Reviewed, UniProtKB/Swiss-Prot P98191 (CDS1_MOUSE)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase 1
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase 1
    CDP-diglyceride synthetase 1
    CDP-diacylglycerol synthase 1
      Short name=CDS 1
    CTP:phosphatidate cytidylyltransferase 1
    CDP-DG synthetase 1
    CDP-DAG synthase 1

Gene names

Name:	Cds1
Synonyms:	Cds

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells By similarity.
Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Cofactor	Magnesium By similarity.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Note: Cytoplasmic aspect of the endoplasmic reticulum By similarity.
Tissue specificity	Highly expressed in the inner segment of the photoreceptor layer of adult retina. Ref.4
Developmental stage	Expressed in a structure probably corresponding to the thymic rudiment at embryonic day 12.5 of gestation (E12.5). No expression could be detected at earlier and later stages of embryonic development (E10.5 and E17.5).
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	Magnesium
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Phosphatidate cytidylyltransferase 1		PRO_0000090714
Regions
	Transmembrane	96 – 116	21	Potential
	Transmembrane	149 – 169	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	230 – 250	21	Potential
	Transmembrane	279 – 299	21	Potential
	Transmembrane	357 – 377	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P98191-1 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: B6AD0DB2124E0D71	FASTA	461	52,875
	10 20 30 40 50 60 MLELRHRGGC PGPGGAGAPP PREGEAAGGD HETESTSDKE TDIDDRYGDL DARGDSDVPE 70 80 90 100 110 120 VPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV 130 140 150 160 170 180 KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI 190 200 210 220 230 240 RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI 250 260 270 280 290 300 WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVIF GFIAAYVLSK 310 320 330 340 350 360 YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ NYSLPPFLQA VLSRETVSLY PFQIHSIALS 370 380 390 400 410 420 TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG 430 440 450 460 PNPSKVLQQL LVLQPEQQLN IYRTLKIHLT EKGILQPTLK V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2." Inglis S.L., Hunt D.M., Halford S. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	"The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content." Lykidis A., Jackson P.D., Rock C.O., Jackowski S. J. Biol. Chem. 272:33402-33409(1997) [PubMed: 9407135] [Abstract] Cited for: FUNCTION.
[4]	"Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene." Volta M., Bulfone A., Gattuso C., Rossi E., Mariani M., Consalez G.G., Zuffardi O., Ballabio A., Banfi S., Franco B. Genomics 55:68-77(1999) [PubMed: 9889000] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF533367 mRNA. Translation: AAO16167.2. BC055292 mRNA. Translation: AAH55292.1.
IPI	IPI00229605.
RefSeq	NP_775546.2.
UniGene	Mm.46764
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P98191.
PTM databases
PhosphoSite	P98191.
Proteomic databases
PRIDE	P98191.
Genome annotation databases
Ensembl	ENSMUST00000031273; ENSMUSP00000031273; ENSMUSG00000029330; Mus musculus. [Genome view]
GeneID	74596.
KEGG	mmu:74596.
UCSC	uc008yio.1. mouse.
Organism-specific databases
CTD	74596.
MGI	MGI:1921846. Cds1.
Phylogenomic databases
HOGENOM	P98191.
HOVERGEN	P98191.
OMA	IEISPKK.
Enzyme and pathway databases
BRENDA	2.7.7.41. 244.
Gene expression databases
ArrayExpress	P98191.
Bgee	P98191.
CleanEx	MM_CDS1.
Genevestigator	P98191.
GermOnline	ENSMUSG00000029330. Mus musculus.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	341181.
SOURCE	Search...

Entry information

Entry name

CDS1_MOUSE

Accession

Primary (citable) accession number: P98191
Secondary accession number(s): Q8CGZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 7, 2005
Last modified:	November 3, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)