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Protein

Probable cysteine desulfurase

Gene

csd

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.By similarity

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 3681Cysteine persulfide intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-820-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cysteine desulfurase (EC:2.8.1.7)
Gene namesi
Name:csd
Ordered Locus Names:SA0776
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Probable cysteine desulfurasePRO_0000150311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N6-(pyridoxal phosphate)lysineBy similarity

2D gel databases

SWISS-2DPAGEP99177.

Structurei

3D structure databases

ProteinModelPortaliP99177.
SMRiP99177. Positions 11-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000017511.
OMAiAEKVHGK.
OrthoDBiEOG68DD0M.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.

Sequencei

Sequence statusi: Complete.

P99177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHSFDVNE VIKDFPILDQ KVNGKRLAYL DSTATSQTPM QVLNVLEDYY
60 70 80 90 100
KRYNSNVHRG VHTLGSLATD GYENARETVR RFINAKYFEE IIFTRGTTAS
110 120 130 140 150
INLVAHSYGD ANVEEGDEIV VTEMEHHANI VPWQQLAKRK NATLKFIPMT
160 170 180 190 200
ADGELNIEDI KQTINDKTKI VAIAHISNVL GTINDVKTIA EIAHQHGAII
210 220 230 240 250
SVDGAQAAPH MKLDMQEMNA DFYSFSGHKM LGPTGIGVLF GKRELLQKME
260 270 280 290 300
PIEFGGDMID FVSKYDATWA DLPTKFEAGT PLIAQAIGLA EAIRYLERIG
310 320 330 340 350
FDAIHKYEQE LTIYAYEQMS AIEGIEIYGP PKDRRAGVIT FNLQDVHPHD
360 370 380 390 400
VATAVDTEGV AVRAGHHCAQ PLMKWLNVSS TARASFYIYN TKEDIDQLIN
410
ALKQTKEFFS YEF
Length:413
Mass (Da):46,322
Last modified:October 11, 2004 - v1
Checksum:iCE1E87F33391F6D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42015.1.
PIRiD89857.
RefSeqiWP_000807663.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42015; BAB42015; BAB42015.
PATRICi19573716. VBIStaAur116463_0830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42015.1.
PIRiD89857.
RefSeqiWP_000807663.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP99177.
SMRiP99177. Positions 11-410.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

SWISS-2DPAGEP99177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42015; BAB42015; BAB42015.
PATRICi19573716. VBIStaAur116463_0830.

Phylogenomic databases

HOGENOMiHOG000017511.
OMAiAEKVHGK.
OrthoDBiEOG68DD0M.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-820-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiCSD_STAAN
AccessioniPrimary (citable) accession number: P99177
Secondary accession number(s): Q99VG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.