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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

Uqcrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:Uqcrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913826 Uqcrh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13Mitochondrion1 PublicationAdd BLAST13
ChainiPRO_000003599214 – 89Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 79By similarity
Modified residuei40N6-acetyllysineCombined sources1
Disulfide bondi51 ↔ 65By similarity
Modified residuei83N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP99028
MaxQBiP99028
PaxDbiP99028
PeptideAtlasiP99028
PRIDEiP99028
TopDownProteomicsiP99028

2D gel databases

SWISS-2DPAGEiP99028

PTM databases

iPTMnetiP99028
PhosphoSitePlusiP99028
SwissPalmiP99028

Expressioni

Gene expression databases

BgeeiENSMUSG00000063882
CleanExiMM_UQCRH
ExpressionAtlasiP99028 baseline and differential
GenevisibleiP99028 MM

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

BioGridi211565, 2 interactors
CORUMiP99028
IntActiP99028, 4 interactors
MINTiP99028
STRINGi10090.ENSMUSP00000077744

Structurei

3D structure databases

ProteinModelPortaliP99028
SMRiP99028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 23Poly-Glu6

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763 Eukaryota
ENOG411247S LUCA
GeneTreeiENSGT00390000003860
HOGENOMiHOG000243673
HOVERGENiHBG001487
InParanoidiP99028
KOiK00416
OMAiSQTEEDC
OrthoDBiEOG091G13DH
PhylomeDBiP99028
TreeFamiTF105036

Family and domain databases

Gene3Di1.10.287.20, 1 hit
InterProiView protein in InterPro
IPR003422 Cyt_b-c1_6
IPR023184 Ubol_cytC_Rdtase_hinge_dom
IPR036811 Ubol_cytC_Rdtase_hinge_dom_sf
PANTHERiPTHR15336 PTHR15336, 1 hit
PfamiView protein in Pfam
PF02320 UCR_hinge, 1 hit
PIRSFiPIRSF000019 Bc1_11K, 1 hit
SUPFAMiSSF81531 SSF81531, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P99028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDERKML TGSGDPKEEE EEELVDPLTT VREHCEQLEK CVKARERLEL
60 70 80
CDNRVSSRSQ TEEDCTEELF DFLHARDHCV AHKLFKNLK
Length:89
Mass (Da):10,435
Last modified:August 29, 2001 - v2
Checksum:i6E588E3BDF743E7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003266 mRNA Translation: BAB22681.1
AK003539 mRNA Translation: BAB22845.1
AK012552 mRNA Translation: BAB28312.1
AK018712 mRNA Translation: BAB31360.1
AK054005 mRNA Translation: BAC35617.1
AK088185 mRNA Translation: BAC40195.1
BC011388 mRNA Translation: AAH11388.1
CCDSiCCDS38846.1
RefSeqiNP_079917.1, NM_025641.3
UniGeneiMm.181721

Genome annotation databases

EnsembliENSMUST00000078676; ENSMUSP00000077744; ENSMUSG00000063882
GeneIDi66576
KEGGimmu:66576
UCSCiuc008ufv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQCR6_MOUSE
AccessioniPrimary (citable) accession number: P99028
Secondary accession number(s): Q542K2, Q9CQP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 29, 2001
Last modified: April 25, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health