Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P98167 (SSPO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SCO-spondin
Gene names
Name:SSPO
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length5146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system.

Subcellular location

Secretedextracellular space.

Tissue specificity

Subcommissural organ. Located at the boundary of the diencephalon and mesencephalon beneath the posterior commissure at the point where the axons cross the midline. Ref.1

Developmental stage

Embryo.

Sequence similarities

Belongs to the thrombospondin family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 EGF-like domains.

Contains 1 EMI domain.

Contains 1 F5/8 type C domain.

Contains 10 LDL-receptor class A domains.

Contains 6 TIL (trypsin inhibitory-like) domains.

Contains 25 TSP type-1 domains.

Contains 3 VWFC domains.

Contains 3 VWFD domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 51465129SCO-spondin
PRO_0000186461

Regions

Domain18 – 9477EMI
Domain186 – 392207VWFD 1
Domain464 – 51956TIL 1
Domain558 – 768211VWFD 2
Domain822 – 87554TIL 2
Domain1009 – 1215207VWFD 3
Domain1271 – 132757TIL 3
Domain1372 – 140938LDL-receptor class A 1
Domain1412 – 144736LDL-receptor class A 2
Domain1448 – 148437LDL-receptor class A 3
Domain1488 – 152639LDL-receptor class A 4
Domain1561 – 159737LDL-receptor class A 5
Domain1599 – 163840LDL-receptor class A 6
Domain1652 – 169039LDL-receptor class A 7
Domain1691 – 174555TSP type-1 1
Domain1747 – 180559TSP type-1 2
Domain1821 – 186040EGF-like 1
Domain1861 – 189838EGF-like 2
Domain1906 – 196257TSP type-1 3
Domain1962 – 202261VWFC 1
Domain2062 – 2220159F5/8 type C
Domain2225 – 226137LDL-receptor class A 8
Domain2382 – 241837LDL-receptor class A 9
Domain2442 – 247837LDL-receptor class A 10
Domain2479 – 253254TSP type-1 4
Domain2534 – 258956TSP type-1 5
Domain2612 – 265443TIL 4
Domain2694 – 274855TSP type-1 6
Domain2751 – 280757TSP type-1 7
Domain2809 – 286254TSP type-1 8
Domain2964 – 301956TSP type-1 9
Domain3020 – 307152TSP type-1 10
Domain3163 – 323068TSP type-1 11
Domain3232 – 328756TSP type-1 12
Domain3291 – 334555TIL 5
Domain3388 – 345063TSP type-1 13
Domain3452 – 350756TSP type-1 14
Domain3626 – 367449TSP type-1 15
Domain3802 – 385857TSP type-1 16
Domain3872 – 392453TSP type-1 17
Domain3938 – 399457TSP type-1 18
Domain3996 – 405156TSP type-1 19
Domain4101 – 416868VWFC 2
Domain4151 – 420454TSP type-1 20
Domain4245 – 430056TSP type-1 21
Domain4302 – 435857TSP type-1 22
Domain4360 – 441455TSP type-1 23
Domain4610 – 466152TSP type-1 24
Domain4761 – 481454TSP type-1 25
Domain4816 – 487055TIL 6
Domain4983 – 504159VWFC 3
Domain5052 – 513988CTCK
Compositional bias523 – 5275Poly-Arg

