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P98193

- DMP1_RAT

UniProt

P98193 - DMP1_RAT

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Protein

Dentin matrix acidic phosphoprotein 1

Gene
Dmp1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite By similarity.

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. extracellular matrix organization Source: InterPro
  3. ossification Source: InterPro
  4. regulation of bone mineralization Source: RGD
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Dentin matrix acidic phosphoprotein 1
Short name:
DMP-1
Short name:
Dentin matrix protein 1
Alternative name(s):
AG1
Gene namesi
Name:Dmp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2508. Dmp1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 489473Dentin matrix acidic phosphoprotein 1PRO_0000021112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi378 – 3781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP98193.
PRIDEiP98193.

PTM databases

PhosphoSiteiP98193.

Expressioni

Tissue specificityi

Expressed in tooth particularly in odontoblast and ameloblast.

Gene expression databases

GenevestigatoriP98193.

Interactioni

Subunit structurei

Interacts with importin alpha By similarity.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi334 – 3363Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 444Poly-Pro

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG86154.
HOGENOMiHOG000220909.
HOVERGENiHBG073257.

Family and domain databases

InterProiIPR009889. DMP1.
[Graphical view]
PANTHERiPTHR23400. PTHR23400. 1 hit.
PfamiPF07263. DMP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98193-1 [UniParc]FASTAAdd to Basket

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MKTVILLTFL WGLSCALPVA RYQNTESESS EERTGNLAQS PPPPMANSDH    50
TDSSESGEEL GSDRSQYRPA GGLSKSAGMD ADKEEDEDDS GDDTFGDEDN 100
GPGPEERQWG GPSRLDSDED SADTTQSSED STSQENSAQD TPSDSKDHHS 150
DEADSRPEAG DSTQDSESEE YRVGGGSEGE SSHGDGSEFD DEGMQSDDPG 200
STRSDRGHTR MSSAGIRSEE SKGDHEPTST QDSDDSQDVE FSSRKSFRRS 250
RVSEEDDRGE LADSNSRETQ SVSTEDFRSK EESRSETQED TAETQSQEDS 300
PEGQDPSSES SEEAGEPSQE SSSESQEGVA SESRGDNPDN TSQTGDQRDS 350
ESSEEDRLNT FSSSESQSTE EQGDSESNES LSLSEESQES AQDEDSSSQE 400
GLQSQSASRE SRSQESQSEQ DSRSEENRDS DSQDSSRSKE ESNSTGSTSS 450
SEEDNHPKNI EADNRKLIVD AYHNKPIGDQ DDNDCQDGY 489
Length:489
Mass (Da):53,058
Last modified:May 30, 2000 - v1
Checksum:i59F8381479DDA085
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11354 mRNA. Translation: AAS55638.1.
PIRiA45988.
UniGeneiRn.19340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11354 mRNA. Translation: AAS55638.1 .
PIRi A45988.
UniGenei Rn.19340.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P98193.

Proteomic databases

PaxDbi P98193.
PRIDEi P98193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2508. Dmp1.

Phylogenomic databases

eggNOGi NOG86154.
HOGENOMi HOG000220909.
HOVERGENi HBG073257.

Miscellaneous databases

PROi P98193.

Gene expression databases

Genevestigatori P98193.

Family and domain databases

InterProi IPR009889. DMP1.
[Graphical view ]
PANTHERi PTHR23400. PTHR23400. 1 hit.
Pfami PF07263. DMP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization."
    George A., Sabsay B., Simonian P.A., Veis A.
    J. Biol. Chem. 268:12624-12630(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Tooth.

Entry informationi

Entry nameiDMP1_RAT
AccessioniPrimary (citable) accession number: P98193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 22, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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