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P98196 (AT11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phospholipid-transporting ATPase IH

EC=3.6.3.1
Alternative name(s):
ATPase IS
ATPase class VI type 11A
Gene names
Name:ATP11A
Synonyms:ATPIH, ATPIS, KIAA1021
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1134 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Subunit structure

Interacts with TMEM30A, but not with TMEM30B. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane. Ref.4

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11341134Probable phospholipid-transporting ATPase IH
PRO_0000046369

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 886Extracellular Potential
Transmembrane89 – 11022Helical; Potential
Topological domain111 – 296186Cytoplasmic Potential
Transmembrane297 – 31822Helical; Potential
Topological domain319 – 34931Extracellular Potential
Transmembrane350 – 37223Helical; Potential
Topological domain373 – 881509Cytoplasmic Potential
Transmembrane882 – 90221Helical; Potential
Topological domain903 – 91412Extracellular Potential
Transmembrane915 – 93420Helical; Potential
Topological domain935 – 96430Cytoplasmic Potential
Transmembrane965 – 98622Helical; Potential
Topological domain987 – 100014Extracellular Potential
Transmembrane1001 – 102323Helical; Potential
Topological domain1024 – 10296Cytoplasmic Potential
Transmembrane1030 – 105021Helical; Potential
Topological domain1051 – 106818Extracellular Potential
Transmembrane1069 – 109325Helical; Potential
Topological domain1094 – 113441Cytoplasmic Potential

Sites

Active site41414-aspartylphosphate intermediate By similarity
Metal binding8251Magnesium By similarity
Metal binding8291Magnesium By similarity

Natural variations

Natural variant3171M → V. Ref.2
Corresponds to variant rs368865 [ dbSNP | Ensembl ].
VAR_059139
Natural variant10911V → I.
Corresponds to variant rs11616795 [ dbSNP | Ensembl ].
VAR_048379

Sequences

Sequence LengthMass (Da)Tools
P98196 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: A486BDFC85D6D3B2

FASTA1,134129,756
        10         20         30         40         50         60 
MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI VSSKYTFWNF 

        70         80         90        100        110        120 
IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL FFVITVTAIK QGYEDWLRHK 

       130        140        150        160        170        180 
ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD IVMVKEDETF PCDLIFLSSN RGDGTCHVTT 

       190        200        210        220        230        240 
ASLDGESSHK THYAVQDTKG FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV 

       250        260        270        280        290        300 
VRPLGSENLL LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY 

       310        320        330        340        350        360 
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL AFMVLFNYII 

       370        380        390        400        410        420 
PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD LNEELGQVEY IFTDKTGTLT 

       430        440        450        460        470        480 
ENNMEFKECC IEGHVYVPHV ICNGQVLPES SGIDMIDSSP SVNGREREEL FFRALCLCHT 

       490        500        510        520        530        540 
VQVKDDDSVD GPRKSPDGGK SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN 

       550        560        570        580        590        600 
HIERFELLEI LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER 

       610        620        630        640        650        660 
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE KDLTLLGATA 

       670        680        690        700        710        720 
VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA CKLFRRNTQL LELTTKRIEE 

       730        740        750        760        770        780 
QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS ADMQDYGLII DGAALSLIMK PREDGSSGNY 

       790        800        810        820        830        840 
RELFLEICRS CSAVLCCRMA PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI 

       850        860        870        880        890        900 
GVIGKEGRQA ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY 

       910        920        930        940        950        960 
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL YRDVAKNALL 

       970        980        990       1000       1010       1020 
RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG NWTFGTLVFT VMVFTVTLKL 

      1030       1040       1050       1060       1070       1080 
ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV 

      1090       1100       1110       1120       1130 
LLVTISLLPD VLKKVLCRQL WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1134, VARIANT VAL-317.
Tissue: Brain.
[3]Ohara O., Nagase T., Kikuno R.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TMEM30A, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL356740, AL139384, AL356752 Genomic DNA. Translation: CAH70242.1.
AL139384, AL356740, AL356752 Genomic DNA. Translation: CAI16947.1.
AL356752, AL356740, AL139384 Genomic DNA. Translation: CAI16578.1.
AB028944 mRNA. Translation: BAA82973.2.
RefSeqNP_056020.2. NM_015205.2.
NP_115565.3. NM_032189.3.
XP_005268362.1. XM_005268305.2.
XP_005268363.1. XM_005268306.2.
UniGeneHs.29189.

3D structure databases

ProteinModelPortalP98196.
SMRP98196. Positions 342-900.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116854. 3 interactions.
MINTMINT-5004429.
STRING9606.ENSP00000283558.

PTM databases

PhosphoSiteP98196.

Polymorphism databases

DMDM85700404.

Proteomic databases

PaxDbP98196.
PRIDEP98196.

Protocols and materials databases

DNASU23250.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283558; ENSP00000283558; ENSG00000068650.
ENST00000375645; ENSP00000364796; ENSG00000068650.
ENST00000487903; ENSP00000420387; ENSG00000068650.
GeneID23250.
KEGGhsa:23250.
UCSCuc001vsi.4. human.

Organism-specific databases

CTD23250.
GeneCardsGC13P113344.
HGNCHGNC:13552. ATP11A.
HPAHPA035583.
HPA035584.
MIM605868. gene.
neXtProtNX_P98196.
Orphanet2032. Idiopathic pulmonary fibrosis.
PharmGKBPA25101.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000202528.
HOVERGENHBG050601.
KOK01530.
OrthoDBEOG7HHWRB.
PhylomeDBP98196.
TreeFamTF326897.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP98196.
BgeeP98196.
CleanExHS_ATP11A.
GenevestigatorP98196.

Family and domain databases

Gene3D2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERPTHR24092. PTHR24092. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP11A. human.
GenomeRNAi23250.
NextBio44946.
PROP98196.
SOURCESearch...

Entry information

Entry nameAT11A_HUMAN
AccessionPrimary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM