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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1222387. Tolerance of reactive oxygen produced by macrophages.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:Rv0732
ORF Names:MTV041.06
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0732.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalUniRule annotationAdd
BLAST
Transmembranei78 – 9821HelicalUniRule annotationAdd
BLAST
Transmembranei124 – 14421HelicalUniRule annotationAdd
BLAST
Transmembranei157 – 17721HelicalUniRule annotationAdd
BLAST
Transmembranei180 – 20021HelicalUniRule annotationAdd
BLAST
Transmembranei215 – 23521HelicalUniRule annotationAdd
BLAST
Transmembranei272 – 29221HelicalUniRule annotationAdd
BLAST
Transmembranei318 – 33821HelicalUniRule annotationAdd
BLAST
Transmembranei382 – 40221HelicalUniRule annotationAdd
BLAST
Transmembranei403 – 42321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Protein translocase subunit SecYPRO_0000131732Add
BLAST

Proteomic databases

PaxDbiP9WGN3.

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi83332.Rv0732.

Structurei

3D structure databases

ProteinModelPortaliP9WGN3.
SMRiP9WGN3. Positions 13-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiP9WGN3.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P9WGN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAFISSLR TVDLRRKILF TLGIVILYRV GAALPSPGVN FPNVQQCIKE
60 70 80 90 100
ASAGEAGQIY SLINLFSGGA LLKLTVFAVG VMPYITASII VQLLTVVIPR
110 120 130 140 150
FEELRKEGQA GQSKMTQYTR YLAIALAILQ ATSIVALAAN GGLLQGCSLD
160 170 180 190 200
IIADQSIFTL VVIVLVMTGG AALVMWMGEL ITERGIGNGM SLLIFVGIAA
210 220 230 240 250
RIPAEGQSIL ESRGGVVFTA VCAAALIIIV GVVFVEQGQR RIPVQYAKRM
260 270 280 290 300
VGRRMYGGTS TYLPLKVNQA GVIPVIFASS LIYIPHLITQ LIRSGSGVVG
310 320 330 340 350
NSWWDKFVGT YLSDPSNLVY IGIYFGLIIF FTYFYVSITF NPDERADEMK
360 370 380 390 400
KFGGFIPGIR PGRPTADYLR YVLSRITLPG SIYLGVIAVL PNLFLQIGAG
410 420 430 440
GTVQNLPFGG TAVLIMIGVG LDTVKQIESQ LMQRNYEGFL K
Length:441
Mass (Da):47,611
Last modified:April 16, 2014 - v1
Checksum:i447C85AA879FEBF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43477.1.
PIRiG70822.
RefSeqiNP_215246.1. NC_000962.3.
WP_003403723.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43477; CCP43477; Rv0732.
GeneIDi888559.
KEGGimtu:Rv0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43477.1.
PIRiG70822.
RefSeqiNP_215246.1. NC_000962.3.
WP_003403723.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP9WGN3.
SMRiP9WGN3. Positions 13-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0732.

Proteomic databases

PaxDbiP9WGN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43477; CCP43477; Rv0732.
GeneIDi888559.
KEGGimtu:Rv0732.

Organism-specific databases

TubercuListiRv0732.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiP9WGN3.

Enzyme and pathway databases

ReactomeiR-HSA-1222387. Tolerance of reactive oxygen produced by macrophages.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_MYCTU
AccessioniPrimary (citable) accession number: P9WGN3
Secondary accession number(s): L0T7J9, P0A5Z2, P94926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 8, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.