Probable phospholipid-transporting ATPase IH

Names and origin

Protein names

Recommended name:
    Probable phospholipid-transporting ATPase IH
    EC=3.6.3.1
Alternative name(s):
    ATPase class VI type 11A
    ATPase IS

Gene names

Name:

Atp11a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity	ATP + H₂O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found in heart, muscle, liver and brain. Most abundant in heart. Also detected in fetal tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.

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Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro phospholipid transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1187

1187

Probable phospholipid-transporting ATPase IH

PRO_0000046370

Regions

Topological domain

1 – 61

61

Cytoplasmic Potential

Transmembrane

62 – 82

21

Potential

Topological domain

83 – 88

6

Extracellular Potential

Transmembrane

89 – 110

22

Potential

Topological domain

111 – 296

186

Cytoplasmic Potential

Transmembrane

297 – 318

22

Potential

Topological domain

319 – 349

31

Extracellular Potential

Transmembrane

350 – 372

23

Potential

Topological domain

373 – 884

512

Cytoplasmic Potential

Transmembrane

885 – 905

21

Potential

Topological domain

906 – 917

12

Extracellular Potential

Transmembrane

918 – 937

20

Potential

Topological domain

938 – 967

30

Cytoplasmic Potential

Transmembrane

968 – 989

22

Potential

Topological domain

990 – 1003

14

Extracellular Potential

Transmembrane

1004 – 1026

23

Potential

Topological domain

1027 – 1032

6

Cytoplasmic Potential

Transmembrane

1033 – 1053

21

Potential

Topological domain

1054 – 1071

18

Extracellular Potential

Transmembrane

1072 – 1096

25

Potential

Topological domain

1097 – 1138

42

Cytoplasmic Potential

Sites

Active site

414

1

4-aspartylphosphate intermediate By similarity

Metal binding

828

1

Magnesium By similarity

Metal binding

832

1

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P98197-1 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: 999A8BE19E9296C1
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FASTA

1,187

135,502

        10         20         30         40         50         60 
MDCSLLRTLV RRYCAGEENW VDSRTIYVGH KEPPPGAEAY IPQRYPDNRI VSSKYTFWNF 

        70         80         90        100        110        120 
IPKNLFEQFR RIANFYFLII FLVQLIIDTP TSPVTSGLPL FFVITVTAIK QGYEDWLRHK 

       130        140        150        160        170        180 
ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD IVMVKEDETF PCDLIFLSSN RADGTCHVTT 

       190        200        210        220        230        240 
ASLDGESSHK THYAVQDTKG FHTEADVDSL HATIECEQPQ PDLYKFVGRI NVYNDLNDPV 

       250        260        270        280        290        300 
VRPLGSENLL LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNTFLIVY 

       310        320        330        340        350        360 
LCILVSKALI NTVLKYVWQS EPFRDEPWYN EKTESERQRN LFLRAFTDFL AFMVLFNYII 

       370        380        390        400        410        420 
PVSMYVTVEM QKFLGSYFIT WDEDMFDEEM GEGPLVNTSD LNEELGQVEY IFTDKTGTLT 

       430        440        450        460        470        480 
ENNMAFKECC IEGHVYVPHV ICNGQVLPDS SGIDMIDSSP GVCGREREEL FFRAICLCHT 

       490        500        510        520        530        540 
VQVKDDHCGD DVDGPQKSPD AKSCVYISSS PDEVALVEGV QRLGFTYLRL KDNYMEILNR 

       550        560        570        580        590        600 
ENDIERFELL EVLTFDSVRR RMSVIVKSTT GEIYLFCKGA DSSIFPRVIE GKVDQVRSRV 

       610        620        630        640        650        660 
ERNAVEGLRT LCVAYKRLEP EQYEDACRLL QSAKVALQDR EKKLAEAYEQ IEKDLVLLGA 

       670        680        690        700        710        720 
TAVEDRLQEK AADTIEALQK AGIKVWVLTG DKMETASATC YACKLFRRST QLLELTTKKL 

       730        740        750        760        770        780 
EEQSLHDVLF DLSKTVLRCS GSMTRDSFSG LSTDMHDYGL IIDGAALSLI MKPREDGSSS 

       790        800        810        820        830        840 
GNYRELFLEI CRNCSAVLCC RMAPLQKAQI VKLIKFSKEH PITLAIGDGA NDVSMILEAH 

       850        860        870        880        890        900 
VGIGVIGKEG RQAARNSDYA IPKFKHLKKM LLVHGHFYYI RISELVQYFF YKNVCFIFPQ 

       910        920        930        940        950        960 
FLYQFFCGFS QQTLYDTAYL TLYNISFTSL PILLYSLMEQ HVGIDVLKRD PTLYRDIAKN 

       970        980        990       1000       1010       1020 
ALLRWRVFIY WTFLGVFDAL VFFFGAYFIF ENTTVTINGQ MFGNWTFGTL VFTVMVLTVT 

      1030       1040       1050       1060       1070       1080 
LKLALDTHYW TWINHFVIWG SLLFYIAFSL LWGGVIWPFL SYQRMYYVFI SMLSSGPAWL 

      1090       1100       1110       1120       1130       1140 
GIILLVTVGL LPDVLKKVLC RQLWPTATER TQNIQHQDSI SEFTPLASLP SWGAQGSRLL 

      1150       1160       1170       1180 
AAQCSSPSGR VVCSRWESEE CPVLPLHPGL PHKARYGCCR SSLEMPT

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of putative transbilayer amphipath transporters." Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A. Physiol. Genomics 1:139-150(1999) [PubMed: 11015572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AF156551 mRNA. Translation: AAF09449.1. BC138715 mRNA. Translation: AAI38716.1.
IPI	IPI00126677.
RefSeq	NP_056619.1.
UniGene	Mm.257837
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P98197.
Proteomic databases
PRIDE	P98197.
Genome annotation databases
Ensembl	ENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441; Mus musculus. [Genome view]
GeneID	50770.
KEGG	mmu:50770.
NMPDR	fig\|10090.3.peg.18173.
UCSC	uc009kwg.1. mouse.
Organism-specific databases
CTD	50770.
MGI	MGI:1354735. Atp11a.
Phylogenomic databases
HOVERGEN	P98197.
OMA	DTHYWTW.
Enzyme and pathway databases
BRENDA	3.6.3.1. 244.
Gene expression databases
ArrayExpress	P98197.
Bgee	P98197.
CleanEx	MM_ATP11A.
Genevestigator	P98197.
GermOnline	ENSMUSG00000031441. Mus musculus.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	307687.
SOURCE	Search...

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Entry information

Entry name

AT11A_MOUSE

Accession

Primary (citable) accession number: P98197
Secondary accession number(s): B2RS49

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents