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Protein

Probable phospholipid-transporting ATPase IH

Gene

ATP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.1 PublicationCurated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei414 – 41414-aspartylphosphate intermediateBy similarity
Metal bindingi825 – 8251MagnesiumBy similarity
Metal bindingi829 – 8291MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phospholipid-translocating ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
Gene namesi
Name:ATP11A
Synonyms:ATPIH, ATPIS, KIAA1021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:13552. ATP11A.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Early endosome 1 Publication. Recycling endosome 1 Publication. Endoplasmic reticulum 1 Publication
Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 886ExtracellularSequence Analysis
Transmembranei89 – 11022HelicalSequence AnalysisAdd
BLAST
Topological domaini111 – 296186CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei297 – 31822HelicalSequence AnalysisAdd
BLAST
Topological domaini319 – 34931ExtracellularSequence AnalysisAdd
BLAST
Transmembranei350 – 37223HelicalSequence AnalysisAdd
BLAST
Topological domaini373 – 881509CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei882 – 90221HelicalSequence AnalysisAdd
BLAST
Topological domaini903 – 91412ExtracellularSequence AnalysisAdd
BLAST
Transmembranei915 – 93420HelicalSequence AnalysisAdd
BLAST
Topological domaini935 – 96430CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei965 – 98622HelicalSequence AnalysisAdd
BLAST
Topological domaini987 – 100014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1001 – 102323HelicalSequence AnalysisAdd
BLAST
Topological domaini1024 – 10296CytoplasmicSequence Analysis
Transmembranei1030 – 105021HelicalSequence AnalysisAdd
BLAST
Topological domaini1051 – 106818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1069 – 109325HelicalSequence AnalysisAdd
BLAST
Topological domaini1094 – 113441CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular membrane-bounded organelle Source: HPA
  5. lysosomal membrane Source: UniProtKB
  6. membrane Source: UniProtKB
  7. plasma membrane Source: UniProtKB-SubCell
  8. recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA25101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11341134Probable phospholipid-transporting ATPase IHPRO_0000046369Add
BLAST

Proteomic databases

MaxQBiP98196.
PaxDbiP98196.
PRIDEiP98196.

PTM databases

PhosphoSiteiP98196.

Expressioni

Gene expression databases

BgeeiP98196.
CleanExiHS_ATP11A.
ExpressionAtlasiP98196. baseline and differential.
GenevestigatoriP98196.

Organism-specific databases

HPAiHPA035583.
HPA035584.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.1 PublicationCurated

Protein-protein interaction databases

BioGridi116854. 4 interactions.
MINTiMINT-5004429.
STRINGi9606.ENSP00000283558.

Structurei

3D structure databases

ProteinModelPortaliP98196.
SMRiP98196. Positions 342-900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiP98196.
KOiK01530.
OrthoDBiEOG7HHWRB.
PhylomeDBiP98196.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY
310 320 330 340 350
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES
460 470 480 490 500
SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK
510 520 530 540 550
SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI
560 570 580 590 600
LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER
610 620 630 640 650
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE
660 670 680 690 700
KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA
710 720 730 740 750
CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS
760 770 780 790 800
ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA
810 820 830 840 850
PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA
860 870 880 890 900
ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY
910 920 930 940 950
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL
960 970 980 990 1000
YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG
1010 1020 1030 1040 1050
NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG
1060 1070 1080 1090 1100
GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL
1110 1120 1130
WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF
Length:1,134
Mass (Da):129,756
Last modified:January 24, 2006 - v3
Checksum:iA486BDFC85D6D3B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171M → V.1 Publication
Corresponds to variant rs368865 [ dbSNP | Ensembl ].
VAR_059139
Natural varianti1091 – 10911V → I.
Corresponds to variant rs11616795 [ dbSNP | Ensembl ].
VAR_048379

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1.
AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1.
AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1.
AB028944 mRNA. Translation: BAA82973.2.
CCDSiCCDS32011.1.
RefSeqiNP_056020.2. NM_015205.2.
NP_115565.3. NM_032189.3.
XP_005268362.1. XM_005268305.2.
XP_005268363.1. XM_005268306.2.
XP_006720028.1. XM_006719965.1.
UniGeneiHs.29189.

Genome annotation databases

EnsembliENST00000375645; ENSP00000364796; ENSG00000068650.
ENST00000487903; ENSP00000420387; ENSG00000068650.
GeneIDi23250.
KEGGihsa:23250.
UCSCiuc001vsi.4. human.

Polymorphism databases

DMDMi85700404.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1.
AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1.
AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1.
AB028944 mRNA. Translation: BAA82973.2.
CCDSiCCDS32011.1.
RefSeqiNP_056020.2. NM_015205.2.
NP_115565.3. NM_032189.3.
XP_005268362.1. XM_005268305.2.
XP_005268363.1. XM_005268306.2.
XP_006720028.1. XM_006719965.1.
UniGeneiHs.29189.

3D structure databases

ProteinModelPortaliP98196.
SMRiP98196. Positions 342-900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116854. 4 interactions.
MINTiMINT-5004429.
STRINGi9606.ENSP00000283558.

PTM databases

PhosphoSiteiP98196.

Polymorphism databases

DMDMi85700404.

Proteomic databases

MaxQBiP98196.
PaxDbiP98196.
PRIDEiP98196.

Protocols and materials databases

DNASUi23250.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375645; ENSP00000364796; ENSG00000068650.
ENST00000487903; ENSP00000420387; ENSG00000068650.
GeneIDi23250.
KEGGihsa:23250.
UCSCiuc001vsi.4. human.

Organism-specific databases

CTDi23250.
GeneCardsiGC13P113344.
HGNCiHGNC:13552. ATP11A.
HPAiHPA035583.
HPA035584.
MIMi605868. gene.
neXtProtiNX_P98196.
Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA25101.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiP98196.
KOiK01530.
OrthoDBiEOG7HHWRB.
PhylomeDBiP98196.
TreeFamiTF326897.

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP11A. human.
GenomeRNAii23250.
NextBioi44946.
PROiP98196.
SOURCEiSearch...

Gene expression databases

BgeeiP98196.
CleanExiHS_ATP11A.
ExpressionAtlasiP98196. baseline and differential.
GenevestigatoriP98196.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1134, VARIANT VAL-317.
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a."
    Zhang B., Groffen J., Heisterkamp N.
    Blood 106:1355-1361(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
    Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
    J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMEM30A, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAT11A_HUMAN
AccessioniPrimary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2006
Last modified: February 4, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression of ATP11A confers resistance to lonafarnib.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.