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P98191

- CDS1_MOUSE

UniProt

P98191 - CDS1_MOUSE

Protein

Phosphatidate cytidylyltransferase 1

Gene

Cds1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells By similarity.By similarity

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB
    2. phosphatidylinositol biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BRENDAi2.7.7.41. 3474.
    ReactomeiREACT_199010. Synthesis of PI.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase 1 (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase 1
    CDP-DG synthase 1
    CDP-diacylglycerol synthase 1
    Short name:
    CDS 1
    CDP-diglyceride pyrophosphorylase 1
    CDP-diglyceride synthase 1
    CTP:phosphatidate cytidylyltransferase 1
    Gene namesi
    Name:Cds1
    Synonyms:Cds
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1921846. Cds1.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
    Note: Cytoplasmic aspect of the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Phosphatidate cytidylyltransferase 1PRO_0000090714Add
    BLAST

    Proteomic databases

    MaxQBiP98191.
    PaxDbiP98191.
    PRIDEiP98191.

    PTM databases

    PhosphoSiteiP98191.

    Expressioni

    Tissue specificityi

    Highly expressed in the inner segment of the photoreceptor layer of adult retina.1 Publication

    Developmental stagei

    Expressed in a structure probably corresponding to the thymic rudiment at embryonic day 12.5 of gestation (E12.5). No expression could be detected at earlier and later stages of embryonic development (E10.5 and E17.5).

    Gene expression databases

    BgeeiP98191.
    CleanExiMM_CDS1.
    GenevestigatoriP98191.

    Interactioni

    Subunit structurei

    Interacts with FOS; this interaction may enhance catalytic activity.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031273.

    Structurei

    3D structure databases

    ProteinModelPortaliP98191.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    GeneTreeiENSGT00390000016175.
    HOGENOMiHOG000209582.
    HOVERGENiHBG002485.
    InParanoidiP98191.
    KOiK00981.
    OMAiVKCFQEI.
    OrthoDBiEOG7M98G5.
    PhylomeDBiP98191.
    TreeFamiTF313464.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLELRHRGGC PGPGGAGAPP PREGEAAGGD HETESTSDKE TDIDDRYGDL    50
    DARGDSDVPE VPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF 100
    FLIIYMGSFM LMLLVLGIQV KCFHEIITIG YRVYHSYDLP WFRTLSWYFL 150
    LCVNYFFYGE TVADYFATFV QREEQLQFLI RYHRFISFAL YLAGFCMFVL 200
    SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI WFLVPISSVI 250
    CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVIF GFIAAYVLSK 300
    YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ NYSLPPFLQA VLSRETVSLY 350
    PFQIHSIALS TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF 400
    DCQYLMATFV HVYITSFIRG PNPSKVLQQL LVLQPEQQLN IYRTLKIHLT 450
    EKGILQPTLK V 461
    Length:461
    Mass (Da):52,875
    Last modified:June 7, 2005 - v2
    Checksum:iB6AD0DB2124E0D71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533367 mRNA. Translation: AAO16167.2.
    BC055292 mRNA. Translation: AAH55292.1.
    CCDSiCCDS19472.1.
    RefSeqiNP_775546.2. NM_173370.3.
    UniGeneiMm.46764.

    Genome annotation databases

    EnsembliENSMUST00000031273; ENSMUSP00000031273; ENSMUSG00000029330.
    GeneIDi74596.
    KEGGimmu:74596.
    UCSCiuc008yio.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533367 mRNA. Translation: AAO16167.2 .
    BC055292 mRNA. Translation: AAH55292.1 .
    CCDSi CCDS19472.1.
    RefSeqi NP_775546.2. NM_173370.3.
    UniGenei Mm.46764.

    3D structure databases

    ProteinModelPortali P98191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031273.

    PTM databases

    PhosphoSitei P98191.

    Proteomic databases

    MaxQBi P98191.
    PaxDbi P98191.
    PRIDEi P98191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031273 ; ENSMUSP00000031273 ; ENSMUSG00000029330 .
    GeneIDi 74596.
    KEGGi mmu:74596.
    UCSCi uc008yio.1. mouse.

    Organism-specific databases

    CTDi 1040.
    MGIi MGI:1921846. Cds1.

    Phylogenomic databases

    eggNOGi COG0575.
    GeneTreei ENSGT00390000016175.
    HOGENOMi HOG000209582.
    HOVERGENi HBG002485.
    InParanoidi P98191.
    KOi K00981.
    OMAi VKCFQEI.
    OrthoDBi EOG7M98G5.
    PhylomeDBi P98191.
    TreeFami TF313464.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    BRENDAi 2.7.7.41. 3474.
    Reactomei REACT_199010. Synthesis of PI.

    Miscellaneous databases

    ChiTaRSi CDS1. mouse.
    NextBioi 341181.
    PROi P98191.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98191.
    CleanExi MM_CDS1.
    Genevestigatori P98191.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2."
      Inglis S.L., Hunt D.M., Halford S.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content."
      Lykidis A., Jackson P.D., Rock C.O., Jackowski S.
      J. Biol. Chem. 272:33402-33409(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene."
      Volta M., Bulfone A., Gattuso C., Rossi E., Mariani M., Consalez G.G., Zuffardi O., Ballabio A., Banfi S., Franco B.
      Genomics 55:68-77(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity."
      Ferrero G.O., Velazquez F.N., Caputto B.L.
      Oncogene 31:3381-3391(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FOS.

    Entry informationi

    Entry nameiCDS1_MOUSE
    AccessioniPrimary (citable) accession number: P98191
    Secondary accession number(s): Q8CGZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3