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Protein

Zinc finger protein 200

Gene

ZNF200

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could have a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 200
Gene namesi
Name:ZNF200
Synonyms:ZNFMF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000010539.11
HGNCiHGNC:12993 ZNF200
MIMi603231 gene
neXtProtiNX_P98182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010539
PharmGKBiPA37573

Polymorphism and mutation databases

BioMutaiZNF200
DMDMi218511971

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474491 – 395Zinc finger protein 200Add BLAST395

Proteomic databases

MaxQBiP98182
PaxDbiP98182
PeptideAtlasiP98182
PRIDEiP98182

PTM databases

iPTMnetiP98182
PhosphoSitePlusiP98182

Expressioni

Tissue specificityi

Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small intestine colon and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000010539
CleanExiHS_ZNF200
ExpressionAtlasiP98182 baseline and differential
GenevisibleiP98182 HS

Organism-specific databases

HPAiHPA018981
HPA059310

Interactioni

Protein-protein interaction databases

BioGridi113536, 5 interactors
IntActiP98182, 2 interactors
MINTiP98182
STRINGi9606.ENSP00000395723

Structurei

3D structure databases

ProteinModelPortaliP98182
SMRiP98182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00630000089880
HOGENOMiHOG000261602
HOVERGENiHBG059647
InParanoidiP98182
KOiK09228
OMAiYVDINVI
OrthoDBiEOG091G083V
PhylomeDBiP98182
TreeFamiTF342316

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P98182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF
60 70 80 90 100
LTFLPKPSLV QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE
110 120 130 140 150
QETVSLYLKA NPEELVVFED LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG
160 170 180 190 200
EMMLLAVNGS NPEGEDPERE PVENEDYREK SSDDDEMDSS LVSQQPPDNQ
210 220 230 240 250
EKERLNTSIP QKRKMRNLLV TIENDTPLEE LSKYVDISII ALTRNRRTRR
260 270 280 290 300
WYTCPLCGKQ FNESSYLISH QRTHTGEKPY DCNHCGKSFN HKTNLNKHER
310 320 330 340 350
IHTGEKPYSC SQCGKNFRQN SHRSRHEGIH IREKIFKCPE CGKTFPKNEE
360 370 380 390
FVLHLQSHEA ERPYGCKKCG RRFGRLSNCT RHEKTHSACK TRKQK
Length:395
Mass (Da):45,534
Last modified:December 16, 2008 - v2
Checksum:i6E0B8FC5702A159A
GO
Isoform 2 (identifier: P98182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: Missing.

Show »
Length:394
Mass (Da):45,405
Checksum:i9743926880C65AD6
GO
Isoform 3 (identifier: P98182-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-156: Missing.

Show »
Length:394
Mass (Da):45,463
Checksum:i35B043C4E0131C59
GO

Sequence cautioni

The sequence AAC70008 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH54005 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052790140T → M. Corresponds to variant dbSNP:rs9302870Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036037114Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_046734156Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060866 mRNA Translation: AAC70008.1 Different initiation.
Y14443 mRNA Translation: CAA74795.1
AJ003147 Genomic DNA Translation: CAA05905.1
CH471112 Genomic DNA Translation: EAW85384.1
CH471112 Genomic DNA Translation: EAW85385.1
CH471112 Genomic DNA Translation: EAW85386.1
CH471112 Genomic DNA Translation: EAW85387.1
CH471112 Genomic DNA Translation: EAW85388.1
BC012909 mRNA Translation: AAH12909.1
BC032575 mRNA Translation: AAH32575.1
BC054005 mRNA Translation: AAH54005.1 Different initiation.
CCDSiCCDS10497.1 [P98182-1]
CCDS42112.1 [P98182-2]
CCDS45395.1 [P98182-3]
RefSeqiNP_001138918.1, NM_001145446.1 [P98182-3]
NP_001138919.1, NM_001145447.1 [P98182-3]
NP_001138920.1, NM_001145448.1 [P98182-3]
NP_003445.2, NM_003454.3 [P98182-1]
NP_932353.1, NM_198087.2 [P98182-2]
NP_932354.1, NM_198088.2 [P98182-1]
XP_005255613.1, XM_005255556.1 [P98182-1]
XP_006721003.1, XM_006720940.2 [P98182-1]
XP_006721004.1, XM_006720941.2 [P98182-1]
XP_016879136.1, XM_017023647.1 [P98182-1]
UniGeneiHs.632222

Genome annotation databases

EnsembliENST00000396868; ENSP00000380077; ENSG00000010539 [P98182-2]
ENST00000396870; ENSP00000380079; ENSG00000010539 [P98182-3]
ENST00000396871; ENSP00000380080; ENSG00000010539 [P98182-3]
ENST00000414144; ENSP00000405786; ENSG00000010539 [P98182-1]
ENST00000431561; ENSP00000395723; ENSG00000010539 [P98182-1]
ENST00000575948; ENSP00000458508; ENSG00000010539 [P98182-3]
GeneIDi7752
KEGGihsa:7752
UCSCiuc002cui.3 human [P98182-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiZN200_HUMAN
AccessioniPrimary (citable) accession number: P98182
Secondary accession number(s): D3DUB7
, D3DUB8, O15361, Q5XKM5, Q7Z5V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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