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P98167

- SSPO_BOVIN

UniProt

P98167 - SSPO_BOVIN

Protein

SCO-spondin

Gene

SSPO

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system.

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCO-spondin
    Gene namesi
    Name:SSPO
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 51465129SCO-spondinPRO_0000186461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 5138By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi814 – 8141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi906 – 9061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1349 – 13491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1373 ↔ 1386By similarity
    Disulfide bondi1380 ↔ 1399By similarity
    Disulfide bondi1393 ↔ 1408By similarity
    Disulfide bondi1413 ↔ 1425By similarity
    Disulfide bondi1420 ↔ 1438By similarity
    Disulfide bondi1432 ↔ 1447By similarity
    Disulfide bondi1449 ↔ 1461By similarity
    Disulfide bondi1456 ↔ 1474By similarity
    Disulfide bondi1468 ↔ 1483By similarity
    Disulfide bondi1489 ↔ 1501By similarity
    Disulfide bondi1496 ↔ 1514By similarity
    Disulfide bondi1508 ↔ 1525By similarity
    Disulfide bondi1562 ↔ 1574By similarity
    Disulfide bondi1569 ↔ 1587By similarity
    Disulfide bondi1581 ↔ 1596By similarity
    Disulfide bondi1600 ↔ 1613By similarity
    Disulfide bondi1607 ↔ 1626By similarity
    Disulfide bondi1620 ↔ 1637By similarity
    Glycosylationi1647 – 16471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1653 ↔ 1663By similarity
    Disulfide bondi1658 ↔ 1676By similarity
    Disulfide bondi1670 ↔ 1691By similarity
    Disulfide bondi1703 ↔ 1739By similarity
    Disulfide bondi1707 ↔ 1744By similarity
    Disulfide bondi1718 ↔ 1729By similarity
    Glycosylationi1806 – 18061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1825 ↔ 1840By similarity
    Disulfide bondi1834 ↔ 1845By similarity
    Disulfide bondi1847 ↔ 1859By similarity
    Disulfide bondi1865 ↔ 1884By similarity
    Disulfide bondi1867 ↔ 1887By similarity
    Disulfide bondi1889 ↔ 1897By similarity
    Disulfide bondi1907 ↔ 1946By similarity
    Disulfide bondi1918 ↔ 1922By similarity
    Disulfide bondi1956 ↔ 1961By similarity
    Glycosylationi2027 – 20271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2062 ↔ 2220By similarity
    Glycosylationi2127 – 21271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2226 ↔ 2238By similarity
    Disulfide bondi2233 ↔ 2251By similarity
    Disulfide bondi2245 ↔ 2260By similarity
    Disulfide bondi2383 ↔ 2395By similarity
    Disulfide bondi2390 ↔ 2408By similarity
    Disulfide bondi2402 ↔ 2417By similarity
    Disulfide bondi2443 ↔ 2455By similarity
    Disulfide bondi2450 ↔ 2468By similarity
    Disulfide bondi2462 ↔ 2477By similarity
    Disulfide bondi2480 ↔ 2516By similarity
    Disulfide bondi2491 ↔ 2495By similarity
    Disulfide bondi2526 ↔ 2531By similarity
    Disulfide bondi2546 ↔ 2583By similarity
    Disulfide bondi2550 ↔ 2588By similarity
    Disulfide bondi2561 ↔ 2573By similarity
    Glycosylationi2624 – 26241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2673 – 26731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2695 ↔ 2733By similarity
    Disulfide bondi2706 ↔ 2710By similarity
    Disulfide bondi2743 ↔ 2747By similarity
    Disulfide bondi2763 ↔ 2801By similarity
    Disulfide bondi2767 ↔ 2806By similarity
    Disulfide bondi2783 ↔ 2791By similarity
    Disulfide bondi2821 ↔ 2856By similarity
    Disulfide bondi2825 ↔ 2861By similarity
    Disulfide bondi2836 ↔ 2846By similarity
    Glycosylationi2915 – 29151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2946 – 29461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2965 ↔ 3003By similarity
    Disulfide bondi2976 ↔ 2980By similarity
    Disulfide bondi3013 ↔ 3018By similarity
    Glycosylationi3041 – 30411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3143 – 31431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3153 – 31531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3175 ↔ 3224By similarity
    Disulfide bondi3179 ↔ 3229By similarity
    Disulfide bondi3190 ↔ 3214By similarity
    Disulfide bondi3244 ↔ 3281By similarity
    Disulfide bondi3248 ↔ 3286By similarity
    Disulfide bondi3259 ↔ 3271By similarity
    Glycosylationi3290 – 32901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3400 ↔ 3443By similarity
    Disulfide bondi3404 ↔ 3449By similarity
    Disulfide bondi3415 ↔ 3427By similarity
    Disulfide bondi3464 ↔ 3499By similarity
    Disulfide bondi3467 ↔ 3506By similarity
    Disulfide bondi3477 ↔ 3489By similarity
    Glycosylationi3502 – 35021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3580 – 35801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3607 – 36071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3638 ↔ 3668By similarity
    Disulfide bondi3642 ↔ 3673By similarity
    Disulfide bondi3653 ↔ 3658By similarity
    Glycosylationi3783 – 37831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3814 ↔ 3852By similarity
    Disulfide bondi3818 ↔ 3857By similarity
    Disulfide bondi3830 ↔ 3842By similarity
    Glycosylationi3906 – 39061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3938 – 39381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3939 ↔ 3975By similarity
    Disulfide bondi3950 ↔ 3954By similarity
    Disulfide bondi3988 ↔ 3993By similarity
    Disulfide bondi4008 ↔ 4045By similarity
    Disulfide bondi4012 ↔ 4050By similarity
    Disulfide bondi4023 ↔ 4035By similarity
    Glycosylationi4131 – 41311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4152 ↔ 4188By similarity
    Disulfide bondi4163 ↔ 4167By similarity
    Disulfide bondi4198 ↔ 4203By similarity
    Disulfide bondi4257 ↔ 4294By similarity
    Disulfide bondi4261 ↔ 4299By similarity
    Disulfide bondi4272 ↔ 4284By similarity
    Glycosylationi4341 – 43411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4361 ↔ 4398By similarity
    Disulfide bondi4372 ↔ 4374By similarity
    Disulfide bondi4408 ↔ 4413By similarity
    Glycosylationi4412 – 44121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4611 ↔ 4645By similarity
    Disulfide bondi4622 ↔ 4626By similarity
    Disulfide bondi4655 ↔ 4660By similarity
    Glycosylationi4729 – 47291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4746 – 47461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4751 – 47511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4772 – 47721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4773 ↔ 4808By similarity
    Disulfide bondi4777 ↔ 4813By similarity
    Disulfide bondi4788 ↔ 4797By similarity
    Glycosylationi4861 – 48611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4901 – 49011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4947 – 49471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4954 – 49541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5052 ↔ 5100By similarity
    Glycosylationi5060 – 50601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5066 ↔ 5117By similarity
    Disulfide bondi5076 ↔ 5133By similarity
    Disulfide bondi5080 ↔ 5135By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP98167.

