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P98181 (CP1A1_PAGMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:cyp1a1
OrganismPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifier143350 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaePagrus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed in induced liver, kidney, gill and gut. Weakly expressed in control liver.

Induction

By 3-methylcholanthrene (3MC).

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Cytochrome P450 1A1
PRO_0000051645

Regions

Compositional bias416 – 4194Poly-Asp

Sites

Metal binding4571Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P98181 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: D670A8F70826DA5B

FASTA51558,541
        10         20         30         40         50         60 
MVLMILPFIG SVSVSESLVA MITMCLAYLI LKFFRTEIPE GLRELPGPKP LPIIGNVLEV 

        70         80         90        100        110        120 
GRNPYLSLTA MTAPRTDVFQ IQIGMRPVVV LSGNETVRQA LIKQGQEFAG RPDLYSFKFI 

       130        140        150        160        170        180 
NDGKSLAFST DGPAVWRARR KLAYSALRSF ATKEGTTPEY SVRLFEHVSK ERYAAISMFM 

       190        200        210        220        230        240 
KLMADFDPVR HIVVSVANVI CGMCFGRRYD HNNRSWLNLV NPRRDVRKVV ASGNPADFIP 

       250        260        270        280        290        300 
ILQYLPSTTM KKFLNINARF NEFVQKIVSE HYTTFNKDNI RDITDSLIDH CEDEPMDPMP 

       310        320        330        340        350        360 
DADDKIVGIV NDLFGAGFDT ISTALSWSVM YLVAYPEIQE RLYQEMETVM GPDRMPCLSD 

       370        380        390        400        410        420 
RTQLTLPEAF ILEIFRHSSF LPFTIPHCTT KDTSLNGYFI PKAPCIYIKQ WPVIHDDDDV 

       430        440        450        460        470        480 
LDPSSFNPDR FLKADGTEVN KLNGEKMMVF GMGKRRCIGE VIARNEVYLF LAILLVQLQF 

       490        500        510 
HAMPGEPLDM TPEYGLTMKH KRCHLRAAMR RGTEE 

« Hide

References

[1]"Isolation and sequence of cDNA encoding a 3-methylcholanthrene-inducible cytochrome p450 from wild red sea bream, Pagrus major."
Mizukami Y., Okauchi M., Arizono K., Ariyoshi T., Kito H.
Mar. Biol. 120:343-349(1994)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.

Cross-references

3D structure databases

ProteinModelPortalP98181.
SMRP98181. Positions 38-511.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_PAGMA
AccessionPrimary (citable) accession number: P98181
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families