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Protein

Probable malate:quinone oxidoreductase 2

Gene

mqo2

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 1 (mqo1), Probable malate:quinone oxidoreductase 2 (mqo2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2563-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 2UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 2UniRule annotation
Malate dehydrogenase [quinone] 2UniRule annotation
Gene namesi
Name:mqo2UniRule annotation
Ordered Locus Names:SA2400
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Probable malate:quinone oxidoreductase 2PRO_0000128742Add
BLAST

Proteomic databases

PRIDEiP99115.

2D gel databases

SWISS-2DPAGEP99115.

Structurei

3D structure databases

ProteinModelPortaliP99115.
SMRiP99115. Positions 9-43, 194-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379.
OMAiDLSRQFW.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

P99115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSNSKDIV LIGAGVLSTT FGSMLKEIEP DWNIHVYERL DRPAIESSNE
60 70 80 90 100
RNNAGTGHAA LCELNYTVLQ PDGSIDIEKA KVINEEFEIS KQFWGHLVKS
110 120 130 140 150
GSIENPREFI NPLPHISYVR GKNNVKFLKD RYEAMKAFPM FDNIEYTEDI
160 170 180 190 200
EVMKKWIPLM MKGREDNPGI MAASKIDEGT DVNFGELTRK MAKSIEAHPN
210 220 230 240 250
ATVQFNHEVV DFEQLSNGQW EVTVKNRLTG EKFKQVTDYV FIGAGGGAIP
260 270 280 290 300
LLQKTGIPES KHLGGFPISG QFLACTNPQV IEQHDAKVYG KEPPGTPPMT
310 320 330 340 350
VPHLDTRYID GQRTLLFGPF ANVGPKFLKN GSNLDLFKSV KTYNITTLLA
360 370 380 390 400
AAVKNLPLIK YSFDQVIMTK EGCMNHLRTF YPEARNEDWQ LYTAGKRVQV
410 420 430 440 450
IKDTPEHGKG FIQFGTEVVN SQDHTVIALL GESPGASTSV SVALEVLERN
460 470 480 490
FPEYKTEWAP KIKKMIPSYG ESLIEDEKLM RKIRKQTSKD LELGYYEN
Length:498
Mass (Da):55,999
Last modified:October 11, 2004 - v1
Checksum:i7D8D5ED706A4D183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43705.1.
PIRiG90067.
RefSeqiWP_001130051.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43705; BAB43705; BAB43705.
PATRICi19577366. VBIStaAur116463_2601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43705.1.
PIRiG90067.
RefSeqiWP_001130051.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP99115.
SMRiP99115. Positions 9-43, 194-259.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

SWISS-2DPAGEP99115.

Proteomic databases

PRIDEiP99115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43705; BAB43705; BAB43705.
PATRICi19577366. VBIStaAur116463_2601.

Phylogenomic databases

HOGENOMiHOG000109379.
OMAiDLSRQFW.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciSAUR158879:GJCB-2563-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiMQO2_STAAN
AccessioniPrimary (citable) accession number: P99115
Secondary accession number(s): Q99R30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.