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Protein

Ribosomal RNA small subunit methyltransferase G

Gene

rsmG

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei74S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei137S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase GUniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
16S rRNA 7-methylguanosine methyltransferaseUniRule annotation
Short name:
16S rRNA m7G methyltransferaseUniRule annotation
Glucose-inhibited division protein B
Gene namesi
Name:rsmGUniRule annotation
Synonyms:gidB
Ordered Locus Names:Rv3919c
ORF Names:MTV028.10c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3919c.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: GO_Central
  • plasma membrane Source: MTBBASE

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Confers low-level streptomycin resistance. Seems to be an important cause of resistance in resistant M.tuberculosis isolates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001842831 – 224Ribosomal RNA small subunit methyltransferase GAdd BLAST224

Proteomic databases

PaxDbiP9WGW9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3919c.

Structurei

3D structure databases

ProteinModelPortaliP9WGW9.
SMRiP9WGW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 120S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0357. LUCA.
KOiK03501.

Family and domain databases

HAMAPiMF_00074. 16SrRNA_methyltr_G. 1 hit.
InterProiView protein in InterPro
IPR003682. rRNA_ssu_MeTfrase_G.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR31760. PTHR31760. 1 hit.
PfamiView protein in Pfam
PF02527. GidB. 1 hit.
PIRSFiPIRSF003078. GidB. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00138. rsmG_gidB. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WGW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPIEPAASA IFGPRLGLAR RYAEALAGPG VERGLVGPRE VGRLWDRHLL
60 70 80 90 100
NCAVIGELLE RGDRVVDIGS GAGLPGVPLA IARPDLQVVL LEPLLRRTEF
110 120 130 140 150
LREMVTDLGV AVEIVRGRAE ESWVQDQLGG SDAAVSRAVA ALDKLTKWSM
160 170 180 190 200
PLIRPNGRML AIKGERAHDE VREHRRVMIA SGAVDVRVVT CGANYLRPPA
210 220
TVVFARRGKQ IARGSARMAS GGTA
Length:224
Mass (Da):24,032
Last modified:April 16, 2014 - v1
Checksum:iB56E90FBF91A1DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ611141 Genomic DNA. Translation: ADU15870.1.
AL123456 Genomic DNA. Translation: CCP46748.1.
PIRiG70851.
RefSeqiNP_218436.2. NC_000962.3.
WP_003899763.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiCCP46748; CCP46748; Rv3919c.
GeneIDi886243.
KEGGimtu:Rv3919c.
mtv:RVBD_3919c.
PATRICifig|83332.111.peg.4365.

Similar proteinsi

Entry informationi

Entry nameiRSMG_MYCTU
AccessioniPrimary (citable) accession number: P9WGW9
Secondary accession number(s): E7E4Z6, O53597
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 5, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families