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P99085

- HPRT_STAAN

UniProt

P99085 - HPRT_STAAN

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Protein
Hypoxanthine-guanine phosphoribosyltransferase
Gene
hpt, SA0468
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021Proton acceptor By similarity
Binding sitei130 – 1301IMP By similarity
Binding sitei152 – 1521IMP; via carbonyl oxygen By similarity
Metal bindingi158 – 1581Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi98 – 10710IMP By similarity
Nucleotide bindingi157 – 1582IMP By similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-489-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:SA0468
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139614Add
BLAST

Proteomic databases

PRIDEiP99085.

2D gel databases

SWISS-2DPAGEP99085.

Interactioni

Protein-protein interaction databases

STRINGi158879.SA0468.

Structurei

3D structure databases

ProteinModelPortaliP99085.
SMRiP99085. Positions 4-177.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0634.
HOGENOMiHOG000236520.
KOiK00760.
OMAiVDFMTVS.
OrthoDBiEOG693GNP.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

P99085-1 [UniParc]FASTAAdd to Basket

« Hide

MHNDLKEVLL TEEDIQNICK ELGAQLTKDY QGKPLVCVGI LKGSAMFMSD    50
LIKRIDTHLS IDFMDVSSYH GGTESTGEVQ IIKDLGSSIE NKDVLIIEDI 100
LETGTTLKSI TELLQSRKVN SLEIVTLLDK PNRRKADIEA KYVGKKIPDE 150
FVVGYGLDYR ELYRNLPYIG TLKPEVYSN 179
Length:179
Mass (Da):20,154
Last modified:October 11, 2004 - v1
Checksum:iE7D35987B435EFB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB41698.1.
PIRiG89817.
RefSeqiNP_373720.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41698; BAB41698; BAB41698.
GeneIDi1123259.
KEGGisau:SA0468.
PATRICi19573020. VBIStaAur116463_0493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB41698.1 .
PIRi G89817.
RefSeqi NP_373720.1. NC_002745.2.

3D structure databases

ProteinModelPortali P99085.
SMRi P99085. Positions 4-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0468.

2D gel databases

SWISS-2DPAGE P99085.

Proteomic databases

PRIDEi P99085.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB41698 ; BAB41698 ; BAB41698 .
GeneIDi 1123259.
KEGGi sau:SA0468.
PATRICi 19573020. VBIStaAur116463_0493.

Phylogenomic databases

eggNOGi COG0634.
HOGENOMi HOG000236520.
KOi K00760.
OMAi VDFMTVS.
OrthoDBi EOG693GNP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci SAUR158879:GJCB-489-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.

Entry informationi

Entry nameiHPRT_STAAN
AccessioniPrimary (citable) accession number: P99085
Secondary accession number(s): Q99W93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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