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P99063

- ODPB_STAAN

UniProt

P99063 - ODPB_STAAN

Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601Thiamine pyrophosphateBy similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-998-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
    Gene namesi
    Name:pdhB
    Ordered Locus Names:SA0944
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Pyruvate dehydrogenase E1 component subunit betaPRO_0000162230Add
    BLAST

    2D gel databases

    SWISS-2DPAGEP99063.

    PTM databases

    PhosSiteiP0909753.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi158879.SA0944.

    Structurei

    3D structure databases

    ProteinModelPortaliP99063.
    SMRiP99063. Positions 2-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0022.
    HOGENOMiHOG000281451.
    KOiK00162.
    OMAiWSKHELG.
    OrthoDBiEOG6JQH4C.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProiIPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view]
    PfamiPF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P99063-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQMTMVQAI NDALKTELKN DQDVLIFGED VGVNGGVFRV TEGLQKEFGE    50
    DRVFDTPLAE SGIGGLAMGL AVEGFRPVME VQFLGFVFEV FDAIAGQIAR 100
    TRFRSGGTKT APVTIRSPFG GGVHTPELHA DNLEGILAQS PGLKVVIPSG 150
    PYDAKGLLIS SIRSNDPVVY LEHMKLYRSF REEVPEEEYT IDIGKANVKK 200
    EGNDISIITY GAMVQESMKA AEELEKDGYS VEVIDLRTVQ PIDVDTIVAS 250
    VEKTGRAVVV QEAQRQAGVG AAVVAELSER AILSLEAPIG RVAAADTIYP 300
    FTQAENVWLP NKNDIIEKAK ETLEF 325
    Length:325
    Mass (Da):35,246
    Last modified:March 1, 2005 - v1
    Checksum:i432ABDF6E4A720D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42190.1.
    PIRiC89879.
    RefSeqiNP_374212.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB42190; BAB42190; BAB42190.
    GeneIDi1123769.
    KEGGisau:SA0944.
    PATRICi19574080. VBIStaAur116463_1010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42190.1 .
    PIRi C89879.
    RefSeqi NP_374212.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali P99063.
    SMRi P99063. Positions 2-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA0944.

    PTM databases

    PhosSitei P0909753.

    2D gel databases

    SWISS-2DPAGE P99063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB42190 ; BAB42190 ; BAB42190 .
    GeneIDi 1123769.
    KEGGi sau:SA0944.
    PATRICi 19574080. VBIStaAur116463_1010.

    Phylogenomic databases

    eggNOGi COG0022.
    HOGENOMi HOG000281451.
    KOi K00162.
    OMAi WSKHELG.
    OrthoDBi EOG6JQH4C.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-998-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProi IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view ]
    Pfami PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: N315.
    3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry nameiODPB_STAAN
    AccessioniPrimary (citable) accession number: P99063
    Secondary accession number(s): Q9L6H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3