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation8141N-linked (GlcNAc...) Potential
Glycosylation9061N-linked (GlcNAc...) Potential
Glycosylation13491N-linked (GlcNAc...) Potential
Glycosylation16471N-linked (GlcNAc...) Potential
Glycosylation18061N-linked (GlcNAc...) Potential
Glycosylation20271N-linked (GlcNAc...) Potential
Glycosylation21271N-linked (GlcNAc...) Potential
Glycosylation26241N-linked (GlcNAc...) Potential
Glycosylation26731N-linked (GlcNAc...) Potential
Glycosylation29151N-linked (GlcNAc...) Potential
Glycosylation29461N-linked (GlcNAc...) Potential
Glycosylation30411N-linked (GlcNAc...) Potential
Glycosylation31431N-linked (GlcNAc...) Potential
Glycosylation31531N-linked (GlcNAc...) Potential
Glycosylation32901N-linked (GlcNAc...) Potential
Glycosylation35021N-linked (GlcNAc...) Potential
Glycosylation35801N-linked (GlcNAc...) Potential
Glycosylation36071N-linked (GlcNAc...) Potential
Glycosylation37831N-linked (GlcNAc...) Potential
Glycosylation39061N-linked (GlcNAc...) Potential
Glycosylation39381N-linked (GlcNAc...) Potential
Glycosylation41311N-linked (GlcNAc...) Potential
Glycosylation43411N-linked (GlcNAc...) Potential
Glycosylation44121N-linked (GlcNAc...) Potential
Glycosylation47291N-linked (GlcNAc...) Potential
Glycosylation47461N-linked (GlcNAc...) Potential
Glycosylation47511N-linked (GlcNAc...) Potential
Glycosylation47721N-linked (GlcNAc...) Potential
Glycosylation48611N-linked (GlcNAc...) Potential
Glycosylation49011N-linked (GlcNAc...) Potential
Glycosylation49471N-linked (GlcNAc...) Potential
Glycosylation49541N-linked (GlcNAc...) Potential
Glycosylation50601N-linked (GlcNAc...) Potential
Disulfide bond1373 ↔ 1386 By similarity
Disulfide bond1380 ↔ 1399 By similarity
Disulfide bond1393 ↔ 1408 By similarity
Disulfide bond1413 ↔ 1425 By similarity
Disulfide bond1420 ↔ 1438 By similarity
Disulfide bond1432 ↔ 1447 By similarity
Disulfide bond1449 ↔ 1461 By similarity
Disulfide bond1456 ↔ 1474 By similarity
Disulfide bond1468 ↔ 1483 By similarity
Disulfide bond1489 ↔ 1501 By similarity
Disulfide bond1496 ↔ 1514 By similarity
Disulfide bond1508 ↔ 1525 By similarity
Disulfide bond1562 ↔ 1574 By similarity
Disulfide bond1569 ↔ 1587 By similarity
Disulfide bond1581 ↔ 1596 By similarity
Disulfide bond1600 ↔ 1613 By similarity
Disulfide bond1607 ↔ 1626 By similarity
Disulfide bond1620 ↔ 1637 By similarity
Disulfide bond1653 ↔ 1663 By similarity
Disulfide bond1658 ↔ 1676 By similarity
Disulfide bond1670 ↔ 1691 By similarity
Disulfide bond1703 ↔ 1739 By similarity
Disulfide bond1707 ↔ 1744 By similarity
Disulfide bond1718 ↔ 1729 By similarity
Disulfide bond1825 ↔ 1840 By similarity
Disulfide bond1834 ↔ 1845 By similarity
Disulfide bond1847 ↔ 1859 By similarity
Disulfide bond1865 ↔ 1884 By similarity
Disulfide bond1867 ↔ 1887 By similarity
Disulfide bond1889 ↔ 1897 By similarity
Disulfide bond1907 ↔ 1946 By similarity
Disulfide bond1918 ↔ 1922 By similarity
Disulfide bond1956 ↔ 1961 By similarity
Disulfide bond2062 ↔ 2220 By similarity
Disulfide bond2226 ↔ 2238 By similarity
Disulfide bond2233 ↔ 2251 By similarity
Disulfide bond2245 ↔ 2260 By similarity
Disulfide bond2383 ↔ 2395 By similarity
Disulfide bond2390 ↔ 2408 By similarity
Disulfide bond2402 ↔ 2417 By similarity
Disulfide bond2443 ↔ 2455 By similarity
Disulfide bond2450 ↔ 2468 By similarity
Disulfide bond2462 ↔ 2477 By similarity
Disulfide bond2480 ↔ 2516 By similarity
Disulfide bond2491 ↔ 2495 By similarity
Disulfide bond2526 ↔ 2531 By similarity
Disulfide bond2546 ↔ 2583 By similarity
Disulfide bond2550 ↔ 2588 By similarity
Disulfide bond2561 ↔ 2573 By similarity
Disulfide bond2695 ↔ 2733 By similarity
Disulfide bond2706 ↔ 2710 By similarity
Disulfide bond2743 ↔ 2747 By similarity
Disulfide bond2763 ↔ 2801 By similarity
Disulfide bond2767 ↔ 2806 By similarity
Disulfide bond2783 ↔ 2791 By similarity
Disulfide bond2821 ↔ 2856 By similarity
Disulfide bond2825 ↔ 2861 By similarity
Disulfide bond2836 ↔ 2846 By similarity
Disulfide bond2965 ↔ 3003 By similarity
Disulfide bond2976 ↔ 2980 By similarity
Disulfide bond3013 ↔ 3018 By similarity
Disulfide bond3175 ↔ 3224 By similarity
Disulfide bond3179 ↔ 3229 By similarity
Disulfide bond3190 ↔ 3214 By similarity
Disulfide bond3244 ↔ 3281 By similarity
Disulfide bond3248 ↔ 3286 By similarity
Disulfide bond3259 ↔ 3271 By similarity
Disulfide bond3400 ↔ 3443 By similarity
Disulfide bond3404 ↔ 3449 By similarity
Disulfide bond3415 ↔ 3427 By similarity
Disulfide bond3464 ↔ 3499 By similarity
Disulfide bond3467 ↔ 3506 By similarity
Disulfide bond3477 ↔ 3489 By similarity
Disulfide bond3638 ↔ 3668 By similarity
Disulfide bond3642 ↔ 3673 By similarity
Disulfide bond3653 ↔ 3658 By similarity
Disulfide bond3814 ↔ 3852 By similarity
Disulfide bond3818 ↔ 3857 By similarity
Disulfide bond3830 ↔ 3842 By similarity
Disulfide bond3939 ↔ 3975 By similarity
Disulfide bond3950 ↔ 3954 By similarity
Disulfide bond3988 ↔ 3993 By similarity
Disulfide bond4008 ↔ 4045 By similarity
Disulfide bond4012 ↔ 4050 By similarity
Disulfide bond4023 ↔ 4035 By similarity
Disulfide bond4152 ↔ 4188 By similarity
Disulfide bond4163 ↔ 4167 By similarity
Disulfide bond4198 ↔ 4203 By similarity
Disulfide bond4257 ↔ 4294 By similarity
Disulfide bond4261 ↔ 4299 By similarity
Disulfide bond4272 ↔ 4284 By similarity
Disulfide bond4361 ↔ 4398 By similarity
Disulfide bond4372 ↔ 4374 By similarity
Disulfide bond4408 ↔ 4413 By similarity
Disulfide bond4611 ↔ 4645 By similarity
Disulfide bond4622 ↔ 4626 By similarity
Disulfide bond4655 ↔ 4660 By similarity
Disulfide bond4773 ↔ 4808 By similarity
Disulfide bond4777 ↔ 4813 By similarity
Disulfide bond4788 ↔ 4797 By similarity
Disulfide bond5052 ↔ 5100 By similarity
Disulfide bond5066 ↔ 5117 By similarity
Disulfide bond5076 ↔ 5133 By similarity
Disulfide bond5080 ↔ 5135 By similarity
Disulfide bond? ↔ 5138 By similarity

