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P98169 (ZXDB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger X-linked protein ZXDB
Gene names
Name:ZXDB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length803 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes By similarity.

Subunit structure

Self-associates. Interacts with ZXDC and CIITA By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta. Ref.4

Sequence similarities

Belongs to the ZXD family.

Contains 10 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 803803Zinc finger X-linked protein ZXDB
PRO_0000047777

Regions

Zinc finger271 – 29525C2H2-type 1
Zinc finger304 – 32825C2H2-type 2
Zinc finger334 – 35825C2H2-type 3
Zinc finger364 – 38623C2H2-type 4
Zinc finger393 – 41725C2H2-type 5
Zinc finger424 – 44825C2H2-type 6
Zinc finger454 – 47825C2H2-type 7
Zinc finger484 – 50825C2H2-type 8
Zinc finger514 – 53825C2H2-type 9
Zinc finger547 – 57226C2H2-type 10
Region271 – 577307Required for interaction with ZXDC By similarity
Region576 – 703128Required for transcriptional activation By similarity
Compositional bias15 – 206Poly-Gly
Compositional bias83 – 897Poly-Gly

Natural variations

Natural variant7361A → T.
Corresponds to variant rs1057338 [ dbSNP | Ensembl ].
VAR_033003
Natural variant7601N → S.
Corresponds to variant rs1057340 [ dbSNP | Ensembl ].
VAR_033004
Natural variant7641D → N.
Corresponds to variant rs1057341 [ dbSNP | Ensembl ].
VAR_033005
Natural variant7911T → R.
Corresponds to variant rs1057343 [ dbSNP | Ensembl ].
VAR_033006

Sequences

Sequence LengthMass (Da)Tools
P98169 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: FD5A6D326FF5A5D4

FASTA80384,792
        10         20         30         40         50         60 
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP QDGGPGRRRE 

        70         80         90        100        110        120 
EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV GGDVETAGSG QAAGPVLREE 

       130        140        150        160        170        180 
AEEGPGLQGG ESGANPAGPT ALGPRCLSAV PTPAPISAPG PAAAFAGTVT IHNQDLLLRF 

       190        200        210        220        230        240 
ENGVLTLATP PPHAWEPGAA PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA 

       250        260        270        280        290        300 
PAPAPEEEAE GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG 

       310        320        330        340        350        360 
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN LKAHMKGHEQ 

       370        380        390        400        410        420 
ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC KKTFITVSAL FSHNRAHFRE 

       430        440        450        460        470        480 
QELFSCSFPG CSKQYDKACR LKIHLRSHTG ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD 

       490        500        510        520        530        540 
DRRFMCPVEG CGKSFTRAEH LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ 

       550        560        570        580        590        600 
DVDTWKSRCP ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN 

       610        620        630        640        650        660 
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA NNNNSVGQAV 

       670        680        690        700        710        720 
DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS VSVGPLGSLD SLAMKNSSPE 

       730        740        750        760        770        780 
PQALTPSSKL TVDTDALTPS STLCENSVSE LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN 

       790        800 
AAGNHGSQKE TDLITVTGSS FLV 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
Greig G.M., Sharp C.B., Carrel L., Willard H.F.
Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, TISSUE SPECIFICITY.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK289766 mRNA. Translation: BAF82455.1.
AL031115 Genomic DNA. Translation: CAD92603.2.
Z99130 Genomic DNA. Translation: CAB16205.1.
CH471154 Genomic DNA. Translation: EAW93246.1.
L14788 mRNA. Translation: AAC37522.1.
CCDSCCDS35313.1.
PIRI54340.
RefSeqNP_009088.1. NM_007157.3.
UniGeneHs.156257.
Hs.649423.

3D structure databases

ProteinModelPortalP98169.
SMRP98169. Positions 271-599.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127694. 1 interaction.
STRING9606.ENSP00000364023.

PTM databases

PhosphoSiteP98169.

Polymorphism databases

DMDM12644370.

Proteomic databases

MaxQBP98169.
PaxDbP98169.
PRIDEP98169.

Protocols and materials databases

DNASU158586.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374888; ENSP00000364023; ENSG00000198455.
GeneID158586.
KEGGhsa:158586.
UCSCuc004dvd.3. human.

Organism-specific databases

CTD158586.
GeneCardsGC0XP057634.
H-InvDBHIX0028352.
HIX0176759.
HGNCHGNC:13199. ZXDB.
HPAHPA043789.
MIM300236. gene.
neXtProtNX_P98169.
PharmGKBPA37764.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000013019.
HOVERGENHBG002277.
InParanoidP98169.
OMAGCLIAPQ.
OrthoDBEOG776SPF.
PhylomeDBP98169.
TreeFamTF330996.

Gene expression databases

BgeeP98169.
CleanExHS_ZXDB.
GenevestigatorP98169.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi158586.
NextBio87774.
PROP98169.
SOURCESearch...

Entry information

Entry nameZXDB_HUMAN
AccessionPrimary (citable) accession number: P98169
Secondary accession number(s): A8K151, Q9UBB3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM