P99507 (SUCB1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
EC=6.2.1.5

Alternative name(s):
ATP-specific succinyl-CoA synthetase subunit beta
Succinyl-CoA synthetase beta-A chain
Short name=SCS-betaA

Gene names

Name:

SUCLA2

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA By similarity.
Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial		PRO_0000102813
Regions
	Domain	8 – ›20	›13	ATP-grasp
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P99507 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: BE8AEFD54DBDAC2E	FASTA	20	2,248
	10 20 LSLHEYMSME LLQEAGVSIP

References

[1]	"HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins." Dunn M.J., Corbett J.M., Wheeler C.H. Electrophoresis 18:2795-2802(1997) [PubMed: 9504812] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.

Cross-references

3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P99507.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	maNOG12224.
Family and domain databases
PROSITE	PS50975. ATP_GRASP. Partial match. PS01217. SUCCINYL_COA_LIG_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCB1_CANFA

Accession

Primary (citable) accession number: P99507

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	October 19, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program