Sequences

Sequence LengthMass (Da)Tools
P98167 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 724C5FB8727E13DA

FASTA5,146543,593
        10         20         30         40         50         60 
MLLPALLFGA AWALANGRWC EQTETVLVEE EVTPHQEDLV PCASLQHYQR RGWRLDLTWS 

        70         80         90        100        110        120 
GRAGLCAIYK PPETRPAAWN RTVRACCPGW GGTHCTLALA EASPEGHCFA TWLCNLGAGS 

       130        140        150        160        170        180 
VNASAGSLEE CCAQPWGHSW RDGRSQTCHS CSNHSRLGST PSPAILQPLA GAVAQLWSQR 

       190        200        210        220        230        240 
QRPSATCATW SGFHYRTFDG RHFHFLGRCT YLLAGAADAT WAVHLQPMGH CPQPGHCQLA 

       250        260        270        280        290        300 
RVMMGPEEVL IRGENVTVNG RLVPEGASQL LPGLSLQWQG DWLVLSGGLG VVVRLDRSSS 

       310        320        330        340        350        360 
VSISVDQELQ GQTQGLCGVY NGQPEDDFLE PGRGLAALAA TFGNSWRLPD SELGCLDAVE 

       370        380        390        400        410        420 
AAQGCEDPLR GTETGTEAGQ LRAEAQDVCH QLLEGPFREC HTQVPPAEYH EACLFAYCAG 

