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P99028

- QCR6_MOUSE

UniProt

P99028 - QCR6_MOUSE

Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

Uqcrh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 By similarity.By similarity

    GO - Molecular functioni

    1. ubiquinol-cytochrome-c reductase activity Source: InterPro

    GO - Biological processi

    1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
    2. protein heterooligomerization Source: Ensembl

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Alternative name(s):
    Complex III subunit 6
    Complex III subunit VIII
    Cytochrome c1 non-heme 11 kDa protein
    Mitochondrial hinge protein
    Ubiquinol-cytochrome c reductase complex 11 kDa protein
    Gene namesi
    Name:Uqcrh
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1913826. Uqcrh.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial respiratory chain complex III Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1313Mitochondrion1 PublicationAdd
    BLAST
    Chaini14 – 8976Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 79By similarity
    Modified residuei40 – 401N6-acetyllysine1 Publication
    Disulfide bondi51 ↔ 65By similarity
    Modified residuei83 – 831N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    MaxQBiP99028.
    PaxDbiP99028.
    PRIDEiP99028.

    2D gel databases

    SWISS-2DPAGEP99028.

    PTM databases

    PhosphoSiteiP99028.

    Expressioni

    Gene expression databases

    BgeeiP99028.
    CleanExiMM_UQCRH.
    GenevestigatoriP99028.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

    Protein-protein interaction databases

    IntActiP99028. 3 interactions.
    MINTiMINT-4997067.

    Structurei

    3D structure databases

    ProteinModelPortaliP99028.
    SMRiP99028. Positions 24-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 236Poly-Glu

    Sequence similaritiesi

    Belongs to the UQCRH/QCR6 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG312125.
    GeneTreeiENSGT00390000003860.
    HOGENOMiHOG000243673.
    HOVERGENiHBG001487.
    InParanoidiP99028.
    KOiK00416.
    OMAiCEQTEKC.
    PhylomeDBiP99028.
    TreeFamiTF105036.

    Family and domain databases

    Gene3Di1.10.287.20. 1 hit.
    InterProiIPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view]
    PANTHERiPTHR15336. PTHR15336. 1 hit.
    PfamiPF02320. UCR_hinge. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000019. Bc1_11K. 1 hit.
    SUPFAMiSSF81531. SSF81531. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P99028-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLEDERKML TGSGDPKEEE EEELVDPLTT VREHCEQLEK CVKARERLEL   50
    CDNRVSSRSQ TEEDCTEELF DFLHARDHCV AHKLFKNLK 89
    Length:89
    Mass (Da):10,435
    Last modified:August 29, 2001 - v2
    Checksum:i6E588E3BDF743E7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003266 mRNA. Translation: BAB22681.1.
    AK003539 mRNA. Translation: BAB22845.1.
    AK012552 mRNA. Translation: BAB28312.1.
    AK018712 mRNA. Translation: BAB31360.1.
    AK054005 mRNA. Translation: BAC35617.1.
    AK088185 mRNA. Translation: BAC40195.1.
    BC011388 mRNA. Translation: AAH11388.1.
    CCDSiCCDS38846.1.
    RefSeqiNP_079917.1. NM_025641.3.
    UniGeneiMm.181721.

    Genome annotation databases

    EnsembliENSMUST00000078676; ENSMUSP00000077744; ENSMUSG00000063882.
    GeneIDi66576.
    KEGGimmu:66576.
    UCSCiuc008ufv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003266 mRNA. Translation: BAB22681.1 .
    AK003539 mRNA. Translation: BAB22845.1 .
    AK012552 mRNA. Translation: BAB28312.1 .
    AK018712 mRNA. Translation: BAB31360.1 .
    AK054005 mRNA. Translation: BAC35617.1 .
    AK088185 mRNA. Translation: BAC40195.1 .
    BC011388 mRNA. Translation: AAH11388.1 .
    CCDSi CCDS38846.1.
    RefSeqi NP_079917.1. NM_025641.3.
    UniGenei Mm.181721.

    3D structure databases

    ProteinModelPortali P99028.
    SMRi P99028. Positions 24-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P99028. 3 interactions.
    MINTi MINT-4997067.

    PTM databases

    PhosphoSitei P99028.

    2D gel databases

    SWISS-2DPAGE P99028.

    Proteomic databases

    MaxQBi P99028.
    PaxDbi P99028.
    PRIDEi P99028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078676 ; ENSMUSP00000077744 ; ENSMUSG00000063882 .
    GeneIDi 66576.
    KEGGi mmu:66576.
    UCSCi uc008ufv.1. mouse.

    Organism-specific databases

    CTDi 7388.
    MGIi MGI:1913826. Uqcrh.

    Phylogenomic databases

    eggNOGi NOG312125.
    GeneTreei ENSGT00390000003860.
    HOGENOMi HOG000243673.
    HOVERGENi HBG001487.
    InParanoidi P99028.
    KOi K00416.
    OMAi CEQTEKC.
    PhylomeDBi P99028.
    TreeFami TF105036.

    Miscellaneous databases

    ChiTaRSi UQCRH. mouse.
    NextBioi 322050.
    PROi P99028.
    SOURCEi Search...

    Gene expression databases

    Bgeei P99028.
    CleanExi MM_UQCRH.
    Genevestigatori P99028.

    Family and domain databases

    Gene3Di 1.10.287.20. 1 hit.
    InterProi IPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view ]
    PANTHERi PTHR15336. PTHR15336. 1 hit.
    Pfami PF02320. UCR_hinge. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000019. Bc1_11K. 1 hit.
    SUPFAMi SSF81531. SSF81531. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Kidney, Oviduct and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. Cited for: PROTEIN SEQUENCE OF 14-25.
      Tissue: Liver.
    4. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 18-32; 45-54 AND 59-76, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.
    5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40 AND LYS-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiQCR6_MOUSE
    AccessioniPrimary (citable) accession number: P99028
    Secondary accession number(s): Q542K2, Q9CQP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3