##gff-version 3 P98170 UniProtKB Chain 1 497 . . . ID=PRO_0000122352;Note=E3 ubiquitin-protein ligase XIAP P98170 UniProtKB Repeat 26 93 . . . Note=BIR 1 P98170 UniProtKB Repeat 163 230 . . . Note=BIR 2 P98170 UniProtKB Repeat 265 330 . . . Note=BIR 3 P98170 UniProtKB Zinc finger 450 485 . . . Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 P98170 UniProtKB Region 141 149 . . . Note=Interaction with caspase-7 P98170 UniProtKB Region 262 277 . . . Note=Required for interaction with SEPTIN4 isoform ARTS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21695558;Dbxref=PMID:21695558 P98170 UniProtKB Region 329 350 . . . Note=Required for interaction with DIABLO;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21695558;Dbxref=PMID:21695558 P98170 UniProtKB Region 450 497 . . . Note=Required for ubiquitination and subsequent degradation of BCL2 during apoptosis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29020630;Dbxref=PMID:29020630 P98170 UniProtKB Binding site 300 300 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00029 P98170 UniProtKB Binding site 303 303 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00029 P98170 UniProtKB Binding site 320 320 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00029 P98170 UniProtKB Binding site 327 327 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00029 P98170 UniProtKB Modified residue 450 450 . . . Note=S-nitrosocysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20670888;Dbxref=PMID:20670888 P98170 UniProtKB Cross-link 322 322 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12747801;Dbxref=PMID:12747801 P98170 UniProtKB Cross-link 328 328 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12747801;Dbxref=PMID:12747801 P98170 UniProtKB Natural variant 104 497 . . . ID=VAR_088127;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489057;Dbxref=PMID:20489057 P98170 UniProtKB Natural variant 107 107 . . . ID=VAR_022282;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28382721 P98170 UniProtKB Natural variant 118 497 . . . ID=VAR_088128;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21119115;Dbxref=PMID:21119115 P98170 UniProtKB Natural variant 133 133 . . . ID=VAR_022283;Note=S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28382722 P98170 UniProtKB Natural variant 188 188 . . . ID=VAR_088129;Note=In XLP2%3B uncertain significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489057;Dbxref=PMID:20489057 P98170 UniProtKB Natural variant 194 194 . . . ID=VAR_088130;Note=In XLP2%3B uncertain significance. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489057;Dbxref=PMID:20489057 P98170 UniProtKB Natural variant 238 497 . . . ID=VAR_088131;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21119115;Dbxref=PMID:21119115 P98170 UniProtKB Natural variant 242 242 . . . ID=VAR_022284;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.3;Dbxref=dbSNP:rs28382723 P98170 UniProtKB Natural variant 333 497 . . . ID=VAR_088132;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489057;Dbxref=PMID:20489057 P98170 UniProtKB Natural variant 381 497 . . . ID=VAR_088133;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21119115;Dbxref=PMID:21119115 P98170 UniProtKB Natural variant 423 423 . . . ID=VAR_022285;Note=Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8654366,ECO:0000269|Ref.3;Dbxref=dbSNP:rs5956583,PMID:8654366 P98170 UniProtKB Natural variant 466 497 . . . ID=VAR_088134;Note=In XLP2%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21119115;Dbxref=PMID:21119115 P98170 UniProtKB Natural variant 482 482 . . . ID=VAR_088135;Note=In XLP2%3B uncertain significance. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20489057;Dbxref=PMID:20489057 P98170 UniProtKB Mutagenesis 75 75 . . . Note=Loss of interaction with TAB1/MAP3K7IP1%3B when associated with G-75. Y->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17560374;Dbxref=PMID:17560374 P98170 UniProtKB Mutagenesis 80 80 . . . Note=Strongly reduced interaction with TAB1/MAP3K7IP1. Reduced activation of MAP3K7/TAK1. Reduced activation of NF-kappa-B. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17560374;Dbxref=PMID:17560374 P98170 UniProtKB Mutagenesis 80 80 . . . Note=Loss of interaction with TAB1/MAP3K7IP1. Reduced activation of MAP3K7/TAK1. Strongly reduced activation of NF-kappa-B. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17560374;Dbxref=PMID:17560374 P98170 UniProtKB Mutagenesis 86 86 . . . Note=Loss of dimerization. Reduces activation of NF-kappa-B. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17560374;Dbxref=PMID:17560374 P98170 UniProtKB Mutagenesis 87 87 . . . Note=No effect on dimerization. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698078;Dbxref=PMID:17698078 P98170 UniProtKB Mutagenesis 87 87 . . . Note=Abolishes dimerization. Interferes with ubiquitination. S->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698078;Dbxref=PMID:17698078 P98170 UniProtKB Mutagenesis 98 98 . . . Note=Loss of interaction with TAB1/MAP3K7IP1%3B when associated with G-75. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17560374;Dbxref=PMID:17560374 P98170 UniProtKB Mutagenesis 141 141 . . . Note=Reduced inhibition of caspase-3. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 147 147 . . . Note=Reduced inhibition of caspase-3. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 148 148 . . . Note=Abolishes inhibition of caspase-3. Reduced interaction with HTRA2%3B when associated with S-214. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10548111,ECO:0000269|PubMed:11604410;Dbxref=PMID:10548111,PMID:11604410 P98170 UniProtKB Mutagenesis 149 149 . . . Note=Reduced inhibition of caspase-3. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 151 151 . . . Note=Reduced inhibition of caspase-3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 167 167 . . . Note=Reduced inhibition of caspase-3. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 196 196 . . . Note=Reduced inhibition of caspase-3. May affect protein folding and stability. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10548111;Dbxref=PMID:10548111 P98170 UniProtKB Mutagenesis 214 214 . . . Note=Reduced interaction with HTRA2. Reduced interaction with HTRA2%3B when associated with A-148. D->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11604410;Dbxref=PMID:11604410 P98170 UniProtKB Mutagenesis 259 259 . . . Note=Reduced interaction with HTRA2%3B when associated with S-314. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11604410;Dbxref=PMID:11604410 P98170 UniProtKB Mutagenesis 310 310 . . . Note=No effect on interaction with SEPTIN4 isoform ARTS. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21695558;Dbxref=PMID:21695558 P98170 UniProtKB Mutagenesis 310 310 . . . Note=Reduced interaction with HTRA2%3B when associated with S-314. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11604410;Dbxref=PMID:11604410 P98170 UniProtKB Mutagenesis 314 314 . . . Note=Decreased interaction with DIABLO/SMAC and with HTRA2. Decreases interaction with HTRA2%3B when associated with D-259 or A-310. No effect on interaction with SEPTIN4 isoform ARTS. E->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11604410,ECO:0000269|PubMed:21695558;Dbxref=PMID:11604410,PMID:21695558 P98170 UniProtKB Mutagenesis 343 343 . . . Note=No effect on interaction with SEPTIN4 isoform ARTS. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21695558;Dbxref=PMID:21695558 P98170 UniProtKB Mutagenesis 450 450 . . . Note=Inhibits degradation of active caspase-3. C->A%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11447297;Dbxref=PMID:11447297 P98170 UniProtKB Mutagenesis 467 467 . . . Note=Loss of E3 ubiquitin-protein ligase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17967870;Dbxref=PMID:17967870 P98170 UniProtKB Mutagenesis 495 495 . . . Note=Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate RIPK2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22607974;Dbxref=PMID:22607974 P98170 UniProtKB Sequence conflict 162 162 . . . Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98170 UniProtKB Helix 22 24 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6GJW P98170 UniProtKB Helix 26 30 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Helix 31 33 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Beta strand 40 42 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Helix 44 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Beta strand 52 54 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Beta strand 61 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Turn 64 66 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Helix 79 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Turn 91 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2POI P98170 UniProtKB Turn 128 130 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1I3O P98170 UniProtKB Helix 136 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1I4O P98170 UniProtKB Helix 150 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1I3O P98170 UniProtKB Helix 158 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Helix 163 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Turn 169 172 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Helix 175 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4WVT P98170 UniProtKB Helix 181 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Beta strand 189 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Beta strand 198 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Turn 201 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Beta strand 206 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Helix 216 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Helix 228 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J44 P98170 UniProtKB Helix 244 246 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1F9X P98170 UniProtKB Beta strand 249 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1F9X P98170 UniProtKB Beta strand 254 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5C3K P98170 UniProtKB Helix 260 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Helix 265 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Turn 272 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Beta strand 277 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Helix 281 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Beta strand 289 291 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Beta strand 293 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2OPZ P98170 UniProtKB Beta strand 298 300 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Turn 301 303 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Beta strand 306 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Beta strand 311 313 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1F9X P98170 UniProtKB Helix 316 323 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8GH7 P98170 UniProtKB Helix 328 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HL5 P98170 UniProtKB Helix 336 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3UW5 P98170 UniProtKB Turn 343 345 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HL5 P98170 UniProtKB Helix 346 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1G73 P98170 UniProtKB Helix 354 356 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1G73 P98170 UniProtKB Helix 368 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KNA P98170 UniProtKB Helix 375 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KNA P98170 UniProtKB Helix 386 400 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KNA P98170 UniProtKB Helix 407 419 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KNA P98170 UniProtKB Helix 437 447 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Turn 451 453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Beta strand 454 457 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Beta strand 460 463 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Helix 472 475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Turn 482 484 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59 P98170 UniProtKB Beta strand 489 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8W59