P98194 (AT2C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-transporting ATPase type 2C member 1
Short name=ATPase 2C1
EC=3.6.3.8

Alternative name(s):
ATP-dependent Ca(2+) pump PMR1

Gene names

Name:	ATP2C1
Synonyms:	KIAA1347, PMR1L
ORF Names:	HUSSY-28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	919 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Catalytic activity	ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein Ref.3.
Tissue specificity	Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.
Involvement in disease	Hailey-Hailey disease (HHD) [MIM:169600]: Autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.2 Ref.12 Ref.13
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]
Sequence caution	The sequence BAA92585.1 differs from that shown. Reason: Frameshift at position 8. The sequence BAC11142.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi calcium ion homeostasis Inferred from mutant phenotype PubMed 14632183. Source: UniProtKB Golgi calcium ion transport Inferred from mutant phenotype PubMed 14632183. Source: UniProtKB actin cytoskeleton reorganization Inferred from mutant phenotype PubMed 14632182. Source: UniProtKB calcium-dependent cell-cell adhesion Inferred from mutant phenotype PubMed 14632182. Source: UniProtKB cellular calcium ion homeostasis Inferred from direct assay Ref.3. Source: UniProtKB cellular manganese ion homeostasis Inferred from direct assay Ref.3. Source: UniProtKB epidermis development Inferred from mutant phenotype Ref.1. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay Ref.3. Source: UniProtKB Golgi membrane Inferred from direct assay PubMed 12804581. Source: UniProtKB integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB trans-Golgi network Inferred from direct assay PubMed 14632183. Source: UniProtKB
Molecular_function	ATP binding Inferred from direct assay PubMed 16192278PubMed 16192278Ref.3PubMed 16192278. Source: UniProtKB calcium ion binding Inferred from direct assay PubMed 16192278PubMed 16192278Ref.3PubMed 16192278. Source: UniProtKB calcium-transporting ATPase activity Inferred from direct assay PubMed 12810057PubMed 16192278PubMed 16192278Ref.3PubMed 16192278. Source: UniProtKB manganese ion binding Inferred from direct assay Ref.3. Source: UniProtKB manganese-transporting ATPase activity Inferred from direct assay Ref.3. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Isoform 1 and isoform 2 are expressed in the same tissues.

Isoform 1 (identifier: P98194-1)

Also known as: ATP2C1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P98194-2)

Also known as: ATP2C1B; ATP2C1C;

The sequence of this isoform differs from the canonical sequence as follows:
     877-919: DLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEV → GLALGEEWTAAG

Isoform 3 (identifier: P98194-3)

Also known as: ATP2C1B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Isoform 4 (identifier: P98194-4)

Also known as: ATP2C1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Isoform 5 (identifier: P98194-5)

Also known as: ATP2C1B;

The sequence of this isoform differs from the canonical sequence as follows:
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Isoform 6 (identifier: P98194-6)

Also known as: ATP2C1D;

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: V → VSSTSSSFLEVWLWERSGQQLVEIHPHLETGLPLTEDVSCV

Isoform 7 (identifier: P98194-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MK → MDSLLPPSRFSYFKKYPLHAIRRYLSTLRNQRAEEQ
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Note: No experimental confirmation available.

Isoform 8 (identifier: P98194-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MK → MDSLLPPSRFSYFKKYPLHAIRRYLSTLRNQRAEEQ
     39-77: Missing.
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 919	919	Calcium-transporting ATPase type 2C member 1		PRO_0000046223
Regions
	Topological domain	1 – 70	70	Cytoplasmic By similarity
	Transmembrane	71 – 91	21	Helical; Name=1; By similarity
	Topological domain	92 – 104	13	Lumenal By similarity
	Transmembrane	105 – 123	19	Helical; Name=2; By similarity
	Topological domain	124 – 262	139	Cytoplasmic By similarity
	Transmembrane	263 – 282	20	Helical; Name=3; By similarity
	Topological domain	283 – 294	12	Lumenal By similarity
	Transmembrane	295 – 312	18	Helical; Name=4; By similarity
	Topological domain	313 – 699	387	Cytoplasmic By similarity
	Transmembrane	700 – 719	20	Helical; Name=5; By similarity
	Topological domain	720 – 729	10	Lumenal By similarity
	Transmembrane	730 – 750	21	Helical; Name=6; By similarity
	Topological domain	751 – 770	20	Cytoplasmic By similarity
	Transmembrane	771 – 793	23	Helical; Name=7; By similarity
	Topological domain	794 – 808	15	Lumenal By similarity
	Transmembrane	809 – 828	20	Helical; Name=8; By similarity
	Topological domain	829 – 841	13	Cytoplasmic By similarity
	Transmembrane	842 – 860	19	Helical; Name=9; By similarity
	Topological domain	861 – 875	15	Lumenal By similarity
	Transmembrane	876 – 896	21	Helical; Name=10; By similarity
	Topological domain	897 – 919	23	Cytoplasmic By similarity
Sites
	Active site	350	1	4-aspartylphosphate intermediate By similarity
	Metal binding	303	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	304	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	306	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	308	1	Calcium 2 By similarity
	Metal binding	644	1	Magnesium By similarity
	Metal binding	648	1	Magnesium By similarity
	Metal binding	738	1	Calcium 2 By similarity
	Metal binding	742	1	Calcium 2 By similarity
Natural variations
	Alternative sequence	1 – 16	16	Missing in isoform 3 and isoform 4.		VSP_000408
	Alternative sequence	1 – 2	2	MK → MDSLLPPSRFSYFKKYPLHA IRRYLSTLRNQRAEEQ in isoform 7 and isoform 8.		VSP_045892
	Alternative sequence	39 – 77	39	Missing in isoform 8.		VSP_045893
	Alternative sequence	877 – 919	43	DLLFL…SFLEV → GLALGEEWTAAG in isoform 2.		VSP_000409
	Alternative sequence	910 – 919	10	SSTSSSFLEV → WLWERSGQQLVEIHPHLETG LPLTEDVSCV in isoform 3, isoform 5, isoform 7 and isoform 8.		VSP_000410
	Alternative sequence	919	1	V → VSSTSSSFLEVWLWERSGQQ LVEIHPHLETGLPLTEDVSC V in isoform 6.		VSP_014102
	Natural variant	201	1	P → L in HHD. Ref.2		VAR_010130
	Natural variant	304	1	A → T in HHD. Ref.1		VAR_008803
	Natural variant	309	1	G → C in HHD; unable to bind manganese, reduced affinity for calcium. Ref.12		VAR_022672
	Natural variant	318	1	L → P in HHD. Ref.1		VAR_008804
	Natural variant	341	1	L → P in HHD; unstable protein. Ref.12		VAR_022673
	Natural variant	344	1	C → Y in HHD; unstable protein. Ref.2		VAR_010131
	Natural variant	411	1	C → R in HHD; unstable protein. Ref.12		VAR_022674
	Natural variant	450	1	A → T. Corresponds to variant rs41434650 [ dbSNP | Ensembl ].		VAR_048373
	Natural variant	490	1	C → F in HHD. Ref.13		VAR_019523
	Natural variant	570	1	T → I in HHD; unstable protein. Ref.2		VAR_010132
	Natural variant	580	1	I → V in HHD; unable to undergo conformational change necessary for ion transport. Ref.12		VAR_022675
	Natural variant	584	1	L → P in HHD. Ref.13		VAR_019524
	Natural variant	641	1	M → R in HHD. Ref.1		VAR_008805
	Natural variant	645	1	G → R in HHD. Ref.1		VAR_008806
	Natural variant	709	1	T → M in HHD. Ref.1		VAR_008807
	Natural variant	742	1	D → Y in HHD; unable to bind calcium or manganese. Ref.12		VAR_022676
	Natural variant	744	1	P → R in HHD. Ref.1		VAR_008808
	Natural variant	789	1	G → R in HHD; unstable protein. Ref.12		VAR_022677
Experimental info
	Sequence conflict	62	1	E → K in AAF26295. Ref.1
	Sequence conflict	62	1	E → K in AAF26296. Ref.1
	Sequence conflict	112	1	I → F in AAF35375. Ref.2
	Sequence conflict	150	1	T → I in BAC11142. Ref.5
	Sequence conflict	346	1	V → A in BAH12365. Ref.5
	Sequence conflict	373	1	A → T in AAF26295. Ref.1
	Sequence conflict	373	1	A → T in AAF26296. Ref.1
	Sequence conflict	516	1	R → H in CAA09425. Ref.9
