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Protein

Probable malate:quinone oxidoreductase 2

Gene

mqo2

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 1 (mqo1), Probable malate:quinone oxidoreductase 2 (mqo2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 2UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 2UniRule annotation
Malate dehydrogenase [quinone] 2UniRule annotation
Gene namesi
Name:mqo2UniRule annotation
Ordered Locus Names:SA2400
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287421 – 498Probable malate:quinone oxidoreductase 2Add BLAST498

Proteomic databases

PRIDEiP99115

2D gel databases

SWISS-2DPAGEiP99115

Structurei

3D structure databases

ProteinModelPortaliP99115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OMAiPQHDMAL

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

P99115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSNSKDIV LIGAGVLSTT FGSMLKEIEP DWNIHVYERL DRPAIESSNE
60 70 80 90 100
RNNAGTGHAA LCELNYTVLQ PDGSIDIEKA KVINEEFEIS KQFWGHLVKS
110 120 130 140 150
GSIENPREFI NPLPHISYVR GKNNVKFLKD RYEAMKAFPM FDNIEYTEDI
160 170 180 190 200
EVMKKWIPLM MKGREDNPGI MAASKIDEGT DVNFGELTRK MAKSIEAHPN
210 220 230 240 250
ATVQFNHEVV DFEQLSNGQW EVTVKNRLTG EKFKQVTDYV FIGAGGGAIP
260 270 280 290 300
LLQKTGIPES KHLGGFPISG QFLACTNPQV IEQHDAKVYG KEPPGTPPMT
310 320 330 340 350
VPHLDTRYID GQRTLLFGPF ANVGPKFLKN GSNLDLFKSV KTYNITTLLA
360 370 380 390 400
AAVKNLPLIK YSFDQVIMTK EGCMNHLRTF YPEARNEDWQ LYTAGKRVQV
410 420 430 440 450
IKDTPEHGKG FIQFGTEVVN SQDHTVIALL GESPGASTSV SVALEVLERN
460 470 480 490
FPEYKTEWAP KIKKMIPSYG ESLIEDEKLM RKIRKQTSKD LELGYYEN
Length:498
Mass (Da):55,999
Last modified:October 11, 2004 - v1
Checksum:i7D8D5ED706A4D183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB43705.1
PIRiG90067
RefSeqiWP_001130051.1, NC_002745.2

Genome annotation databases

EnsemblBacteriaiBAB43705; BAB43705; BAB43705
KEGGisau:SA2400

Similar proteinsi

Entry informationi

Entry nameiMQO2_STAAN
AccessioniPrimary (citable) accession number: P99115
Secondary accession number(s): Q99R30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health