       430        440        450        460        470        480 
APAGSGRAER LEAVCATLAS YAQDCAARRI AVRWRKPGFC ERLCPGGQLY SDCASACPPS 

       490        500        510        520        530        540 
CSAVGEGSEW SCGEECVSGC ECPPGLFWDG ALCVPAARCP CYRRRRRYEP GDTVRQLCNP 

       550        560        570        580        590        600 
CECRDGRWLC AQAPCAAECA VGGDGHYVTF DGRSFSFRGR AGCRFILVQD FAKRQLLIVL 

       610        620        630        640        650        660 
EHGDCDAGSC LHAISVSLGD TLVQLRDSGV VLVDGQDVAL PWSAAGGLSV SRASSSFLLL 

       670        680        690        700        710        720 
RWPGARILWG VSDPAAYITL DPHHAHQVQG LCGTFTRNQQ DDFLTPAGDV ETSITAFASK 

       730        740        750        760        770        780 
FQVAGGGTCS LEACTPLSPC STHTERQVFA EVACAILHGP TFQECHGLVD REAFHLRCLA 

       790        800        810        820        830        840 
AVCGCTPGRD CLCPVLAAYA RRCAQEGALP SWRNQTFCPV LCPGGQEYQE CAPACDRNCG 

       850        860        870        880        890        900 
EPEDCGELDN CVAGCNCPLG LLWDPEGQCV PPNLCPCQLG AHRYAPGSAT MKDCNHCVCQ 

       910        920        930        940        950        960 
ERGLWNCTAH HCAPPRTFCP RELVYVPGAC LLTCDSLDAD RTCPPGSPGG CVCPPGTVLL 

       970        980        990       1000       1010       1020 
EERCVPPELC PCRHGGQWYL PNAAIQEDCN LCVCQGQQWH CTGQRCDGRC RASGAPHYVT 

      1030       1040       1050       1060       1070       1080 
FDGLALTFPG ACEYLLVREA SGQFMVSAQN LPCGASGLTC TKALTVRLQG TVVHMLRGRA 

      1090       1100       1110       1120       1130       1140 
VMVNGVSVTP PKVYSGPGLS LHTAGLFLLL STRLGLTLLW DGGTRVPVQL SPQLRGRVAG 

      1150       1160       1170       1180       1190       1200 
LCGDFDGDAS NDLRSRQGVL EPTAELAAHS WRLGPLCPEP GDLPHPCAVN AHRAGWARAR 

      1210       1220       1230       1240       1250       1260 
CGVVLQPLFA RCHVEVPPQQ HYEQCVYDAC GCDSGGDCEC LCSAIATYAD ECARHGIHVR 

      1270       1280       1290       1300       1310       1320 
WRSQELCPLQ CERGQVYEAC GPTCPATCHD HRPEPGWPCR AVACVEGCFC PEGTLLHGGV 

      1330       1340       1350       1360       1370       1380 
CLEPAACPCE WGGSFFPPGT VLQKDCGNNC TCRESQWLCG DDGGRCVEPG PGCAEGETPC 

      1390       1400       1410       1420       1430       1440 
RESGHCVPHG WLCDNQDDCG DGSDEEGCAT RVCGEGQVSC CSGRCLPLVL LCDGQDDCGD 

      1450       1460       1470       1480       1490       1500 
GMDEQGCPCP QDSLTCADGH CLPPARLCDG HPDCPDGADE ESCLGQVDCA PGEVSCVDGT 

      1510       1520       1530       1540       1550       1560 
CLGAIQLCDG VWDCLDGGDE GPGHCPLPSL PTPPAGTLPG PSAVSWKLHL PPWPVSALRL 

      1570       1580       1590       1600       1610       1620 
PCGPLDFACG SGECAPRGWR CDGEEDCADG SDESGCDRPC APHHAPCARG SHCVAAEQLC 

      1630       1640       1650       1660       1670       1680 
DGVPHCPDGS DEDPGACERL QAPGGPNRTG LPCPEYSCPD GLCIGFQQVC DGQPDCELAG 

      1690       1700       1710       1720       1730       1740 
TAGPSPEEQG CGAWGPWSPW ELCSRTCGPG VQGWSRRCSP PSLPVLWHCP GPERQTRACF 

