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Protein

Probable phospholipid-transporting ATPase IIB

Gene

Atp9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4674-aspartylphosphate intermediateBy similarity1
Metal bindingi873MagnesiumBy similarity1
Metal bindingi877MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIB (EC:3.6.3.1)
Alternative name(s):
ATPase class II type 9B
Gene namesi
Name:Atp9b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354757. Atp9b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 143CytoplasmicSequence analysisAdd BLAST143
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 172ExtracellularSequence analysis8
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 381CytoplasmicSequence analysisAdd BLAST188
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 407ExtracellularSequence analysis5
Transmembranei408 – 427HelicalSequence analysisAdd BLAST20
Topological domaini428 – 938CytoplasmicSequence analysisAdd BLAST511
Transmembranei939 – 959HelicalSequence analysisAdd BLAST21
Topological domaini960 – 961ExtracellularSequence analysis2
Transmembranei962 – 982HelicalSequence analysisAdd BLAST21
Topological domaini983 – 1011CytoplasmicSequence analysisAdd BLAST29
Transmembranei1012 – 1032HelicalSequence analysisAdd BLAST21
Topological domaini1033 – 1040ExtracellularSequence analysis8
Transmembranei1041 – 1061HelicalSequence analysisAdd BLAST21
Topological domaini1062 – 1065CytoplasmicSequence analysis4
Transmembranei1066 – 1086HelicalSequence analysisAdd BLAST21
Topological domaini1087 – 1105ExtracellularSequence analysisAdd BLAST19
Transmembranei1106 – 1128HelicalSequence analysisAdd BLAST23
Topological domaini1129 – 1146CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463781 – 1146Probable phospholipid-transporting ATPase IIBAdd BLAST1146

Proteomic databases

MaxQBiP98195.
PaxDbiP98195.
PRIDEiP98195.

PTM databases

iPTMnetiP98195.
PhosphoSitePlusiP98195.
SwissPalmiP98195.

Expressioni

Tissue specificityi

Found in most tissues except spleen and muscle. Most abundant in testis. Also detected in fetal tissues.

Gene expression databases

CleanExiMM_ATP9B.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089394.

Structurei

3D structure databases

ProteinModelPortaliP98195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0210. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000201571.
HOVERGENiHBG050617.
InParanoidiP98195.
KOiK01530.
PhylomeDBiP98195.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030355. ATP9B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF50. PTHR24092:SF50. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P98195-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADQIPLYPV RSAGAAASHR RAAYYSSAGP GPGADRRGRY QLEDESAHLD
60 70 80 90 100
EMPLMMSEEG FENDESDYHT LPRARITRRK RGLEWFVCGG WKFLCTSCCD
110 120 130 140 150
WLINVCQRKK ELKARTVWLG CPEKCEEKHP RNSIKNQKYN VFTFIPGVLY
160 170 180 190 200
EQFKFFLNLY FLVVSCSQFV PALKIGYLYT YWAPLGFVLA VTIAREAIDE
210 220 230 240 250
FRRFQRDKEM NSQLYSKLTV RGKVQVKSSD IQVGDLIIVE KNQRIPSDMV
260 270 280 290 300
FLRTSEKAGS CFIRTDQLDG ETDWKLKVAV SCTQRLPALG DLFSISAYVY
310 320 330 340 350
AQKPQLDIHS FEGTFTREDS DPPIHESLSI ENTLWASTIV ASGTVIGVVI
360 370 380 390 400
YTGKETRSVM NTSNPNNKVG LLDLELNQLT KALFLALVVL SVVMVTLQGF
410 420 430 440 450
AGPWYRNLFR FLLLFSYIIP ISLRVNLDMG KAAYGWMIMK DENIPGTVVR
460 470 480 490 500
TSTIPEELGR LVYLLTDKTG TLTQNEMVFK RLHLGTVSYG TDTMDEIQSH
510 520 530 540 550
VLNSYLQVHS QPSGHNPSSA PLRRSQSSTP KVKKSVSSRI HEAVKAIALC
560 570 580 590 600
HNVTPVYEAR AGITGETEFA EADQDFSDEN RTYQASSPDE VALVRWTESV
610 620 630 640 650
GLTLVSRDLA SMQLKTPSGQ VLTYCILQMF PFTSESKRMG IIVRDESTAE
660 670 680 690 700
ITFYMKGADV AMSTIVQYND WLEEECGNMA REGLRTLVVA KRTLTEEQYQ
710 720 730 740 750
DFESRYSQAK LSIHDRALKV AAVVESLERE MELLCLTGVE DQLQADVRPT
760 770 780 790 800
LEMLRNAGIK IWMLTGDKLE TATCIAKSSH LVSRTQDIHV FRPVTSRGEA
810 820 830 840 850
HLELNAFRRK HDCALVISGD SLEVCLRYYE HELVELACQC PAVVCCRCSP
860 870 880 890 900
TQKAHIVTLL RQHTRKRTCA IGDGGNDVSM IQAADCGIGI EGKEGKQASL
910 920 930 940 950
AADFSITQFR HIGRLLMVHG RNSYKRSAAL GQFVMHRGLI ISTMQAVFSS
960 970 980 990 1000
VFYFASVPLY QGFLMVGYAT IYTMFPVFSL VLDQDVKPEM AILYPELYKD
1010 1020 1030 1040 1050
LTKGRSLSFK TFLIWVLISI YQGGILMYGA LLLFEDEFVH VVAISFTALI
1060 1070 1080 1090 1100
LTELLMVALT IRTWHWLMVV AEFLSLGCYV ASLAFLNEYF GIGRVSFGAF
1110 1120 1130 1140
LDVAFITTVT FLWKVSAITV VSCLPLYVLK YLKRKLSPPS YSKLSS
Length:1,146
Mass (Da):129,017
Last modified:December 16, 2008 - v4
Checksum:i334AAEE291DFDC2E
GO
Isoform 2 (identifier: P98195-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1091-1101: Missing.

Note: No experimental confirmation available.
Show »
Length:1,135
Mass (Da):127,912
Checksum:iFF41C197C7AA7D58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366N → K in AAH79626 (PubMed:15489334).Curated1
Sequence conflicti605V → I in AAH79626 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0359081091 – 1101Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003246 mRNA. Translation: AAH03246.1.
BC079626 mRNA. Translation: AAH79626.1.
AF155913 mRNA. Translation: AAF08476.1.
CCDSiCCDS29370.1. [P98195-2]
RefSeqiNP_001188498.1. NM_001201569.1.
NP_056620.2. NM_015805.3.
UniGeneiMm.247138.

Genome annotation databases

GeneIDi50771.
KEGGimmu:50771.
UCSCiuc008fti.2. mouse. [P98195-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003246 mRNA. Translation: AAH03246.1.
BC079626 mRNA. Translation: AAH79626.1.
AF155913 mRNA. Translation: AAF08476.1.
CCDSiCCDS29370.1. [P98195-2]
RefSeqiNP_001188498.1. NM_001201569.1.
NP_056620.2. NM_015805.3.
UniGeneiMm.247138.

3D structure databases

ProteinModelPortaliP98195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089394.

PTM databases

iPTMnetiP98195.
PhosphoSitePlusiP98195.
SwissPalmiP98195.

Proteomic databases

MaxQBiP98195.
PaxDbiP98195.
PRIDEiP98195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50771.
KEGGimmu:50771.
UCSCiuc008fti.2. mouse. [P98195-1]

Organism-specific databases

CTDi374868.
MGIiMGI:1354757. Atp9b.

Phylogenomic databases

eggNOGiKOG0210. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000201571.
HOVERGENiHBG050617.
InParanoidiP98195.
KOiK01530.
PhylomeDBiP98195.

Miscellaneous databases

PROiP98195.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ATP9B.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030355. ATP9B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF50. PTHR24092:SF50. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP9B_MOUSE
AccessioniPrimary (citable) accession number: P98195
Secondary accession number(s): Q68FM3, Q99LI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.