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Protein

Probable phospholipid-transporting ATPase IH

Gene

Atp11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity).By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4144-aspartylphosphate intermediateBy similarity1
Metal bindingi828MagnesiumBy similarity1
Metal bindingi832MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
Gene namesi
Name:Atp11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354735. Atp11a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 88ExtracellularSequence analysis6
Transmembranei89 – 110HelicalSequence analysisAdd BLAST22
Topological domaini111 – 296CytoplasmicSequence analysisAdd BLAST186
Transmembranei297 – 318HelicalSequence analysisAdd BLAST22
Topological domaini319 – 349ExtracellularSequence analysisAdd BLAST31
Transmembranei350 – 372HelicalSequence analysisAdd BLAST23
Topological domaini373 – 884CytoplasmicSequence analysisAdd BLAST512
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 917ExtracellularSequence analysisAdd BLAST12
Transmembranei918 – 937HelicalSequence analysisAdd BLAST20
Topological domaini938 – 967CytoplasmicSequence analysisAdd BLAST30
Transmembranei968 – 989HelicalSequence analysisAdd BLAST22
Topological domaini990 – 1003ExtracellularSequence analysisAdd BLAST14
Transmembranei1004 – 1026HelicalSequence analysisAdd BLAST23
Topological domaini1027 – 1032CytoplasmicSequence analysis6
Transmembranei1033 – 1053HelicalSequence analysisAdd BLAST21
Topological domaini1054 – 1071ExtracellularSequence analysisAdd BLAST18
Transmembranei1072 – 1096HelicalSequence analysisAdd BLAST25
Topological domaini1097 – 1138CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463701 – 1187Probable phospholipid-transporting ATPase IHAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP98197.
PaxDbiP98197.
PRIDEiP98197.

PTM databases

iPTMnetiP98197.
PhosphoSitePlusiP98197.

Expressioni

Tissue specificityi

Found in heart, muscle, liver and brain. Most abundant in heart. Also detected in fetal tissues.

Gene expression databases

BgeeiENSMUSG00000031441.
CleanExiMM_ATP11A.
ExpressionAtlasiP98197. baseline and differential.
GenevisibleiP98197. MM.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A (By similarity).By similarity

Protein-protein interaction databases

IntActiP98197. 1 interactor.
MINTiMINT-1850358.
STRINGi10090.ENSMUSP00000088779.

Structurei

3D structure databases

ProteinModelPortaliP98197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOVERGENiHBG050601.
InParanoidiP98197.
KOiK01530.
OMAiKECCIEG.
OrthoDBiEOG091G03B1.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSLLRTLV RRYCAGEENW VDSRTIYVGH KEPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RIANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RADGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEADVDSL HATIECEQPQ PDLYKFVGRI NVYNDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNTFLIVY
310 320 330 340 350
LCILVSKALI NTVLKYVWQS EPFRDEPWYN EKTESERQRN LFLRAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEEM GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMAFKECC IEGHVYVPHV ICNGQVLPDS
460 470 480 490 500
SGIDMIDSSP GVCGREREEL FFRAICLCHT VQVKDDHCGD DVDGPQKSPD
510 520 530 540 550
AKSCVYISSS PDEVALVEGV QRLGFTYLRL KDNYMEILNR ENDIERFELL
560 570 580 590 600
EVLTFDSVRR RMSVIVKSTT GEIYLFCKGA DSSIFPRVIE GKVDQVRSRV
610 620 630 640 650
ERNAVEGLRT LCVAYKRLEP EQYEDACRLL QSAKVALQDR EKKLAEAYEQ
660 670 680 690 700
IEKDLVLLGA TAVEDRLQEK AADTIEALQK AGIKVWVLTG DKMETASATC
710 720 730 740 750
YACKLFRRST QLLELTTKKL EEQSLHDVLF DLSKTVLRCS GSMTRDSFSG
760 770 780 790 800
LSTDMHDYGL IIDGAALSLI MKPREDGSSS GNYRELFLEI CRNCSAVLCC
810 820 830 840 850
RMAPLQKAQI VKLIKFSKEH PITLAIGDGA NDVSMILEAH VGIGVIGKEG
860 870 880 890 900
RQAARNSDYA IPKFKHLKKM LLVHGHFYYI RISELVQYFF YKNVCFIFPQ
910 920 930 940 950
FLYQFFCGFS QQTLYDTAYL TLYNISFTSL PILLYSLMEQ HVGIDVLKRD
960 970 980 990 1000
PTLYRDIAKN ALLRWRVFIY WTFLGVFDAL VFFFGAYFIF ENTTVTINGQ
1010 1020 1030 1040 1050
MFGNWTFGTL VFTVMVLTVT LKLALDTHYW TWINHFVIWG SLLFYIAFSL
1060 1070 1080 1090 1100
LWGGVIWPFL SYQRMYYVFI SMLSSGPAWL GIILLVTVGL LPDVLKKVLC
1110 1120 1130 1140 1150
RQLWPTATER TQNIQHQDSI SEFTPLASLP SWGAQGSRLL AAQCSSPSGR
1160 1170 1180
VVCSRWESEE CPVLPLHPGL PHKARYGCCR SSLEMPT
Length:1,187
Mass (Da):135,502
Last modified:May 30, 2000 - v1
Checksum:i999A8BE19E9296C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156551 mRNA. Translation: AAF09449.1.
BC138715 mRNA. Translation: AAI38716.1.
CCDSiCCDS40223.1.
RefSeqiNP_056619.1. NM_015804.3.
XP_011240370.1. XM_011242068.1.
UniGeneiMm.257837.

Genome annotation databases

EnsembliENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441.
GeneIDi50770.
KEGGimmu:50770.
UCSCiuc009kwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156551 mRNA. Translation: AAF09449.1.
BC138715 mRNA. Translation: AAI38716.1.
CCDSiCCDS40223.1.
RefSeqiNP_056619.1. NM_015804.3.
XP_011240370.1. XM_011242068.1.
UniGeneiMm.257837.

3D structure databases

ProteinModelPortaliP98197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98197. 1 interactor.
MINTiMINT-1850358.
STRINGi10090.ENSMUSP00000088779.

PTM databases

iPTMnetiP98197.
PhosphoSitePlusiP98197.

Proteomic databases

MaxQBiP98197.
PaxDbiP98197.
PRIDEiP98197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441.
GeneIDi50770.
KEGGimmu:50770.
UCSCiuc009kwg.1. mouse.

Organism-specific databases

CTDi23250.
MGIiMGI:1354735. Atp11a.

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOVERGENiHBG050601.
InParanoidiP98197.
KOiK01530.
OMAiKECCIEG.
OrthoDBiEOG091G03B1.
TreeFamiTF326897.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiAtp11a. mouse.
PROiP98197.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031441.
CleanExiMM_ATP11A.
ExpressionAtlasiP98197. baseline and differential.
GenevisibleiP98197. MM.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT11A_MOUSE
AccessioniPrimary (citable) accession number: P98197
Secondary accession number(s): B2RS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.