P98175 (RBM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding protein 10

Alternative name(s):
G patch domain-containing protein 9
RNA-binding motif protein 10
RNA-binding protein S1-1
Short name=S1-1

Gene names

Name:	RBM10
Synonyms:	DXS8237E, GPATC9, GPATCH9, KIAA0122

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) By similarity. Ref.20
Subunit structure	Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Ref.19
Subcellular location	Nucleus. Note: In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains). Ref.20
Involvement in disease	TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15
Sequence similarities	Contains 1 C2H2-type zinc finger. Contains 1 G-patch domain. Contains 1 RanBP2-type zinc finger. Contains 2 RRM (RNA recognition motif) domains.
Sequence caution	The sequence AAB33572.1 differs from that shown. Reason: Frameshift at position 696. The sequence BAA09471.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB70731.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB70731.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding RNA-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	3'-UTR-mediated mRNA stabilization Inferred from electronic annotation. Source: Compara RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell apoptotic process Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	RNA binding Non-traceable author statement. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P98175-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P98175-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: Missing.

Isoform 3 (identifier: P98175-3)

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.

Isoform 4 (identifier: P98175-4)

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.
     354-354: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 930

930

RNA-binding protein 10

PRO_0000081767

Regions

Domain

129 – 209

81

RRM 1

Domain

300 – 384

85

RRM 2

Domain

858 – 904

47

G-patch

Zinc finger

212 – 242

31

RanBP2-type

Zinc finger

759 – 784

26

C2H2-type; atypical

Compositional bias

80 – 87

8

Poly-Arg

Compositional bias

113 – 125

13

Poly-Glu

Compositional bias

561 – 607

47

Tyr-rich

Amino acid modifications

Modified residue

61

1

Phosphoserine Ref.12

Modified residue

89

1

Phosphoserine Ref.16

Modified residue

383

1

N6-acetyllysine Ref.14

Modified residue

718

1

Phosphoserine Ref.16 Ref.18

Modified residue

723

1

Phosphoserine Ref.11 Ref.12 Ref.16 Ref.18

Modified residue

733

1

Phosphoserine Ref.12 Ref.13

Modified residue

736

1

Phosphoserine Ref.12 Ref.13 Ref.18

Modified residue

738

1

Phosphoserine Ref.12 Ref.13 Ref.16

Modified residue

781

1

Phosphoserine Ref.16

Modified residue

797

1

Phosphoserine Ref.9 Ref.13 Ref.16 Ref.18

Natural variations

Alternative sequence

68 – 144

77

Missing in isoform 3 and isoform 4.

VSP_036173

Alternative sequence

354

1

Missing in isoform 2 and isoform 4.

VSP_036035

Natural variant

396

1

R → H in a colorectal cancer sample; somatic mutation. Ref.21

VAR_035486

Experimental info

Sequence conflict

499

1

A → P in BAA09471. Ref.1

Sequence conflict

672

1

S → T in CAB70731. Ref.3

Secondary structure

1

.

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930

Helix Strand Turn

Details...

