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P99028 (QCR6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene names
Name:Uqcrh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the UQCRH/QCR6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1313Mitochondrion Ref.3
Chain14 – 8976Cytochrome b-c1 complex subunit 6, mitochondrial
PRO_0000035992

Regions

Compositional bias18 – 236Poly-Glu

Amino acid modifications

Modified residue401N6-acetyllysine Ref.5
Modified residue831N6-acetyllysine Ref.5
Disulfide bond35 ↔ 79 By similarity
Disulfide bond51 ↔ 65 By similarity

Sequences

Sequence LengthMass (Da)Tools
P99028 [UniParc].

Last modified August 29, 2001. Version 2.
Checksum: 6E588E3BDF743E7B

FASTA8910,435
        10         20         30         40         50         60 
MGLEDERKML TGSGDPKEEE EEELVDPLTT VREHCEQLEK CVKARERLEL CDNRVSSRSQ 

        70         80 
TEEDCTEELF DFLHARDHCV AHKLFKNLK 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Kidney, Oviduct and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]Sanchez J.-C., Rouge V., Frutiger S., Hughes G., Yan J.X., Hoogland C., Appel R.D., Binz P.-A., Hochstrasser D.F., Cowthorne M.
Submitted (AUG-1998) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 14-25.
Tissue: Liver.
[4]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-32; 45-54 AND 59-76, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
[5]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40 AND LYS-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK003266 mRNA. Translation: BAB22681.1.
AK003539 mRNA. Translation: BAB22845.1.
AK012552 mRNA. Translation: BAB28312.1.
AK018712 mRNA. Translation: BAB31360.1.
AK054005 mRNA. Translation: BAC35617.1.
AK088185 mRNA. Translation: BAC40195.1.
BC011388 mRNA. Translation: AAH11388.1.
CCDSCCDS38846.1.
RefSeqNP_079917.1. NM_025641.3.
UniGeneMm.181721.

3D structure databases

ProteinModelPortalP99028.
SMRP99028. Positions 24-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP99028. 3 interactions.
MINTMINT-4997067.

PTM databases

PhosphoSiteP99028.

2D gel databases

SWISS-2DPAGEP99028.

Proteomic databases

MaxQBP99028.
PaxDbP99028.
PRIDEP99028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078676; ENSMUSP00000077744; ENSMUSG00000063882.
GeneID66576.
KEGGmmu:66576.
UCSCuc008ufv.1. mouse.

Organism-specific databases

CTD7388.
MGIMGI:1913826. Uqcrh.

Phylogenomic databases

eggNOGNOG312125.
GeneTreeENSGT00390000003860.
HOGENOMHOG000243673.
HOVERGENHBG001487.
InParanoidP99028.
KOK00416.
OMACEQTEKC.
PhylomeDBP99028.
TreeFamTF105036.

Gene expression databases

BgeeP99028.
CleanExMM_UQCRH.
GenevestigatorP99028.

Family and domain databases

Gene3D1.10.287.20. 1 hit.
InterProIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERPTHR15336. PTHR15336. 1 hit.
PfamPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFPIRSF000019. Bc1_11K. 1 hit.
SUPFAMSSF81531. SSF81531. 1 hit.
ProtoNetSearch...

Other

ChiTaRSUQCRH. mouse.
NextBio322050.
PROP99028.
SOURCESearch...

Entry information

Entry nameQCR6_MOUSE
AccessionPrimary (citable) accession number: P99028
Secondary accession number(s): Q542K2, Q9CQP4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 29, 2001
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot