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P98175

- RBM10_HUMAN

UniProt

P98175 - RBM10_HUMAN

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Protein

RNA-binding protein 10

Gene
RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 24231RanBP2-typeAdd
BLAST
Zinc fingeri759 – 78426C2H2-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. nucleotide binding Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: IntAct
  5. protein complex binding Source: UniProtKB
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. 3'-UTR-mediated mRNA stabilization Source: Ensembl
  2. mRNA processing Source: UniProtKB-KW
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  6. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 10
Alternative name(s):
G patch domain-containing protein 9
RNA-binding motif protein 10
RNA-binding protein S1-1
Short name:
S1-1
Gene namesi
Name:RBM10
Synonyms:DXS8237E, GPATC9, GPATCH9, KIAA0122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:9896. RBM10.

Subcellular locationi

Nucleus
Note: In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).1 Publication

GO - Cellular componenti

  1. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi311900. phenotype.
Orphaneti2886. TARP syndrome.
PharmGKBiPA34259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930RNA-binding protein 10PRO_0000081767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphoserine1 Publication
Modified residuei89 – 891Phosphoserine1 Publication
Modified residuei383 – 3831N6-acetyllysine1 Publication
Modified residuei718 – 7181Phosphoserine2 Publications
Modified residuei723 – 7231Phosphoserine4 Publications
Modified residuei733 – 7331Phosphoserine2 Publications
Modified residuei736 – 7361Phosphoserine3 Publications
Modified residuei738 – 7381Phosphoserine3 Publications
Modified residuei781 – 7811Phosphoserine1 Publication
Modified residuei797 – 7971Phosphoserine4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP98175.
PaxDbiP98175.
PRIDEiP98175.

PTM databases

PhosphoSiteiP98175.

Expressioni

Gene expression databases

BgeeiP98175.
CleanExiHS_RBM10.
GenevestigatoriP98175.

Organism-specific databases

HPAiHPA034972.

Interactioni

Subunit structurei

Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-721525,EBI-721525
DHX15O431432EBI-721525,EBI-1237044
DHX38Q926202EBI-721525,EBI-1043041
GPKOWQ929172EBI-721525,EBI-746309
IKQ131232EBI-721525,EBI-713456
PRPF19Q9UMS42EBI-721525,EBI-395746
SF3A1Q154592EBI-721525,EBI-1054743
SF3B4Q154272EBI-721525,EBI-348469
SNRPCP092342EBI-721525,EBI-766589
SUGP1Q8IWZ82EBI-721525,EBI-2691671
U2AF2P263682EBI-721525,EBI-742339
U2SURPO150422EBI-721525,EBI-310697

Protein-protein interaction databases

BioGridi113869. 52 interactions.
IntActiP98175. 40 interactions.
MINTiMINT-2864879.
STRINGi9606.ENSP00000366829.

Structurei

Secondary structure

1
930
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi130 – 1345
Helixi142 – 15211
Beta strandi161 – 1633
Beta strandi165 – 1673
Beta strandi171 – 1777
Helixi181 – 1899
Turni190 – 1934
Beta strandi194 – 1974
Beta strandi200 – 2056
Beta strandi301 – 3044
Helixi314 – 3207
Helixi321 – 3233
Turni328 – 3303
Beta strandi337 – 3426
Beta strandi346 – 3494
Helixi354 – 36310
Helixi372 – 3743

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LXINMR-A128-218[»]
2M2BNMR-A277-408[»]
ProteinModelPortaliP98175.
SMRiP98175. Positions 128-218, 277-408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 20981RRM 1Add
BLAST
Domaini300 – 38485RRM 2Add
BLAST
Domaini858 – 90447G-patchAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 878Poly-Arg
Compositional biasi113 – 12513Poly-GluAdd
BLAST
Compositional biasi561 – 60747Tyr-richAdd
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 24231RanBP2-typeAdd
BLAST
Zinc fingeri759 – 78426C2H2-type; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG290849.
HOVERGENiHBG000318.
InParanoidiP98175.
KOiK13094.
OMAiKGDPAGT.
OrthoDBiEOG7NSB1M.
PhylomeDBiP98175.
TreeFamiTF315789.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P98175-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS    50
QEGKHDYDDS SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG 100
DYRDQDYRTE QGEEEEEEED EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ 150
SHGVQAREVR LMRNKSSGQS RGFAFVEFSH LQDATRWMEA NQHSLNILGQ 200
KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK SEAEQKLPLG 250
TRLDQQTLPL GGRELSQGLL PLPQPYQAQG VLASQALSQG SEPSSENAND 300
TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL 350
STIVEAAQLL QILQALHPPL TIDGKTINVE FAKGSKRDMA SNEGSRISAA 400
SVASTAIAAA QWAISQASQG GEGTWATSEE PPVDYSYYQQ DEGYGNSQGT 450
ESSLYAHGYL KGTKGPGITG TKGDPTGAGP EASLEPGADS VSMQAFSRAQ 500
PGAAPGIYQQ SAEASSSQGT AANSQSYTIM SPAVLKSELQ SPTHPSSALP 550
PATSPTAQES YSQYPVPDVS TYQYDETSGY YYDPQTGLYY DPNSQYYYNA 600
QSQQYLYWDG ERRTYVPALE QSADGHKETG APSKEGKEKK EKHKTKTAQQ 650
IAKDMERWAR SLNKQKENFK NSFQPISSLR DDERRESATA DAGYAILEKK 700
GALAERQHTS MDLPKLASDD RPSPPRGLVA AYSGESDSEE EQERGGPERE 750
EKLTDWQKLA CLLCRRQFPS KEALIRHQQL SGLHKQNLEI HRRAHLSENE 800
LEALEKNDME QMKYRDRAAE RREKYGIPEP PEPKRRKYGG ISTASVDFEQ 850
PTRDGLGSDN IGSRMLQAMG WKEGSGLGRK KQGIVTPIEA QTRVRGSGLG 900
ARGSSYGVTS TESYKETLHK TMVTRFNEAQ 930
Length:930
Mass (Da):103,533
Last modified:December 16, 2008 - v3
Checksum:i472E68F085CA5744
GO
Isoform 2 (identifier: P98175-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: Missing.

