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P98181

- CP1A1_PAGMA

UniProt

P98181 - CP1A1_PAGMA

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Protein
Cytochrome P450 1A1
Gene
cyp1a1
Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifieri143350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaePagrus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytochrome P450 1A1
PRO_0000051645Add
BLAST

Expressioni

Tissue specificityi

Expressed in induced liver, kidney, gill and gut. Weakly expressed in control liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP98181.
SMRiP98181. Positions 38-511.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi416 – 4194Poly-Asp

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98181-1 [UniParc]FASTAAdd to Basket

« Hide

MVLMILPFIG SVSVSESLVA MITMCLAYLI LKFFRTEIPE GLRELPGPKP    50
LPIIGNVLEV GRNPYLSLTA MTAPRTDVFQ IQIGMRPVVV LSGNETVRQA 100
LIKQGQEFAG RPDLYSFKFI NDGKSLAFST DGPAVWRARR KLAYSALRSF 150
ATKEGTTPEY SVRLFEHVSK ERYAAISMFM KLMADFDPVR HIVVSVANVI 200
CGMCFGRRYD HNNRSWLNLV NPRRDVRKVV ASGNPADFIP ILQYLPSTTM 250
KKFLNINARF NEFVQKIVSE HYTTFNKDNI RDITDSLIDH CEDEPMDPMP 300
DADDKIVGIV NDLFGAGFDT ISTALSWSVM YLVAYPEIQE RLYQEMETVM 350
GPDRMPCLSD RTQLTLPEAF ILEIFRHSSF LPFTIPHCTT KDTSLNGYFI 400
PKAPCIYIKQ WPVIHDDDDV LDPSSFNPDR FLKADGTEVN KLNGEKMMVF 450
GMGKRRCIGE VIARNEVYLF LAILLVQLQF HAMPGEPLDM TPEYGLTMKH 500
KRCHLRAAMR RGTEE 515
Length:515
Mass (Da):58,541
Last modified:May 30, 2000 - v1
Checksum:iD670A8F70826DA5B
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P98181.
SMRi P98181. Positions 38-511.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence of cDNA encoding a 3-methylcholanthrene-inducible cytochrome p450 from wild red sea bream, Pagrus major."
    Mizukami Y., Okauchi M., Arizono K., Ariyoshi T., Kito H.
    Mar. Biol. 120:343-349(1994)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_PAGMA
AccessioniPrimary (citable) accession number: P98181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi