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Protein

Cytochrome c

Gene

CYCS

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Heme (covalent)1
Binding sitei18Heme (covalent)1
Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYCS
Synonyms:CYC
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001082272 – 105Cytochrome cAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei49PhosphotyrosineBy similarity1
Modified residuei56N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysine; alternateBy similarity1
Modified residuei73N6-succinyllysine; alternateBy similarity1
Modified residuei98PhosphotyrosineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP99998.
PRIDEiP99998.

Expressioni

Gene expression databases

BgeeiENSPTRG00000018996.

Interactioni

Protein-protein interaction databases

MINTiMINT-144816.
STRINGi9598.ENSPTRP00000032465.

Structurei

3D structure databases

ProteinModelPortaliP99998.
SMRiP99998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP99998.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P99998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT
60 70 80 90 100
AANKNKGIIW GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK

KATNE
Length:105
Mass (Da):11,749
Last modified:January 23, 2007 - v2
Checksum:i8EE9689E0102506B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268594 Genomic DNA. Translation: AAP49489.1.
PIRiA00002. CCCZ.
RefSeqiNP_001065289.1. NM_001071821.1.
XP_001140708.1. XM_001140708.5.
XP_009450812.1. XM_009452537.2.
XP_016802858.1. XM_016947369.1.
XP_016812394.1. XM_016956905.1.
UniGeneiPtr.6290.

Genome annotation databases

EnsembliENSPTRT00000035122; ENSPTRP00000032465; ENSPTRG00000018996.
GeneIDi107972632.
738805.
744779.
KEGGiptr:738805.
ptr:744779.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268594 Genomic DNA. Translation: AAP49489.1.
PIRiA00002. CCCZ.
RefSeqiNP_001065289.1. NM_001071821.1.
XP_001140708.1. XM_001140708.5.
XP_009450812.1. XM_009452537.2.
XP_016802858.1. XM_016947369.1.
XP_016812394.1. XM_016956905.1.
UniGeneiPtr.6290.

3D structure databases

ProteinModelPortaliP99998.
SMRiP99998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-144816.
STRINGi9598.ENSPTRP00000032465.

Proteomic databases

PaxDbiP99998.
PRIDEiP99998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000035122; ENSPTRP00000032465; ENSPTRG00000018996.
GeneIDi107972632.
738805.
744779.
KEGGiptr:738805.
ptr:744779.

Organism-specific databases

CTDi54205.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP99998.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Gene expression databases

BgeeiENSPTRG00000018996.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_PANTR
AccessioniPrimary (citable) accession number: P99998
Secondary accession number(s): P00001, Q96BV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.