Show »
Length:929
Mass (Da):103,433
Checksum:i43D8E086250E441B
GO
Isoform 3 (identifier: P98175-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.

Show »
Length:853
Mass (Da):94,469
Checksum:iBF5689F0C926EDA8
GO
Isoform 4 (identifier: P98175-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.
     354-354: Missing.

Show »
Length:852
Mass (Da):94,370
Checksum:iBB39E0CAC9B4A8A3
GO

Sequence cautioni

The sequence AAB33572.1 differs from that shown. Reason: Frameshift at position 696.
The sequence CAB70731.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAA09471.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB70731.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti396 – 3961R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035486

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 14477Missing in isoform 3 and isoform 4. VSP_036173Add
BLAST
Alternative sequencei354 – 3541Missing in isoform 2 and isoform 4. VSP_036035

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991A → P in BAA09471. 1 Publication
Sequence conflicti672 – 6721S → T in CAB70731. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50912 mRNA. Translation: BAA09471.1. Different initiation.
AK292758 mRNA. Translation: BAF85447.1.
AL137421 mRNA. Translation: CAB70731.1. Sequence problems.
AL513366 Genomic DNA. Translation: CAI41700.1.
CH471164 Genomic DNA. Translation: EAW59284.1.
CH471164 Genomic DNA. Translation: EAW59285.1.
CH471164 Genomic DNA. Translation: EAW59287.1.
CH471164 Genomic DNA. Translation: EAW59283.1.
BC003089 mRNA. Translation: AAH03089.1.
BC004181 mRNA. Translation: AAH04181.1.
BC008733 mRNA. Translation: AAH08733.1.
BC024153 mRNA. Translation: AAH24153.1.
U35373 mRNA. Translation: AAB33572.1. Frameshift.
CCDSiCCDS14274.1. [P98175-1]
CCDS55407.1. [P98175-4]
CCDS56600.1. [P98175-3]
RefSeqiNP_001191395.1. NM_001204466.1. [P98175-3]
NP_001191396.1. NM_001204467.1. [P98175-2]
NP_005667.2. NM_005676.4. [P98175-1]
NP_690595.1. NM_152856.2. [P98175-4]
UniGeneiHs.401509.

Genome annotation databases

EnsembliENST00000329236; ENSP00000328848; ENSG00000182872. [P98175-4]
ENST00000345781; ENSP00000329659; ENSG00000182872. [P98175-3]
ENST00000377604; ENSP00000366829; ENSG00000182872. [P98175-1]
ENST00000603045; ENSP00000474744; ENSG00000271352. [P98175-1]
ENST00000603922; ENSP00000475019; ENSG00000271352. [P98175-3]
ENST00000604931; ENSP00000474848; ENSG00000271352. [P98175-4]
GeneIDi8241.
KEGGihsa:8241.
UCSCiuc004dhf.3. human. [P98175-1]
uc004dhg.3. human. [P98175-4]
uc004dhh.3. human. [P98175-2]
uc010nhq.3. human. [P98175-3]

