P98181 (CP1A1_PAGMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 1A1
EC=1.14.14.1

Alternative name(s):
CYPIA1

Gene names

Name:

cyp1a1

Organism

Pagrus major (Red sea bream) (Chrysophrys major)

Taxonomic identifier

143350 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Pagrus

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Expressed in induced liver, kidney, gill and gut. Weakly expressed in control liver.
Induction	By 3-methylcholanthrene (3MC).
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Cytochrome P450 1A1		PRO_0000051645
Regions
	Compositional bias	416 – 419	4	Poly-Asp
Sites
	Metal binding	457	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P98181 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: D670A8F70826DA5B	FASTA	515	58,541
	10 20 30 40 50 60 MVLMILPFIG SVSVSESLVA MITMCLAYLI LKFFRTEIPE GLRELPGPKP LPIIGNVLEV 70 80 90 100 110 120 GRNPYLSLTA MTAPRTDVFQ IQIGMRPVVV LSGNETVRQA LIKQGQEFAG RPDLYSFKFI 130 140 150 160 170 180 NDGKSLAFST DGPAVWRARR KLAYSALRSF ATKEGTTPEY SVRLFEHVSK ERYAAISMFM 190 200 210 220 230 240 KLMADFDPVR HIVVSVANVI CGMCFGRRYD HNNRSWLNLV NPRRDVRKVV ASGNPADFIP 250 260 270 280 290 300 ILQYLPSTTM KKFLNINARF NEFVQKIVSE HYTTFNKDNI RDITDSLIDH CEDEPMDPMP 310 320 330 340 350 360 DADDKIVGIV NDLFGAGFDT ISTALSWSVM YLVAYPEIQE RLYQEMETVM GPDRMPCLSD 370 380 390 400 410 420 RTQLTLPEAF ILEIFRHSSF LPFTIPHCTT KDTSLNGYFI PKAPCIYIKQ WPVIHDDDDV 430 440 450 460 470 480 LDPSSFNPDR FLKADGTEVN KLNGEKMMVF GMGKRRCIGE VIARNEVYLF LAILLVQLQF 490 500 510 HAMPGEPLDM TPEYGLTMKH KRCHLRAAMR RGTEE

References

[1]	"Isolation and sequence of cDNA encoding a 3-methylcholanthrene-inducible cytochrome p450 from wild red sea bream, Pagrus major." Mizukami Y., Okauchi M., Arizono K., Ariyoshi T., Kito H. Mar. Biol. 120:343-349(1994) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver.

Cross-references

3D structure databases
ProteinModelPortal	P98181.
SMR	P98181. Positions 38-511.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106944.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_PAGMA

Accession

Primary (citable) accession number: P98181

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	March 6, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program