    Expressioni

    Tissue specificityi

    Subcommissural organ. Located at the boundary of the diencephalon and mesencephalon beneath the posterior commissure at the point where the axons cross the midline.1 Publication

    Developmental stagei

    Embryo.

    Structurei

    3D structure databases

    ProteinModelPortaliP98167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9477EMIAdd
    BLAST
    Domaini186 – 392207VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini464 – 51956TIL 1Add
    BLAST
    Domaini558 – 768211VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini822 – 87554TIL 2Add
    BLAST
    Domaini1009 – 1215207VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1271 – 132757TIL 3Add
    BLAST
    Domaini1372 – 140938LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1412 – 144736LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1448 – 148437LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1488 – 152639LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1561 – 159737LDL-receptor class A 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1599 – 163840LDL-receptor class A 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1652 – 169039LDL-receptor class A 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1691 – 174555TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1747 – 180559TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1821 – 186040EGF-like 1Add
    BLAST
    Domaini1861 – 189838EGF-like 2Add
    BLAST
    Domaini1906 – 196257TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1962 – 202261VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2062 – 2220159F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini2225 – 226137LDL-receptor class A 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2382 – 241837LDL-receptor class A 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini2442 – 247837LDL-receptor class A 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini2479 – 253254TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2534 – 258956TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini2612 – 265443TIL 4Add
    BLAST
    Domaini2694 – 274855TSP type-1 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini2751 – 280757TSP type-1 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini2809 – 286254TSP type-1 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2964 – 301956TSP type-1 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini3020 – 307152TSP type-1 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini3163 – 323068TSP type-1 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini3232 – 328756TSP type-1 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini3291 – 334555TIL 5Add
    BLAST
    Domaini3388 – 345063TSP type-1 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini3452 – 350756TSP type-1 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini3626 – 367449TSP type-1 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini3802 – 385857TSP type-1 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini3872 – 392453TSP type-1 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini3938 – 399457TSP type-1 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini3996 – 405156TSP type-1 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini4101 – 416868VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini4151 – 420454TSP type-1 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini4245 – 430056TSP type-1 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini4302 – 435857TSP type-1 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini4360 – 441455TSP type-1 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini4610 – 466152TSP type-1 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini4761 – 481454TSP type-1 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini4816 – 487055TIL 6Add
    BLAST
    Domaini4983 – 504159VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini5052 – 513988CTCKPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi523 – 5275Poly-Arg

