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P98181

- CP1A1_PAGMA

UniProt

P98181 - CP1A1_PAGMA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiPagrus major (Red sea bream) (Chrysophrys major)
    Taxonomic identifieri143350 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaePagrus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Cytochrome P450 1A1PRO_0000051645Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in induced liver, kidney, gill and gut. Weakly expressed in control liver.

    Inductioni

    By 3-methylcholanthrene (3MC).

    Structurei

    3D structure databases

    ProteinModelPortaliP98181.
    SMRiP98181. Positions 38-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi416 – 4194Poly-Asp

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLMILPFIG SVSVSESLVA MITMCLAYLI LKFFRTEIPE GLRELPGPKP    50
    LPIIGNVLEV GRNPYLSLTA MTAPRTDVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGQEFAG RPDLYSFKFI NDGKSLAFST DGPAVWRARR KLAYSALRSF 150
    ATKEGTTPEY SVRLFEHVSK ERYAAISMFM KLMADFDPVR HIVVSVANVI 200
    CGMCFGRRYD HNNRSWLNLV NPRRDVRKVV ASGNPADFIP ILQYLPSTTM 250
    KKFLNINARF NEFVQKIVSE HYTTFNKDNI RDITDSLIDH CEDEPMDPMP 300
    DADDKIVGIV NDLFGAGFDT ISTALSWSVM YLVAYPEIQE RLYQEMETVM 350
    GPDRMPCLSD RTQLTLPEAF ILEIFRHSSF LPFTIPHCTT KDTSLNGYFI 400
    PKAPCIYIKQ WPVIHDDDDV LDPSSFNPDR FLKADGTEVN KLNGEKMMVF 450
    GMGKRRCIGE VIARNEVYLF LAILLVQLQF HAMPGEPLDM TPEYGLTMKH 500
    KRCHLRAAMR RGTEE 515
    Length:515
    Mass (Da):58,541
    Last modified:May 30, 2000 - v1
    Checksum:iD670A8F70826DA5B
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P98181.
    SMRi P98181. Positions 38-511.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of cDNA encoding a 3-methylcholanthrene-inducible cytochrome p450 from wild red sea bream, Pagrus major."
      Mizukami Y., Okauchi M., Arizono K., Ariyoshi T., Kito H.
      Mar. Biol. 120:343-349(1994)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_PAGMA
    AccessioniPrimary (citable) accession number: P98181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3