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P98156

- VLDLR_MOUSE

UniProt

P98156 - VLDLR_MOUSE

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Protein

Very low-density lipoprotein receptor

Gene

Vldlr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. glycoprotein transporter activity Source: Ensembl
  3. reelin receptor activity Source: BHF-UCL
  4. very-low-density lipoprotein particle binding Source: Ensembl
  5. very-low-density lipoprotein particle receptor activity Source: BHF-UCL

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB-KW
  2. lipid transport Source: UniProtKB-KW
  3. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  4. positive regulation of dendrite development Source: BHF-UCL
  5. positive regulation of protein kinase activity Source: MGI
  6. reelin-mediated signaling pathway Source: BHF-UCL
  7. ventral spinal cord development Source: UniProtKB
  8. very-low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Very low-density lipoprotein receptor
Short name:
VLDL receptor
Short name:
VLDL-R
Gene namesi
Name:Vldlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:98935. Vldlr.

Subcellular locationi

GO - Cellular componenti

  1. coated pit Source: UniProtKB-KW
  2. extracellular space Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. receptor complex Source: MGI
  6. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 873846Very low-density lipoprotein receptorPRO_0000017344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 45By similarity
Disulfide bondi40 ↔ 58By similarity
Disulfide bondi52 ↔ 67By similarity
Disulfide bondi72 ↔ 84By similarity
Disulfide bondi79 ↔ 97By similarity
Disulfide bondi91 ↔ 108By similarity
Disulfide bondi113 ↔ 127By similarity
Disulfide bondi120 ↔ 140By similarity
Disulfide bondi134 ↔ 149By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 166By similarity
Disulfide bondi161 ↔ 179By similarity
Disulfide bondi173 ↔ 188By similarity
Disulfide bondi193 ↔ 205By similarity
Disulfide bondi200 ↔ 218By similarity
Disulfide bondi212 ↔ 229By similarity
Disulfide bondi239 ↔ 251By similarity
Disulfide bondi246 ↔ 264By similarity
Disulfide bondi258 ↔ 273By similarity
Disulfide bondi278 ↔ 290By similarity
Disulfide bondi285 ↔ 303By similarity
Disulfide bondi297 ↔ 312By similarity
Disulfide bondi318 ↔ 331By similarity
Disulfide bondi326 ↔ 344By similarity
Disulfide bondi338 ↔ 355By similarity
Disulfide bondi360 ↔ 371By similarity
Disulfide bondi367 ↔ 380By similarity
Disulfide bondi382 ↔ 394By similarity
Disulfide bondi400 ↔ 410By similarity
Disulfide bondi406 ↔ 419By similarity
Disulfide bondi421 ↔ 434By similarity
Disulfide bondi706 ↔ 719By similarity
Disulfide bondi715 ↔ 734By similarity
Disulfide bondi736 ↔ 749By similarity
Glycosylationi765 – 7651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi781 – 7811N-linked (GlcNAc...)Sequence Analysis
Cross-linki839 – 839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated at Lys-839 by MYLIP leading to degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP98156.
PaxDbiP98156.
PRIDEiP98156.

Expressioni

Tissue specificityi

Abundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue.

Gene expression databases

BgeeiP98156.
CleanExiMM_VLDLR.
ExpressionAtlasiP98156. baseline and differential.
GenevestigatoriP98156.

Interactioni

Subunit structurei

Binds to the extracellular matrix protein Reelin. Interacts with DAB1. Interacts with VLDLR. Interacts with SNX17. Interacts with PCSK9 By similarity.By similarity

Protein-protein interaction databases

BioGridi204529. 3 interactions.
DIPiDIP-33283N.
IntActiP98156. 2 interactions.
MINTiMINT-4140012.

Structurei

3D structure databases

ProteinModelPortaliP98156.
SMRiP98156. Positions 21-789.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 797770ExtracellularSequence AnalysisAdd
BLAST
Topological domaini820 – 87354CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei798 – 81922HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6939LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini70 – 11041LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 15141LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST
Domaini152 – 19039LDL-receptor class A 4PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 23141LDL-receptor class A 5PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 27539LDL-receptor class A 6PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 31439LDL-receptor class A 7PROSITE-ProRule annotationAdd
BLAST
Domaini316 – 35540LDL-receptor class A 8PROSITE-ProRule annotationAdd
BLAST
Domaini356 – 39136EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini396 – 43136EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Repeati439 – 48042LDL-receptor class B 1Add
BLAST
Repeati481 – 52444LDL-receptor class B 2Add
BLAST
Repeati525 – 56743LDL-receptor class B 3Add
BLAST
Repeati568 – 61144LDL-receptor class B 4Add
BLAST
Repeati612 – 65443LDL-receptor class B 5Add
BLAST
Repeati655 – 69743LDL-receptor class B 6Add
BLAST
Domaini702 – 75049EGF-like 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni751 – 79040Clustered O-linked oligosaccharidesAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi832 – 8376Endocytosis signalSequence Analysis

