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P99152

- EFTU_STAAN

UniProt

P99152 - EFTU_STAAN

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Protein

Elongation factor Tu

Gene
tuf, tufA, SA0506
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-540-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf
Synonyms:tufA
Ordered Locus Names:SA0506
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuUniRule annotationPRO_0000091391Add
BLAST

Proteomic databases

PRIDEiP99152.

2D gel databases

SWISS-2DPAGEP99152.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi158879.SA0506.

Structurei

3D structure databases

ProteinModelPortaliP99152.
SMRiP99152. Positions 9-393.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P99152-1 [UniParc]FASTAAdd to Basket

« Hide

MAKEKFDRSK EHANIGTIGH VDHGKTTLTA AIATVLAKNG DSVAQSYDMI    50
DNAPEEKERG ITINTSHIEY QTDKRHYAHV DCPGHADYVK NMITGAAQMD 100
GGILVVSAAD GPMPQTREHI LLSRNVGVPA LVVFLNKVDM VDDEELLELV 150
EMEVRDLLSE YDFPGDDVPV IAGSALKALE GDAQYEEKIL ELMEAVDTYI 200
PTPERDSDKP FMMPVEDVFS ITGRGTVATG RVERGQIKVG EEVEIIGLHD 250
TSKTTVTGVE MFRKLLDYAE AGDNIGALLR GVAREDVQRG QVLAAPGSIT 300
PHTEFKAEVY VLSKDEGGRH TPFFSNYRPQ FYFRTTDVTG VVHLPEGTEM 350
VMPGDNVEMT VELIAPIAIE DGTRFSIREG GRTVGSGVVT EIIK 394
Length:394
Mass (Da):43,104
Last modified:October 11, 2004 - v1
Checksum:iA107A786B452C03A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB41737.1.
PIRiF89822.
RefSeqiNP_373759.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41737; BAB41737; BAB41737.
GeneIDi1123311.
KEGGisau:SA0506.
PATRICi19573124. VBIStaAur116463_0532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB41737.1 .
PIRi F89822.
RefSeqi NP_373759.1. NC_002745.2.

3D structure databases

ProteinModelPortali P99152.
SMRi P99152. Positions 9-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0506.

2D gel databases

SWISS-2DPAGE P99152.

Proteomic databases

PRIDEi P99152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB41737 ; BAB41737 ; BAB41737 .
GeneIDi 1123311.
KEGGi sau:SA0506.
PATRICi 19573124. VBIStaAur116463_0532.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-540-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiEFTU_STAAN
AccessioniPrimary (citable) accession number: P99152
Secondary accession number(s): Q99W61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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