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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifieri143350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaePagrus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytochrome P450 1A1PRO_0000051645Add
BLAST

Expressioni

Tissue specificityi

Expressed in induced liver, kidney, gill and gut. Weakly expressed in control liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP98181.
SMRiP98181. Positions 38-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi416 – 4194Poly-Asp

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMILPFIG SVSVSESLVA MITMCLAYLI LKFFRTEIPE GLRELPGPKP
60 70 80 90 100
LPIIGNVLEV GRNPYLSLTA MTAPRTDVFQ IQIGMRPVVV LSGNETVRQA
110 120 130 140 150
LIKQGQEFAG RPDLYSFKFI NDGKSLAFST DGPAVWRARR KLAYSALRSF
160 170 180 190 200
ATKEGTTPEY SVRLFEHVSK ERYAAISMFM KLMADFDPVR HIVVSVANVI
210 220 230 240 250
CGMCFGRRYD HNNRSWLNLV NPRRDVRKVV ASGNPADFIP ILQYLPSTTM
260 270 280 290 300
KKFLNINARF NEFVQKIVSE HYTTFNKDNI RDITDSLIDH CEDEPMDPMP
310 320 330 340 350
DADDKIVGIV NDLFGAGFDT ISTALSWSVM YLVAYPEIQE RLYQEMETVM
360 370 380 390 400
GPDRMPCLSD RTQLTLPEAF ILEIFRHSSF LPFTIPHCTT KDTSLNGYFI
410 420 430 440 450
PKAPCIYIKQ WPVIHDDDDV LDPSSFNPDR FLKADGTEVN KLNGEKMMVF
460 470 480 490 500
GMGKRRCIGE VIARNEVYLF LAILLVQLQF HAMPGEPLDM TPEYGLTMKH
510
KRCHLRAAMR RGTEE
Length:515
Mass (Da):58,541
Last modified:May 30, 2000 - v1
Checksum:iD670A8F70826DA5B
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP98181.
SMRiP98181. Positions 38-511.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and sequence of cDNA encoding a 3-methylcholanthrene-inducible cytochrome p450 from wild red sea bream, Pagrus major."
    Mizukami Y., Okauchi M., Arizono K., Ariyoshi T., Kito H.
    Mar. Biol. 120:343-349(1994)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_PAGMA
AccessioniPrimary (citable) accession number: P98181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.