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.Curated
    Contains 1 EMI domain.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 25 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000154433.
    HOVERGENiHBG080794.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    4.10.400.10. 8 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR001545. Gonadotropin_bsu.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR008037. Prot_inh_PMP.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 13 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00231. FA58C. 1 hit.
    SM00068. GHB. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 3 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF57283. SSF57283. 1 hit.
    SSF57424. SSF57424. 9 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 24 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 7 hits.
    PS50068. LDLRA_2. 9 hits.
    PS50092. TSP1. 25 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98167-1 [UniParc]FASTAAdd to Basket

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    MLLPALLFGA AWALANGRWC EQTETVLVEE EVTPHQEDLV PCASLQHYQR     50
    RGWRLDLTWS GRAGLCAIYK PPETRPAAWN RTVRACCPGW GGTHCTLALA 100
    EASPEGHCFA TWLCNLGAGS VNASAGSLEE CCAQPWGHSW RDGRSQTCHS 150
    CSNHSRLGST PSPAILQPLA GAVAQLWSQR QRPSATCATW SGFHYRTFDG 200
    RHFHFLGRCT YLLAGAADAT WAVHLQPMGH CPQPGHCQLA RVMMGPEEVL 250
    IRGENVTVNG RLVPEGASQL LPGLSLQWQG DWLVLSGGLG VVVRLDRSSS 300
    VSISVDQELQ GQTQGLCGVY NGQPEDDFLE PGRGLAALAA TFGNSWRLPD 350
    SELGCLDAVE AAQGCEDPLR GTETGTEAGQ LRAEAQDVCH QLLEGPFREC 400
    HTQVPPAEYH EACLFAYCAG APAGSGRAER LEAVCATLAS YAQDCAARRI 450
    AVRWRKPGFC ERLCPGGQLY SDCASACPPS CSAVGEGSEW SCGEECVSGC 500
    ECPPGLFWDG ALCVPAARCP CYRRRRRYEP GDTVRQLCNP CECRDGRWLC 550
    AQAPCAAECA VGGDGHYVTF DGRSFSFRGR AGCRFILVQD FAKRQLLIVL 600
    EHGDCDAGSC LHAISVSLGD TLVQLRDSGV VLVDGQDVAL PWSAAGGLSV 650
    SRASSSFLLL RWPGARILWG VSDPAAYITL DPHHAHQVQG LCGTFTRNQQ 700
    DDFLTPAGDV ETSITAFASK FQVAGGGTCS LEACTPLSPC STHTERQVFA 750
    EVACAILHGP TFQECHGLVD REAFHLRCLA AVCGCTPGRD CLCPVLAAYA 800
    RRCAQEGALP SWRNQTFCPV LCPGGQEYQE CAPACDRNCG EPEDCGELDN 850
    CVAGCNCPLG LLWDPEGQCV PPNLCPCQLG AHRYAPGSAT MKDCNHCVCQ 900
    ERGLWNCTAH HCAPPRTFCP RELVYVPGAC LLTCDSLDAD RTCPPGSPGG 950
    CVCPPGTVLL EERCVPPELC PCRHGGQWYL PNAAIQEDCN LCVCQGQQWH 1000
    CTGQRCDGRC RASGAPHYVT FDGLALTFPG ACEYLLVREA SGQFMVSAQN 1050
    LPCGASGLTC TKALTVRLQG TVVHMLRGRA VMVNGVSVTP PKVYSGPGLS 1100
    LHTAGLFLLL STRLGLTLLW DGGTRVPVQL SPQLRGRVAG LCGDFDGDAS 1150
    NDLRSRQGVL EPTAELAAHS WRLGPLCPEP GDLPHPCAVN AHRAGWARAR 1200
    CGVVLQPLFA RCHVEVPPQQ HYEQCVYDAC GCDSGGDCEC LCSAIATYAD 1250
