Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P98169

- ZXDB_HUMAN

UniProt

P98169 - ZXDB_HUMAN

Protein

Zinc finger X-linked protein ZXDB

Gene

ZXDB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 29525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35825C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41725C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44825C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47825C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50825C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53825C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri547 – 57226C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger X-linked protein ZXDB
    Gene namesi
    Name:ZXDB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:13199. ZXDB.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37764.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Zinc finger X-linked protein ZXDBPRO_0000047777Add
    BLAST

    Proteomic databases

    MaxQBiP98169.
    PaxDbiP98169.
    PRIDEiP98169.

    PTM databases

    PhosphoSiteiP98169.

    Expressioni

    Tissue specificityi

    May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

    Gene expression databases

    BgeeiP98169.
    CleanExiHS_ZXDB.
    GenevestigatoriP98169.

    Organism-specific databases

    HPAiHPA043789.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with ZXDC and CIITA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi127694. 1 interaction.
    STRINGi9606.ENSP00000364023.

    Structurei

    3D structure databases

    ProteinModelPortaliP98169.
    SMRiP98169. Positions 271-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 577307Required for interaction with ZXDCBy similarityAdd
    BLAST
    Regioni576 – 703128Required for transcriptional activationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 206Poly-Gly
    Compositional biasi83 – 897Poly-Gly

    Sequence similaritiesi

    Belongs to the ZXD family.Curated
    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 29525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35825C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41725C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44825C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47825C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50825C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53825C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri547 – 57226C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013019.
    HOVERGENiHBG002277.
    InParanoidiP98169.
    OMAiGCLIAPQ.
    OrthoDBiEOG776SPF.
    PhylomeDBiP98169.
    TreeFamiTF330996.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 6 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98169-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP    50
    QDGGPGRRRE EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV 100
    GGDVETAGSG QAAGPVLREE AEEGPGLQGG ESGANPAGPT ALGPRCLSAV 150
    PTPAPISAPG PAAAFAGTVT IHNQDLLLRF ENGVLTLATP PPHAWEPGAA 200
    PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA PAPAPEEEAE 250
    GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG 300
    QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN 350
    LKAHMKGHEQ ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC 400
    KKTFITVSAL FSHNRAHFRE QELFSCSFPG CSKQYDKACR LKIHLRSHTG 450
    ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD DRRFMCPVEG CGKSFTRAEH 500
    LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ DVDTWKSRCP 550
    ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN 600
    DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA 650
    NNNNSVGQAV DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS 700
    VSVGPLGSLD SLAMKNSSPE PQALTPSSKL TVDTDALTPS STLCENSVSE 750
    LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN AAGNHGSQKE TDLITVTGSS 800
    FLV 803
    Length:803
    Mass (Da):84,792
    Last modified:January 11, 2001 - v2
    Checksum:iFD5A6D326FF5A5D4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti736 – 7361A → T.
    Corresponds to variant rs1057338 [ dbSNP | Ensembl ].
    VAR_033003
    Natural varianti760 – 7601N → S.
    Corresponds to variant rs1057340 [ dbSNP | Ensembl ].
    VAR_033004
    Natural varianti764 – 7641D → N.
    Corresponds to variant rs1057341 [ dbSNP | Ensembl ].
    VAR_033005
    Natural varianti791 – 7911T → R.
    Corresponds to variant rs1057343 [ dbSNP | Ensembl ].
    VAR_033006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289766 mRNA. Translation: BAF82455.1.
    AL031115 Genomic DNA. Translation: CAD92603.2.
    Z99130 Genomic DNA. Translation: CAB16205.1.
    CH471154 Genomic DNA. Translation: EAW93246.1.
    L14788 mRNA. Translation: AAC37522.1.
    CCDSiCCDS35313.1.
    PIRiI54340.
    RefSeqiNP_009088.1. NM_007157.3.
    UniGeneiHs.156257.
    Hs.649423.

    Genome annotation databases

    EnsembliENST00000374888; ENSP00000364023; ENSG00000198455.
    GeneIDi158586.
    KEGGihsa:158586.
    UCSCiuc004dvd.3. human.

    Polymorphism databases

    DMDMi12644370.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289766 mRNA. Translation: BAF82455.1 .
    AL031115 Genomic DNA. Translation: CAD92603.2 .
    Z99130 Genomic DNA. Translation: CAB16205.1 .
    CH471154 Genomic DNA. Translation: EAW93246.1 .
    L14788 mRNA. Translation: AAC37522.1 .
    CCDSi CCDS35313.1.
    PIRi I54340.
    RefSeqi NP_009088.1. NM_007157.3.
    UniGenei Hs.156257.
    Hs.649423.

    3D structure databases

    ProteinModelPortali P98169.
    SMRi P98169. Positions 271-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127694. 1 interaction.
    STRINGi 9606.ENSP00000364023.

    PTM databases

    PhosphoSitei P98169.

    Polymorphism databases

    DMDMi 12644370.

    Proteomic databases

    MaxQBi P98169.
    PaxDbi P98169.
    PRIDEi P98169.

    Protocols and materials databases

    DNASUi 158586.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374888 ; ENSP00000364023 ; ENSG00000198455 .
    GeneIDi 158586.
    KEGGi hsa:158586.
    UCSCi uc004dvd.3. human.

    Organism-specific databases

    CTDi 158586.
    GeneCardsi GC0XP057634.
    H-InvDB HIX0028352.
    HIX0176759.
    HGNCi HGNC:13199. ZXDB.
    HPAi HPA043789.
    MIMi 300236. gene.
    neXtProti NX_P98169.
    PharmGKBi PA37764.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013019.
    HOVERGENi HBG002277.
    InParanoidi P98169.
    OMAi GCLIAPQ.
    OrthoDBi EOG776SPF.
    PhylomeDBi P98169.
    TreeFami TF330996.

    Miscellaneous databases

    GenomeRNAii 158586.
    NextBioi 87774.
    PROi P98169.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98169.
    CleanExi HS_ZXDB.
    Genevestigatori P98169.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 6 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
      Greig G.M., Sharp C.B., Carrel L., Willard H.F.
      Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiZXDB_HUMAN
    AccessioniPrimary (citable) accession number: P98169
    Secondary accession number(s): A8K151, Q9UBB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3