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Protein

Very low-density lipoprotein receptor

Gene

VLDLR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-GGA-8866376 Reelin signalling pathway
R-GGA-8866427 VLDLR internalisation and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Very low-density lipoprotein receptor
Short name:
VLDL receptor
Short name:
VLDL-R
Alternative name(s):
Vitellogenin receptor
Short name:
VTG receptor
Gene namesi
Name:VLDLR
Synonyms:VTGR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 785ExtracellularSequence analysisAdd BLAST742
Transmembranei786 – 809HelicalSequence analysisAdd BLAST24
Topological domaini810 – 863CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Coated pit, Membrane, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000001734244 – 863Very low-density lipoprotein receptorAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 63By similarity
Disulfide bondi58 ↔ 76By similarity
Disulfide bondi70 ↔ 85By similarity
Disulfide bondi90 ↔ 102By similarity
Disulfide bondi97 ↔ 115By similarity
Disulfide bondi109 ↔ 126By similarity
Disulfide bondi131 ↔ 145By similarity
Disulfide bondi138 ↔ 158By similarity
Disulfide bondi152 ↔ 167By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 184By similarity
Disulfide bondi179 ↔ 197By similarity
Disulfide bondi191 ↔ 206By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi218 ↔ 236By similarity
Disulfide bondi230 ↔ 247By similarity
Disulfide bondi257 ↔ 269By similarity
Disulfide bondi264 ↔ 282By similarity
Disulfide bondi276 ↔ 291By similarity
Disulfide bondi296 ↔ 308By similarity
Disulfide bondi303 ↔ 321By similarity
Disulfide bondi315 ↔ 330By similarity
Disulfide bondi336 ↔ 349By similarity
Disulfide bondi344 ↔ 362By similarity
Disulfide bondi356 ↔ 373By similarity
Disulfide bondi378 ↔ 389By similarity
Disulfide bondi385 ↔ 398By similarity
Disulfide bondi400 ↔ 412By similarity
Disulfide bondi418 ↔ 428By similarity
Disulfide bondi424 ↔ 437By similarity
Disulfide bondi439 ↔ 452By similarity
Disulfide bondi726 ↔ 739By similarity
Disulfide bondi735 ↔ 754By similarity
Disulfide bondi756 ↔ 769By similarity
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98165

Expressioni

Tissue specificityi

Abundant in oocytes; much less in heart and skeletal muscle.

Gene expression databases

ExpressionAtlasiP98165 baseline and differential

Interactioni

Subunit structurei

Binds to the extracellular matrix protein Reelin. Interacts with LDLRAP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676418, 2 interactors
STRINGi9031.ENSGALP00000016512

Structurei

3D structure databases

ProteinModelPortaliP98165
SMRiP98165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 87LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini88 – 128LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 169LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST41
Domaini170 – 208LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini209 – 249LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST41
Domaini255 – 293LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini294 – 332LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini334 – 373LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST40
Domaini374 – 413EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini414 – 453EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Repeati457 – 498LDL-receptor class B 1Add BLAST42
Repeati499 – 544LDL-receptor class B 2Add BLAST46
Repeati545 – 587LDL-receptor class B 3Add BLAST43
Repeati588 – 631LDL-receptor class B 4Add BLAST44
Repeati632 – 674LDL-receptor class B 5Add BLAST43
Repeati675 – 717LDL-receptor class B 6Add BLAST43
Domaini722 – 770EGF-like 3PROSITE-ProRule annotationAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi822 – 827Endocytosis signalSequence analysis6

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA
GeneTreeiENSGT00760000118968
HOGENOMiHOG000115656
HOVERGENiHBG006250
InParanoidiP98165
KOiK20053
PhylomeDBiP98165

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR
PANTHERiPTHR43966:SF6 PTHR43966:SF6, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits
SUPFAMiSSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSRQRGDR SAATGGGCGA RRWALPRCGA LCLLLALGCL RTATDGAKAK
60 70 80 90 100
CEESQFQCSN GRCIPLLWKC DGDEDCSDGS DESACVKKTC AESDFVCNSG
110 120 130 140 150
QCVPNRWQCD GDPDCEDGSD ESAELCHMRT CRVNEISCGP QSTQCIPVSW
160 170 180 190 200
KCDGEKDCDS GEDEENCGNV TCSAAEFTCS SGQCISKSFV CNGQDDCSDG
210 220 230 240 250
SDELECAPPT CGVHEFQCKS STCIPISWVC DDDADCSDHS DESLEQCGRQ
260 270 280 290 300
PAPPVKCSTS EVQCGSGECI HKKWRCDGDP DCKDGSDEIN CPSRTCRPDQ
310 320 330 340 350
FRCEDGNCIH GSRQCNGVRD CLDGTDEANC NNVIQCSGPG KFKCRSGECI
360 370 380 390 400
DINKVCNHHG DCKDWSDEPL KECNINECLV NNGGCSHICR DLVIGYECDC
410 420 430 440 450
PAGFELVDRR TCGDIDECQN PGICSQICIN LKGGYKCECS RGYQMDLATG
460 470 480 490 500
VCKAVGKEPC LIFTNRRDIR KIGLERKEYI QLVEQLRNTV ALDADIAEQK
510 520 530 540 550
LYWADFSQKA IFSASIDTRD KVGTHTRILD NIHSPAGIAV DWIYKNIYWT
560 570 580 590 600
DSSAKTISVA SLNGKKRKVL FLSELREPAS IAVDPLSGFM YWSDWGEPAK
610 620 630 640 650
IEKAGMNGFD RQQLVTTEIQ WPNGIALDLV KSRLYWLDSK LHMLSSVDLN
660 670 680 690 700
GQDRRLVLKS HMFLPHPLAL TIFEDRVFWI DGENEAVYGA NKFTGAELVT
710 720 730 740 750
LVNNLNDAQD IIVYHELVQP SGRNWCEENM VNGGCSYLCL PAPQINEHSP
760 770 780 790 800
KYTCTCPAGY FLQEDGLRCG GFNISSVVSE VAARGAAGAW AVLPILLLVT
810 820 830 840 850
AALAGYFMWR NWQHKNMKSM NFDNPVYLKT TEEDLTIDIG RHSGSVGHTY
860
PAISVVSTDD DML
Length:863
Mass (Da):94,905
Last modified:October 1, 1996 - v1
Checksum:i0672A8748F9A2245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80207 mRNA Translation: CAA56505.1
PIRiS51789
RefSeqiNP_990560.1, NM_205229.1
UniGeneiGga.679

Genome annotation databases

EnsembliENSGALT00000016531; ENSGALP00000016512; ENSGALG00000010166
GeneIDi396154
KEGGigga:396154

Similar proteinsi

Entry informationi

Entry nameiVLDLR_CHICK
AccessioniPrimary (citable) accession number: P98165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health