P98198 (AT8B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase ID
EC=3.6.3.1

Alternative name(s):
ATPase class I type 8B member 2

Gene names

Name:	ATP8B2
Synonyms:	ATPID, KIAA1137

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus. Ref.1
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]
Sequence caution	The sequence AAH30288.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB70822.1 differs from that shown. Reason: Frameshift at position 364. The sequence BAG65556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation-transporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P98198-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: P98198-2)

The sequence of this isoform differs from the canonical sequence as follows:
     434-461: GDVFDVLGHKAELGERPEPVDFSFNPLA → VGSEGPRRKGPSWPGTVAHAYSHSTLGG
     462-1209: Missing.

Isoform 3 (identifier: P98198-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MTVPKEMPEKWARAQAPPSWSRKKPSWGT → MDTLRAVPLFSISGLFSFPYRVSHGIAGILLGEMAVCAKKRPP

Isoform 4 (identifier: P98198-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MTVPKEMPEKWARAQAPPSWSRKKPSWGT → MAVCAKKRPP
     364-406: SVEVIRLGHS...TLNEELGQVE → RYVPSLTWGL...KSSSSCTVNI
     407-1209: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1209	1209	Probable phospholipid-transporting ATPase ID		PRO_0000046365
Regions
	Topological domain	1 – 64	64	Cytoplasmic Potential
	Transmembrane	65 – 86	22	Helical; Potential
	Topological domain	87 – 92	6	Extracellular Potential
	Transmembrane	93 – 112	20	Helical; Potential
	Topological domain	113 – 295	183	Cytoplasmic Potential
	Transmembrane	296 – 317	22	Helical; Potential
	Topological domain	318 – 346	29	Extracellular Potential
	Transmembrane	347 – 368	22	Helical; Potential
	Topological domain	369 – 889	521	Cytoplasmic Potential
	Transmembrane	890 – 910	21	Helical; Potential
	Topological domain	911 – 922	12	Extracellular Potential
	Transmembrane	923 – 942	20	Helical; Potential
	Topological domain	943 – 972	30	Cytoplasmic Potential
	Transmembrane	973 – 994	22	Helical; Potential
	Topological domain	995 – 1008	14	Extracellular Potential
	Transmembrane	1009 – 1031	23	Helical; Potential
	Topological domain	1032 – 1037	6	Cytoplasmic Potential
	Transmembrane	1038 – 1058	21	Helical; Potential
	Topological domain	1059 – 1078	20	Extracellular Potential
	Transmembrane	1079 – 1103	25	Helical; Potential
	Topological domain	1104 – 1209	106	Cytoplasmic Potential
Sites
	Active site	411	1	4-aspartylphosphate intermediate By similarity
	Metal binding	833	1	Magnesium By similarity
	Metal binding	837	1	Magnesium By similarity
Natural variations
	Alternative sequence	1 – 29	29	MTVPK…PSWGT → MDTLRAVPLFSISGLFSFPY RVSHGIAGILLGEMAVCAKK RPP in isoform 3.		VSP_037147
	Alternative sequence	1 – 29	29	MTVPK…PSWGT → MAVCAKKRPP in isoform 4.		VSP_037148
