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P98999 (ADCY9_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase type 9
EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX
Adenylyl cyclase 9
Short name=xlAC
Gene names
Name:adcy9
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length1305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLyase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13051305Adenylate cyclase type 9
PRO_0000195711

Regions

Topological domain1 – 110110Cytoplasmic Potential
Transmembrane111 – 13121Helical; Potential
Topological domain132 – 1343Extracellular Potential
Transmembrane135 – 15521Helical; Potential
Topological domain156 – 1649Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 20924Extracellular Potential
Transmembrane210 – 22920Helical; Potential
Topological domain230 – 2356Cytoplasmic Potential
Transmembrane236 – 25318Helical; Potential
Topological domain254 – 27421Extracellular Potential
Transmembrane275 – 29521Helical; Potential
Topological domain296 – 778483Cytoplasmic Potential
Transmembrane779 – 79921Helical; Potential
Topological domain800 – 81011Extracellular Potential
Transmembrane811 – 83121Helical; Potential
Topological domain832 – 85928Cytoplasmic Potential
Transmembrane860 – 88021Helical; Potential
Topological domain881 – 8833Extracellular Potential
Transmembrane884 – 90421Helical; Potential
Topological domain905 – 9117Cytoplasmic Potential
Transmembrane912 – 93221Helical; Potential
Topological domain933 – 96634Extracellular Potential
Transmembrane967 – 98721Helical; Potential
Topological domain988 – 1305318Cytoplasmic Potential
Compositional bias152 – 1576Poly-Phe

Sites

Metal binding3931Magnesium 1 By similarity
Metal binding3931Magnesium 2 By similarity
Metal binding3941Magnesium 2; via carbonyl oxygen By similarity
Metal binding4371Magnesium 1 By similarity
Metal binding4371Magnesium 2 By similarity

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation9461N-linked (GlcNAc...) Potential
Glycosylation9511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P98999 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 8E1A5B79466B556A

FASTA1,305145,411
        10         20         30         40         50         60 
MASPVNQQLL HHTEVRCDGS GDGSSVTVRI NRQHHQAPSR RCKYSISSSC SSGESGVKKT 

        70         80         90        100        110        120 
GGSGGARRQK KLPQLFERST SNWWNPKFDS NNLEEACVER CFPQTQRRFR YALMYLSVAG 

       130        140        150        160        170        180 
LLWSIYFSVH MKTKLVSHLV PTLCFLIVCL GFFFFTFTKS YARHCTAISL LVTLLVFTLT 

       190        200        210        220        230        240 
LASQFQVLNP GLGSDSLSNL TSFSATGSSS CLSQVGSFSI CVEVLLLLYT VMHLPLYLSA 

       250        260        270        280        290        300 
CLGVAYSILF ETFGYHFRDE SCFVLLVGRM AHWELLSKAL LHVCIHAIGV HLFIMSEVRS 

       310        320        330        340        350        360 
RSTFLKVGQS IMHGKDLEVE KALKERMIHS VMPRIIADDL MKQGDDESEN SVKRHSASSP 

       370        380        390        400        410        420 
KSRKKKSSIQ KTPIIFRPFK MQRIEQVSIL FADIVGFTKM SANKSAHALV GLLNDLFGRF 

       430        440        450        460        470        480 
DRLCEETKCE KISTLGDCYY CVAGCPEPRP DHAYCCIEMG LGMIEAIDQF CQEKKEMVNM 

       490        500        510        520        530        540 
RVGVHTGTVL CGILGMRRFK FDVWSNDVNL ANLMEQLGVA GKVHISEKTA RYLDDRYLME 

       550        560        570        580        590        600 
DSMVVERLGQ IVAADQLKGL KTFLISGGRT RVPSCSCSQT LIPVQEGTDL SSPSLAPHVQ 

       610        620        630        640        650        660 
AAISETSDSH TNCTQPETLK SCPSCGETAA RDGPEEGVSA ANGGGEEWKG GAPRPSAIGA 

       670        680        690        700        710        720 
SLKDPERSPE SSTGDTLTNS QASLYDMLQE KGRWCGVSMD QSALLPLRFK NIREKTDAHF 

       730        740        750        760        770        780 
VEVIKEDSLM KDYFFKPPIN PLSLNFLDKE LETSYRASYQ EEVIRMAPVK TFASATFSSL 

       790        800        810        820        830        840 
QDVLLNYFIF VLLSVACLLK PGTNTVSPPT LALVLLSVCG LLGFLSLLVS VRMAFYLEDM 

       850        860        870        880        890        900 
LLCTRRLLEI ISGWVPRHFI GTVLVCLPAA VIFSYLSSDF YTDIHYTMFL CSALLIPMVQ 

       910        920        930        940        950        960 
YCNFCQLSSS ALLLATITGA TMLILIYLPL CPQRPPLDPG TDIEANLSTS NSSYETLDNP 

       970        980        990       1000       1010       1020 
RTELPFTRLG QEIAVAYFLL LLLVWFLNRE FDVSYRLHYH GDVEADLHRT KIQSMRDQAD 

      1030       1040       1050       1060       1070       1080 
WLLRNIIPYH VAEQLKVSQS YSKNHDDAGV IFASIVNFSE FYEENYEGGK ECYRALNELI 

      1090       1100       1110       1120       1130       1140 
GDFDELLSKP HYSCIEKIKT IGATYMAASG LNPSQCQDSS QPHRHLQTLF EFAKEMMSVV 

      1150       1160       1170       1180       1190       1200 
DEFNNNMLWF NFKLRIGFNH GPLTAGVIGT TKLLYDIWGD TVNIASRMDT TGVECRIQAS 

      1210       1220       1230       1240       1250       1260 
EESYRVLVKM GYDFDYRGTV NVKGKGQMKT YHFPKCTDNG GLVPHHQLCI SPDIRVQVDG 

      1270       1280       1290       1300 
SIGRSPTDEI SSLVTGGKGA VELGSGEAER KREKAEERGR DGGAR

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References

[1]"Molecular cloning and expression of an adenylyl cyclase from Xenopus laevis oocytes."
Torrejon M., Echeverria V., Retamales G., Herrera L., Hinrichs M.V., Olate J.
FEBS Lett. 404:91-94(1997) [PubMed: 9074644] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46958 mRNA. Translation: CAA87082.1.
RefSeqNP_001079302.1. NM_001085833.1.
UniGeneXl.1123.

3D structure databases

ProteinModelPortalP98999.
SMRP98999. Positions 374-540, 1041-1215.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378610.
KEGGxla:378610.

Organism-specific databases

CTD115.
XenbaseXB-GENE-999261. adcy9.

Phylogenomic databases

HOVERGENHBG050459.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
KOK08049.
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. A/G_cyclase. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADCY9_XENLA
AccessionPrimary (citable) accession number: P98999
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 16, 2011
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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