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Protein

Probable phospholipid-transporting ATPase IH

Gene

Atp11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity).By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei414 – 41414-aspartylphosphate intermediateBy similarity
Metal bindingi828 – 8281MagnesiumBy similarity
Metal bindingi832 – 8321MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
Gene namesi
Name:Atp11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354735. Atp11a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 886ExtracellularSequence analysis
Transmembranei89 – 11022HelicalSequence analysisAdd
BLAST
Topological domaini111 – 296186CytoplasmicSequence analysisAdd
BLAST
Transmembranei297 – 31822HelicalSequence analysisAdd
BLAST
Topological domaini319 – 34931ExtracellularSequence analysisAdd
BLAST
Transmembranei350 – 37223HelicalSequence analysisAdd
BLAST
Topological domaini373 – 884512CytoplasmicSequence analysisAdd
BLAST
Transmembranei885 – 90521HelicalSequence analysisAdd
BLAST
Topological domaini906 – 91712ExtracellularSequence analysisAdd
BLAST
Transmembranei918 – 93720HelicalSequence analysisAdd
BLAST
Topological domaini938 – 96730CytoplasmicSequence analysisAdd
BLAST
Transmembranei968 – 98922HelicalSequence analysisAdd
BLAST
Topological domaini990 – 100314ExtracellularSequence analysisAdd
BLAST
Transmembranei1004 – 102623HelicalSequence analysisAdd
BLAST
Topological domaini1027 – 10326CytoplasmicSequence analysis
Transmembranei1033 – 105321HelicalSequence analysisAdd
BLAST
Topological domaini1054 – 107118ExtracellularSequence analysisAdd
BLAST
Transmembranei1072 – 109625HelicalSequence analysisAdd
BLAST
Topological domaini1097 – 113842CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11871187Probable phospholipid-transporting ATPase IHPRO_0000046370Add
BLAST

Proteomic databases

MaxQBiP98197.
PaxDbiP98197.
PRIDEiP98197.

PTM databases

iPTMnetiP98197.
PhosphoSiteiP98197.

Expressioni

Tissue specificityi

Found in heart, muscle, liver and brain. Most abundant in heart. Also detected in fetal tissues.

Gene expression databases

BgeeiP98197.
CleanExiMM_ATP11A.
ExpressionAtlasiP98197. baseline and differential.
GenevisibleiP98197. MM.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A (By similarity).By similarity

Protein-protein interaction databases

IntActiP98197. 1 interaction.
MINTiMINT-1850358.
STRINGi10090.ENSMUSP00000088779.

Structurei

3D structure databases

ProteinModelPortaliP98197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOVERGENiHBG050601.
InParanoidiP98197.
KOiK01530.
OMAiKECCIEG.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSLLRTLV RRYCAGEENW VDSRTIYVGH KEPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RIANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RADGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEADVDSL HATIECEQPQ PDLYKFVGRI NVYNDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNTFLIVY
310 320 330 340 350
LCILVSKALI NTVLKYVWQS EPFRDEPWYN EKTESERQRN LFLRAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEEM GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMAFKECC IEGHVYVPHV ICNGQVLPDS
460 470 480 490 500
SGIDMIDSSP GVCGREREEL FFRAICLCHT VQVKDDHCGD DVDGPQKSPD
510 520 530 540 550
AKSCVYISSS PDEVALVEGV QRLGFTYLRL KDNYMEILNR ENDIERFELL
560 570 580 590 600
EVLTFDSVRR RMSVIVKSTT GEIYLFCKGA DSSIFPRVIE GKVDQVRSRV
610 620 630 640 650
ERNAVEGLRT LCVAYKRLEP EQYEDACRLL QSAKVALQDR EKKLAEAYEQ
660 670 680 690 700
IEKDLVLLGA TAVEDRLQEK AADTIEALQK AGIKVWVLTG DKMETASATC
710 720 730 740 750
YACKLFRRST QLLELTTKKL EEQSLHDVLF DLSKTVLRCS GSMTRDSFSG
760 770 780 790 800
LSTDMHDYGL IIDGAALSLI MKPREDGSSS GNYRELFLEI CRNCSAVLCC
810 820 830 840 850
RMAPLQKAQI VKLIKFSKEH PITLAIGDGA NDVSMILEAH VGIGVIGKEG
860 870 880 890 900
RQAARNSDYA IPKFKHLKKM LLVHGHFYYI RISELVQYFF YKNVCFIFPQ
910 920 930 940 950
FLYQFFCGFS QQTLYDTAYL TLYNISFTSL PILLYSLMEQ HVGIDVLKRD
960 970 980 990 1000
PTLYRDIAKN ALLRWRVFIY WTFLGVFDAL VFFFGAYFIF ENTTVTINGQ
1010 1020 1030 1040 1050
MFGNWTFGTL VFTVMVLTVT LKLALDTHYW TWINHFVIWG SLLFYIAFSL
1060 1070 1080 1090 1100
LWGGVIWPFL SYQRMYYVFI SMLSSGPAWL GIILLVTVGL LPDVLKKVLC
1110 1120 1130 1140 1150
RQLWPTATER TQNIQHQDSI SEFTPLASLP SWGAQGSRLL AAQCSSPSGR
1160 1170 1180
VVCSRWESEE CPVLPLHPGL PHKARYGCCR SSLEMPT
Length:1,187
Mass (Da):135,502
Last modified:May 30, 2000 - v1
Checksum:i999A8BE19E9296C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156551 mRNA. Translation: AAF09449.1.
BC138715 mRNA. Translation: AAI38716.1.
CCDSiCCDS40223.1.
RefSeqiNP_056619.1. NM_015804.3.
XP_011240370.1. XM_011242068.1.
UniGeneiMm.257837.

Genome annotation databases

EnsembliENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441.
GeneIDi50770.
KEGGimmu:50770.
UCSCiuc009kwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156551 mRNA. Translation: AAF09449.1.
BC138715 mRNA. Translation: AAI38716.1.
CCDSiCCDS40223.1.
RefSeqiNP_056619.1. NM_015804.3.
XP_011240370.1. XM_011242068.1.
UniGeneiMm.257837.

3D structure databases

ProteinModelPortaliP98197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98197. 1 interaction.
MINTiMINT-1850358.
STRINGi10090.ENSMUSP00000088779.

PTM databases

iPTMnetiP98197.
PhosphoSiteiP98197.

Proteomic databases

MaxQBiP98197.
PaxDbiP98197.
PRIDEiP98197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441.
GeneIDi50770.
KEGGimmu:50770.
UCSCiuc009kwg.1. mouse.

Organism-specific databases

CTDi23250.
MGIiMGI:1354735. Atp11a.

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOVERGENiHBG050601.
InParanoidiP98197.
KOiK01530.
OMAiKECCIEG.
TreeFamiTF326897.

Miscellaneous databases

ChiTaRSiAtp11a. mouse.
NextBioi307687.
PROiP98197.
SOURCEiSearch...

Gene expression databases

BgeeiP98197.
CleanExiMM_ATP11A.
ExpressionAtlasiP98197. baseline and differential.
GenevisibleiP98197. MM.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of putative transbilayer amphipath transporters."
    Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A.
    Physiol. Genomics 1:139-150(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Testis.

Entry informationi

Entry nameiAT11A_MOUSE
AccessioniPrimary (citable) accession number: P98197
Secondary accession number(s): B2RS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.