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P98169

- ZXDB_HUMAN

UniProt

P98169 - ZXDB_HUMAN

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Protein

Zinc finger X-linked protein ZXDB

Gene

ZXDB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41725C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44825C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47825C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50825C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53825C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 57226C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDB
Gene namesi
Name:ZXDB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:13199. ZXDB.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Zinc finger X-linked protein ZXDBPRO_0000047777Add
BLAST

Proteomic databases

MaxQBiP98169.
PaxDbiP98169.
PRIDEiP98169.

PTM databases

PhosphoSiteiP98169.

Expressioni

Tissue specificityi

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

Gene expression databases

BgeeiP98169.
CleanExiHS_ZXDB.
GenevestigatoriP98169.

Organism-specific databases

HPAiHPA043789.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA (By similarity).By similarity

Protein-protein interaction databases

BioGridi127694. 1 interaction.
STRINGi9606.ENSP00000364023.

Structurei

3D structure databases

ProteinModelPortaliP98169.
SMRiP98169. Positions 271-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 577307Required for interaction with ZXDCBy similarityAdd
BLAST
Regioni576 – 703128Required for transcriptional activationBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 206Poly-Gly
Compositional biasi83 – 897Poly-Gly

Sequence similaritiesi

Belongs to the ZXD family.Curated
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41725C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44825C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47825C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50825C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53825C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 57226C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120526.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98169.
OMAiGCLIAPQ.
OrthoDBiEOG776SPF.
PhylomeDBiP98169.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98169-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP
60 70 80 90 100
QDGGPGRRRE EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV
110 120 130 140 150
GGDVETAGSG QAAGPVLREE AEEGPGLQGG ESGANPAGPT ALGPRCLSAV
160 170 180 190 200
PTPAPISAPG PAAAFAGTVT IHNQDLLLRF ENGVLTLATP PPHAWEPGAA
210 220 230 240 250
PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA PAPAPEEEAE
260 270 280 290 300
GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
310 320 330 340 350
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN
360 370 380 390 400
LKAHMKGHEQ ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC
410 420 430 440 450
KKTFITVSAL FSHNRAHFRE QELFSCSFPG CSKQYDKACR LKIHLRSHTG
460 470 480 490 500
ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD DRRFMCPVEG CGKSFTRAEH
510 520 530 540 550
LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ DVDTWKSRCP
560 570 580 590 600
ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
610 620 630 640 650
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA
660 670 680 690 700
NNNNSVGQAV DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS
710 720 730 740 750
VSVGPLGSLD SLAMKNSSPE PQALTPSSKL TVDTDALTPS STLCENSVSE
760 770 780 790 800
LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN AAGNHGSQKE TDLITVTGSS

FLV
Length:803
Mass (Da):84,792
Last modified:January 11, 2001 - v2
Checksum:iFD5A6D326FF5A5D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti736 – 7361A → T.
Corresponds to variant rs1057338 [ dbSNP | Ensembl ].
VAR_033003
Natural varianti760 – 7601N → S.
Corresponds to variant rs1057340 [ dbSNP | Ensembl ].
VAR_033004
Natural varianti764 – 7641D → N.
Corresponds to variant rs1057341 [ dbSNP | Ensembl ].
VAR_033005
Natural varianti791 – 7911T → R.
Corresponds to variant rs1057343 [ dbSNP | Ensembl ].
VAR_033006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289766 mRNA. Translation: BAF82455.1.
AL031115 Genomic DNA. Translation: CAD92603.2.
Z99130 Genomic DNA. Translation: CAB16205.1.
CH471154 Genomic DNA. Translation: EAW93246.1.
L14788 mRNA. Translation: AAC37522.1.
CCDSiCCDS35313.1.
PIRiI54340.
RefSeqiNP_009088.1. NM_007157.3.
UniGeneiHs.156257.
Hs.649423.

Genome annotation databases

EnsembliENST00000374888; ENSP00000364023; ENSG00000198455.
GeneIDi158586.
KEGGihsa:158586.
UCSCiuc004dvd.3. human.

Polymorphism databases

DMDMi12644370.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289766 mRNA. Translation: BAF82455.1 .
AL031115 Genomic DNA. Translation: CAD92603.2 .
Z99130 Genomic DNA. Translation: CAB16205.1 .
CH471154 Genomic DNA. Translation: EAW93246.1 .
L14788 mRNA. Translation: AAC37522.1 .
CCDSi CCDS35313.1.
PIRi I54340.
RefSeqi NP_009088.1. NM_007157.3.
UniGenei Hs.156257.
Hs.649423.

3D structure databases

ProteinModelPortali P98169.
SMRi P98169. Positions 271-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127694. 1 interaction.
STRINGi 9606.ENSP00000364023.

PTM databases

PhosphoSitei P98169.

Polymorphism databases

DMDMi 12644370.

Proteomic databases

MaxQBi P98169.
PaxDbi P98169.
PRIDEi P98169.

Protocols and materials databases

DNASUi 158586.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374888 ; ENSP00000364023 ; ENSG00000198455 .
GeneIDi 158586.
KEGGi hsa:158586.
UCSCi uc004dvd.3. human.

Organism-specific databases

CTDi 158586.
GeneCardsi GC0XP057634.
H-InvDB HIX0028352.
HIX0176759.
HGNCi HGNC:13199. ZXDB.
HPAi HPA043789.
MIMi 300236. gene.
neXtProti NX_P98169.
PharmGKBi PA37764.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120526.
HOGENOMi HOG000013019.
HOVERGENi HBG002277.
InParanoidi P98169.
OMAi GCLIAPQ.
OrthoDBi EOG776SPF.
PhylomeDBi P98169.
TreeFami TF330996.

Miscellaneous databases

GenomeRNAii 158586.
NextBioi 87774.
PROi P98169.
SOURCEi Search...

Gene expression databases

Bgeei P98169.
CleanExi HS_ZXDB.
Genevestigatori P98169.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 6 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
    Greig G.M., Sharp C.B., Carrel L., Willard H.F.
    Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiZXDB_HUMAN
AccessioniPrimary (citable) accession number: P98169
Secondary accession number(s): A8K151, Q9UBB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3