	Sequence conflict	713	1	A → T in BAC11142. Ref.5
	Sequence conflict	868	1	F → L in BAG61775. Ref.5
	Sequence conflict	901	1	S → G in BAC11142. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ATP2C1A) [UniParc]. Last modified June 21, 2005. Version 3. Checksum: 4C1495D58FDA7EA1	FASTA	919	100,577
	10 20 30 40 50 60 MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 70 80 90 100 110 120 NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 130 140 150 160 170 180 EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 190 200 210 220 230 240 LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 250 260 270 280 290 300 FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 310 320 330 340 350 360 LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 370 380 390 400 410 420 TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 430 440 450 460 470 480 LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 490 500 510 520 530 540 GAYEQVIKYC TTYQSKGQTL TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG 550 560 570 580 590 600 LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 610 620 630 640 650 660 AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 670 680 690 700 710 720 MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 730 740 750 760 770 780 TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 790 800 810 820 830 840 VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 850 860 870 880 890 900 NRMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER 910 SREKIQKHVS STSSSFLEV
	Isoform 2 (ATP2C1B) (ATP2C1C) [UniParc]. Checksum: 27E2B0E13378BB98	FASTA	888	96,960
	10 20 30 40 50 60 MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 70 80 90 100 110 120 NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 130 140 150 160 170 180 EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 190 200 210 220 230 240 LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 250 260 270 280 290 300 FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 310 320 330 340 350 360 LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 370 380 390 400 410 420 TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 430 440 450 460 470 480 LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 490 500 510 520 530 540 GAYEQVIKYC TTYQSKGQTL TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG 550 560 570 580 590 600 LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 610 620 630 640 650 660 AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 670 680 690 700 710 720 MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 730 740 750 760 770 780 TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 790 800 810 820 830 840 VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 850 860 870 880 NRMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILGLAL GEEWTAAG
	Isoform 3 (ATP2C1B) [UniParc]. Checksum: A7962E652B936D76	FASTA	923	101,163
	10 20 30 40 50 60 MIPVLTSKKA SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI 70 80 90 100 110 120 SQFKNPLIML LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLVP 130 140 150 160 170 180 PECHCVREGK LEHTLARDLV PGDTVCLSVG DRVPADLRLF EAVDLSIDES SLTGETTPCS 190 200 210 220 230 240 KVTAPQPAAT NGDLASRSNI AFMGTLVRCG KAKGVVIGTG ENSEFGEVFK MMQAEEAPKT 250 260 270 280 290 300 PLQKSMDLLG KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV 310 320 330 340 350 360 TLALGVMRMV KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLHAEVT 370 380 390 400 410 420 GVGYNQFGEV IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK 430 440 450 460 470 480 MGLDGLQQDY IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYQSK 490 500 510 520 530 540 GQTLTLTQQQ RDVYQQEKAR MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV 550 560 570 580 590 600 TTLIASGVSI KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV 610 620 630 640 650 660 FYRASPRHKM KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI 670 680 690 700 710 720 LVDDDFQTIM SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW 730 740 750 760 770 780 INIIMDGPPA QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR 790 800 810 820 830 840 ELRDNVITPR DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNRMFCY AVLGSIMGQL 850 860 870 880 890 900 LVIYFPPLQK VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KHVWLWERSG 910 920 QQLVEIHPHL ETGLPLTEDV SCV
