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Protein

Dentin matrix acidic phosphoprotein 1

Gene

Dmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processBiomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Dentin matrix acidic phosphoprotein 1
Short name:
DMP-1
Short name:
Dentin matrix protein 1
Alternative name(s):
AG1
Gene namesi
Name:Dmp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2508 Dmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002111217 – 489Dentin matrix acidic phosphoprotein 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP98193
PRIDEiP98193

PTM databases

PhosphoSitePlusiP98193

Expressioni

Tissue specificityi

Expressed in tooth particularly in odontoblast and ameloblast.

Interactioni

Subunit structurei

Interacts with importin alpha.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057936

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 336Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Pro4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1181 Eukaryota
ENOG4111M3T LUCA
HOGENOMiHOG000220909
HOVERGENiHBG073257
InParanoidiP98193

Family and domain databases

InterProiView protein in InterPro
IPR009889 DMP1
PANTHERiPTHR23400 PTHR23400, 1 hit
PfamiView protein in Pfam
PF07263 DMP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVILLTFL WGLSCALPVA RYQNTESESS EERTGNLAQS PPPPMANSDH
60 70 80 90 100
TDSSESGEEL GSDRSQYRPA GGLSKSAGMD ADKEEDEDDS GDDTFGDEDN
110 120 130 140 150
GPGPEERQWG GPSRLDSDED SADTTQSSED STSQENSAQD TPSDSKDHHS
160 170 180 190 200
DEADSRPEAG DSTQDSESEE YRVGGGSEGE SSHGDGSEFD DEGMQSDDPG
210 220 230 240 250
STRSDRGHTR MSSAGIRSEE SKGDHEPTST QDSDDSQDVE FSSRKSFRRS
260 270 280 290 300
RVSEEDDRGE LADSNSRETQ SVSTEDFRSK EESRSETQED TAETQSQEDS
310 320 330 340 350
PEGQDPSSES SEEAGEPSQE SSSESQEGVA SESRGDNPDN TSQTGDQRDS
360 370 380 390 400
ESSEEDRLNT FSSSESQSTE EQGDSESNES LSLSEESQES AQDEDSSSQE
410 420 430 440 450
GLQSQSASRE SRSQESQSEQ DSRSEENRDS DSQDSSRSKE ESNSTGSTSS
460 470 480
SEEDNHPKNI EADNRKLIVD AYHNKPIGDQ DDNDCQDGY
Length:489
Mass (Da):53,058
Last modified:May 30, 2000 - v1
Checksum:i59F8381479DDA085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11354 mRNA Translation: AAS55638.1
PIRiA45988
UniGeneiRn.19340

Similar proteinsi

Entry informationi

Entry nameiDMP1_RAT
AccessioniPrimary (citable) accession number: P98193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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