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P98193

- DMP1_RAT

UniProt

P98193 - DMP1_RAT

Protein

Dentin matrix acidic phosphoprotein 1

Gene

Dmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
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    Functioni

    May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite By similarity.By similarity

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. extracellular matrix organization Source: InterPro
    3. ossification Source: InterPro
    4. regulation of bone mineralization Source: RGD

    Keywords - Biological processi

    Biomineralization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dentin matrix acidic phosphoprotein 1
    Short name:
    DMP-1
    Short name:
    Dentin matrix protein 1
    Alternative name(s):
    AG1
    Gene namesi
    Name:Dmp1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2508. Dmp1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Secretedextracellular spaceextracellular matrix By similarity
    Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Extracellular matrix, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 489473Dentin matrix acidic phosphoprotein 1PRO_0000021112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP98193.
    PRIDEiP98193.

    PTM databases

    PhosphoSiteiP98193.

    Expressioni

    Tissue specificityi

    Expressed in tooth particularly in odontoblast and ameloblast.

    Gene expression databases

    GenevestigatoriP98193.

    Interactioni

    Subunit structurei

    Interacts with importin alpha.By similarity

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi334 – 3363Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 444Poly-Pro

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG86154.
    HOGENOMiHOG000220909.
    HOVERGENiHBG073257.

    Family and domain databases

    InterProiIPR009889. DMP1.
    [Graphical view]
    PANTHERiPTHR23400. PTHR23400. 1 hit.
    PfamiPF07263. DMP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98193-1 [UniParc]FASTAAdd to Basket

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    MKTVILLTFL WGLSCALPVA RYQNTESESS EERTGNLAQS PPPPMANSDH    50
    TDSSESGEEL GSDRSQYRPA GGLSKSAGMD ADKEEDEDDS GDDTFGDEDN 100
    GPGPEERQWG GPSRLDSDED SADTTQSSED STSQENSAQD TPSDSKDHHS 150
    DEADSRPEAG DSTQDSESEE YRVGGGSEGE SSHGDGSEFD DEGMQSDDPG 200
    STRSDRGHTR MSSAGIRSEE SKGDHEPTST QDSDDSQDVE FSSRKSFRRS 250
    RVSEEDDRGE LADSNSRETQ SVSTEDFRSK EESRSETQED TAETQSQEDS 300
    PEGQDPSSES SEEAGEPSQE SSSESQEGVA SESRGDNPDN TSQTGDQRDS 350
    ESSEEDRLNT FSSSESQSTE EQGDSESNES LSLSEESQES AQDEDSSSQE 400
    GLQSQSASRE SRSQESQSEQ DSRSEENRDS DSQDSSRSKE ESNSTGSTSS 450
    SEEDNHPKNI EADNRKLIVD AYHNKPIGDQ DDNDCQDGY 489
    Length:489
    Mass (Da):53,058
    Last modified:May 30, 2000 - v1
    Checksum:i59F8381479DDA085
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11354 mRNA. Translation: AAS55638.1.
    PIRiA45988.
    UniGeneiRn.19340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11354 mRNA. Translation: AAS55638.1 .
    PIRi A45988.
    UniGenei Rn.19340.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P98193.

    Proteomic databases

    PaxDbi P98193.
    PRIDEi P98193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2508. Dmp1.

    Phylogenomic databases

    eggNOGi NOG86154.
    HOGENOMi HOG000220909.
    HOVERGENi HBG073257.

    Miscellaneous databases

    PROi P98193.

    Gene expression databases

    Genevestigatori P98193.

    Family and domain databases

    InterProi IPR009889. DMP1.
    [Graphical view ]
    PANTHERi PTHR23400. PTHR23400. 1 hit.
    Pfami PF07263. DMP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization."
      George A., Sabsay B., Simonian P.A., Veis A.
      J. Biol. Chem. 268:12624-12630(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Tooth.

    Entry informationi

    Entry nameiDMP1_RAT
    AccessioniPrimary (citable) accession number: P98193
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3