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P98168

- ZXDA_HUMAN

UniProt

P98168 - ZXDA_HUMAN

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Protein

Zinc finger X-linked protein ZXDA

Gene

ZXDA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri267 – 29125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44425C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47425C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53425C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56826C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. C2H2 zinc finger domain binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDA
Gene namesi
Name:ZXDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:13198. ZXDA.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Zinc finger X-linked protein ZXDAPRO_0000047776Add
BLAST

Proteomic databases

PaxDbiP98168.
PRIDEiP98168.

PTM databases

PhosphoSiteiP98168.

Expressioni

Tissue specificityi

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

Gene expression databases

BgeeiP98168.
CleanExiHS_ZXDA.
GenevestigatoriP98168.

Organism-specific databases

HPAiHPA043789.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CIITAP330764EBI-1538980,EBI-1538819
ZXDCQ2QGD75EBI-1538980,EBI-1538838

Protein-protein interaction databases

IntActiP98168. 2 interactions.
STRINGi9606.ENSP00000351530.

Structurei

3D structure databases

ProteinModelPortaliP98168.
SMRiP98168. Positions 267-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni267 – 573307Required for interaction with ZXDCAdd
BLAST
Regioni572 – 699128Required for transcriptional activationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 206Poly-Gly

Sequence similaritiesi

Belongs to the ZXD family.Curated
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri267 – 29125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44425C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47425C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53425C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56826C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120526.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98168.
OMAiLCPEALC.
OrthoDBiEOG776SPF.
PhylomeDBiP98168.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98168-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP
60 70 80 90 100
QDGGPGRRRE EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV
110 120 130 140 150
ETAGSGQAAG PVLREEAKAG PGLQGDESGA NPAGCSAQGP HCLSAVPTPA
160 170 180 190 200
PISAPGPAAA FAGTVTIHNQ DLLLRFENGV LTLATPPPHA WEPGAAPAQQ
210 220 230 240 250
PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA PQEEAEGLAA
260 270 280 290 300
ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF
310 320 330 340 350
KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH
360 370 380 390 400
MKGHEQENSF KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF
410 420 430 440 450
ITVSALFSHN RAHFREQELF SCSFPGCSKQ YDKACRLKIH LRSHTGERPF
460 470 480 490 500
LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF MCPVEGCGKS FTRAEHLKGH
510 520 530 540 550
SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT WKSRCPISSC
560 570 580 590 600
NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD
610 620 630 640 650
AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN
660 670 680 690 700
SVGQAVDPPS LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG
710 720 730 740 750
PLGSLDSLAM KNSSPEPQAL TPSSKLTVDT DTLTPSSTLC ENSVSELLTP
760 770 780 790
AKAEWSVHPN SDFFGQEGET QFGFPNAAGN HGSQKERNLI TVTGSSFLV
Length:799
Mass (Da):84,771
Last modified:January 11, 2001 - v2
Checksum:i112BF6C6D0CAA670
GO

Sequence cautioni

The sequence AAC37521.1 differs from that shown. Reason: Frameshift at position 753. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti376 – 3761G → S.
Corresponds to variant rs1057327 [ dbSNP | Ensembl ].
VAR_033002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034396 Genomic DNA. Translation: CAB46717.1.
BC059356 mRNA. Translation: AAH59356.1.
L14787 mRNA. Translation: AAC37521.1. Frameshift.
CCDSiCCDS14376.1.
PIRiI54340.
RefSeqiNP_009087.1. NM_007156.4.
UniGeneiHs.550094.

Genome annotation databases

EnsembliENST00000358697; ENSP00000351530; ENSG00000198205.
GeneIDi7789.
KEGGihsa:7789.
UCSCiuc004dve.3. human.

Polymorphism databases

DMDMi12644369.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034396 Genomic DNA. Translation: CAB46717.1 .
BC059356 mRNA. Translation: AAH59356.1 .
L14787 mRNA. Translation: AAC37521.1 . Frameshift.
CCDSi CCDS14376.1.
PIRi I54340.
RefSeqi NP_009087.1. NM_007156.4.
UniGenei Hs.550094.

3D structure databases

ProteinModelPortali P98168.
SMRi P98168. Positions 267-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P98168. 2 interactions.
STRINGi 9606.ENSP00000351530.

PTM databases

PhosphoSitei P98168.

Polymorphism databases

DMDMi 12644369.

Proteomic databases

PaxDbi P98168.
PRIDEi P98168.

Protocols and materials databases

DNASUi 7789.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358697 ; ENSP00000351530 ; ENSG00000198205 .
GeneIDi 7789.
KEGGi hsa:7789.
UCSCi uc004dve.3. human.

Organism-specific databases

CTDi 7789.
GeneCardsi GC0XM057949.
HGNCi HGNC:13198. ZXDA.
HPAi HPA043789.
MIMi 300235. gene.
neXtProti NX_P98168.
PharmGKBi PA37763.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120526.
HOGENOMi HOG000013019.
HOVERGENi HBG002277.
InParanoidi P98168.
OMAi LCPEALC.
OrthoDBi EOG776SPF.
PhylomeDBi P98168.
TreeFami TF330996.

Miscellaneous databases

GenomeRNAii 7789.
NextBioi 30149.
PROi P98168.
SOURCEi Search...

Gene expression databases

Bgeei P98168.
CleanExi HS_ZXDA.
Genevestigatori P98168.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 6 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
    Greig G.M., Sharp C.B., Carrel L., Willard H.F.
    Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 303-799, TISSUE SPECIFICITY.
    Tissue: Brain.
  4. "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription."
    Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D.
    J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDC AND CIITA.

Entry informationi

Entry nameiZXDA_HUMAN
AccessioniPrimary (citable) accession number: P98168
Secondary accession number(s): Q9UJP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3