P98168 (ZXDA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger X-linked protein ZXDA

Gene names

Name:

ZXDA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	799 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Ref.4
Subunit structure	Self-associates. Interacts with ZXDC and CIITA. Ref.4
Subcellular location	Nucleus Probable.
Tissue specificity	May be expressed in brain, heart, kidney, liver, lung, muscle and placenta. Ref.3
Sequence similarities	Belongs to the ZXD family. Contains 10 C2H2-type zinc fingers.
Sequence caution	The sequence AAC37521.1 differs from that shown. Reason: Frameshift at position 753.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Inferred from mutant phenotype Ref.4. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype Ref.4. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CIITA	P33076	4	EBI-1538980,EBI-1538819
ZXDC	Q2QGD7	5	EBI-1538980,EBI-1538838

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 799	799	Zinc finger X-linked protein ZXDA		PRO_0000047776
Regions
	Zinc finger	267 – 291	25	C2H2-type 1
	Zinc finger	300 – 324	25	C2H2-type 2
	Zinc finger	330 – 354	25	C2H2-type 3
	Zinc finger	360 – 382	23	C2H2-type 4
	Zinc finger	389 – 413	25	C2H2-type 5
	Zinc finger	420 – 444	25	C2H2-type 6
	Zinc finger	450 – 474	25	C2H2-type 7
	Zinc finger	480 – 504	25	C2H2-type 8
	Zinc finger	510 – 534	25	C2H2-type 9
	Zinc finger	543 – 568	26	C2H2-type 10
	Region	267 – 573	307	Required for interaction with ZXDC
	Region	572 – 699	128	Required for transcriptional activation
	Compositional bias	15 – 20	6	Poly-Gly
Natural variations
	Natural variant	376	1	G → S. Corresponds to variant rs1057327 [ dbSNP | Ensembl ].		VAR_033002

Sequences

	Sequence		Length	Mass (Da)
	P98168 [UniParc]. Last modified January 11, 2001. Version 2. Checksum: 112BF6C6D0CAA670	FASTA	799	84,771
	10 20 30 40 50 60 MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP QDGGPGRRRE 70 80 90 100 110 120 EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV ETAGSGQAAG PVLREEAKAG 130 140 150 160 170 180 PGLQGDESGA NPAGCSAQGP HCLSAVPTPA PISAPGPAAA FAGTVTIHNQ DLLLRFENGV 190 200 210 220 230 240 LTLATPPPHA WEPGAAPAQQ PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA 250 260 270 280 290 300 PQEEAEGLAA ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF 310 320 330 340 350 360 KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH MKGHEQENSF 370 380 390 400 410 420 KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF ITVSALFSHN RAHFREQELF 430 440 450 460 470 480 SCSFPGCSKQ YDKACRLKIH LRSHTGERPF LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF 490 500 510 520 530 540 MCPVEGCGKS FTRAEHLKGH SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT 550 560 570 580 590 600 WKSRCPISSC NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD 610 620 630 640 650 660 AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN SVGQAVDPPS 670 680 690 700 710 720 LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG PLGSLDSLAM KNSSPEPQAL 730 740 750 760 770 780 TPSSKLTVDT DTLTPSSTLC ENSVSELLTP AKAEWSVHPN SDFFGQEGET QFGFPNAAGN 790 HGSQKERNLI TVTGSSFLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies." Greig G.M., Sharp C.B., Carrel L., Willard H.F. Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 303-799, TISSUE SPECIFICITY. Tissue: Brain.
[4]	"The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription." Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D. J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDC AND CIITA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL034396 Genomic DNA. Translation: CAB46717.1. BC059356 mRNA. Translation: AAH59356.1. L14787 mRNA. Translation: AAC37521.1. Frameshift.
IPI	IPI00024295.
PIR	I54340.
RefSeq	NP_009087.1. NM_007156.4.
UniGene	Hs.550094.
3D structure databases
ProteinModelPortal	P98168.
ModBase	Search...
Protein-protein interaction databases
IntAct	P98168. 2 interactions.
STRING	9606.ENSP00000351530.
PTM databases
PhosphoSite	P98168.
Polymorphism databases
DMDM	12644369.
Proteomic databases
PaxDb	P98168.
PRIDE	P98168.
Protocols and materials databases
DNASU	7789.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358697; ENSP00000351530; ENSG00000198205.
GeneID	7789.
KEGG	hsa:7789.
UCSC	uc004dve.3. human.
Organism-specific databases
CTD	7789.
GeneCards	GC0XM057949.
HGNC	HGNC:13198. ZXDA.
HPA	HPA043789.
MIM	300235. gene.
neXtProt	NX_P98168.
PharmGKB	PA37763.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013019.
HOVERGEN	HBG002277.
InParanoid	P98168.
OMA	LCPEALC.
OrthoDB	EOG4DNF44.
PhylomeDB	P98168.
Gene expression databases
Bgee	P98168.
CleanEx	HS_ZXDA.
Genevestigator	P98168.
GermOnline	ENSG00000198205. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 9 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 10 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7789.
NextBio	30149.
SOURCE	Search...

Entry information

Entry name

ZXDA_HUMAN

Accession

Primary (citable) accession number: P98168
Secondary accession number(s): Q9UJP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 11, 2001
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.