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Protein

Zinc finger X-linked protein ZXDB

Gene

ZXDB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri304 – 328C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri334 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri424 – 448C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri454 – 478C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri484 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri514 – 538C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri547 – 572C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDB
Gene namesi
Name:ZXDB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13199. ZXDB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198455.
PharmGKBiPA37764.

Polymorphism and mutation databases

BioMutaiZXDB.
DMDMi12644370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477771 – 803Zinc finger X-linked protein ZXDBAdd BLAST803

Proteomic databases

EPDiP98169.
MaxQBiP98169.
PaxDbiP98169.
PeptideAtlasiP98169.
PRIDEiP98169.

PTM databases

iPTMnetiP98169.
PhosphoSitePlusiP98169.

Expressioni

Tissue specificityi

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

Gene expression databases

BgeeiENSG00000198455.
CleanExiHS_ZXDB.
GenevisibleiP98169. HS.

Organism-specific databases

HPAiHPA043789.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA (By similarity).By similarity

Protein-protein interaction databases

BioGridi127694. 1 interactor.
STRINGi9606.ENSP00000364023.

Structurei

3D structure databases

ProteinModelPortaliP98169.
SMRiP98169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 577Required for interaction with ZXDCBy similarityAdd BLAST307
Regioni576 – 703Required for transcriptional activationBy similarityAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Gly6
Compositional biasi83 – 89Poly-Gly7

Sequence similaritiesi

Belongs to the ZXD family.Curated
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri304 – 328C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri334 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri424 – 448C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri454 – 478C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri484 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri514 – 538C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri547 – 572C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98169.
OMAiFPHAAHP.
OrthoDBiEOG091G0K27.
PhylomeDBiP98169.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP
60 70 80 90 100
QDGGPGRRRE EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV
110 120 130 140 150
GGDVETAGSG QAAGPVLREE AEEGPGLQGG ESGANPAGPT ALGPRCLSAV
160 170 180 190 200
PTPAPISAPG PAAAFAGTVT IHNQDLLLRF ENGVLTLATP PPHAWEPGAA
210 220 230 240 250
PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA PAPAPEEEAE
260 270 280 290 300
GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
310 320 330 340 350
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN
360 370 380 390 400
LKAHMKGHEQ ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC
410 420 430 440 450
KKTFITVSAL FSHNRAHFRE QELFSCSFPG CSKQYDKACR LKIHLRSHTG
460 470 480 490 500
ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD DRRFMCPVEG CGKSFTRAEH
510 520 530 540 550
LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ DVDTWKSRCP
560 570 580 590 600
ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
610 620 630 640 650
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA
660 670 680 690 700
NNNNSVGQAV DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS
710 720 730 740 750
VSVGPLGSLD SLAMKNSSPE PQALTPSSKL TVDTDALTPS STLCENSVSE
760 770 780 790 800
LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN AAGNHGSQKE TDLITVTGSS

FLV
Length:803
Mass (Da):84,792
Last modified:January 11, 2001 - v2
Checksum:iFD5A6D326FF5A5D4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033003736A → T.Corresponds to variant rs1057338dbSNPEnsembl.1
Natural variantiVAR_033004760N → S.Corresponds to variant rs1057340dbSNPEnsembl.1
Natural variantiVAR_033005764D → N.Corresponds to variant rs1057341dbSNPEnsembl.1
Natural variantiVAR_033006791T → R.Corresponds to variant rs1057343dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289766 mRNA. Translation: BAF82455.1.
AL031115 Genomic DNA. Translation: CAD92603.2.
Z99130 Genomic DNA. Translation: CAB16205.1.
CH471154 Genomic DNA. Translation: EAW93246.1.
L14788 mRNA. Translation: AAC37522.1.
CCDSiCCDS35313.1.
PIRiI54340.
RefSeqiNP_009088.1. NM_007157.3.
UniGeneiHs.156257.
Hs.649423.

Genome annotation databases

EnsembliENST00000374888; ENSP00000364023; ENSG00000198455.
GeneIDi158586.
KEGGihsa:158586.
UCSCiuc004dvd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289766 mRNA. Translation: BAF82455.1.
AL031115 Genomic DNA. Translation: CAD92603.2.
Z99130 Genomic DNA. Translation: CAB16205.1.
CH471154 Genomic DNA. Translation: EAW93246.1.
L14788 mRNA. Translation: AAC37522.1.
CCDSiCCDS35313.1.
PIRiI54340.
RefSeqiNP_009088.1. NM_007157.3.
UniGeneiHs.156257.
Hs.649423.

3D structure databases

ProteinModelPortaliP98169.
SMRiP98169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127694. 1 interactor.
STRINGi9606.ENSP00000364023.

PTM databases

iPTMnetiP98169.
PhosphoSitePlusiP98169.

Polymorphism and mutation databases

BioMutaiZXDB.
DMDMi12644370.

Proteomic databases

EPDiP98169.
MaxQBiP98169.
PaxDbiP98169.
PeptideAtlasiP98169.
PRIDEiP98169.

Protocols and materials databases

DNASUi158586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374888; ENSP00000364023; ENSG00000198455.
GeneIDi158586.
KEGGihsa:158586.
UCSCiuc004dvd.4. human.

Organism-specific databases

CTDi158586.
GeneCardsiZXDB.
H-InvDBHIX0028352.
HIX0176759.
HGNCiHGNC:13199. ZXDB.
HPAiHPA043789.
MIMi300236. gene.
neXtProtiNX_P98169.
OpenTargetsiENSG00000198455.
PharmGKBiPA37764.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98169.
OMAiFPHAAHP.
OrthoDBiEOG091G0K27.
PhylomeDBiP98169.
TreeFamiTF330996.

Enzyme and pathway databases

BioCyciZFISH:G66-31955-MONOMER.

Miscellaneous databases

GenomeRNAii158586.
PROiP98169.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198455.
CleanExiHS_ZXDB.
GenevisibleiP98169. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZXDB_HUMAN
AccessioniPrimary (citable) accession number: P98169
Secondary accession number(s): A8K151, Q9UBB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.