Probable phospholipid-transporting ATPase IIB

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Sites

Natural variations

Experimental info

Molecule processing

Regions

Sites

Natural variations

Experimental info

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Protein names

Recommended name:
    Probable phospholipid-transporting ATPase IIB
    EC=3.6.3.1
Alternative name(s):
    ATPase class II type 9B

Gene names

Name:

Atp9b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Sequence length	1146 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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Catalytic activity	ATP + H₂O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found in most tissues except spleen and muscle. Most abundant in testis. Also detected in fetal tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.

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Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro phospholipid transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 1146

1146

Probable phospholipid-transporting ATPase IIB

PRO_0000046378

Topological domain

1 – 143

143

Cytoplasmic Potential

Transmembrane

144 – 164

21

Potential

Topological domain

165 – 172

8

Extracellular Potential

Transmembrane

173 – 193

21

Potential

Topological domain

194 – 381

188

Cytoplasmic Potential

Transmembrane

382 – 402

21

Potential

Topological domain

403 – 407

5

Extracellular Potential

Transmembrane

408 – 427

20

Potential

Topological domain

428 – 938

511

Cytoplasmic Potential

Transmembrane

939 – 959

21

Potential

Topological domain

960 – 961

2

Extracellular Potential

Transmembrane

962 – 982

21

Potential

Topological domain

983 – 1011

29

Cytoplasmic Potential

Transmembrane

1012 – 1032

21

Potential

Topological domain

1033 – 1040

8

Extracellular Potential

Transmembrane

1041 – 1061

21

Potential

Topological domain

1062 – 1065

4

Cytoplasmic Potential

Transmembrane

1066 – 1086

21

Potential

Topological domain

1087 – 1105

19

Extracellular Potential

Transmembrane

1106 – 1128

23

Potential

Topological domain

1129 – 1146

18

Cytoplasmic Potential

Active site

467

1

4-aspartylphosphate intermediate By similarity

Metal binding

873

1

Magnesium By similarity

Metal binding

877

1

Magnesium By similarity

Alternative sequence

1091 – 1101

11

Missing in isoform 2.

VSP_035908

Sequence conflict

366

1

N → K in AAH79626. Ref.1

Sequence conflict

605

1

V → I in AAH79626. Ref.1

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Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified December 16, 2008. Version 4. Checksum: 334AAEE291DFDC2E Show »	FASTA	1,146	129,017
10 20 30 40 50 60 MADQIPLYPV RSAGAAASHR RAAYYSSAGP GPGADRRGRY QLEDESAHLD EMPLMMSEEG 70 80 90 100 110 120 FENDESDYHT LPRARITRRK RGLEWFVCGG WKFLCTSCCD WLINVCQRKK ELKARTVWLG 130 140 150 160 170 180 CPEKCEEKHP RNSIKNQKYN VFTFIPGVLY EQFKFFLNLY FLVVSCSQFV PALKIGYLYT 190 200 210 220 230 240 YWAPLGFVLA VTIAREAIDE FRRFQRDKEM NSQLYSKLTV RGKVQVKSSD IQVGDLIIVE 250 260 270 280 290 300 KNQRIPSDMV FLRTSEKAGS CFIRTDQLDG ETDWKLKVAV SCTQRLPALG DLFSISAYVY 310 320 330 340 350 360 AQKPQLDIHS FEGTFTREDS DPPIHESLSI ENTLWASTIV ASGTVIGVVI YTGKETRSVM 370 380 390 400 410 420 NTSNPNNKVG LLDLELNQLT KALFLALVVL SVVMVTLQGF AGPWYRNLFR FLLLFSYIIP 430 440 450 460 470 480 ISLRVNLDMG KAAYGWMIMK DENIPGTVVR TSTIPEELGR LVYLLTDKTG TLTQNEMVFK 490 500 510 520 530 540 RLHLGTVSYG TDTMDEIQSH VLNSYLQVHS QPSGHNPSSA PLRRSQSSTP KVKKSVSSRI 550 560 570 580 590 600 HEAVKAIALC HNVTPVYEAR AGITGETEFA EADQDFSDEN RTYQASSPDE VALVRWTESV 610 620 630 640 650 660 GLTLVSRDLA SMQLKTPSGQ VLTYCILQMF PFTSESKRMG IIVRDESTAE ITFYMKGADV 670 680 690 700 710 720 AMSTIVQYND WLEEECGNMA REGLRTLVVA KRTLTEEQYQ DFESRYSQAK LSIHDRALKV 730 740 750 760 770 780 AAVVESLERE MELLCLTGVE DQLQADVRPT LEMLRNAGIK IWMLTGDKLE TATCIAKSSH 790 800 810 820 830 840 LVSRTQDIHV FRPVTSRGEA HLELNAFRRK HDCALVISGD SLEVCLRYYE HELVELACQC 850 860 870 880 890 900 PAVVCCRCSP TQKAHIVTLL RQHTRKRTCA IGDGGNDVSM IQAADCGIGI EGKEGKQASL 910 920 930 940 950 960 AADFSITQFR HIGRLLMVHG RNSYKRSAAL GQFVMHRGLI ISTMQAVFSS VFYFASVPLY 970 980 990 1000 1010 1020 QGFLMVGYAT IYTMFPVFSL VLDQDVKPEM AILYPELYKD LTKGRSLSFK TFLIWVLISI 1030 1040 1050 1060 1070 1080 YQGGILMYGA LLLFEDEFVH VVAISFTALI LTELLMVALT IRTWHWLMVV AEFLSLGCYV 1090 1100 1110 1120 1130 1140 ASLAFLNEYF GIGRVSFGAF LDVAFITTVT FLWKVSAITV VSCLPLYVLK YLKRKLSPPS YSKLSS « Hide
Isoform 2. Checksum: FF41C197C7AA7D58 Show »	FASTA	1,135	127,912
10 20 30 40 50 60 MADQIPLYPV RSAGAAASHR RAAYYSSAGP GPGADRRGRY QLEDESAHLD EMPLMMSEEG 70 80 90 100 110 120 FENDESDYHT LPRARITRRK RGLEWFVCGG WKFLCTSCCD WLINVCQRKK ELKARTVWLG 130 140 150 160 170 180 CPEKCEEKHP RNSIKNQKYN VFTFIPGVLY EQFKFFLNLY FLVVSCSQFV PALKIGYLYT 190 200 210 220 230 240 YWAPLGFVLA VTIAREAIDE FRRFQRDKEM NSQLYSKLTV RGKVQVKSSD IQVGDLIIVE 250 260 270 280 290 300 KNQRIPSDMV FLRTSEKAGS CFIRTDQLDG ETDWKLKVAV SCTQRLPALG DLFSISAYVY 310 320 330 340 350 360 AQKPQLDIHS FEGTFTREDS DPPIHESLSI ENTLWASTIV ASGTVIGVVI YTGKETRSVM 370 380 390 400 410 420 NTSNPNNKVG LLDLELNQLT KALFLALVVL SVVMVTLQGF AGPWYRNLFR FLLLFSYIIP 430 440 450 460 470 480 ISLRVNLDMG KAAYGWMIMK DENIPGTVVR TSTIPEELGR LVYLLTDKTG TLTQNEMVFK 490 500 510 520 530 540 RLHLGTVSYG TDTMDEIQSH VLNSYLQVHS QPSGHNPSSA PLRRSQSSTP KVKKSVSSRI 550 560 570 580 590 600 HEAVKAIALC HNVTPVYEAR AGITGETEFA EADQDFSDEN RTYQASSPDE VALVRWTESV 610 620 630 640 650 660 GLTLVSRDLA SMQLKTPSGQ VLTYCILQMF PFTSESKRMG IIVRDESTAE ITFYMKGADV 670 680 690 700 710 720 AMSTIVQYND WLEEECGNMA REGLRTLVVA KRTLTEEQYQ DFESRYSQAK LSIHDRALKV 730 740 750 760 770 780 AAVVESLERE MELLCLTGVE DQLQADVRPT LEMLRNAGIK IWMLTGDKLE TATCIAKSSH 790 800 810 820 830 840 LVSRTQDIHV FRPVTSRGEA HLELNAFRRK HDCALVISGD SLEVCLRYYE HELVELACQC 850 860 870 880 890 900 PAVVCCRCSP TQKAHIVTLL RQHTRKRTCA IGDGGNDVSM IQAADCGIGI EGKEGKQASL 910 920 930 940 950 960 AADFSITQFR HIGRLLMVHG RNSYKRSAAL GQFVMHRGLI ISTMQAVFSS VFYFASVPLY 970 980 990 1000 1010 1020 QGFLMVGYAT IYTMFPVFSL VLDQDVKPEM AILYPELYKD LTKGRSLSFK TFLIWVLISI 1030 1040 1050 1060 1070 1080 YQGGILMYGA LLLFEDEFVH VVAISFTALI LTELLMVALT IRTWHWLMVV AEFLSLGCYV 1090 1100 1110 1120 1130 ASLAFLNEYF DVAFITTVTF LWKVSAITVV SCLPLYVLKY LKRKLSPPSY SKLSS « Hide

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[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 709-1146 (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[2]	"Differential expression of putative transbilayer amphipath transporters." Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A. Physiol. Genomics 1:139-150(1999) [PubMed: 11015572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-1095 (ISOFORM 1). Strain: ICR. Tissue: Brain.
+	Additional computationally mapped references.

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Sequence databases
EMBL GenBank DDBJ	BC003246 mRNA. Translation: AAH03246.1. BC079626 mRNA. Translation: AAH79626.1. AF155913 mRNA. Translation: AAF08476.1.
IPI	IPI00471005. IPI00475210.
UniGene	Mm.247138
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P98195.
PTM databases
PhosphoSite	P98195.
Proteomic databases
PRIDE	P98195.
Genome annotation databases
Ensembl	ENSMUST00000025458; ENSMUSP00000025458; ENSMUSG00000024566; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1354757. Atp9b.
Phylogenomic databases
eggNOG	roNOG05302.
HOGENOM	HBG720821.
HOVERGEN	P98195.
InParanoid	P98195.
OrthoDB	EOG954CHZ.
Enzyme and pathway databases
BRENDA	3.6.3.1. 244.
Gene expression databases
ArrayExpress	P98195.
Bgee	P98195.
CleanEx	MM_ATP9B.
Genevestigator	P98195.
GermOnline	ENSMUSG00000024566. Mus musculus.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry name

ATP9B_MOUSE

Accession

Primary (citable) accession number: P98195
Secondary accession number(s): Q68FM3, Q99LI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 16, 2008
Last modified:	February 9, 2010
This is version 80 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P98195-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P98195-2)

The sequence of this isoform differs from the canonical sequence as follows:
1091-1101: Missing.

Note: No experimental confirmation available.