	Isoform 4 (ATP2C1A) [UniParc]. Checksum: D15118E067B15ED4	FASTA	903	98,733
	10 20 30 40 50 60 MIPVLTSKKA SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI 70 80 90 100 110 120 SQFKNPLIML LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLVP 130 140 150 160 170 180 PECHCVREGK LEHTLARDLV PGDTVCLSVG DRVPADLRLF EAVDLSIDES SLTGETTPCS 190 200 210 220 230 240 KVTAPQPAAT NGDLASRSNI AFMGTLVRCG KAKGVVIGTG ENSEFGEVFK MMQAEEAPKT 250 260 270 280 290 300 PLQKSMDLLG KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV 310 320 330 340 350 360 TLALGVMRMV KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLHAEVT 370 380 390 400 410 420 GVGYNQFGEV IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK 430 440 450 460 470 480 MGLDGLQQDY IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYQSK 490 500 510 520 530 540 GQTLTLTQQQ RDVYQQEKAR MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV 550 560 570 580 590 600 TTLIASGVSI KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV 610 620 630 640 650 660 FYRASPRHKM KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI 670 680 690 700 710 720 LVDDDFQTIM SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW 730 740 750 760 770 780 INIIMDGPPA QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR 790 800 810 820 830 840 ELRDNVITPR DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNRMFCY AVLGSIMGQL 850 860 870 880 890 900 LVIYFPPLQK VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KHVSSTSSSF LEV
	Isoform 5 (ATP2C1B) [UniParc]. Checksum: E6B6914D20DFD0B7	FASTA	939	103,007
	10 20 30 40 50 60 MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 70 80 90 100 110 120 NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 130 140 150 160 170 180 EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 190 200 210 220 230 240 LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 250 260 270 280 290 300 FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 310 320 330 340 350 360 LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 370 380 390 400 410 420 TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 430 440 450 460 470 480 LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 490 500 510 520 530 540 GAYEQVIKYC TTYQSKGQTL TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG 550 560 570 580 590 600 LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 610 620 630 640 650 660 AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 670 680 690 700 710 720 MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 730 740 750 760 770 780 TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 790 800 810 820 830 840 VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 850 860 870 880 890 900 NRMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER 910 920 930 SREKIQKHVW LWERSGQQLV EIHPHLETGL PLTEDVSCV
	Isoform 6 (ATP2C1D) [UniParc]. Checksum: C25B54ABDE014607	FASTA	959	105,057
	10 20 30 40 50 60 MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 70 80 90 100 110 120 NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 130 140 150 160 170 180 EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 190 200 210 220 230 240 LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 250 260 270 280 290 300 FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 310 320 330 340 350 360 LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 370 380 390 400 410 420 TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 430 440 450 460 470 480 LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 490 500 510 520 530 540 GAYEQVIKYC TTYQSKGQTL TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG 550 560 570 580 590 600 LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 610 620 630 640 650 660 AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 670 680 690 700 710 720 MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 730 740 750 760 770 780 TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 790 800 810 820 830 840 VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 850 860 870 880 890 900 NRMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER 910 920 930 940 950 SREKIQKHVS STSSSFLEVS STSSSFLEVW LWERSGQQLV EIHPHLETGL PLTEDVSCV
	Isoform 7 [UniParc]. Checksum: 0AC81DFDBA5DAB98	FASTA	973	107,143
	10 20 30 40 50 60 MDSLLPPSRF SYFKKYPLHA IRRYLSTLRN QRAEEQVARF QKIPNGENET MIPVLTSKKA 70 80 90 100 110 120 SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI SQFKNPLIML 130 140 150 160 170 180 LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLVP PECHCVREGK 190 200 210 220 230 240 LEHTLARDLV PGDTVCLSVG DRVPADLRLF EAVDLSIDES SLTGETTPCS KVTAPQPAAT 250 260 270 280 290 300 NGDLASRSNI AFMGTLVRCG KAKGVVIGTG ENSEFGEVFK MMQAEEAPKT PLQKSMDLLG 310 320 330 340 350 360 KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV TLALGVMRMV 370 380 390 400 410 420 KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLHAEVT GVGYNQFGEV 430 440 450 460 470 480 IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK MGLDGLQQDY 490 500 510 520 530 540 IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYQSK GQTLTLTQQQ 550 560 570 580 590 600 RDVYQQEKAR MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV TTLIASGVSI 610 620 630 640 650 660 KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV FYRASPRHKM 670 680 690 700 710 720 KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI LVDDDFQTIM 730 740 750 760 770 780 SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW INIIMDGPPA 790 800 810 820 830 840 QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR ELRDNVITPR 850 860 870 880 890 900 DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNRMFCY AVLGSIMGQL LVIYFPPLQK 910 920 930 940 950 960 VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KHVWLWERSG QQLVEIHPHL 970 ETGLPLTEDV SCV
	Isoform 8 [UniParc]. Checksum: CAA887F3AEB7C056	FASTA	934	102,499
	10 20 30 40 50 60 MDSLLPPSRF SYFKKYPLHA IRRYLSTLRN QRAEEQVARF QKIPNGENET MIPVLTSKKA 70 80 90 100 110 120 SELPVSEVAS ILQFKNPLIM LLLASAVISV LMHQFDDAVS ITVAILIVVT VAFVQEYRSE 130 140 150 160 170 180 KSLEELSKLV PPECHCVREG KLEHTLARDL VPGDTVCLSV GDRVPADLRL FEAVDLSIDE 190 200 210 220 230 240 SSLTGETTPC SKVTAPQPAA TNGDLASRSN IAFMGTLVRC GKAKGVVIGT GENSEFGEVF 250 260 270 280 290 300 KMMQAEEAPK TPLQKSMDLL GKQLSFYSFG IIGIIMLVGW LLGKDILEMF TISVSLAVAA 310 320 330 340 350 360 IPEGLPIVVT VTLALGVMRM VKKRAIVKKL PIVETLGCCN VICSDKTGTL TKNEMTVTHI 370 380 390 400 410 420 FTSDGLHAEV TGVGYNQFGE VIVDGDVVHG FYNPAVSRIV EAGCVCNDAV IRNNTLMGKP 430 440 450 460 470 480 TEGALIALAM KMGLDGLQQD YIRKAEYPFS SEQKWMAVKC VHRTQQDRPE ICFMKGAYEQ 490 500 510 520 530 540 VIKYCTTYQS KGQTLTLTQQ QRDVYQQEKA RMGSAGLRVL ALASGPELGQ LTFLGLVGII 550 560 570 580 590 600 DPPRTGVKEA VTTLIASGVS IKMITGDSQE TAVAIASRLG LYSKTSQSVS GEEIDAMDVQ 610 620 630 640 650 660 QLSQIVPKVA VFYRASPRHK MKIIKSLQKN GSVVAMTGDG VNDAVALKAA DIGVAMGQTG 670 680 690 700 710 720 TDVCKEAADM ILVDDDFQTI MSAIEEGKGI YNNIKNFVRF QLSTSIAALT LISLATLMNF 730 740 750 760 770 780 PNPLNAMQIL WINIIMDGPP AQSLGVEPVD KDVIRKPPRN WKDSILTKNL ILKILVSSII 790 800 810 820 830 840 IVCGTLFVFW RELRDNVITP RDTTMTFTCF VFFDMFNALS SRSQTKSVFE IGLCSNRMFC 850 860 870 880 890 900 YAVLGSIMGQ LLVIYFPPLQ KVFQTESLSI LDLLFLLGLT SSVCIVAEII KKVERSREKI 910 920 930 QKHVWLWERS GQQLVEIHPH LETGLPLTED VSCV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease." Hu Z., Bonifas J.M., Beech J., Bench G., Shigihara T., Ogawa H., Ikeda S., Mauro T., Epstein E.H. Jr. Nat. Genet. 24:61-65(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HHD THR-304; PRO-318; ARG-641; ARG-645; MET-709 AND ARG-744.
[2]	"Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump." Sudbrak R., Brown J., Dobson-Stone C., Carter S., Ramser J., White J., Healy E., Dissanayake M., Larregue M., Perrussel M., Lehrach H., Munro C.S., Strachan T., Burge S., Hovnanian A., Monaco A.P. Hum. Mol. Genet. 9:1131-1140(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANTS HHD LEU-201; TYR-344 AND ILE-570. Tissue: Keratinocyte.
[3]	"Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)." Fairclough R.J., Dode L., Vanoevelen J., Andersen J.P., Missiaen L., Raeymaekers L., Wuytack F., Hovnanian A. J. Biol. Chem. 278:24721-24730(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), SUBCELLULAR LOCATION, MUTAGENESIS. Tissue: Keratinocyte.
[4]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 6; 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-919 (ISOFORM 1). Tissue: Mammary gland, Neuron and Thalamus.
[6]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Blood.
