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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate; shared with dimeric partnerBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei176 – 1761SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:Rv1379
ORF Names:MTCY02B12.13
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1379.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Bifunctional protein PyrRPRO_0000183046Add
BLAST

Proteomic databases

PaxDbiP9WHK3.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1379.

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 175Combined sources
Helixi19 – 3618Combined sources
Turni37 – 404Combined sources
Beta strandi50 – 545Combined sources
Helixi58 – 7417Combined sources
Beta strandi79 – 824Combined sources
Helixi86 – 883Combined sources
Beta strandi114 – 12512Combined sources
Helixi126 – 13813Combined sources
Beta strandi142 – 15110Combined sources
Beta strandi156 – 1594Combined sources
Beta strandi162 – 1676Combined sources
Beta strandi175 – 1795Combined sources
Helixi181 – 1844Combined sources
Beta strandi188 – 1925Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W30X-ray1.90A/B1-193[»]
5IAOX-ray2.60A/B/C/D/E/F1-193[»]
ProteinModelPortaliP9WHK3.
SMRiP9WHK3. Positions 12-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 582Substrate-bindingBy similarity
Regioni119 – 1279Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 12713PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
KOiK02825.
OMAiVPTSRKE.
PhylomeDBiP9WHK3.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAGDAAIG RESRELMSAA DVGRTISRIA HQIIEKTALD DPVGPDAPRV
60 70 80 90 100
VLLGIPTRGV TLANRLAGNI TEYSGIHVGH GALDITLYRD DLMIKPPRPL
110 120 130 140 150
ASTSIPAGGI DDALVILVDD VLYSGRSVRS ALDALRDVGR PRAVQLAVLV
160 170 180 190
DRGHRELPLR ADYVGKNVPT SRSESVHVRL REHDGRDGVV ISR
Length:193
Mass (Da):20,627
Last modified:April 16, 2014 - v1
Checksum:i07A499B7D4E66159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44138.1.
PIRiH70958.
RefSeqiNP_215895.1. NC_000962.3.
WP_003407196.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44138; CCP44138; Rv1379.
GeneIDi886769.
KEGGimtu:Rv1379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44138.1.
PIRiH70958.
RefSeqiNP_215895.1. NC_000962.3.
WP_003407196.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W30X-ray1.90A/B1-193[»]
5IAOX-ray2.60A/B/C/D/E/F1-193[»]
ProteinModelPortaliP9WHK3.
SMRiP9WHK3. Positions 12-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1379.

Proteomic databases

PaxDbiP9WHK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44138; CCP44138; Rv1379.
GeneIDi886769.
KEGGimtu:Rv1379.

Organism-specific databases

TubercuListiRv1379.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
KOiK02825.
OMAiVPTSRKE.
PhylomeDBiP9WHK3.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiPYRR_MYCTU
AccessioniPrimary (citable) accession number: P9WHK3
Secondary accession number(s): L0T9G5, P65941, P71807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 11, 2016
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.