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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

Uqcrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:Uqcrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913826. Uqcrh.

Subcellular locationi

  • Mitochondrion inner membrane By similarity

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex III Source: Ensembl
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313Mitochondrion1 PublicationAdd
BLAST
Chaini14 – 8976Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 79By similarity
Modified residuei40 – 401N6-acetyllysineCombined sources
Disulfide bondi51 ↔ 65By similarity
Modified residuei83 – 831N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP99028.
MaxQBiP99028.
PaxDbiP99028.
PeptideAtlasiP99028.
PRIDEiP99028.
TopDownProteomicsiP99028.

2D gel databases

SWISS-2DPAGEP99028.

PTM databases

iPTMnetiP99028.
PhosphoSiteiP99028.
SwissPalmiP99028.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063882.
CleanExiMM_UQCRH.
ExpressionAtlasiP99028. baseline and differential.
GenevisibleiP99028. MM.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

IntActiP99028. 3 interactions.
MINTiMINT-4997067.
STRINGi10090.ENSMUSP00000077744.

Structurei

3D structure databases

ProteinModelPortaliP99028.
SMRiP99028. Positions 24-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 236Poly-Glu

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP99028.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
PhylomeDBiP99028.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P99028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDERKML TGSGDPKEEE EEELVDPLTT VREHCEQLEK CVKARERLEL
60 70 80
CDNRVSSRSQ TEEDCTEELF DFLHARDHCV AHKLFKNLK
Length:89
Mass (Da):10,435
Last modified:August 29, 2001 - v2
Checksum:i6E588E3BDF743E7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003266 mRNA. Translation: BAB22681.1.
AK003539 mRNA. Translation: BAB22845.1.
AK012552 mRNA. Translation: BAB28312.1.
AK018712 mRNA. Translation: BAB31360.1.
AK054005 mRNA. Translation: BAC35617.1.
AK088185 mRNA. Translation: BAC40195.1.
BC011388 mRNA. Translation: AAH11388.1.
CCDSiCCDS38846.1.
RefSeqiNP_079917.1. NM_025641.3.
UniGeneiMm.181721.

Genome annotation databases

EnsembliENSMUST00000078676; ENSMUSP00000077744; ENSMUSG00000063882.
GeneIDi66576.
KEGGimmu:66576.
UCSCiuc008ufv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003266 mRNA. Translation: BAB22681.1.
AK003539 mRNA. Translation: BAB22845.1.
AK012552 mRNA. Translation: BAB28312.1.
AK018712 mRNA. Translation: BAB31360.1.
AK054005 mRNA. Translation: BAC35617.1.
AK088185 mRNA. Translation: BAC40195.1.
BC011388 mRNA. Translation: AAH11388.1.
CCDSiCCDS38846.1.
RefSeqiNP_079917.1. NM_025641.3.
UniGeneiMm.181721.

3D structure databases

ProteinModelPortaliP99028.
SMRiP99028. Positions 24-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP99028. 3 interactions.
MINTiMINT-4997067.
STRINGi10090.ENSMUSP00000077744.

PTM databases

iPTMnetiP99028.
PhosphoSiteiP99028.
SwissPalmiP99028.

2D gel databases

SWISS-2DPAGEP99028.

Proteomic databases

EPDiP99028.
MaxQBiP99028.
PaxDbiP99028.
PeptideAtlasiP99028.
PRIDEiP99028.
TopDownProteomicsiP99028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078676; ENSMUSP00000077744; ENSMUSG00000063882.
GeneIDi66576.
KEGGimmu:66576.
UCSCiuc008ufv.1. mouse.

Organism-specific databases

CTDi7388.
MGIiMGI:1913826. Uqcrh.

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP99028.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
PhylomeDBiP99028.
TreeFamiTF105036.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiUqcrh. mouse.
PROiP99028.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063882.
CleanExiMM_UQCRH.
ExpressionAtlasiP99028. baseline and differential.
GenevisibleiP99028. MM.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR6_MOUSE
AccessioniPrimary (citable) accession number: P99028
Secondary accession number(s): Q542K2, Q9CQP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 29, 2001
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.