	Alternative sequence	364 – 406	43	SVEVI…LGQVE → RYVPSLTWGLSRESGGPIEL FFSMKMKSLRSNEKSSSSCT VNI in isoform 4.		VSP_037149
	Alternative sequence	407 – 1209	803	Missing in isoform 4.		VSP_037150
	Alternative sequence	434 – 461	28	GDVFD…FNPLA → VGSEGPRRKGPSWPGTVAHA YSHSTLGG in isoform 2.		VSP_007302
	Alternative sequence	462 – 1209	748	Missing in isoform 2.		VSP_007303
Experimental info
	Sequence conflict	834	1	G → E in BAA86451. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 30, 2003. Version 2. Checksum: D905A97E9D9724BD	FASTA	1,209	137,440
	10 20 30 40 50 60 MTVPKEMPEK WARAQAPPSW SRKKPSWGTE EERRARANDR EYNEKFQYAS NCIKTSKYNI 70 80 90 100 110 120 LTFLPVNLFE QFQEVANTYF LFLLILQLIP QISSLSWFTT IVPLVLVLTI TAVKDATDDY 130 140 150 160 170 180 FRHKSDNQVN NRQSQVLING ILQQEQWMNV CVGDIIKLEN NQFVAADLLL LSSSEPHGLC 190 200 210 220 230 240 YIETAELDGE TNMKVRQAIP VTSELGDISK LAKFDGEVIC EPPNNKLDKF SGTLYWKENK 250 260 270 280 290 300 FPLSNQNMLL RGCVLRNTEW CFGLVIFAGP DTKLMQNSGR TKFKRTSIDR LMNTLVLWIF 310 320 330 340 350 360 GFLVCMGVIL AIGNAIWEHE VGMRFQVYLP WDEAVDSAFF SGFLSFWSYI IILNTVVPIS 370 380 390 400 410 420 LYVSVEVIRL GHSYFINWDK KMFCMKKRTP AEARTTTLNE ELGQVEYIFS DKTGTLTQNI 430 440 450 460 470 480 MVFNKCSING HSYGDVFDVL GHKAELGERP EPVDFSFNPL ADKKFLFWDP SLLEAVKIGD 490 500 510 520 530 540 PHTHEFFRLL SLCHTVMSEE KNEGELYYKA QSPDEGALVT AARNFGFVFR SRTPKTITVH 550 560 570 580 590 600 EMGTAITYQL LAILDFNNIR KRMSVIVRNP EGKIRLYCKG ADTILLDRLH HSTQELLNTT 610 620 630 640 650 660 MDHLNEYAGE GLRTLVLAYK DLDEEYYEEW AERRLQASLA QDSREDRLAS IYEEVENNMM 670 680 690 700 710 720 LLGATAIEDK LQQGVPETIA LLTLANIKIW VLTGDKQETA VNIGYSCKML TDDMTEVFIV 730 740 750 760 770 780 TGHTVLEVRE ELRKAREKMM DSSRSVGNGF TYQDKLSSSK LTSVLEAVAG EYALVINGHS 790 800 810 820 830 840 LAHALEADME LEFLETACAC KAVICCRVTP LQKAQVVELV KKYKKAVTLA IGDGANDVSM 850 860 870 880 890 900 IKTAHIGVGI SGQEGIQAVL ASDYSFSQFK FLQRLLLVHG RWSYLRMCKF LCYFFYKNFA 910 920 930 940 950 960 FTMVHFWFGF FCGFSAQTVY DQYFITLYNI VYTSLPVLAM GVFDQDVPEQ RSMEYPKLYE 970 980 990 1000 1010 1020 PGQLNLLFNK REFFICIAQG IYTSVLMFFI PYGVFADATR DDGTQLADYQ SFAVTVATSL 1030 1040 1050 1060 1070 1080 VIVVSVQIGL DTGYWTAINH FFIWGSLAVY FAILFAMHSN GLFDMFPNQF RFVGNAQNTL 1090 1100 1110 1120 1130 1140 AQPTVWLTIV LTTVVCIMPV VAFRFLRLNL KPDLSDTVRY TQLVRKKQKA QHRCMRRVGR 1150 1160 1170 1180 1190 1200 TGSRRSGYAF SHQEGFGELI MSGKNMRLSS LALSSFTTRS SSSWIESLRR KKSDSASSPS GGADKPLKG
	Isoform 2 [UniParc]. Checksum: 15CAABEAAE6862DC	FASTA	461	52,624
	10 20 30 40 50 60 MTVPKEMPEK WARAQAPPSW SRKKPSWGTE EERRARANDR EYNEKFQYAS NCIKTSKYNI 70 80 90 100 110 120 LTFLPVNLFE QFQEVANTYF LFLLILQLIP QISSLSWFTT IVPLVLVLTI TAVKDATDDY 130 140 150 160 170 180 FRHKSDNQVN NRQSQVLING ILQQEQWMNV CVGDIIKLEN NQFVAADLLL LSSSEPHGLC 190 200 210 220 230 240 YIETAELDGE TNMKVRQAIP VTSELGDISK LAKFDGEVIC EPPNNKLDKF SGTLYWKENK 250 260 270 280 290 300 FPLSNQNMLL RGCVLRNTEW CFGLVIFAGP DTKLMQNSGR TKFKRTSIDR LMNTLVLWIF 310 320 330 340 350 360 GFLVCMGVIL AIGNAIWEHE VGMRFQVYLP WDEAVDSAFF SGFLSFWSYI IILNTVVPIS 370 380 390 400 410 420 LYVSVEVIRL GHSYFINWDK KMFCMKKRTP AEARTTTLNE ELGQVEYIFS DKTGTLTQNI 430 440 450 460 MVFNKCSING HSYVGSEGPR RKGPSWPGTV AHAYSHSTLG G