      1750       1760       1770       1780       1790       1800 
AAACPEDGVW TSWSRWSPCS EPCGGVTARH RECHPPQNGG RTCATLPGGP PSTRETRPCP 

      1810       1820       1830       1840       1850       1860 
QDGCPNVTCS GELVFHACVP CPLTCDDISG QATCPPDRPC GGPGCWCPAG QVLGAQGRCV 

      1870       1880       1890       1900       1910       1920 
WPRQCPCLVD GSRYWPGQRV KTDCQLCVCQ DGRPRRCQPS LDCAVNCGWS AWSPWAECLG 

      1930       1940       1950       1960       1970       1980 
PCGSRSVQWS FRSPNNPRPA GRGHQCRGLH RKARRCQTEP CEGCEQDGRV HRVGERWRAG 

      1990       2000       2010       2020       2030       2040 
PCRVCQCLHD GSARCSPYCP LGSCPQDWVL VEGVGESCCH CVPPGENQTV HPMATPVPAP 

      2050       2060       2070       2080       2090       2100 
TPSPQIGAPL ITYLLPPPGD PCYSPLGLAR LPEGSLPASS QQLEHPAWAA ILRPAPGAPG 

      2110       2120       2130       2140       2150       2160 
WSPVEHADTQ GHTPPPYLQL DLLQPRNLTG IIVQGAGSSD WLQVSSDGLH WHSYRDIQHG 

      2170       2180       2190       2200       2210       2220 
TQPAPQLFPK NWNGPSTVWM FARMVQARHV RVWPSDGHHQ AAPSSDANLD GPLRVELLGC 

      2230       2240       2250       2260       2270       2280 
EPAPLCLGVG HRCVSGECAP RGAPCDGVED CKDGSDEEGC VTPPAGAGRI ESTAWSSAPS 

      2290       2300       2310       2320       2330       2340 
SAQPGQLPPQ PSEGLAEAEA DHWHPGRGSP VPPTGKGPAS LGSEPHPSPG GSVQTVTPTS 

      2350       2360       2370       2380       2390       2400 
QPEAQALRPE MAAVTVLPPH PMVTPEVPAG RSTTPGPFPH VQCSPGQVPC EVLGCVELEQ 

      2410       2420       2430       2440       2450       2460 
LCDGREDCLD GSDERPCAWA AGTVPFTVPT TTLPGLPASR DLCSPSQLTC GSGECLPVER 

      2470       2480       2490       2500       2510       2520 
RCDLQLDCQD GSDENGCVDC GLAPWSGWSS CSRSCGLGLA FQRRELLRPP LPGGSCPPDR 

      2530       2540       2550       2560       2570       2580 
LRSQPCFVQA CPVAGAWAEW EAWGPCSVSC GGGHRSRRRS CMDPPPKNGG APCPGPPQER 

      2590       2600       2610       2620       2630       2640 
APCGLQPCAG GTDCGQGRVH VSAELCRKGL VPPCPPSCLD PEANRSCSGL CLEGCRCPPG 

      2650       2660       2670       2680       2690       2700 
LLLQDAGCLP LSECPCLVGE ELQQPGVPFL LDNCSRCVCE KGALLCEPGG CPVPCGWSAW 

      2710       2720       2730       2740       2750       2760 
SSWGPCDRSC GSGLRARFRS PSNPPAASGG APCEGQRQEL QACYSACGAE VPGWTPWAPW 

      2770       2780       2790       2800       2810       2820 
SACSQSCLVP GGGPALRSRS RLCPGPGDTS CIGEATEEEP CSPPVCLGLG VWGQWAAWSA 

      2830       2840       2850       2860       2870       2880 
CSAPCNGGVQ TRGRRCSASA PGDPGCQGPH SQTRDCNTQP CTAQCPGDMV FRSAEQCRWE 

      2890       2900       2910       2920       2930       2940 
GGPCPGLCLA RGPGVECTGV CTAGCACPTG LFLHNSSCLP PSQCPCQLRG QLYAPGAVAR 

      2950       2960       2970       2980       2990       3000 
LDSCSNCTCI SGEMVCASEP CPVACGWSPW TPWSLCSRSC NVGVRRRFRA GTAPPAAFGG 

