ID   DEOC2_STAAN             Reviewed;         220 AA.
AC   P99174; Q99SC2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Deoxyribose-phosphate aldolase 2;
DE            EC=4.1.2.4;
DE   AltName: Full=Phosphodeoxyriboaldolase 2;
DE            Short=Deoxyriboaldolase 2;
DE            Short=DERA 2;
GN   Name=deoC2; OrderedLocusNames=SA1939;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21311952; PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=15590099; DOI=10.1016/j.mimet.2004.09.017;
RA   Scherl A., Francois P., Bento M., Deshusses J.M., Charbonnier Y.,
RA   Converset V., Huyghe A., Walter N., Hoogland C., Appel R.D.,
RA   Sanchez J.-C., Zimmermann-Ivol C.G., Corthals G.L., Hochstrasser D.F.,
RA   Schrenzel J.;
RT   "Correlation of proteomic and transcriptomic profiles of
RT   Staphylococcus aureus during the post-exponential phase of growth.";
RL   J. Microbiol. Methods 60:247-257(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of
RT   S. aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: 2-deoxy-D-ribose 5-phosphate = D-
CC       glyceraldehyde 3-phosphate + acetaldehyde.
CC   -!- PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate
CC       degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-
CC       deoxy-D-ribose 1-phosphate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the deoC/fbaB aldolase family. DeoC type 1
CC       subfamily.
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DR   EMBL; BA000018; BAB43223.1; -; Genomic_DNA.
DR   PIR; F90007; F90007.
DR   RefSeq; NP_375244.1; -.
DR   HSSP; Q9X1P5; 1O0Y.
DR   SWISS-2DPAGE; P99174; -.
DR   GeneID; 1124840; -.
DR   GenomeReviews; BA000018_GR; SA1939.
DR   KEGG; sau:SA1939; -.
DR   HOGENOM; P99174; -.
DR   OMA; P99174; FPSGKHH.
DR   BioCyc; SAUR158879:SA1939-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004139; F:deoxyribose-phosphate aldolase activity; IEA:HAMAP.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:HAMAP.
DR   GO; GO:0009264; P:deoxyribonucleotide catabolic process; IEA:InterPro.
DR   HAMAP; MF_00114; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011343; DeoC.
DR   InterPro; IPR002915; DeoC/AroFGH_arch.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR10889; DeoC; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF001357; DeoC; 1.
DR   TIGRFAMs; TIGR00126; deoC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Lyase; Schiff base.
FT   CHAIN         1    220       Deoxyribose-phosphate aldolase 2.
FT                                /FTId=PRO_0000057260.
FT   ACT_SITE    151    151       Schiff-base intermediate with
FT                                acetaldehyde (By similarity).
FT   ACT_SITE    180    180       By similarity.
SQ   SEQUENCE   220 AA;  23341 MW;  4C658CF15A637077 CRC64;
     MNSAKLIDHT LLKPESTRTQ IDQIIDEAKA YHFKSVCVNP THVKYAAERL ADSEVLVCTV
     IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG RFDDVQQDIE AVVKAAKGHT
     VKVIIETVLL DHDEIVKASE LTKVAGADFV KTSTGFAGGG ATAEDVKLMK DTVGADVEVK
     ASGGVRNLED FNKMVEAGAT RIGASAGVQI MQGLEADSDY
//