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P99117

- ALF1_STAAN

UniProt

P99117 - ALF1_STAAN

Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751Proton acceptorBy similarity
    Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-2562-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolase
    Gene namesi
    Name:fda
    Ordered Locus Names:SA2399
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 296295Fructose-bisphosphate aldolase class 1PRO_0000216905Add
    BLAST

    Proteomic databases

    PRIDEiP99117.

    2D gel databases

    SWISS-2DPAGEP99117.

    PTM databases

    PhosSiteiP0909757.

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA2399.

    Structurei

    3D structure databases

    ProteinModelPortaliP99117.
    SMRiP99117. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    HOGENOMiHOG000073502.
    KOiK01623.
    OMAiYTGDYLA.
    OrthoDBiEOG6M6JJT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00729. FBP_aldolase_1.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P99117-1 [UniParc]FASTAAdd to Basket

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    MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV    50
    HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTADY LADKGVVPFL 100
    KVDKGLAEEQ NGVQLMKPID NLDSLLDRAN ERHIFGTKMR SNILELNEQG 150
    IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI NAKDKAEIEK VLKAELKKGL 200
    DSLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG YSREKANELL 250
    KDNDELIASF SRALASDLRA DQSKEEFDKA LGDAVESIYD ASVNKN 296
    Length:296
    Mass (Da):33,042
    Last modified:January 23, 2007 - v2
    Checksum:iD63B1A3C7646725B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43704.1.
    PIRiF90067.
    RefSeqiNP_375725.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB43704; BAB43704; BAB43704.
    GeneIDi1125328.
    KEGGisau:SA2399.
    PATRICi19577364. VBIStaAur116463_2600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43704.1 .
    PIRi F90067.
    RefSeqi NP_375725.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali P99117.
    SMRi P99117. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA2399.

    PTM databases

    PhosSitei P0909757.

    2D gel databases

    SWISS-2DPAGE P99117.

    Proteomic databases

    PRIDEi P99117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB43704 ; BAB43704 ; BAB43704 .
    GeneIDi 1125328.
    KEGGi sau:SA2399.
    PATRICi 19577364. VBIStaAur116463_2600.

    Phylogenomic databases

    eggNOGi COG3588.
    HOGENOMi HOG000073502.
    KOi K01623.
    OMAi YTGDYLA.
    OrthoDBi EOG6M6JJT.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci SAUR158879:GJCB-2562-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00729. FBP_aldolase_1.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: N315.
    3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry nameiALF1_STAAN
    AccessioniPrimary (citable) accession number: P99117
    Secondary accession number(s): Q99R31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3