Reviewed, UniProtKB/Swiss-Prot P99507 (SUCB1_CANFA)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
    EC=6.2.1.5
Alternative name(s):
    ATP-specific succinyl-CoA synthetase subunit beta
    Succinyl-CoA synthetase beta-A chain
      Short name=SCS-betaA

Gene names

Name:

SUCLA2

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial		PRO_0000102813
Regions
	Domain	8 – ›20	›13	ATP-grasp
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P99507-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: BE8AEFD54DBDAC2E	FASTA	20	2,248
	10 20 LSLHEYMSME LLQEAGVSIP

References

[1]	"HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins." Dunn M.J., Corbett J.M., Wheeler C.H. Electrophoresis 18:2795-2802(1997) [PubMed: 9504812] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.

Cross-references

3D structure databases
ModBase	Search...
2-D gel databases
HSC-2DPAGE	P99507.
Phylogenomic databases
HOVERGEN	P99507.
Enzyme and pathway databases
BRENDA	6.2.1.5. 463.
Family and domain databases
InterPro	IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. [Graphical view]
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
PROSITE	PS50975. ATP_GRASP. Partial match. PS01217. SUCCINYL_COA_LIG_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCB1_CANFA

Accession

Primary (citable) accession number: P99507

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)