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Protein

Deoxyribose-phosphate aldolase 1

Gene

deoC1

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase 1 (deoC1), Deoxyribose-phosphate aldolase 2 (deoC2)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151Schiff-base intermediate with acetaldehydeBy similarity1
Active sitei180By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase 1 (EC:4.1.2.4)
Short name:
DERA 1
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 1
Phosphodeoxyriboaldolase 1
Short name:
Deoxyriboaldolase 1
Gene namesi
Name:deoC1
Synonyms:dra
Ordered Locus Names:SA0133
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572591 – 220Deoxyribose-phosphate aldolase 1Add BLAST220

2D gel databases

SWISS-2DPAGEP99102.

Structurei

3D structure databases

ProteinModelPortaliP99102.
SMRiP99102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000241645.
KOiK01619.
OMAiFFSVCVN.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

P99102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFEKYIDHT LLKPESTRTQ IDQIIDEAKA YNFKSVCVNP THVKYAAERL
60 70 80 90 100
ADSEVLVCTV IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG
110 120 130 140 150
RFDDVQQDIE AVVKAAKGHT VKVIIETVLL DHDEIVKASE LTKAAGADFV
160 170 180 190 200
KTSTGFAGGG ATAEDVKLMK DTVGADVEVK ASGGVRNLED FNKMVEAGAT
210 220
RIGASAGVQI MQGLEADSDY
Length:220
Mass (Da):23,472
Last modified:April 26, 2004 - v1
Checksum:iA77DAC561C6B70A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41353.1.
PIRiF89774.
RefSeqiWP_000667269.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41353; BAB41353; BAB41353.
GeneIDi28379547.
KEGGisau:SA0133.
PATRICi19572297. VBIStaAur116463_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41353.1.
PIRiF89774.
RefSeqiWP_000667269.1. NC_002745.2.

3D structure databases

ProteinModelPortaliP99102.
SMRiP99102.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

SWISS-2DPAGEP99102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB41353; BAB41353; BAB41353.
GeneIDi28379547.
KEGGisau:SA0133.
PATRICi19572297. VBIStaAur116463_0138.

Phylogenomic databases

HOGENOMiHOG000241645.
KOiK01619.
OMAiFFSVCVN.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC1_STAAN
AccessioniPrimary (citable) accession number: P99102
Secondary accession number(s): Q99X77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.