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P98191

- CDS1_MOUSE

UniProt

P98191 - CDS1_MOUSE

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Protein

Phosphatidate cytidylyltransferase 1

Gene

Cds1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity).By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB
  2. phosphatidylinositol biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BRENDAi2.7.7.41. 3474.
ReactomeiREACT_199010. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 1 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 1
CDP-DG synthase 1
CDP-diacylglycerol synthase 1
Short name:
CDS 1
CDP-diglyceride pyrophosphorylase 1
CDP-diglyceride synthase 1
CTP:phosphatidate cytidylyltransferase 1
Gene namesi
Name:Cds1
Synonyms:Cds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1921846. Cds1.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Note: Cytoplasmic aspect of the endoplasmic reticulum.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Phosphatidate cytidylyltransferase 1PRO_0000090714Add
BLAST

Proteomic databases

MaxQBiP98191.
PaxDbiP98191.
PRIDEiP98191.

PTM databases

PhosphoSiteiP98191.

Expressioni

Tissue specificityi

Highly expressed in the inner segment of the photoreceptor layer of adult retina.1 Publication

Developmental stagei

Expressed in a structure probably corresponding to the thymic rudiment at embryonic day 12.5 of gestation (E12.5). No expression could be detected at earlier and later stages of embryonic development (E10.5 and E17.5).

Gene expression databases

BgeeiP98191.
CleanExiMM_CDS1.
GenevestigatoriP98191.

Interactioni

Subunit structurei

Interacts with FOS; this interaction may enhance catalytic activity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031273.

Structurei

3D structure databases

ProteinModelPortaliP98191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
InParanoidiP98191.
KOiK00981.
OMAiVKCFQEI.
OrthoDBiEOG7M98G5.
PhylomeDBiP98191.
TreeFamiTF313464.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLELRHRGGC PGPGGAGAPP PREGEAAGGD HETESTSDKE TDIDDRYGDL
60 70 80 90 100
DARGDSDVPE VPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF
110 120 130 140 150
FLIIYMGSFM LMLLVLGIQV KCFHEIITIG YRVYHSYDLP WFRTLSWYFL
160 170 180 190 200
LCVNYFFYGE TVADYFATFV QREEQLQFLI RYHRFISFAL YLAGFCMFVL
210 220 230 240 250
SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI WFLVPISSVI
260 270 280 290 300
CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVIF GFIAAYVLSK
310 320 330 340 350
YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ NYSLPPFLQA VLSRETVSLY
360 370 380 390 400
PFQIHSIALS TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF
410 420 430 440 450
DCQYLMATFV HVYITSFIRG PNPSKVLQQL LVLQPEQQLN IYRTLKIHLT
460
EKGILQPTLK V
Length:461
Mass (Da):52,875
Last modified:June 7, 2005 - v2
Checksum:iB6AD0DB2124E0D71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533367 mRNA. Translation: AAO16167.2.
BC055292 mRNA. Translation: AAH55292.1.
CCDSiCCDS19472.1.
RefSeqiNP_775546.2. NM_173370.3.
UniGeneiMm.46764.

Genome annotation databases

EnsembliENSMUST00000031273; ENSMUSP00000031273; ENSMUSG00000029330.
GeneIDi74596.
KEGGimmu:74596.
UCSCiuc008yio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533367 mRNA. Translation: AAO16167.2 .
BC055292 mRNA. Translation: AAH55292.1 .
CCDSi CCDS19472.1.
RefSeqi NP_775546.2. NM_173370.3.
UniGenei Mm.46764.

3D structure databases

ProteinModelPortali P98191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000031273.

PTM databases

PhosphoSitei P98191.

Proteomic databases

MaxQBi P98191.
PaxDbi P98191.
PRIDEi P98191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031273 ; ENSMUSP00000031273 ; ENSMUSG00000029330 .
GeneIDi 74596.
KEGGi mmu:74596.
UCSCi uc008yio.1. mouse.

Organism-specific databases

CTDi 1040.
MGIi MGI:1921846. Cds1.

Phylogenomic databases

eggNOGi COG0575.
GeneTreei ENSGT00390000016175.
HOGENOMi HOG000209582.
HOVERGENi HBG002485.
InParanoidi P98191.
KOi K00981.
OMAi VKCFQEI.
OrthoDBi EOG7M98G5.
PhylomeDBi P98191.
TreeFami TF313464.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BRENDAi 2.7.7.41. 3474.
Reactomei REACT_199010. Synthesis of PI.

Miscellaneous databases

NextBioi 341181.
PROi P98191.
SOURCEi Search...

Gene expression databases

Bgeei P98191.
CleanExi MM_CDS1.
Genevestigatori P98191.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2."
    Inglis S.L., Hunt D.M., Halford S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content."
    Lykidis A., Jackson P.D., Rock C.O., Jackowski S.
    J. Biol. Chem. 272:33402-33409(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene."
    Volta M., Bulfone A., Gattuso C., Rossi E., Mariani M., Consalez G.G., Zuffardi O., Ballabio A., Banfi S., Franco B.
    Genomics 55:68-77(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity."
    Ferrero G.O., Velazquez F.N., Caputto B.L.
    Oncogene 31:3381-3391(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOS.

Entry informationi

Entry nameiCDS1_MOUSE
AccessioniPrimary (citable) accession number: P98191
Secondary accession number(s): Q8CGZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3