    ECARHGIHVR WRSQELCPLQ CERGQVYEAC GPTCPATCHD HRPEPGWPCR 1300
    AVACVEGCFC PEGTLLHGGV CLEPAACPCE WGGSFFPPGT VLQKDCGNNC 1350
    TCRESQWLCG DDGGRCVEPG PGCAEGETPC RESGHCVPHG WLCDNQDDCG 1400
    DGSDEEGCAT RVCGEGQVSC CSGRCLPLVL LCDGQDDCGD GMDEQGCPCP 1450
    QDSLTCADGH CLPPARLCDG HPDCPDGADE ESCLGQVDCA PGEVSCVDGT 1500
    CLGAIQLCDG VWDCLDGGDE GPGHCPLPSL PTPPAGTLPG PSAVSWKLHL 1550
    PPWPVSALRL PCGPLDFACG SGECAPRGWR CDGEEDCADG SDESGCDRPC 1600
    APHHAPCARG SHCVAAEQLC DGVPHCPDGS DEDPGACERL QAPGGPNRTG 1650
    LPCPEYSCPD GLCIGFQQVC DGQPDCELAG TAGPSPEEQG CGAWGPWSPW 1700
    ELCSRTCGPG VQGWSRRCSP PSLPVLWHCP GPERQTRACF AAACPEDGVW 1750
    TSWSRWSPCS EPCGGVTARH RECHPPQNGG RTCATLPGGP PSTRETRPCP 1800
    QDGCPNVTCS GELVFHACVP CPLTCDDISG QATCPPDRPC GGPGCWCPAG 1850
    QVLGAQGRCV WPRQCPCLVD GSRYWPGQRV KTDCQLCVCQ DGRPRRCQPS 1900
    LDCAVNCGWS AWSPWAECLG PCGSRSVQWS FRSPNNPRPA GRGHQCRGLH 1950
    RKARRCQTEP CEGCEQDGRV HRVGERWRAG PCRVCQCLHD GSARCSPYCP 2000
    LGSCPQDWVL VEGVGESCCH CVPPGENQTV HPMATPVPAP TPSPQIGAPL 2050
    ITYLLPPPGD PCYSPLGLAR LPEGSLPASS QQLEHPAWAA ILRPAPGAPG 2100
    WSPVEHADTQ GHTPPPYLQL DLLQPRNLTG IIVQGAGSSD WLQVSSDGLH 2150
    WHSYRDIQHG TQPAPQLFPK NWNGPSTVWM FARMVQARHV RVWPSDGHHQ 2200
    AAPSSDANLD GPLRVELLGC EPAPLCLGVG HRCVSGECAP RGAPCDGVED 2250
    CKDGSDEEGC VTPPAGAGRI ESTAWSSAPS SAQPGQLPPQ PSEGLAEAEA 2300
    DHWHPGRGSP VPPTGKGPAS LGSEPHPSPG GSVQTVTPTS QPEAQALRPE 2350
    MAAVTVLPPH PMVTPEVPAG RSTTPGPFPH VQCSPGQVPC EVLGCVELEQ 2400
    LCDGREDCLD GSDERPCAWA AGTVPFTVPT TTLPGLPASR DLCSPSQLTC 2450
    GSGECLPVER RCDLQLDCQD GSDENGCVDC GLAPWSGWSS CSRSCGLGLA 2500
    FQRRELLRPP LPGGSCPPDR LRSQPCFVQA CPVAGAWAEW EAWGPCSVSC 2550
    GGGHRSRRRS CMDPPPKNGG APCPGPPQER APCGLQPCAG GTDCGQGRVH 2600
    VSAELCRKGL VPPCPPSCLD PEANRSCSGL CLEGCRCPPG LLLQDAGCLP 2650
    LSECPCLVGE ELQQPGVPFL LDNCSRCVCE KGALLCEPGG CPVPCGWSAW 2700
    SSWGPCDRSC GSGLRARFRS PSNPPAASGG APCEGQRQEL QACYSACGAE 2750
    VPGWTPWAPW SACSQSCLVP GGGPALRSRS RLCPGPGDTS CIGEATEEEP 2800
    CSPPVCLGLG VWGQWAAWSA CSAPCNGGVQ TRGRRCSASA PGDPGCQGPH 2850
    SQTRDCNTQP CTAQCPGDMV FRSAEQCRWE GGPCPGLCLA RGPGVECTGV 2900
    CTAGCACPTG LFLHNSSCLP PSQCPCQLRG QLYAPGAVAR LDSCSNCTCI 2950
    SGEMVCASEP CPVACGWSPW TPWSLCSRSC NVGVRRRFRA GTAPPAAFGG 3000
    AACQGPNMEA EFCSLRPCGG PAGEWGPWSP CSVPCGGGYR NRTRGSSGPS 3050
    PVDFSTCGLQ PCAGPAPGVC PPGKRWLDCA QGPASCAELS APRGADQPCH 3100
    PGCYCPSGML LLNNACVPTQ DCPCTHGGRL HPPGSAVLRP CENCSCVSGL 3150
    ITNCTSWPCK EGQPTWSPWT PWSECSASCG PARRHKHRFC TRPPGGAPSS 3200
    MAPPLLLSSV PPLCPGPEAE EEPCLLPECD RAGGWGPWGP WSSCSRSCGG 3250
    GLRSRSRACD QPPPQGLGDY CEGPRAQGAA CQALPCPVTN CTAIEGAEYS 3300
    ACGPPCPRSC DDLVHCVWHC QPGCYCPPGQ VLSADGTVHV QPGHCSCLDL 3350
    LTGERHRPGA QLAKPDGCNY CTCSEGQLTC TDLPCPVPGA WCPWSEWTAC 3400
    SQPCQGQTRT RSRACSCPAP QHGGAPCPGE AGEAGAQHQR ETCASTPECP 3450
    VDGAWSPWGP WSPCEVCLGR SHRSRECSWP PTSEGGRPCP GGHRQSRPCQ 3500
    GNSTQCTDCA GGQDLLPCGQ PCPRSCEDLS PGVECQPDSM GCQQPRCGCP 3550
    PGQLSQDGLC VTPSQCRCQY QPGAMGIPEN QSRSAGSGLS SWESLEPGEV 3600
    VTGPCDNCTC VAGILQCQEV PACSGLGLWG SWGPWEDCSV SCGGGEQLRF 3650
    RRCPRPPCPG PARQSRTCRT QVCREAGCPA GRLYRECQPS EGCPFSCAHV 3700
    TGQVGCFSAG CEEGCHCPEG TFLHRSACVQ ECPCVLTALW LQGLGAAGAD 3750
    PGAHLSVLGE NGQPLGPGDE LGSGQSLRTG CHNCSCAHGK LSCSVEACSK 3800
    AAGGFSPWGP WGPCSRSCGG LGTRTRSRQC VRPMPAPGGQ GCHGPHWDLE 3850
    YCPSPECPGA AGSTAEPATG LPGGWGLWSP WSPCSGTCTD PAHPAWRSRS 3900
    RLCLANCTGG AASQERPCNL PSCTELPLCP GPGCEAGNCS WTAWAPWEPC 3950
    SRSCGVGQQR RLRAYHPPGP GGHWCPDVLT AYQERRFCNL RACPVPGGWS 4000
    RWSPWSWCDR SCGGGRSLRS RSCSSPPPKN GGAPCVGERH HARLCNPTPC 4050
    EEGCPAGMEV VSCANRCPRR CSDLQEGIVC QEDQACQQGC RCPEGSLEQD 4100
    GGCVPLGHCE CTDAQGHSWA PGSQHQEACN NCTCRAGQLS CTAQPCPPPA 4150
    HCAWSRWSAW SPCSRSCGPA GQQSRFRSST SGSWAPECRE EQSQSQPCPQ 4200
    SPCPPLCLQG TRPRSLGDSW LQDGCQQCSC TPEGIICEDA ECAGLGAWTP 4250
    WSPWSDCPVS CGGGNQVRTR VCVASAPPRG GSPCLGPDVQ SQRCGLWPCP 4300
    ALPDTCSWGP WGPCSRSCGP GLASRSASCP CLLAEAEPAC NSTSPRLDTQ 4350
    ACYAGPCLEE CVWSSWSSWT RCSCEVLVQQ RYRHQRPAPG GAGAGPPCTR 4400
    LDGHFRPCLT GNCSEDSCAP PFEFQACGSP CTGLCATYLS PWLCQDLPPC 4450
    QPGCYCPEGL LEQAGGCVPP EQCNCQHVSG EGAGVTLAPG DRLQLGCKEC 4500
    ECQRGELQCT SQGCQGLLPL SGWSEWSPCG PCLPLGLLAP ASRAALEERW 4550
    PQDTAGLSPT SAPTLASEQH RHRLCLDPET GRPWAGDPDL CTVPLSQQRL 4600
    CPDPGACQDL CQWGPWGAWS PCQVPCSGGF RLRWREAGIP PGGGCRGPWA 4650
    QTESCNMGPC PGESCEAQDT VPTPDCANQC PRSCVDLWDR VECLQGPCRP 4700
    GCRCPPGQLV QDGHCVPVSS CRCGLPSPNA SWALAPAEVV RLDCRNCTCV 4750
    NGSLACSSHE CPTLGPWSAW SNCSAPCGGG TTKRHRSCKE GPGVTPCQAQ 4800
    DMEQQQDCNL QPCPECPPGQ VLSACAVSCP RLCSHLQPGT PCMQEPCQLG 4850
    CDCPRGQLLH NGTCVPPAEC PCTQLSLPWG LTLTLEEQHR ELPPGTLLTQ 4900
    NCTHCICQGG AFSCSLTDCQ ECPPGETWQQ VAPGELGPCE QTCREPNATE 4950
    TQGNCSGRQA PGCVCQRGHF RSQEGPCVPV DLCECWHHGR PHPPGSEWQK 5000
    ACESCRCVSG ESICTQHCPP LTCAQGETAV QEPGGCCPTC RQEAPEEQPV 5050
    SCRHLTELRN LTKGACYLEQ VEVNYCSGHC PSSTNVLPEE PYLQSQCDCC 5100
    SYRLDPENPV RILNLRCPGG RTELVVLPVI HSCQCSACQG GDFSER 5146
    Length:5,146
    Mass (Da):543,593
    Last modified:July 11, 2006 - v2
    Checksum:i724C5FB8727E13DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ416457 mRNA. Translation: CAC94914.1.
    X93922 mRNA. Translation: CAA63815.1.
    RefSeqiNP_777131.1. NM_174706.2.
    UniGeneiBt.4812.

