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Protein

Elongation factor Tu

Gene

tuf

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPUniRule annotation8
Nucleotide bindingi81 – 85GTPUniRule annotation5
Nucleotide bindingi136 – 139GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Synonyms:tufA
Ordered Locus Names:SA0506
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000913911 – 394Elongation factor TuAdd BLAST394

Proteomic databases

PRIDEiP99152

2D gel databases

SWISS-2DPAGEiP99152

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP99152
SMRiP99152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 204tr-type GAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 26G1By similarity8
Regioni60 – 64G2By similarity5
Regioni81 – 84G3By similarity4
Regioni136 – 139G4By similarity4
Regioni174 – 176G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229290
KOiK02358
OMAiYGHIDCP

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P99152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKFDRSK EHANIGTIGH VDHGKTTLTA AIATVLAKNG DSVAQSYDMI
60 70 80 90 100
DNAPEEKERG ITINTSHIEY QTDKRHYAHV DCPGHADYVK NMITGAAQMD
110 120 130 140 150
GGILVVSAAD GPMPQTREHI LLSRNVGVPA LVVFLNKVDM VDDEELLELV
160 170 180 190 200
EMEVRDLLSE YDFPGDDVPV IAGSALKALE GDAQYEEKIL ELMEAVDTYI
210 220 230 240 250
PTPERDSDKP FMMPVEDVFS ITGRGTVATG RVERGQIKVG EEVEIIGLHD
260 270 280 290 300
TSKTTVTGVE MFRKLLDYAE AGDNIGALLR GVAREDVQRG QVLAAPGSIT
310 320 330 340 350
PHTEFKAEVY VLSKDEGGRH TPFFSNYRPQ FYFRTTDVTG VVHLPEGTEM
360 370 380 390
VMPGDNVEMT VELIAPIAIE DGTRFSIREG GRTVGSGVVT EIIK
Length:394
Mass (Da):43,104
Last modified:October 11, 2004 - v1
Checksum:iA107A786B452C03A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB41737.1
PIRiF89822
RefSeqiWP_001040568.1, NC_002745.2

Genome annotation databases

EnsemblBacteriaiBAB41737; BAB41737; BAB41737
KEGGisau:SA0506

Similar proteinsi

Entry informationi

Entry nameiEFTU_STAAN
AccessioniPrimary (citable) accession number: P99152
Secondary accession number(s): Q99W61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health