      3010       3020       3030       3040       3050       3060 
AACQGPNMEA EFCSLRPCGG PAGEWGPWSP CSVPCGGGYR NRTRGSSGPS PVDFSTCGLQ 

      3070       3080       3090       3100       3110       3120 
PCAGPAPGVC PPGKRWLDCA QGPASCAELS APRGADQPCH PGCYCPSGML LLNNACVPTQ 

      3130       3140       3150       3160       3170       3180 
DCPCTHGGRL HPPGSAVLRP CENCSCVSGL ITNCTSWPCK EGQPTWSPWT PWSECSASCG 

      3190       3200       3210       3220       3230       3240 
PARRHKHRFC TRPPGGAPSS MAPPLLLSSV PPLCPGPEAE EEPCLLPECD RAGGWGPWGP 

      3250       3260       3270       3280       3290       3300 
WSSCSRSCGG GLRSRSRACD QPPPQGLGDY CEGPRAQGAA CQALPCPVTN CTAIEGAEYS 

      3310       3320       3330       3340       3350       3360 
ACGPPCPRSC DDLVHCVWHC QPGCYCPPGQ VLSADGTVHV QPGHCSCLDL LTGERHRPGA 

      3370       3380       3390       3400       3410       3420 
QLAKPDGCNY CTCSEGQLTC TDLPCPVPGA WCPWSEWTAC SQPCQGQTRT RSRACSCPAP 

      3430       3440       3450       3460       3470       3480 
QHGGAPCPGE AGEAGAQHQR ETCASTPECP VDGAWSPWGP WSPCEVCLGR SHRSRECSWP 

      3490       3500       3510       3520       3530       3540 
PTSEGGRPCP GGHRQSRPCQ GNSTQCTDCA GGQDLLPCGQ PCPRSCEDLS PGVECQPDSM 

      3550       3560       3570       3580       3590       3600 
GCQQPRCGCP PGQLSQDGLC VTPSQCRCQY QPGAMGIPEN QSRSAGSGLS SWESLEPGEV 

      3610       3620       3630       3640       3650       3660 
VTGPCDNCTC VAGILQCQEV PACSGLGLWG SWGPWEDCSV SCGGGEQLRF RRCPRPPCPG 

      3670       3680       3690       3700       3710       3720 
PARQSRTCRT QVCREAGCPA GRLYRECQPS EGCPFSCAHV TGQVGCFSAG CEEGCHCPEG 

      3730       3740       3750       3760       3770       3780 
TFLHRSACVQ ECPCVLTALW LQGLGAAGAD PGAHLSVLGE NGQPLGPGDE LGSGQSLRTG 

      3790       3800       3810       3820       3830       3840 
CHNCSCAHGK LSCSVEACSK AAGGFSPWGP WGPCSRSCGG LGTRTRSRQC VRPMPAPGGQ 

      3850       3860       3870       3880       3890       3900 
GCHGPHWDLE YCPSPECPGA AGSTAEPATG LPGGWGLWSP WSPCSGTCTD PAHPAWRSRS 

      3910       3920       3930       3940       3950       3960 
RLCLANCTGG AASQERPCNL PSCTELPLCP GPGCEAGNCS WTAWAPWEPC SRSCGVGQQR 

      3970       3980       3990       4000       4010       4020 
RLRAYHPPGP GGHWCPDVLT AYQERRFCNL RACPVPGGWS RWSPWSWCDR SCGGGRSLRS 

      4030       4040       4050       4060       4070       4080 
RSCSSPPPKN GGAPCVGERH HARLCNPTPC EEGCPAGMEV VSCANRCPRR CSDLQEGIVC 

      4090       4100       4110       4120       4130       4140 
QEDQACQQGC RCPEGSLEQD GGCVPLGHCE CTDAQGHSWA PGSQHQEACN NCTCRAGQLS 

      4150       4160       4170       4180       4190       4200 
CTAQPCPPPA HCAWSRWSAW SPCSRSCGPA GQQSRFRSST SGSWAPECRE EQSQSQPCPQ 

      4210       4220       4230       4240       4250       4260 
SPCPPLCLQG TRPRSLGDSW LQDGCQQCSC TPEGIICEDA ECAGLGAWTP WSPWSDCPVS 

