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P98168

- ZXDA_HUMAN

UniProt

P98168 - ZXDA_HUMAN

Protein

Zinc finger X-linked protein ZXDA

Gene

ZXDA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri267 – 29125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri300 – 32425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri330 – 35425C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44425C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47425C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50425C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53425C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri543 – 56826C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. C2H2 zinc finger domain binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro
    4. protein binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger X-linked protein ZXDA
    Gene namesi
    Name:ZXDA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:13198. ZXDA.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37763.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 799799Zinc finger X-linked protein ZXDAPRO_0000047776Add
    BLAST

    Proteomic databases

    PaxDbiP98168.
    PRIDEiP98168.

    PTM databases

    PhosphoSiteiP98168.

    Expressioni

    Tissue specificityi

    May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication

    Gene expression databases

    BgeeiP98168.
    CleanExiHS_ZXDA.
    GenevestigatoriP98168.

    Organism-specific databases

    HPAiHPA043789.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with ZXDC and CIITA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CIITAP330764EBI-1538980,EBI-1538819
    ZXDCQ2QGD75EBI-1538980,EBI-1538838

    Protein-protein interaction databases

    IntActiP98168. 2 interactions.
    STRINGi9606.ENSP00000351530.

    Structurei

    3D structure databases

    ProteinModelPortaliP98168.
    SMRiP98168. Positions 267-595.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni267 – 573307Required for interaction with ZXDCAdd
    BLAST
    Regioni572 – 699128Required for transcriptional activationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 206Poly-Gly

    Sequence similaritiesi

    Belongs to the ZXD family.Curated
    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri267 – 29125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri300 – 32425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri330 – 35425C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44425C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47425C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50425C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53425C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri543 – 56826C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013019.
    HOVERGENiHBG002277.
    InParanoidiP98168.
    OMAiLCPEALC.
    OrthoDBiEOG776SPF.
    PhylomeDBiP98168.
    TreeFamiTF330996.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 6 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP    50
    QDGGPGRRRE EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV 100
    ETAGSGQAAG PVLREEAKAG PGLQGDESGA NPAGCSAQGP HCLSAVPTPA 150
    PISAPGPAAA FAGTVTIHNQ DLLLRFENGV LTLATPPPHA WEPGAAPAQQ 200
    PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA PQEEAEGLAA 250
    ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF 300
    KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH 350
    MKGHEQENSF KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF 400
    ITVSALFSHN RAHFREQELF SCSFPGCSKQ YDKACRLKIH LRSHTGERPF 450
    LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF MCPVEGCGKS FTRAEHLKGH 500
    SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT WKSRCPISSC 550
    NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD 600
    AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN 650
    SVGQAVDPPS LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG 700
    PLGSLDSLAM KNSSPEPQAL TPSSKLTVDT DTLTPSSTLC ENSVSELLTP 750
    AKAEWSVHPN SDFFGQEGET QFGFPNAAGN HGSQKERNLI TVTGSSFLV 799
    Length:799
    Mass (Da):84,771
    Last modified:January 11, 2001 - v2
    Checksum:i112BF6C6D0CAA670
    GO

    Sequence cautioni

    The sequence AAC37521.1 differs from that shown. Reason: Frameshift at position 753.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti376 – 3761G → S.
    Corresponds to variant rs1057327 [ dbSNP | Ensembl ].
    VAR_033002

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034396 Genomic DNA. Translation: CAB46717.1.
    BC059356 mRNA. Translation: AAH59356.1.
    L14787 mRNA. Translation: AAC37521.1. Frameshift.
    CCDSiCCDS14376.1.
    PIRiI54340.
    RefSeqiNP_009087.1. NM_007156.4.
    UniGeneiHs.550094.

    Genome annotation databases

    EnsembliENST00000358697; ENSP00000351530; ENSG00000198205.
    GeneIDi7789.
    KEGGihsa:7789.
    UCSCiuc004dve.3. human.

    Polymorphism databases

    DMDMi12644369.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034396 Genomic DNA. Translation: CAB46717.1 .
    BC059356 mRNA. Translation: AAH59356.1 .
    L14787 mRNA. Translation: AAC37521.1 . Frameshift.
    CCDSi CCDS14376.1.
    PIRi I54340.
    RefSeqi NP_009087.1. NM_007156.4.
    UniGenei Hs.550094.

    3D structure databases

    ProteinModelPortali P98168.
    SMRi P98168. Positions 267-595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P98168. 2 interactions.
    STRINGi 9606.ENSP00000351530.

    PTM databases

    PhosphoSitei P98168.

    Polymorphism databases

    DMDMi 12644369.

    Proteomic databases

    PaxDbi P98168.
    PRIDEi P98168.

    Protocols and materials databases

    DNASUi 7789.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358697 ; ENSP00000351530 ; ENSG00000198205 .
    GeneIDi 7789.
    KEGGi hsa:7789.
    UCSCi uc004dve.3. human.

    Organism-specific databases

    CTDi 7789.
    GeneCardsi GC0XM057949.
    HGNCi HGNC:13198. ZXDA.
    HPAi HPA043789.
    MIMi 300235. gene.
    neXtProti NX_P98168.
    PharmGKBi PA37763.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013019.
    HOVERGENi HBG002277.
    InParanoidi P98168.
    OMAi LCPEALC.
    OrthoDBi EOG776SPF.
    PhylomeDBi P98168.
    TreeFami TF330996.

    Miscellaneous databases

    GenomeRNAii 7789.
    NextBioi 30149.
    PROi P98168.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98168.
    CleanExi HS_ZXDA.
    Genevestigatori P98168.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 6 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies."
      Greig G.M., Sharp C.B., Carrel L., Willard H.F.
      Hum. Mol. Genet. 2:1611-1618(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 303-799, TISSUE SPECIFICITY.
      Tissue: Brain.
    4. "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription."
      Al-Kandari W., Koneni R., Navalgund V., Aleksandrova A., Jambunathan S., Fontes J.D.
      J. Mol. Biol. 369:1175-1187(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ZXDC AND CIITA.

    Entry informationi

    Entry nameiZXDA_HUMAN
    AccessioniPrimary (citable) accession number: P98168
    Secondary accession number(s): Q9UJP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3