Beta strand

130 – 134

5

Helix

142 – 152

11

Beta strand

161 – 163

3

Beta strand

165 – 167

3

Beta strand

171 – 177

7

Helix

181 – 189

9

Turn

190 – 193

4

Beta strand

194 – 197

4

Beta strand

200 – 205

6

Beta strand

301 – 304

4

Helix

314 – 320

7

Helix

321 – 323

3

Turn

328 – 330

3

Beta strand

337 – 342

6

Beta strand

346 – 349

4

Helix

355 – 363

9

Helix

372 – 374

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 16, 2008. Version 3. Checksum: 472E68F085CA5744	FASTA	930	103,533
	10 20 30 40 50 60 MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS QEGKHDYDDS 70 80 90 100 110 120 SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG DYRDQDYRTE QGEEEEEEED 130 140 150 160 170 180 EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ SHGVQAREVR LMRNKSSGQS RGFAFVEFSH 190 200 210 220 230 240 LQDATRWMEA NQHSLNILGQ KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK 250 260 270 280 290 300 SEAEQKLPLG TRLDQQTLPL GGRELSQGLL PLPQPYQAQG VLASQALSQG SEPSSENAND 310 320 330 340 350 360 TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL STIVEAAQLL 370 380 390 400 410 420 QILQALHPPL TIDGKTINVE FAKGSKRDMA SNEGSRISAA SVASTAIAAA QWAISQASQG 430 440 450 460 470 480 GEGTWATSEE PPVDYSYYQQ DEGYGNSQGT ESSLYAHGYL KGTKGPGITG TKGDPTGAGP 490 500 510 520 530 540 EASLEPGADS VSMQAFSRAQ PGAAPGIYQQ SAEASSSQGT AANSQSYTIM SPAVLKSELQ 550 560 570 580 590 600 SPTHPSSALP PATSPTAQES YSQYPVPDVS TYQYDETSGY YYDPQTGLYY DPNSQYYYNA 610 620 630 640 650 660 QSQQYLYWDG ERRTYVPALE QSADGHKETG APSKEGKEKK EKHKTKTAQQ IAKDMERWAR 670 680 690 700 710 720 SLNKQKENFK NSFQPISSLR DDERRESATA DAGYAILEKK GALAERQHTS MDLPKLASDD 730 740 750 760 770 780 RPSPPRGLVA AYSGESDSEE EQERGGPERE EKLTDWQKLA CLLCRRQFPS KEALIRHQQL 790 800 810 820 830 840 SGLHKQNLEI HRRAHLSENE LEALEKNDME QMKYRDRAAE RREKYGIPEP PEPKRRKYGG 850 860 870 880 890 900 ISTASVDFEQ PTRDGLGSDN IGSRMLQAMG WKEGSGLGRK KQGIVTPIEA QTRVRGSGLG 910 920 930 ARGSSYGVTS TESYKETLHK TMVTRFNEAQ
	Isoform 2 [UniParc]. Checksum: 43D8E086250E441B	FASTA	929	103,433
	10 20 30 40 50 60 MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS QEGKHDYDDS 70 80 90 100 110 120 SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG DYRDQDYRTE QGEEEEEEED 130 140 150 160 170 180 EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ SHGVQAREVR LMRNKSSGQS RGFAFVEFSH 190 200 210 220 230 240 LQDATRWMEA NQHSLNILGQ KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK 250 260 270 280 290 300 SEAEQKLPLG TRLDQQTLPL GGRELSQGLL PLPQPYQAQG VLASQALSQG SEPSSENAND 310 320 330 340 350 360 TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL STIEAAQLLQ 370 380 390 400 410 420 ILQALHPPLT IDGKTINVEF AKGSKRDMAS NEGSRISAAS VASTAIAAAQ WAISQASQGG 430 440 450 460 470 480 EGTWATSEEP PVDYSYYQQD EGYGNSQGTE SSLYAHGYLK GTKGPGITGT KGDPTGAGPE 490 500 510 520 530 540 ASLEPGADSV SMQAFSRAQP GAAPGIYQQS AEASSSQGTA ANSQSYTIMS PAVLKSELQS 550 560 570 580 590 600 PTHPSSALPP ATSPTAQESY SQYPVPDVST YQYDETSGYY YDPQTGLYYD PNSQYYYNAQ 610 620 630 640 650 660 SQQYLYWDGE RRTYVPALEQ SADGHKETGA PSKEGKEKKE KHKTKTAQQI AKDMERWARS 670 680 690 700 710 720 LNKQKENFKN SFQPISSLRD DERRESATAD AGYAILEKKG ALAERQHTSM DLPKLASDDR 730 740 750 760 770 780 PSPPRGLVAA YSGESDSEEE QERGGPEREE KLTDWQKLAC LLCRRQFPSK EALIRHQQLS 790 800 810 820 830 840 GLHKQNLEIH RRAHLSENEL EALEKNDMEQ MKYRDRAAER REKYGIPEPP EPKRRKYGGI 850 860 870 880 890 900 STASVDFEQP TRDGLGSDNI GSRMLQAMGW KEGSGLGRKK QGIVTPIEAQ TRVRGSGLGA 910 920 RGSSYGVTST ESYKETLHKT MVTRFNEAQ
	Isoform 3 [UniParc]. Checksum: BF5689F0C926EDA8	FASTA	853	94,469
	10 20 30 40 50 60 MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS QEGKHDYDDS 70 80 90 100 110 120 SEEQSAEIRG QLQSHGVQAR EVRLMRNKSS GQSRGFAFVE FSHLQDATRW MEANQHSLNI 130 140 150 160 170 180 LGQKVSMHYS DPKPKINEDW LCNKCGVQNF KRREKCFKCG VPKSEAEQKL PLGTRLDQQT 190 200 210 220 230 240 LPLGGRELSQ GLLPLPQPYQ AQGVLASQAL SQGSEPSSEN ANDTIILRNL NPHSTMDSIL 250 260 270 280 290 300 GALAPYAVLS SSNVRVIKDK QTQLNRGFAF IQLSTIVEAA QLLQILQALH PPLTIDGKTI 310 320 330 340 350 360 NVEFAKGSKR DMASNEGSRI SAASVASTAI AAAQWAISQA SQGGEGTWAT SEEPPVDYSY 370 380 390 400 410 420 YQQDEGYGNS QGTESSLYAH GYLKGTKGPG ITGTKGDPTG AGPEASLEPG ADSVSMQAFS 430 440 450 460 470 480 RAQPGAAPGI YQQSAEASSS QGTAANSQSY TIMSPAVLKS ELQSPTHPSS ALPPATSPTA 490 500 510 520 530 540 QESYSQYPVP DVSTYQYDET SGYYYDPQTG LYYDPNSQYY YNAQSQQYLY WDGERRTYVP 550 560 570 580 590 600 ALEQSADGHK ETGAPSKEGK EKKEKHKTKT AQQIAKDMER WARSLNKQKE NFKNSFQPIS 610 620 630 640 650 660 SLRDDERRES ATADAGYAIL EKKGALAERQ HTSMDLPKLA SDDRPSPPRG LVAAYSGESD 670 680 690 700 710 720 SEEEQERGGP EREEKLTDWQ KLACLLCRRQ FPSKEALIRH QQLSGLHKQN LEIHRRAHLS 730 740 750 760 770 780 ENELEALEKN DMEQMKYRDR AAERREKYGI PEPPEPKRRK YGGISTASVD FEQPTRDGLG 790 800 810 820 830 840 SDNIGSRMLQ AMGWKEGSGL GRKKQGIVTP IEAQTRVRGS GLGARGSSYG VTSTESYKET 850 LHKTMVTRFN EAQ
