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Protein

Zinc finger X-linked protein ZXDA

Gene

ZXDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri330 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri420 – 444C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri450 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri480 – 504C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri510 – 534C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri543 – 568C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDA
Gene namesi
Name:ZXDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13198. ZXDA.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198205.
PharmGKBiPA37763.

Polymorphism and mutation databases

BioMutaiZXDA.
DMDMi12644369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477761 – 799Zinc finger X-linked protein ZXDAAdd BLAST799

Proteomic databases

MaxQBiP98168.
PaxDbiP98168.
PeptideAtlasiP98168.
PRIDEiP98168.

PTM databases

iPTMnetiP98168.
PhosphoSitePlusiP98168.

Expressioni

Tissue specificityi

May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

Gene expression databases

BgeeiENSG00000198205.
CleanExiHS_ZXDA.
GenevisibleiP98168. HS.

Organism-specific databases

HPAiHPA043789.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB

Protein-protein interaction databases

IntActiP98168. 2 interactors.
STRINGi9606.ENSP00000351530.

Structurei

3D structure databases

ProteinModelPortaliP98168.
SMRiP98168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 573Required for interaction with ZXDC1 PublicationAdd BLAST307
Regioni572 – 699Required for transcriptional activationAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Gly6

Sequence similaritiesi

Belongs to the ZXD family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri330 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri420 – 444C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri450 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri480 – 504C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri510 – 534C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri543 – 568C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98168.
OMAiGANPAGC.
OrthoDBiEOG091G0K27.
PhylomeDBiP98168.
TreeFamiTF330996.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequencei

Sequence statusi: Complete.

P98168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP
60 70 80 90 100
QDGGPGRRRE EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV
110 120 130 140 150
ETAGSGQAAG PVLREEAKAG PGLQGDESGA NPAGCSAQGP HCLSAVPTPA
160 170 180 190 200
PISAPGPAAA FAGTVTIHNQ DLLLRFENGV LTLATPPPHA WEPGAAPAQQ
210 220 230 240 250
PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA PQEEAEGLAA
260 270 280 290 300
ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF
310 320 330 340 350
KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH
360 370 380 390 400
MKGHEQENSF KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF
410 420 430 440 450
ITVSALFSHN RAHFREQELF SCSFPGCSKQ YDKACRLKIH LRSHTGERPF
460 470 480 490 500
LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF MCPVEGCGKS FTRAEHLKGH
510 520 530 540 550
SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT WKSRCPISSC
560 570 580 590 600
NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD
610 620 630 640 650
AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN
660 670 680 690 700
SVGQAVDPPS LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG
710 720 730 740 750
PLGSLDSLAM KNSSPEPQAL TPSSKLTVDT DTLTPSSTLC ENSVSELLTP
760 770 780 790
AKAEWSVHPN SDFFGQEGET QFGFPNAAGN HGSQKERNLI TVTGSSFLV
Length:799
Mass (Da):84,771
Last modified:January 11, 2001 - v2
Checksum:i112BF6C6D0CAA670
GO

Sequence cautioni

The sequence AAC37521 differs from that shown. Reason: Frameshift at position 753.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076439202R → G1 PublicationCorresponds to variant dbSNP:rs139564495Ensembl.1
Natural variantiVAR_033002376G → S. Corresponds to variant dbSNP:rs1057327Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034396 Genomic DNA. No translation available.
BC059356 mRNA. Translation: AAH59356.1.
L14787 mRNA. Translation: AAC37521.1. Frameshift.
CCDSiCCDS14376.1.
PIRiI54340.
RefSeqiNP_009087.1. NM_007156.4.
UniGeneiHs.550094.

Genome annotation databases

EnsembliENST00000358697; ENSP00000351530; ENSG00000198205.
GeneIDi7789.
KEGGihsa:7789.
UCSCiuc004dve.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034396 Genomic DNA. No translation available.
BC059356 mRNA. Translation: AAH59356.1.
L14787 mRNA. Translation: AAC37521.1. Frameshift.
CCDSiCCDS14376.1.
PIRiI54340.
RefSeqiNP_009087.1. NM_007156.4.
UniGeneiHs.550094.

3D structure databases

ProteinModelPortaliP98168.
SMRiP98168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98168. 2 interactors.
STRINGi9606.ENSP00000351530.

PTM databases

iPTMnetiP98168.
PhosphoSitePlusiP98168.

Polymorphism and mutation databases

BioMutaiZXDA.
DMDMi12644369.

Proteomic databases

MaxQBiP98168.
PaxDbiP98168.
PeptideAtlasiP98168.
PRIDEiP98168.

Protocols and materials databases

DNASUi7789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358697; ENSP00000351530; ENSG00000198205.
GeneIDi7789.
KEGGihsa:7789.
UCSCiuc004dve.4. human.

Organism-specific databases

CTDi7789.
GeneCardsiZXDA.
HGNCiHGNC:13198. ZXDA.
HPAiHPA043789.
MIMi300235. gene.
neXtProtiNX_P98168.
OpenTargetsiENSG00000198205.
PharmGKBiPA37763.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOGENOMiHOG000013019.
HOVERGENiHBG002277.
InParanoidiP98168.
OMAiGANPAGC.
OrthoDBiEOG091G0K27.
PhylomeDBiP98168.
TreeFamiTF330996.

Miscellaneous databases

GenomeRNAii7789.
PROiPR:P98168.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198205.
CleanExiHS_ZXDA.
GenevisibleiP98168. HS.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZXDA_HUMAN
AccessioniPrimary (citable) accession number: P98168
Secondary accession number(s): Q9UJP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: May 10, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.