	Isoform 3 [UniParc]. Checksum: 61AF805A0511A143	FASTA	1,223	138,719
	10 20 30 40 50 60 MDTLRAVPLF SISGLFSFPY RVSHGIAGIL LGEMAVCAKK RPPEEERRAR ANDREYNEKF 70 80 90 100 110 120 QYASNCIKTS KYNILTFLPV NLFEQFQEVA NTYFLFLLIL QLIPQISSLS WFTTIVPLVL 130 140 150 160 170 180 VLTITAVKDA TDDYFRHKSD NQVNNRQSQV LINGILQQEQ WMNVCVGDII KLENNQFVAA 190 200 210 220 230 240 DLLLLSSSEP HGLCYIETAE LDGETNMKVR QAIPVTSELG DISKLAKFDG EVICEPPNNK 250 260 270 280 290 300 LDKFSGTLYW KENKFPLSNQ NMLLRGCVLR NTEWCFGLVI FAGPDTKLMQ NSGRTKFKRT 310 320 330 340 350 360 SIDRLMNTLV LWIFGFLVCM GVILAIGNAI WEHEVGMRFQ VYLPWDEAVD SAFFSGFLSF 370 380 390 400 410 420 WSYIIILNTV VPISLYVSVE VIRLGHSYFI NWDKKMFCMK KRTPAEARTT TLNEELGQVE 430 440 450 460 470 480 YIFSDKTGTL TQNIMVFNKC SINGHSYGDV FDVLGHKAEL GERPEPVDFS FNPLADKKFL 490 500 510 520 530 540 FWDPSLLEAV KIGDPHTHEF FRLLSLCHTV MSEEKNEGEL YYKAQSPDEG ALVTAARNFG 550 560 570 580 590 600 FVFRSRTPKT ITVHEMGTAI TYQLLAILDF NNIRKRMSVI VRNPEGKIRL YCKGADTILL 610 620 630 640 650 660 DRLHHSTQEL LNTTMDHLNE YAGEGLRTLV LAYKDLDEEY YEEWAERRLQ ASLAQDSRED 670 680 690 700 710 720 RLASIYEEVE NNMMLLGATA IEDKLQQGVP ETIALLTLAN IKIWVLTGDK QETAVNIGYS 730 740 750 760 770 780 CKMLTDDMTE VFIVTGHTVL EVREELRKAR EKMMDSSRSV GNGFTYQDKL SSSKLTSVLE 790 800 810 820 830 840 AVAGEYALVI NGHSLAHALE ADMELEFLET ACACKAVICC RVTPLQKAQV VELVKKYKKA 850 860 870 880 890 900 VTLAIGDGAN DVSMIKTAHI GVGISGQEGI QAVLASDYSF SQFKFLQRLL LVHGRWSYLR 910 920 930 940 950 960 MCKFLCYFFY KNFAFTMVHF WFGFFCGFSA QTVYDQYFIT LYNIVYTSLP VLAMGVFDQD 970 980 990 1000 1010 1020 VPEQRSMEYP KLYEPGQLNL LFNKREFFIC IAQGIYTSVL MFFIPYGVFA DATRDDGTQL 1030 1040 1050 1060 1070 1080 ADYQSFAVTV ATSLVIVVSV QIGLDTGYWT AINHFFIWGS LAVYFAILFA MHSNGLFDMF 1090 1100 1110 1120 1130 1140 PNQFRFVGNA QNTLAQPTVW LTIVLTTVVC IMPVVAFRFL RLNLKPDLSD TVRYTQLVRK 1150 1160 1170 1180 1190 1200 KQKAQHRCMR RVGRTGSRRS GYAFSHQEGF GELIMSGKNM RLSSLALSSF TTRSSSSWIE 1210 1220 SLRRKKSDSA SSPSGGADKP LKG
	Isoform 4 [UniParc]. Checksum: B4C17CA615F4F952	FASTA	387	44,213
	10 20 30 40 50 60 MAVCAKKRPP EEERRARAND REYNEKFQYA SNCIKTSKYN ILTFLPVNLF EQFQEVANTY 70 80 90 100 110 120 FLFLLILQLI PQISSLSWFT TIVPLVLVLT ITAVKDATDD YFRHKSDNQV NNRQSQVLIN 130 140 150 160 170 180 GILQQEQWMN VCVGDIIKLE NNQFVAADLL LLSSSEPHGL CYIETAELDG ETNMKVRQAI 190 200 210 220 230 240 PVTSELGDIS KLAKFDGEVI CEPPNNKLDK FSGTLYWKEN KFPLSNQNML LRGCVLRNTE 250 260 270 280 290 300 WCFGLVIFAG PDTKLMQNSG RTKFKRTSID RLMNTLVLWI FGFLVCMGVI LAIGNAIWEH 310 320 330 340 350 360 EVGMRFQVYL PWDEAVDSAF FSGFLSFWSY IIILNTVVPI SLYVRYVPSL TWGLSRESGG 370 380 PIELFFSMKM KSLRSNEKSS SSCTVNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body." Harris M.J., Arias I.M. Biochim. Biophys. Acta 1633:127-131(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Colon.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 671-1209 (ISOFORMS 1/3). Tissue: Cerebellum and Uterus.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 447-1209 (ISOFORMS 1/3). Tissue: Lung, Mammary gland and Muscle.
[6]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-1209 (ISOFORMS 1/3). Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1112-1209 (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY302537 mRNA. Translation: AAQ19027.1. AK054886 mRNA. Translation: BAB70822.1. Frameshift. AK304806 mRNA. Translation: BAG65556.1. Different initiation. AL162591 Genomic DNA. Translation: CAH72858.1. CH471121 Genomic DNA. Translation: EAW53205.1. BC007837 mRNA. Translation: AAH07837.2. BC030288 mRNA. Translation: AAH30288.1. Different initiation. BC069264 mRNA. Translation: AAH69264.1. AB032963 mRNA. Translation: BAA86451.1. AL137537 mRNA. Translation: CAB70799.1.
IPI	IPI00258027. IPI00396074. IPI00431800. IPI00844415.
PIR	T46381.
RefSeq	NP_001005855.1. NM_001005855.1. NP_065185.1. NM_020452.3.
UniGene	Hs.435700.
3D structure databases
ProteinModelPortal	P98198.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357475.
PTM databases
PhosphoSite	P98198.
Polymorphism databases
DMDM	30316371.
Proteomic databases
PaxDb	P98198.
PRIDE	P98198.
Protocols and materials databases
DNASU	57198.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341822; ENSP00000340448; ENSG00000143515. ENST00000368487; ENSP00000357472; ENSG00000143515. ENST00000368489; ENSP00000357475; ENSG00000143515.
GeneID	57198.
KEGG	hsa:57198.
UCSC	uc001few.3. human. uc001fex.3. human. uc001fey.1. human.
Organism-specific databases
CTD	57198.
GeneCards	GC01P154298.
HGNC	HGNC:13534. ATP8B2.
HPA	HPA046680.
MIM	605867. gene.
neXtProt	NX_P98198.
PharmGKB	PA25167.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0474.
HOGENOM	HOG000202528.
HOVERGEN	HBG050601.
KO	K01530.
OMA	TLYWKES.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P98198.
Bgee	P98198.
CleanEx	HS_ATP8B2.
Genevestigator	P98198.
GermOnline	ENSG00000143515. Homo sapiens.
Family and domain databases
Gene3D	2.70.150.10. 2 hits. 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transp. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24092. PTHR24092. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57198.
NextBio	63288.
SOURCE	Search...

Entry information

Entry name

AT8B2_HUMAN

Accession

Primary (citable) accession number: P98198
Secondary accession number(s): B4E3P4 , Q6NT69, Q7Z486, Q96I43, Q96NQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 30, 2003
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.