	Isoform 4 [UniParc]. Checksum: BB39E0CAC9B4A8A3	FASTA	852	94,370
	10 20 30 40 50 60 MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS QEGKHDYDDS 70 80 90 100 110 120 SEEQSAEIRG QLQSHGVQAR EVRLMRNKSS GQSRGFAFVE FSHLQDATRW MEANQHSLNI 130 140 150 160 170 180 LGQKVSMHYS DPKPKINEDW LCNKCGVQNF KRREKCFKCG VPKSEAEQKL PLGTRLDQQT 190 200 210 220 230 240 LPLGGRELSQ GLLPLPQPYQ AQGVLASQAL SQGSEPSSEN ANDTIILRNL NPHSTMDSIL 250 260 270 280 290 300 GALAPYAVLS SSNVRVIKDK QTQLNRGFAF IQLSTIEAAQ LLQILQALHP PLTIDGKTIN 310 320 330 340 350 360 VEFAKGSKRD MASNEGSRIS AASVASTAIA AAQWAISQAS QGGEGTWATS EEPPVDYSYY 370 380 390 400 410 420 QQDEGYGNSQ GTESSLYAHG YLKGTKGPGI TGTKGDPTGA GPEASLEPGA DSVSMQAFSR 430 440 450 460 470 480 AQPGAAPGIY QQSAEASSSQ GTAANSQSYT IMSPAVLKSE LQSPTHPSSA LPPATSPTAQ 490 500 510 520 530 540 ESYSQYPVPD VSTYQYDETS GYYYDPQTGL YYDPNSQYYY NAQSQQYLYW DGERRTYVPA 550 560 570 580 590 600 LEQSADGHKE TGAPSKEGKE KKEKHKTKTA QQIAKDMERW ARSLNKQKEN FKNSFQPISS 610 620 630 640 650 660 LRDDERRESA TADAGYAILE KKGALAERQH TSMDLPKLAS DDRPSPPRGL VAAYSGESDS 670 680 690 700 710 720 EEEQERGGPE REEKLTDWQK LACLLCRRQF PSKEALIRHQ QLSGLHKQNL EIHRRAHLSE 730 740 750 760 770 780 NELEALEKND MEQMKYRDRA AERREKYGIP EPPEPKRRKY GGISTASVDF EQPTRDGLGS 790 800 810 820 830 840 DNIGSRMLQA MGWKEGSGLG RKKQGIVTPI EAQTRVRGSG LGARGSSYGV TSTESYKETL 850 HKTMVTRFNE AQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N. DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Liver.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain, Lung, Muscle and Placenta.
[7]	"A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status." Coleman M.P., Ambrose H.J., Carrel L., Nemeth A.H., Willard H.F., Davies K.E. Genomics 31:135-138(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 544-930. Tissue: Fetal brain.
[8]	"Large-scale proteomic analysis of the human spliceosome." Rappsilber J., Ryder U., Lamond A.I., Mann M. Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH THE SPLICEOSOME, MASS SPECTROMETRY.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-723, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-723; SER-733; SER-736 AND SER-738, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733; SER-736; SER-738 AND SER-797, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-383, MASS SPECTROMETRY.
[15]	"Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate." Johnston J.J., Teer J.K., Cherukuri P.F., Hansen N.F., Loftus S.K., Chong K., Mullikin J.C., Biesecker L.G. Am. J. Hum. Genet. 86:743-748(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN TARPS.
[16]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89; SER-718; SER-723; SER-738; SER-781 AND SER-797, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-718; SER-723; SER-736 AND SER-797, MASS SPECTROMETRY.
[19]	"A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation." Zhu P., Zhou W., Wang J., Puc J., Ohgi K.A., Erdjument-Bromage H., Tempst P., Glass C.K., Rosenfeld M.G. Mol. Cell 27:609-621(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A LARGE CHROMATIN REMODELING COMPLEX.
[20]	"S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity." Inoue A., Tsugawa K., Tokunaga K., Takahashi K.P., Uni S., Kimura M., Nishio K., Yamamoto N., Honda K., Watanabe T., Yamane H., Tani T. Biol. Cell 100:523-535(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[21]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-396.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D50912 mRNA. Translation: BAA09471.1. Different initiation.
AK292758 mRNA. Translation: BAF85447.1.
AL137421 mRNA. Translation: CAB70731.1. Sequence problems.
AL513366 Genomic DNA. Translation: CAI41700.1.
CH471164 Genomic DNA. Translation: EAW59284.1.
CH471164 Genomic DNA. Translation: EAW59285.1.
CH471164 Genomic DNA. Translation: EAW59287.1.
CH471164 Genomic DNA. Translation: EAW59283.1.
BC003089 mRNA. Translation: AAH03089.1.
BC004181 mRNA. Translation: AAH04181.1.
BC008733 mRNA. Translation: AAH08733.1.
BC024153 mRNA. Translation: AAH24153.1.
U35373 mRNA. Translation: AAB33572.1. Frameshift.