    Genome annotation databases

    GeneIDi282659.
    KEGGibta:282659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ416457 mRNA. Translation: CAC94914.1 .
    X93922 mRNA. Translation: CAA63815.1 .
    RefSeqi NP_777131.1. NM_174706.2.
    UniGenei Bt.4812.

    3D structure databases

    ProteinModelPortali P98167.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P98167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282659.
    KEGGi bta:282659.

    Organism-specific databases

    CTDi 23145.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000154433.
    HOVERGENi HBG080794.

    Miscellaneous databases

    NextBioi 20806337.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    4.10.400.10. 8 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR001545. Gonadotropin_bsu.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR008037. Prot_inh_PMP.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 13 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00231. FA58C. 1 hit.
    SM00068. GHB. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 3 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF57283. SSF57283. 1 hit.
    SSF57424. SSF57424. 9 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 24 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 7 hits.
    PS50068. LDLRA_2. 9 hits.
    PS50092. TSP1. 25 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth."
      Gobron S.
      Glia 32:177-191(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Subcommissural organ.
    2. "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation."
      Gobron S., Monnerie H., Meiniel R., Creveaux I., Lehmann W., Lamalle D., Dastugue B., Meiniel A.
      J. Cell Sci. 109:1053-1061(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1719-2585.
      Tissue: Ependymocyte.

    Entry informationi

    Entry nameiSSPO_BOVIN
    AccessioniPrimary (citable) accession number: P98167
    Secondary accession number(s): Q8SPM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3