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P98196

- AT11A_HUMAN

UniProt

P98196 - AT11A_HUMAN

Protein

Probable phospholipid-transporting ATPase IH

Gene

ATP11A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules Probable. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.1 PublicationCurated

    Catalytic activityi

    ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei414 – 41414-aspartylphosphate intermediateBy similarity
    Metal bindingi825 – 8251MagnesiumBy similarity
    Metal bindingi829 – 8291MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. phospholipid-translocating ATPase activity Source: UniProtKB-EC
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. phospholipid translocation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
    Alternative name(s):
    ATPase IS
    ATPase class VI type 11A
    P4-ATPase flippase complex alpha subunit ATP11A
    Gene namesi
    Name:ATP11A
    Synonyms:ATPIH, ATPIS, KIAA1021
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:13552. ATP11A.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Early endosome 1 Publication. Recycling endosome 1 Publication. Endoplasmic reticulum 1 Publication
    Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosomal membrane Source: UniProtKB
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB-SubCell
    7. recycling endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2032. Idiopathic pulmonary fibrosis.
    PharmGKBiPA25101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11341134Probable phospholipid-transporting ATPase IHPRO_0000046369Add
    BLAST

    Proteomic databases

    MaxQBiP98196.
    PaxDbiP98196.
    PRIDEiP98196.

    PTM databases

    PhosphoSiteiP98196.

    Expressioni

    Gene expression databases

    ArrayExpressiP98196.
    BgeeiP98196.
    CleanExiHS_ATP11A.
    GenevestigatoriP98196.

    Organism-specific databases

    HPAiHPA035583.
    HPA035584.

    Interactioni

    Subunit structurei

    Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit Probable. Interacts with beta subunit TMEM30A.1 PublicationCurated

    Protein-protein interaction databases

    BioGridi116854. 3 interactions.
    MINTiMINT-5004429.
    STRINGi9606.ENSP00000283558.

    Structurei

    3D structure databases

    ProteinModelPortaliP98196.
    SMRiP98196. Positions 342-900.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 886ExtracellularSequence Analysis
    Topological domaini111 – 296186CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 34931ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini373 – 881509CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini903 – 91412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini935 – 96430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini987 – 100014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1024 – 10296CytoplasmicSequence Analysis
    Topological domaini1051 – 106818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1094 – 113441CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 11022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei882 – 90221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei915 – 93420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei965 – 98622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1001 – 102323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1030 – 105021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1069 – 109325HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000202528.
    HOVERGENiHBG050601.
    KOiK01530.
    OrthoDBiEOG7HHWRB.
    PhylomeDBiP98196.
    TreeFamiTF326897.

    Family and domain databases

    Gene3Di2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PANTHERiPTHR24092. PTHR24092. 1 hit.
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI     50
    VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL 100
    FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD 150
    IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG 200
    FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL 250
    LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY 300
    LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL 350
    AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD 400
    LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES 450
    SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK 500
    SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI 550
    LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER 600
    NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE 650
    KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA 700
    CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS 750
    ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA 800
    PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA 850
    ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY 900
    QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL 950
    YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG 1000
    NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG 1050
    GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL 1100
    WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF 1134
    Length:1,134
    Mass (Da):129,756
    Last modified:January 24, 2006 - v3
    Checksum:iA486BDFC85D6D3B2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171M → V.1 Publication
    Corresponds to variant rs368865 [ dbSNP | Ensembl ].
    VAR_059139
    Natural varianti1091 – 10911V → I.
    Corresponds to variant rs11616795 [ dbSNP | Ensembl ].
    VAR_048379

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1.
    AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1.
    AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1.
    AB028944 mRNA. Translation: BAA82973.2.
    CCDSiCCDS32011.1.
    RefSeqiNP_056020.2. NM_015205.2.
    NP_115565.3. NM_032189.3.
    XP_005268362.1. XM_005268305.2.
    XP_005268363.1. XM_005268306.2.
    XP_006720028.1. XM_006719965.1.
    UniGeneiHs.29189.

    Genome annotation databases

    EnsembliENST00000375645; ENSP00000364796; ENSG00000068650.
    ENST00000487903; ENSP00000420387; ENSG00000068650.
    GeneIDi23250.
    KEGGihsa:23250.
    UCSCiuc001vsi.4. human.

    Polymorphism databases

    DMDMi85700404.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356740 , AL139384 , AL356752 Genomic DNA. Translation: CAH70242.1 .
    AL139384 , AL356740 , AL356752 Genomic DNA. Translation: CAI16947.1 .
    AL356752 , AL356740 , AL139384 Genomic DNA. Translation: CAI16578.1 .
    AB028944 mRNA. Translation: BAA82973.2 .
    CCDSi CCDS32011.1.
    RefSeqi NP_056020.2. NM_015205.2.
    NP_115565.3. NM_032189.3.
    XP_005268362.1. XM_005268305.2.
    XP_005268363.1. XM_005268306.2.
    XP_006720028.1. XM_006719965.1.
    UniGenei Hs.29189.

    3D structure databases

    ProteinModelPortali P98196.
    SMRi P98196. Positions 342-900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116854. 3 interactions.
    MINTi MINT-5004429.
    STRINGi 9606.ENSP00000283558.

    PTM databases

    PhosphoSitei P98196.

    Polymorphism databases

    DMDMi 85700404.

    Proteomic databases

    MaxQBi P98196.
    PaxDbi P98196.
    PRIDEi P98196.

    Protocols and materials databases

    DNASUi 23250.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375645 ; ENSP00000364796 ; ENSG00000068650 .
    ENST00000487903 ; ENSP00000420387 ; ENSG00000068650 .
    GeneIDi 23250.
    KEGGi hsa:23250.
    UCSCi uc001vsi.4. human.

    Organism-specific databases

    CTDi 23250.
    GeneCardsi GC13P113344.
    HGNCi HGNC:13552. ATP11A.
    HPAi HPA035583.
    HPA035584.
    MIMi 605868. gene.
    neXtProti NX_P98196.
    Orphaneti 2032. Idiopathic pulmonary fibrosis.
    PharmGKBi PA25101.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000202528.
    HOVERGENi HBG050601.
    KOi K01530.
    OrthoDBi EOG7HHWRB.
    PhylomeDBi P98196.
    TreeFami TF326897.

    Enzyme and pathway databases

    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    ChiTaRSi ATP11A. human.
    GenomeRNAii 23250.
    NextBioi 44946.
    PROi P98196.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P98196.
    Bgeei P98196.
    CleanExi HS_ATP11A.
    Genevestigatori P98196.

    Family and domain databases

    Gene3Di 2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    PANTHERi PTHR24092. PTHR24092. 1 hit.
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01652. ATPase-Plipid. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1134, VARIANT VAL-317.
      Tissue: Brain.
    3. Ohara O., Nagase T., Kikuno R.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a."
      Zhang B., Groffen J., Heisterkamp N.
      Blood 106:1355-1361(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
      Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
      J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMEM30A, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAT11A_HUMAN
    AccessioniPrimary (citable) accession number: P98196
    Secondary accession number(s): Q5VXT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Overexpression of ATP11A confers resistance to lonafarnib.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3