IPI

IPI00375731.
IPI00549342.
IPI00915253.
IPI00916428.

RefSeq

NP_001191395.1. NM_001204466.1.
NP_001191396.1. NM_001204467.1.
NP_005667.2. NM_005676.4.
NP_690595.1. NM_152856.2.

UniGene

Hs.401509.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LXI	NMR	-	A	128-218	[»]
2M2B	NMR	-	A	277-408	[»]

ProteinModelPortal

P98175.

ModBase

Search...

Protein-protein interaction databases

IntAct

P98175. 14 interactions.

MINT

MINT-2864879.

STRING

9606.ENSP00000366829.

PTM databases

PhosphoSite

P98175.

Polymorphism databases

DMDM

218512116.

Proteomic databases

PaxDb

P98175.

PRIDE

P98175.

Protocols and materials databases

DNASU

8241.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000329236; ENSP00000328848; ENSG00000182872.
ENST00000345781; ENSP00000329659; ENSG00000182872.
ENST00000377604; ENSP00000366829; ENSG00000182872.

GeneID

8241.

KEGG

hsa:8241.

UCSC

uc004dhf.3. human.
uc004dhg.3. human.
uc004dhh.3. human.
uc010nhq.3. human.

Organism-specific databases

CTD

8241.

GeneCards

GC0XP047004.

HGNC

HGNC:9896. RBM10.

HPA

HPA034972.

MIM

300080. gene.
311900. phenotype.

neXtProt

NX_P98175.

Orphanet

2886. TARP syndrome.

PharmGKB

PA34259.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG290849.

HOVERGEN

HBG000318.

InParanoid

P98175.

KO

K13094.

OMA

NQHSLNI.

OrthoDB

EOG4DZ1TN.

PhylomeDB

P98175.

Gene expression databases

Bgee

P98175.

CleanEx

HS_RBM10.

Genevestigator

P98175.

GermOnline

ENSG00000182872. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.330. 2 hits.

InterPro

IPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view]

Pfam

PF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]

SMART

SM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]

PROSITE

PS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RBM10. human.

GenomeRNAi

8241.

NextBio

30996.

SOURCE

Search...

Entry information

Entry name

RBM10_HUMAN

Accession

Primary (citable) accession number: P98175
Secondary accession number(s): C4AM81 , Q14136, Q5JRR2, Q9BTE4, Q9BTX0, Q9NTB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 131 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.