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P98169

- ZXDB_HUMAN

UniProt

P98169 - ZXDB_HUMAN

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Protein
Zinc finger X-linked protein ZXDB
Gene
ZXDB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29525C2H2-type 1
Add
BLAST
Zinc fingeri304 – 32825C2H2-type 2
Add
BLAST
Zinc fingeri334 – 35825C2H2-type 3
Add
BLAST
Zinc fingeri364 – 38623C2H2-type 4
Add
BLAST
Zinc fingeri393 – 41725C2H2-type 5
Add
BLAST
Zinc fingeri424 – 44825C2H2-type 6
Add
BLAST
Zinc fingeri454 – 47825C2H2-type 7
Add
BLAST
Zinc fingeri484 – 50825C2H2-type 8
Add
BLAST
Zinc fingeri514 – 53825C2H2-type 9
Add
BLAST
Zinc fingeri547 – 57226C2H2-type 10
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDB
Gene namesi
Name:ZXDB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:13199. ZXDB.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Zinc finger X-linked protein ZXDB
PRO_0000047777Add
BLAST

Proteomic databases

MaxQBiP98169.
PaxDbiP98169.
PRIDEiP98169.

PTM databases

PhosphoSiteiP98169.

Expressioni

Tissue specificityi

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

Gene expression databases

BgeeiP98169.
CleanExiHS_ZXDB.
GenevestigatoriP98169.

Organism-specific databases

HPAiHPA043789.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA By similarity.

Protein-protein interaction databases

BioGridi127694. 1 interaction.
STRINGi9606.ENSP00000364023.

Structurei

3D structure databases

ProteinModelPortaliP98169.
SMRiP98169. Positions 271-599.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 577307Required for interaction with ZXDC By similarity
Add
BLAST
Regioni576 – 703128Required for transcriptional activation By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 206Poly-Gly
Compositional biasi83 – 897Poly-Gly

Sequence similaritiesi

Belongs to the ZXD family.
Contains 10 C2H2-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98169.
OMAiGCLIAPQ.
OrthoDBiEOG776SPF.
PhylomeDBiP98169.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98169-1 [UniParc]FASTAAdd to Basket

« Hide

MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP    50
QDGGPGRRRE EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV 100
GGDVETAGSG QAAGPVLREE AEEGPGLQGG ESGANPAGPT ALGPRCLSAV 150
PTPAPISAPG PAAAFAGTVT IHNQDLLLRF ENGVLTLATP PPHAWEPGAA 200
PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA PAPAPEEEAE 250
GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG 300
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN 350
LKAHMKGHEQ ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC 400
KKTFITVSAL FSHNRAHFRE QELFSCSFPG CSKQYDKACR LKIHLRSHTG 450
ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD DRRFMCPVEG CGKSFTRAEH 500
LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ DVDTWKSRCP 550
ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN 600
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA 650
NNNNSVGQAV DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS 700
VSVGPLGSLD SLAMKNSSPE PQALTPSSKL TVDTDALTPS STLCENSVSE 750
LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN AAGNHGSQKE TDLITVTGSS 800
FLV 803
Length:803
Mass (Da):84,792
Last modified:January 11, 2001 - v2
Checksum:iFD5A6D326FF5A5D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti736 – 7361A → T.
Corresponds to variant rs1057338 [ dbSNP | Ensembl ].
VAR_033003
Natural varianti760 – 7601N → S.
Corresponds to variant rs1057340 [ dbSNP | Ensembl ].
VAR_033004
Natural varianti764 – 7641D → N.
Corresponds to variant rs1057341 [ dbSNP | Ensembl ].
VAR_033005
Natural varianti791 – 7911T → R.
Corresponds to variant rs1057343 [ dbSNP | Ensembl ].
VAR_033006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289766 mRNA. Translation: BAF82455.1.
AL031115 Genomic DNA. Translation: CAD92603.2.
Z99130 Genomic DNA. Translation: CAB16205.1.
CH471154 Genomic DNA. Translation: EAW93246.1.
L14788 mRNA. Translation: AAC37522.1.
CCDSiCCDS35313.1.
PIRiI54340.
RefSeqiNP_009088.1. NM_007157.3.
UniGeneiHs.156257.
Hs.649423.

Genome annotation databases

EnsembliENST00000374888; ENSP00000364023; ENSG00000198455.
GeneIDi158586.
KEGGihsa:158586.
UCSCiuc004dvd.3. human.

Polymorphism databases

DMDMi12644370.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289766 mRNA. Translation: BAF82455.1 .
AL031115 Genomic DNA. Translation: CAD92603.2 .
Z99130 Genomic DNA. Translation: CAB16205.1 .
CH471154 Genomic DNA. Translation: EAW93246.1 .
L14788 mRNA. Translation: AAC37522.1 .
CCDSi CCDS35313.1.
PIRi I54340.
RefSeqi NP_009088.1. NM_007157.3.
UniGenei Hs.156257.
Hs.649423.

3D structure databases

ProteinModelPortali P98169.
SMRi P98169. Positions 271-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127694. 1 interaction.
STRINGi 9606.ENSP00000364023.

PTM databases

PhosphoSitei P98169.

Polymorphism databases

DMDMi 12644370.

Proteomic databases

MaxQBi P98169.
PaxDbi P98169.
PRIDEi P98169.

Protocols and materials databases

DNASUi 158586.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374888 ; ENSP00000364023 ; ENSG00000198455 .
GeneIDi 158586.
KEGGi hsa:158586.
UCSCi uc004dvd.3. human.

Organism-specific databases

CTDi 158586.
GeneCardsi GC0XP057634.
H-InvDB HIX0028352.
HIX0176759.
HGNCi HGNC:13199. ZXDB.
HPAi HPA043789.
MIMi 300236. gene.
neXtProti NX_P98169.
PharmGKBi PA37764.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000013019.
HOVERGENi HBG002277.
InParanoidi P98169.
OMAi GCLIAPQ.
OrthoDBi EOG776SPF.
PhylomeDBi P98169.
TreeFami TF330996.

Miscellaneous databases

GenomeRNAii 158586.
NextBioi 87774.
PROi P98169.
SOURCEi Search...

Gene expression databases

Bgeei P98169.
CleanExi HS_ZXDB.
Genevestigatori P98169.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 6 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
    Greig G.M., Sharp C.B., Carrel L., Willard H.F.
    Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiZXDB_HUMAN
AccessioniPrimary (citable) accession number: P98169
Secondary accession number(s): A8K151, Q9UBB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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