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Protein

Protein FAM3A

Gene

FAM3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a defensin against invading fungal microorganisms.

GO - Biological processi

  • antifungal humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • negative regulation of antifungal innate immune response Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3A
Alternative name(s):
Cytokine-like protein 2-19
Gene namesi
Name:FAM3A
Synonyms:2-19, 2.19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000071889.16.
HGNCiHGNC:13749. FAM3A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000071889.
PharmGKBiPA38366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000874834 – 230Protein FAM3AAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 87By similarity
Disulfide bondi65 ↔ 222By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP98173.
MaxQBiP98173.
PaxDbiP98173.
PeptideAtlasiP98173.
PRIDEiP98173.

Expressioni

Tissue specificityi

In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.

Gene expression databases

BgeeiENSG00000071889.
CleanExiHS_FAM3A.
ExpressionAtlasiP98173. baseline and differential.
GenevisibleiP98173. HS.

Organism-specific databases

HPAiCAB025016.
HPA056991.

Interactioni

Protein-protein interaction databases

BioGridi121898. 12 interactors.
IntActiP98173. 3 interactors.
MINTiMINT-4722471.
STRINGi9606.ENSP00000352955.

Structurei

3D structure databases

ProteinModelPortaliP98173.
SMRiP98173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKQR. Eukaryota.
ENOG410ZQT7. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiP98173.
PhylomeDBiP98173.
TreeFamiTF353414.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P98173-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLAGPLRIV VLVVSVGVTW IVVSILLGGP GSGFPRIQQL FTSPESSVTA
60 70 80 90 100
APRARKYKCG LPQPCPEEHL AFRVVSGAAN VIGPKICLED KMLMSSVKDN
110 120 130 140 150
VGRGLNIALV NGVSGELIEA RAFDMWAGDV NDLLKFIRPL HEGTLVFVAS
160 170 180 190 200
YDDPATKMNE ETRKLFSELG SRNAKELAFR DSWVFVGAKG VQNKSPFEQH
210 220 230
VKNSKHSNKY EGWPEALEME GCIPRRSTAS
Length:230
Mass (Da):25,152
Last modified:November 28, 2006 - v2
Checksum:iFE23EE191F98CAAD
GO
Isoform 2 (identifier: P98173-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-128: Missing.

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):23,361
Checksum:iF586DA014DEBFF50
GO
Isoform 3 (identifier: P98173-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-43: Missing.

Note: Gene prediction based on EST data.
Show »
Length:192
Mass (Da):21,164
Checksum:iB7E349DBE65E0A36
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05753121I → M. Corresponds to variant dbSNP:rs35985994Ensembl.1
Natural variantiVAR_011923213W → C3 PublicationsCorresponds to variant dbSNP:rs1050788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467336 – 43Missing in isoform 3. CuratedAdd BLAST38
Alternative sequenceiVSP_042778112 – 128Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55448 Genomic DNA. Translation: CAA39090.1.
X87193 mRNA. Translation: CAA60645.1.
L44140 Genomic DNA. Translation: AAA92652.1.
AK294116 mRNA. Translation: BAG57449.1.
AK314682 mRNA. Translation: BAG37234.1.
BX664739 Genomic DNA. Translation: CAI43239.1.
CH471172 Genomic DNA. Translation: EAW72689.1.
CH471172 Genomic DNA. Translation: EAW72692.1.
CH471172 Genomic DNA. Translation: EAW72693.1.
CH471172 Genomic DNA. Translation: EAW72694.1.
CH471172 Genomic DNA. Translation: EAW72695.1.
BC008912 mRNA. Translation: AAH08912.1.
CCDSiCCDS35453.1. [P98173-1]
CCDS55542.1. [P98173-3]
CCDS55543.1. [P98173-2]
PIRiI37095.
RefSeqiNP_001164603.1. NM_001171132.2. [P98173-1]
NP_001164604.1. NM_001171133.2. [P98173-3]
NP_001164605.1. NM_001171134.2. [P98173-2]
NP_001269240.1. NM_001282311.1.
NP_001269241.1. NM_001282312.1. [P98173-1]
NP_068578.2. NM_021806.3. [P98173-1]
XP_005277936.1. XM_005277879.4. [P98173-2]
UniGeneiHs.289108.

Genome annotation databases

EnsembliENST00000359889; ENSP00000352955; ENSG00000071889. [P98173-1]
ENST00000369643; ENSP00000358657; ENSG00000071889. [P98173-1]
ENST00000393572; ENSP00000377202; ENSG00000071889. [P98173-3]
ENST00000419205; ENSP00000393086; ENSG00000071889. [P98173-2]
ENST00000447601; ENSP00000416146; ENSG00000071889. [P98173-1]
GeneIDi60343.
KEGGihsa:60343.
UCSCiuc004fls.4. human. [P98173-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFAM3A_HUMAN
AccessioniPrimary (citable) accession number: P98173
Secondary accession number(s): A6QRH6
, B2RBI7, B4DFI8, D3DWX4, Q5HY76, Q96H51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2006
Last modified: September 27, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families