Sequence similaritiesi

Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 8 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 6 LDL-receptor class B repeats.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255913.
GeneTreeiENSGT00760000118968.
HOGENOMiHOG000115656.
HOVERGENiHBG006250.
InParanoidiP98156.
OMAiMGTSARW.
PhylomeDBiP98156.
TreeFamiTF351700.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCAD GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRINEISC GARSTQCIPV SWRCDGENDC DNGEDEENCG
160 170 180 190 200
NITCSADEFT CSSGRCVSRN FVCNGQDDCD DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPLSW VCDDDADCSD QSDESLEQCG RQPVIHTKCP TSEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDMSKVCDQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHFKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGAKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTEDIQ
610 620 630 640 650
WPNGITLDLV KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEDDM ENGGCEYLCL PAPQINDHSP KYTCSCPNGY NLEENGRECQ
760 770 780 790 800
STSTPVTYSE TKDINTTDIL RTSGLVPGGI NVTTAVSEVS VPPKGTSAAW
810 820 830 840 850
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG
860 870
RHSASVGHTY PAISVVSTDD DLA
Length:873
Mass (Da):96,373
Last modified:October 1, 1996 - v1
Checksum:i08F09F93825195CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611C → G in AAC37668. (PubMed:7925422)Curated
Sequence conflicti262 – 2621P → L in AAB32228. (PubMed:7919660)Curated
Sequence conflicti297 – 2971C → S in AAA59384. (PubMed:8013374)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33417 mRNA. Translation: AAC37668.1.
U06670 mRNA. Translation: AAA59384.1.
S73732 Genomic DNA. Translation: AAB32228.2.
CCDSiCCDS29721.1.
PIRiI48952.
RefSeqiNP_001154892.1. NM_001161420.1.
NP_038731.2. NM_013703.2.
XP_006526980.1. XM_006526917.1.
XP_006526981.1. XM_006526918.1.
UniGeneiMm.4141.

Genome annotation databases

EnsembliENSMUST00000167487; ENSMUSP00000127329; ENSMUSG00000024924.
GeneIDi22359.
KEGGimmu:22359.
UCSCiuc008hbt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33417 mRNA. Translation: AAC37668.1 .
U06670 mRNA. Translation: AAA59384.1 .
S73732 Genomic DNA. Translation: AAB32228.2 .
CCDSi CCDS29721.1.
PIRi I48952.
RefSeqi NP_001154892.1. NM_001161420.1.
NP_038731.2. NM_013703.2.
XP_006526980.1. XM_006526917.1.
XP_006526981.1. XM_006526918.1.
UniGenei Mm.4141.

3D structure databases

ProteinModelPortali P98156.
SMRi P98156. Positions 21-789.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204529. 3 interactions.
DIPi DIP-33283N.
IntActi P98156. 2 interactions.
MINTi MINT-4140012.

Proteomic databases

MaxQBi P98156.
PaxDbi P98156.
PRIDEi P98156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167487 ; ENSMUSP00000127329 ; ENSMUSG00000024924 .
GeneIDi 22359.
KEGGi mmu:22359.
UCSCi uc008hbt.2. mouse.

Organism-specific databases

CTDi 7436.
MGIi MGI:98935. Vldlr.

Phylogenomic databases

eggNOGi NOG255913.
GeneTreei ENSGT00760000118968.
HOGENOMi HOG000115656.
HOVERGENi HBG006250.
InParanoidi P98156.
OMAi MGTSARW.
PhylomeDBi P98156.
TreeFami TF351700.

Miscellaneous databases

NextBioi 302661.
PROi P98156.
SOURCEi Search...

Gene expression databases

Bgeei P98156.
CleanExi MM_VLDLR.
ExpressionAtlasi P98156. baseline and differential.
Genevestigatori P98156.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor."
    Oka K., Ishimura-Oka K., Chu M.J., Sullivan M., Krushkal J., Li W.H., Chan L.
    Eur. J. Biochem. 224:975-982(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Heart.
  2. "Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19."
    Gafvels M.E., Paavola L.G., Boyd C.O., Nolan P.M., Wittmaack F., Chawla A., Lazar M.A., Bucan M., Angelin B.O., Strauss J.F.
    Endocrinology 135:387-394(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The mouse very low density lipoprotein receptor (Vldlr) gene maps to chromosome 19."
    Naggert J.K., Mu J.L.
    Mamm. Genome 5:453-455(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-262.
  4. "Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation."
    Hiesberger T., Trommsdorff M., Howell B.W., Goffinet A.M., Mumby M.C., Cooper J.A., Herz J.
    Neuron 24:481-489(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REELIN.
  5. "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor."
    Stockinger W., Sailler B., Strasser V., Recheis B., Fasching D., Kahr L., Schneider W.J., Nimpf J.
    EMBO J. 21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX17.
  6. "Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia."
    Jones C., Hammer R.E., Li W.-P., Cohen J.C., Hobbs H.H., Herz J.
    J. Biol. Chem. 278:29024-29030(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDLRAP1.
  7. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
    Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
    J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.

Entry informationi

Entry nameiVLDLR_MOUSE
AccessioniPrimary (citable) accession number: P98156
Secondary accession number(s): Q64022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in "reeler" and "scrambler" mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3