B/C/D/E/F1-193[»]
ProteinModelPortaliP9WHK3.
SMRiP9WHK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1379.

Proteomic databases

PaxDbiP9WHK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44138; CCP44138; Rv1379.
GeneIDi886769.
KEGGimtu:Rv1379.

Organism-specific databases

TubercuListiRv1379.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
KOiK02825.
OMAiLMDMGRP.
PhylomeDBiP9WHK3.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5562-MONOMER.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_MYCTU
AccessioniPrimary (citable) accession number: P9WHK3
Secondary accession number(s): L0T9G5, P65941, P71807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.