      4270       4280       4290       4300       4310       4320 
CGGGNQVRTR VCVASAPPRG GSPCLGPDVQ SQRCGLWPCP ALPDTCSWGP WGPCSRSCGP 

      4330       4340       4350       4360       4370       4380 
GLASRSASCP CLLAEAEPAC NSTSPRLDTQ ACYAGPCLEE CVWSSWSSWT RCSCEVLVQQ 

      4390       4400       4410       4420       4430       4440 
RYRHQRPAPG GAGAGPPCTR LDGHFRPCLT GNCSEDSCAP PFEFQACGSP CTGLCATYLS 

      4450       4460       4470       4480       4490       4500 
PWLCQDLPPC QPGCYCPEGL LEQAGGCVPP EQCNCQHVSG EGAGVTLAPG DRLQLGCKEC 

      4510       4520       4530       4540       4550       4560 
ECQRGELQCT SQGCQGLLPL SGWSEWSPCG PCLPLGLLAP ASRAALEERW PQDTAGLSPT 

      4570       4580       4590       4600       4610       4620 
SAPTLASEQH RHRLCLDPET GRPWAGDPDL CTVPLSQQRL CPDPGACQDL CQWGPWGAWS 

      4630       4640       4650       4660       4670       4680 
PCQVPCSGGF RLRWREAGIP PGGGCRGPWA QTESCNMGPC PGESCEAQDT VPTPDCANQC 

      4690       4700       4710       4720       4730       4740 
PRSCVDLWDR VECLQGPCRP GCRCPPGQLV QDGHCVPVSS CRCGLPSPNA SWALAPAEVV 

      4750       4760       4770       4780       4790       4800 
RLDCRNCTCV NGSLACSSHE CPTLGPWSAW SNCSAPCGGG TTKRHRSCKE GPGVTPCQAQ 

      4810       4820       4830       4840       4850       4860 
DMEQQQDCNL QPCPECPPGQ VLSACAVSCP RLCSHLQPGT PCMQEPCQLG CDCPRGQLLH 

      4870       4880       4890       4900       4910       4920 
NGTCVPPAEC PCTQLSLPWG LTLTLEEQHR ELPPGTLLTQ NCTHCICQGG AFSCSLTDCQ 

      4930       4940       4950       4960       4970       4980 
ECPPGETWQQ VAPGELGPCE QTCREPNATE TQGNCSGRQA PGCVCQRGHF RSQEGPCVPV 

      4990       5000       5010       5020       5030       5040 
DLCECWHHGR PHPPGSEWQK ACESCRCVSG ESICTQHCPP LTCAQGETAV QEPGGCCPTC 

      5050       5060       5070       5080       5090       5100 
RQEAPEEQPV SCRHLTELRN LTKGACYLEQ VEVNYCSGHC PSSTNVLPEE PYLQSQCDCC 

      5110       5120       5130       5140 
SYRLDPENPV RILNLRCPGG RTELVVLPVI HSCQCSACQG GDFSER 

« Hide

References

[1]"Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth."
Gobron S.
Glia 32:177-191(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Subcommissural organ.
[2]"SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation."
Gobron S., Monnerie H., Meiniel R., Creveaux I., Lehmann W., Lamalle D., Dastugue B., Meiniel A.
J. Cell Sci. 109:1053-1061(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1719-2585.
Tissue: Ependymocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ416457 mRNA. Translation: CAC94914.1.
X93922 mRNA. Translation: CAA63815.1.
RefSeqNP_777131.1. NM_174706.2.
UniGeneBt.4812.

3D structure databases

ProteinModelPortalP98167.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP98167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282659.
KEGGbta:282659.

Organism-specific databases

CTD23145.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000154433.
HOVERGENHBG080794.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
4.10.400.10. 8 hits.
InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR001545. Gonadotropin_bsu.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Prot_inh_PMP.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 13 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00231. FA58C. 1 hit.
SM00068. GHB. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 9 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 24 hits.
PROSITEPS01225. CTCK_2. 1 hit.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 7 hits.
PS50068. LDLRA_2. 9 hits.
PS50092. TSP1. 25 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806337.

Entry information

Entry nameSSPO_BOVIN
AccessionPrimary (citable) accession number: P98167
Secondary accession number(s): Q8SPM4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families