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P98196

- AT11A_HUMAN

UniProt

P98196 - AT11A_HUMAN

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Protein
Probable phospholipid-transporting ATPase IH
Gene
ATP11A, ATPIH, ATPIS, KIAA1021
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules Inferred. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei414 – 41414-aspartylphosphate intermediate By similarity
Metal bindingi825 – 8251Magnesium By similarity
Metal bindingi829 – 8291Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phospholipid-translocating ATPase activity Source: UniProtKB-EC
  5. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
Gene namesi
Name:ATP11A
Synonyms:ATPIH, ATPIS, KIAA1021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:13552. ATP11A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum
Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 886Extracellular Reviewed prediction
Transmembranei89 – 11022Helical; Reviewed prediction
Add
BLAST
Topological domaini111 – 296186Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei297 – 31822Helical; Reviewed prediction
Add
BLAST
Topological domaini319 – 34931Extracellular Reviewed prediction
Add
BLAST
Transmembranei350 – 37223Helical; Reviewed prediction
Add
BLAST
Topological domaini373 – 881509Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei882 – 90221Helical; Reviewed prediction
Add
BLAST
Topological domaini903 – 91412Extracellular Reviewed prediction
Add
BLAST
Transmembranei915 – 93420Helical; Reviewed prediction
Add
BLAST
Topological domaini935 – 96430Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei965 – 98622Helical; Reviewed prediction
Add
BLAST
Topological domaini987 – 100014Extracellular Reviewed prediction
Add
BLAST
Transmembranei1001 – 102323Helical; Reviewed prediction
Add
BLAST
Topological domaini1024 – 10296Cytoplasmic Reviewed prediction
Transmembranei1030 – 105021Helical; Reviewed prediction
Add
BLAST
Topological domaini1051 – 106818Extracellular Reviewed prediction
Add
BLAST
Transmembranei1069 – 109325Helical; Reviewed prediction
Add
BLAST
Topological domaini1094 – 113441Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosomal membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB-SubCell
  6. recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA25101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11341134Probable phospholipid-transporting ATPase IH
PRO_0000046369Add
BLAST

Proteomic databases

MaxQBiP98196.
PaxDbiP98196.
PRIDEiP98196.

PTM databases

PhosphoSiteiP98196.

Expressioni

Gene expression databases

ArrayExpressiP98196.
BgeeiP98196.
CleanExiHS_ATP11A.
GenevestigatoriP98196.

Organism-specific databases

HPAiHPA035583.
HPA035584.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit Inferred. Interacts with beta subunit TMEM30A.1 Publication

Protein-protein interaction databases

BioGridi116854. 3 interactions.
MINTiMINT-5004429.
STRINGi9606.ENSP00000283558.

Structurei

3D structure databases

ProteinModelPortaliP98196.
SMRiP98196. Positions 342-900.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
KOiK01530.
OrthoDBiEOG7HHWRB.
PhylomeDBiP98196.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98196-1 [UniParc]FASTAAdd to Basket

« Hide

MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI     50
VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL 100
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD 150
IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG 200
FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL 250
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY 300
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL 350
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD 400
LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES 450
SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK 500
SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI 550
LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER 600
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE 650
KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA 700
CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS 750
ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA 800
PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA 850
ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY 900
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL 950
YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG 1000
NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG 1050
GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL 1100
WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF 1134
Length:1,134
Mass (Da):129,756
Last modified:January 24, 2006 - v3
Checksum:iA486BDFC85D6D3B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171M → V.1 Publication
Corresponds to variant rs368865 [ dbSNP | Ensembl ].
VAR_059139
Natural varianti1091 – 10911V → I.
Corresponds to variant rs11616795 [ dbSNP | Ensembl ].
VAR_048379

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1.
AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1.
AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1.
AB028944 mRNA. Translation: BAA82973.2.
CCDSiCCDS32011.1.
RefSeqiNP_056020.2. NM_015205.2.
NP_115565.3. NM_032189.3.
XP_005268362.1. XM_005268305.2.
XP_005268363.1. XM_005268306.2.
XP_006720028.1. XM_006719965.1.
UniGeneiHs.29189.

Genome annotation databases

EnsembliENST00000283558; ENSP00000283558; ENSG00000068650.
ENST00000375645; ENSP00000364796; ENSG00000068650.
ENST00000487903; ENSP00000420387; ENSG00000068650.
GeneIDi23250.
KEGGihsa:23250.
UCSCiuc001vsi.4. human.

Polymorphism databases

DMDMi85700404.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356740 , AL139384 , AL356752 Genomic DNA. Translation: CAH70242.1 .
AL139384 , AL356740 , AL356752 Genomic DNA. Translation: CAI16947.1 .
AL356752 , AL356740 , AL139384 Genomic DNA. Translation: CAI16578.1 .
AB028944 mRNA. Translation: BAA82973.2 .
CCDSi CCDS32011.1.
RefSeqi NP_056020.2. NM_015205.2.
NP_115565.3. NM_032189.3.
XP_005268362.1. XM_005268305.2.
XP_005268363.1. XM_005268306.2.
XP_006720028.1. XM_006719965.1.
UniGenei Hs.29189.

3D structure databases

ProteinModelPortali P98196.
SMRi P98196. Positions 342-900.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116854. 3 interactions.
MINTi MINT-5004429.
STRINGi 9606.ENSP00000283558.

PTM databases

PhosphoSitei P98196.

Polymorphism databases

DMDMi 85700404.

Proteomic databases

MaxQBi P98196.
PaxDbi P98196.
PRIDEi P98196.

Protocols and materials databases

DNASUi 23250.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283558 ; ENSP00000283558 ; ENSG00000068650 .
ENST00000375645 ; ENSP00000364796 ; ENSG00000068650 .
ENST00000487903 ; ENSP00000420387 ; ENSG00000068650 .
GeneIDi 23250.
KEGGi hsa:23250.
UCSCi uc001vsi.4. human.

Organism-specific databases

CTDi 23250.
GeneCardsi GC13P113344.
HGNCi HGNC:13552. ATP11A.
HPAi HPA035583.
HPA035584.
MIMi 605868. gene.
neXtProti NX_P98196.
Orphaneti 2032. Idiopathic pulmonary fibrosis.
PharmGKBi PA25101.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000202528.
HOVERGENi HBG050601.
KOi K01530.
OrthoDBi EOG7HHWRB.
PhylomeDBi P98196.
TreeFami TF326897.

Enzyme and pathway databases

Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP11A. human.
GenomeRNAii 23250.
NextBioi 44946.
PROi P98196.
SOURCEi Search...

Gene expression databases

ArrayExpressi P98196.
Bgeei P98196.
CleanExi HS_ATP11A.
Genevestigatori P98196.

Family and domain databases

Gene3Di 2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
PANTHERi PTHR24092. PTHR24092. 1 hit.
Pfami PF00122. E1-E2_ATPase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1134, VARIANT VAL-317.
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a."
    Zhang B., Groffen J., Heisterkamp N.
    Blood 106:1355-1361(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
    Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
    J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMEM30A, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAT11A_HUMAN
AccessioniPrimary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression of ATP11A confers resistance to lonafarnib.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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