Polymorphism databases

DMDMi218512116.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50912 mRNA. Translation: BAA09471.1 . Different initiation.
AK292758 mRNA. Translation: BAF85447.1 .
AL137421 mRNA. Translation: CAB70731.1 . Sequence problems.
AL513366 Genomic DNA. Translation: CAI41700.1 .
CH471164 Genomic DNA. Translation: EAW59284.1 .
CH471164 Genomic DNA. Translation: EAW59285.1 .
CH471164 Genomic DNA. Translation: EAW59287.1 .
CH471164 Genomic DNA. Translation: EAW59283.1 .
BC003089 mRNA. Translation: AAH03089.1 .
BC004181 mRNA. Translation: AAH04181.1 .
BC008733 mRNA. Translation: AAH08733.1 .
BC024153 mRNA. Translation: AAH24153.1 .
U35373 mRNA. Translation: AAB33572.1 . Frameshift.
CCDSi CCDS14274.1. [P98175-1 ]
CCDS55407.1. [P98175-4 ]
CCDS56600.1. [P98175-3 ]
RefSeqi NP_001191395.1. NM_001204466.1. [P98175-3 ]
NP_001191396.1. NM_001204467.1. [P98175-2 ]
NP_005667.2. NM_005676.4. [P98175-1 ]
NP_690595.1. NM_152856.2. [P98175-4 ]
UniGenei Hs.401509.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LXI NMR - A 128-218 [» ]
2M2B NMR - A 277-408 [» ]
ProteinModelPortali P98175.
SMRi P98175. Positions 128-218, 277-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113869. 52 interactions.
IntActi P98175. 40 interactions.
MINTi MINT-2864879.
STRINGi 9606.ENSP00000366829.

PTM databases

PhosphoSitei P98175.

Polymorphism databases

DMDMi 218512116.

Proteomic databases

MaxQBi P98175.
PaxDbi P98175.
PRIDEi P98175.

Protocols and materials databases

DNASUi 8241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329236 ; ENSP00000328848 ; ENSG00000182872 . [P98175-4 ]
ENST00000345781 ; ENSP00000329659 ; ENSG00000182872 . [P98175-3 ]
ENST00000377604 ; ENSP00000366829 ; ENSG00000182872 . [P98175-1 ]
ENST00000603045 ; ENSP00000474744 ; ENSG00000271352 . [P98175-1 ]
ENST00000603922 ; ENSP00000475019 ; ENSG00000271352 . [P98175-3 ]
ENST00000604931 ; ENSP00000474848 ; ENSG00000271352 . [P98175-4 ]
GeneIDi 8241.
KEGGi hsa:8241.
UCSCi uc004dhf.3. human. [P98175-1 ]
uc004dhg.3. human. [P98175-4 ]
uc004dhh.3. human. [P98175-2 ]
uc010nhq.3. human. [P98175-3 ]

Organism-specific databases

CTDi 8241.
GeneCardsi GC0XP047004.
HGNCi HGNC:9896. RBM10.
HPAi HPA034972.
MIMi 300080. gene.
311900. phenotype.
neXtProti NX_P98175.
Orphaneti 2886. TARP syndrome.
PharmGKBi PA34259.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290849.
HOVERGENi HBG000318.
InParanoidi P98175.
KOi K13094.
OMAi KGDPAGT.
OrthoDBi EOG7NSB1M.
PhylomeDBi P98175.
TreeFami TF315789.

Miscellaneous databases

ChiTaRSi RBM10. human.
GeneWikii RBM10.
GenomeRNAii 8241.
NextBioi 30996.
PROi P98175.
SOURCEi Search...

Gene expression databases

Bgeei P98175.
CleanExi HS_RBM10.
Genevestigatori P98175.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProi IPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Brain, Lung, Muscle and Placenta.
  7. "A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status."
    Coleman M.P., Ambrose H.J., Carrel L., Nemeth A.H., Willard H.F., Davies K.E.
    Genomics 31:135-138(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 544-930.
    Tissue: Fetal brain.
  8. "Large-scale proteomic analysis of the human spliceosome."
    Rappsilber J., Ryder U., Lamond A.I., Mann M.
    Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-723, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-723; SER-733; SER-736 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733; SER-736; SER-738 AND SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate."
    Johnston J.J., Teer J.K., Cherukuri P.F., Hansen N.F., Loftus S.K., Chong K., Mullikin J.C., Biesecker L.G.
    Am. J. Hum. Genet. 86:743-748(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN TARPS.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89; SER-718; SER-723; SER-738; SER-781 AND SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-718; SER-723; SER-736 AND SER-797, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation."
    Zhu P., Zhou W., Wang J., Puc J., Ohgi K.A., Erdjument-Bromage H., Tempst P., Glass C.K., Rosenfeld M.G.
    Mol. Cell 27:609-621(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A LARGE CHROMATIN REMODELING COMPLEX.
  21. "S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity."
    Inoue A., Tsugawa K., Tokunaga K., Takahashi K.P., Uni S., Kimura M., Nishio K., Yamamoto N., Honda K., Watanabe T., Yamane H., Tani T.
    Biol. Cell 100:523-535(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  22. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-396.

Entry informationi

Entry nameiRBM10_HUMAN
AccessioniPrimary (citable) accession number: P98175
Secondary accession number(s): C4AM81
, Q14136, Q5JRR2, Q9BTE4, Q9BTX0, Q9NTB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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