P98196 (AT11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase IH
EC=3.6.3.1

Alternative name(s):
ATPase IS
ATPase class VI type 11A

Gene names

Name:	ATP11A
Synonyms:	ATPIH, ATPIS, KIAA1021

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1134 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2).
Subunit structure	Interacts with TMEM30A, but not with TMEM30B. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane. Ref.4
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Ontologies

Keywords
Cellular component	Cell membrane Endoplasmic reticulum Endosome Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phospholipid translocation Non-traceable author statement Ref.4. Source: UniProtKB
Cellular_component	early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from direct assay Ref.4. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell recycling endosome Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation-transporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1134	1134	Probable phospholipid-transporting ATPase IH		PRO_0000046369
Regions
	Topological domain	1 – 61	61	Cytoplasmic Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 88	6	Extracellular Potential
	Transmembrane	89 – 110	22	Helical; Potential
	Topological domain	111 – 296	186	Cytoplasmic Potential
	Transmembrane	297 – 318	22	Helical; Potential
	Topological domain	319 – 349	31	Extracellular Potential
	Transmembrane	350 – 372	23	Helical; Potential
	Topological domain	373 – 881	509	Cytoplasmic Potential
	Transmembrane	882 – 902	21	Helical; Potential
	Topological domain	903 – 914	12	Extracellular Potential
	Transmembrane	915 – 934	20	Helical; Potential
	Topological domain	935 – 964	30	Cytoplasmic Potential
	Transmembrane	965 – 986	22	Helical; Potential
	Topological domain	987 – 1000	14	Extracellular Potential
	Transmembrane	1001 – 1023	23	Helical; Potential
	Topological domain	1024 – 1029	6	Cytoplasmic Potential
	Transmembrane	1030 – 1050	21	Helical; Potential
	Topological domain	1051 – 1068	18	Extracellular Potential
	Transmembrane	1069 – 1093	25	Helical; Potential
	Topological domain	1094 – 1134	41	Cytoplasmic Potential
Sites
	Active site	414	1	4-aspartylphosphate intermediate By similarity
	Metal binding	825	1	Magnesium By similarity
	Metal binding	829	1	Magnesium By similarity
Natural variations
	Natural variant	317	1	M → V. Ref.2 Corresponds to variant rs368865 [ dbSNP | Ensembl ].		VAR_059139
	Natural variant	1091	1	V → I. Corresponds to variant rs11616795 [ dbSNP | Ensembl ].		VAR_048379

Sequences

	Sequence		Length	Mass (Da)
	P98196 [UniParc]. Last modified January 24, 2006. Version 3. Checksum: A486BDFC85D6D3B2	FASTA	1,134	129,756
	10 20 30 40 50 60 MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI VSSKYTFWNF 70 80 90 100 110 120 IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL FFVITVTAIK QGYEDWLRHK 130 140 150 160 170 180 ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD IVMVKEDETF PCDLIFLSSN RGDGTCHVTT 190 200 210 220 230 240 ASLDGESSHK THYAVQDTKG FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV 250 260 270 280 290 300 VRPLGSENLL LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY 310 320 330 340 350 360 LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL AFMVLFNYII 370 380 390 400 410 420 PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD LNEELGQVEY IFTDKTGTLT 430 440 450 460 470 480 ENNMEFKECC IEGHVYVPHV ICNGQVLPES SGIDMIDSSP SVNGREREEL FFRALCLCHT 490 500 510 520 530 540 VQVKDDDSVD GPRKSPDGGK SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN 550 560 570 580 590 600 HIERFELLEI LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER 610 620 630 640 650 660 NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE KDLTLLGATA 670 680 690 700 710 720 VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA CKLFRRNTQL LELTTKRIEE 730 740 750 760 770 780 QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS ADMQDYGLII DGAALSLIMK PREDGSSGNY 790 800 810 820 830 840 RELFLEICRS CSAVLCCRMA PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI 850 860 870 880 890 900 GVIGKEGRQA ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY 910 920 930 940 950 960 QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL YRDVAKNALL 970 980 990 1000 1010 1020 RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG NWTFGTLVFT VMVFTVTLKL 1030 1040 1050 1060 1070 1080 ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV 1090 1100 1110 1120 1130 LLVTISLLPD VLKKVLCRQL WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1134, VARIANT VAL-317. Tissue: Brain.
[3]	Ohara O., Nagase T., Kikuno R. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner." Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W. J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TMEM30A, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1. AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1. AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1. AB028944 mRNA. Translation: BAA82973.2.
IPI	IPI00255653.
RefSeq	NP_056020.2. NM_015205.2. NP_115565.3. NM_032189.3.
UniGene	Hs.29189.
3D structure databases
ProteinModelPortal	P98196.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000283558.
PTM databases
PhosphoSite	P98196.
Polymorphism databases
DMDM	85700404.
Proteomic databases
PaxDb	P98196.
PRIDE	P98196.
Protocols and materials databases
DNASU	23250.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283558; ENSP00000283558; ENSG00000068650. ENST00000375645; ENSP00000364796; ENSG00000068650. ENST00000487903; ENSP00000420387; ENSG00000068650.
GeneID	23250.
KEGG	hsa:23250.
UCSC	uc001vsi.4. human.
Organism-specific databases
CTD	23250.
GeneCards	GC13P113344.
HGNC	HGNC:13552. ATP11A.
HPA	HPA035583. HPA035584.
MIM	605868. gene.
neXtProt	NX_P98196.
PharmGKB	PA25101.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0474.
HOGENOM	HOG000202528.
HOVERGEN	HBG050601.
KO	K01530.
OrthoDB	EOG4FTVZT.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P98196.
Bgee	P98196.
CleanEx	HS_ATP11A.
Genevestigator	P98196.
GermOnline	ENSG00000068650. Homo sapiens.
Family and domain databases
Gene3D	2.70.150.10. 2 hits. 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transp. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24092. PTHR24092. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATP11A. human.
GenomeRNAi	23250.
NextBio	44946.
SOURCE	Search...

Entry information

Entry name

AT11A_HUMAN

Accession

Primary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.