[9]	"Characterization of 16 novel human genes showing high similarity to yeast sequences." Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G. Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-919.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene." Dobson-Stone C., Fairclough R., Dunne E., Brown J., Dissanayake M., Munro C.S., Strachan T., Burge S., Sudbrak R., Monaco A.P., Hovnanian A. J. Invest. Dermatol. 118:338-343(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HHD CYS-309; PRO-341; ARG-411; VAL-580; TYR-742 AND ARG-789.
[13]	"Analysis of ATP2C1 gene mutation in 10 unrelated Japanese families with Hailey-Hailey disease." Yokota K., Yasukawa K., Shimizu H. J. Invest. Dermatol. 118:550-551(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HHD PHE-490 AND PRO-584.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF181120 mRNA. Translation: AAF26295.1. AF181121 mRNA. Translation: AAF26296.1. AF189723 mRNA. Translation: AAF27813.2. AF225981 mRNA. Translation: AAF35375.1. AY268374 mRNA. Translation: AAP30008.1. AY268375 mRNA. Translation: AAP30009.1. AB037768 mRNA. Translation: BAA92585.1. Frameshift. AK001684 mRNA. Translation: BAA91835.1. AK074692 mRNA. Translation: BAC11142.1. Different initiation. AK296470 mRNA. Translation: BAH12365.1. AK299945 mRNA. Translation: BAG61775.1. AK314342 mRNA. Translation: BAG36984.1. AC055733 Genomic DNA. No translation available. AC097105 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79218.1. CH471052 Genomic DNA. Translation: EAW79219.1. BC028139 mRNA. Translation: AAH28139.1. AJ010953 mRNA. Translation: CAA09425.1.
IPI	IPI00220473. IPI00413116. IPI00419957. IPI00607568. IPI00607812. IPI00745171. IPI00921961. IPI00975874.
RefSeq	NP_001001485.1. NM_001001485.2. NP_001001486.1. NM_001001486.1. NP_001001487.1. NM_001001487.1. NP_001186108.1. NM_001199179.1. NP_001186109.1. NM_001199180.1. NP_001186110.1. NM_001199181.1. NP_001186111.1. NM_001199182.1. NP_001186112.1. NM_001199183.1. NP_001186113.1. NM_001199184.1. NP_001186114.1. NM_001199185.1. NP_055197.2. NM_014382.3.
UniGene	Hs.584884.
3D structure databases
ProteinModelPortal	P98194.
ModBase	Search...
Protein-protein interaction databases
IntAct	P98194. 1 interaction.
STRING	9606.ENSP00000352665.
Protein family/group databases
TCDB	3.A.3.2.5. P-type ATPase (P-ATPase) superfamily.
PTM databases
PhosphoSite	P98194.
Polymorphism databases
DMDM	68068024.
Proteomic databases
PaxDb	P98194.
PRIDE	P98194.
Protocols and materials databases
DNASU	27032.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328560; ENSP00000329664; ENSG00000017260. ENST00000359644; ENSP00000352665; ENSG00000017260. ENST00000393221; ENSP00000376914; ENSG00000017260. ENST00000422190; ENSP00000402677; ENSG00000017260. ENST00000428331; ENSP00000395809; ENSG00000017260. ENST00000504948; ENSP00000423330; ENSG00000017260. ENST00000505330; ENSP00000423774; ENSG00000017260. ENST00000507488; ENSP00000421326; ENSG00000017260. ENST00000508532; ENSP00000424783; ENSG00000017260. ENST00000510168; ENSP00000427461; ENSG00000017260. ENST00000513801; ENSP00000422872; ENSG00000017260.
GeneID	27032.
KEGG	hsa:27032.
UCSC	uc003enk.3. human. uc003enm.3. human. uc003enn.3. human. uc003ent.3. human.
Organism-specific databases
CTD	27032.
GeneCards	GC03P130613.
HGNC	HGNC:13211. ATP2C1.
HPA	CAB010207. HPA035116.
MIM	169600. phenotype. 604384. gene.
neXtProt	NX_P98194.
Orphanet	2841. Familial benign chronic pemphigus.
PharmGKB	PA25111.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0474.
HOVERGEN	HBG106478.
KO	K01537.
Enzyme and pathway databases
BRENDA	3.6.3.8. 2681.
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P98194.
Bgee	P98194.
CleanEx	HS_ATP2C1.
Genevestigator	P98194.
GermOnline	ENSG00000017260. Homo sapiens.
Family and domain databases
Gene3D	1.20.1110.10. 3 hits.
InterPro	IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATP2C1. human.
DrugBank	DB01169. Arsenic trioxide. DB01189. Desflurane. DB00228. Enflurane. DB01159. Halothane. DB00753. Isoflurane. DB01028. Methoxyflurane. DB01110. Miconazole. DB01236. Sevoflurane.
GenomeRNAi	27032.
NextBio	49568.
SOURCE	Search...

Entry information

Entry name

AT2C1_HUMAN

Accession

Primary (citable) accession number: P98194
Secondary accession number(s): B2RAT7 , B4DSW3, B7Z3X9, G3XAH8, G8JLN9, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 140 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.