SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P98156

- VLDLR_MOUSE

UniProt

P98156 - VLDLR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Very low-density lipoprotein receptor
Gene
Vldlr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. glycoprotein transporter activity Source: Ensembl
  3. protein binding Source: MGI
  4. reelin receptor activity Source: BHF-UCL
  5. very-low-density lipoprotein particle binding Source: Ensembl
  6. very-low-density lipoprotein particle receptor activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB-KW
  2. lipid transport Source: UniProtKB-KW
  3. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  4. positive regulation of dendrite development Source: BHF-UCL
  5. positive regulation of protein kinase activity Source: MGI
  6. reelin-mediated signaling pathway Source: BHF-UCL
  7. ventral spinal cord development Source: UniProtKB
  8. very-low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Very low-density lipoprotein receptor
Short name:
VLDL receptor
Short name:
VLDL-R
Gene namesi
Name:Vldlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:98935. Vldlr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 797770Extracellular Reviewed prediction
Add
BLAST
Transmembranei798 – 81922Helical; Reviewed prediction
Add
BLAST
Topological domaini820 – 87354Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. coated pit Source: UniProtKB-SubCell
  2. extracellular space Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. receptor complex Source: MGI
  6. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 873846Very low-density lipoprotein receptor
PRO_0000017344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 45 By similarity
Disulfide bondi40 ↔ 58 By similarity
Disulfide bondi52 ↔ 67 By similarity
Disulfide bondi72 ↔ 84 By similarity
Disulfide bondi79 ↔ 97 By similarity
Disulfide bondi91 ↔ 108 By similarity
Disulfide bondi113 ↔ 127 By similarity
Disulfide bondi120 ↔ 140 By similarity
Disulfide bondi134 ↔ 149 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi154 ↔ 166 By similarity
Disulfide bondi161 ↔ 179 By similarity
Disulfide bondi173 ↔ 188 By similarity
Disulfide bondi193 ↔ 205 By similarity
Disulfide bondi200 ↔ 218 By similarity
Disulfide bondi212 ↔ 229 By similarity
Disulfide bondi239 ↔ 251 By similarity
Disulfide bondi246 ↔ 264 By similarity
Disulfide bondi258 ↔ 273 By similarity
Disulfide bondi278 ↔ 290 By similarity
Disulfide bondi285 ↔ 303 By similarity
Disulfide bondi297 ↔ 312 By similarity
Disulfide bondi318 ↔ 331 By similarity
Disulfide bondi326 ↔ 344 By similarity
Disulfide bondi338 ↔ 355 By similarity
Disulfide bondi360 ↔ 371 By similarity
Disulfide bondi367 ↔ 380 By similarity
Disulfide bondi382 ↔ 394 By similarity
Disulfide bondi400 ↔ 410 By similarity
Disulfide bondi406 ↔ 419 By similarity
Disulfide bondi421 ↔ 434 By similarity
Disulfide bondi706 ↔ 719 By similarity
Disulfide bondi715 ↔ 734 By similarity
Disulfide bondi736 ↔ 749 By similarity
Glycosylationi765 – 7651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi781 – 7811N-linked (GlcNAc...) Reviewed prediction
Cross-linki839 – 839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Post-translational modificationi

Ubiquitinated at Lys-839 by MYLIP leading to degradation By similarity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP98156.
PaxDbiP98156.
PRIDEiP98156.

Expressioni

Tissue specificityi

Abundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue.

Gene expression databases

ArrayExpressiP98156.
BgeeiP98156.
CleanExiMM_VLDLR.
GenevestigatoriP98156.

Interactioni

Subunit structurei

Binds to the extracellular matrix protein Reelin. Interacts with DAB1. Interacts with VLDLR. Interacts with SNX17. Interacts with PCSK9 By similarity.3 Publications

Protein-protein interaction databases

BioGridi204529. 3 interactions.
DIPiDIP-33283N.
IntActiP98156. 2 interactions.
MINTiMINT-4140012.

Structurei

3D structure databases

ProteinModelPortaliP98156.
SMRiP98156. Positions 21-789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6939LDL-receptor class A 1
Add
BLAST
Domaini70 – 11041LDL-receptor class A 2
Add
BLAST
Domaini111 – 15141LDL-receptor class A 3
Add
BLAST
Domaini152 – 19039LDL-receptor class A 4
Add
BLAST
Domaini191 – 23141LDL-receptor class A 5
Add
BLAST
Domaini237 – 27539LDL-receptor class A 6
Add
BLAST
Domaini276 – 31439LDL-receptor class A 7
Add
BLAST
Domaini316 – 35540LDL-receptor class A 8
Add
BLAST
Domaini356 – 39136EGF-like 1
Add
BLAST
Domaini396 – 43136EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Repeati439 – 48042LDL-receptor class B 1
Add
BLAST
Repeati481 – 52444LDL-receptor class B 2
Add
BLAST
Repeati525 – 56743LDL-receptor class B 3
Add
BLAST
Repeati568 – 61144LDL-receptor class B 4
Add
BLAST
Repeati612 – 65443LDL-receptor class B 5
Add
BLAST
Repeati655 – 69743LDL-receptor class B 6
Add
BLAST
Domaini702 – 75049EGF-like 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni751 – 79040Clustered O-linked oligosaccharides
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi832 – 8376Endocytosis signal Reviewed prediction

Sequence similaritiesi

Contains 3 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255913.
GeneTreeiENSGT00740000114992.
HOGENOMiHOG000115656.
HOVERGENiHBG006250.
InParanoidiP98156.
OMAiMGTSARW.
PhylomeDBiP98156.
TreeFamiTF351700.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98156-1 [UniParc]FASTAAdd to Basket

« Hide

MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW    50
KCDGDEDCAD GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG 100
SDESPEQCHM RTCRINEISC GARSTQCIPV SWRCDGENDC DNGEDEENCG 150
NITCSADEFT CSSGRCVSRN FVCNGQDDCD DGSDELDCAP PTCGAHEFQC 200
STSSCIPLSW VCDDDADCSD QSDESLEQCG RQPVIHTKCP TSEIQCGSGE 250
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI 300
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDMSKVCDQ EQDCRDWSDE 350
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC 400
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD 450
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD 500
KVGRHFKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGAKRKFL 550
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTEDIQ 600
WPNGITLDLV KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL 650
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP 700
SGKNWCEDDM ENGGCEYLCL PAPQINDHSP KYTCSCPNGY NLEENGRECQ 750
STSTPVTYSE TKDINTTDIL RTSGLVPGGI NVTTAVSEVS VPPKGTSAAW 800
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG 850
RHSASVGHTY PAISVVSTDD DLA 873
Length:873
Mass (Da):96,373
Last modified:October 1, 1996 - v1
Checksum:i08F09F93825195CB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611C → G in AAC37668. 1 Publication
Sequence conflicti262 – 2621P → L in AAB32228. 1 Publication
Sequence conflicti297 – 2971C → S in AAA59384. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33417 mRNA. Translation: AAC37668.1.
U06670 mRNA. Translation: AAA59384.1.
S73732 Genomic DNA. Translation: AAB32228.2.
CCDSiCCDS29721.1.
PIRiI48952.
RefSeqiNP_001154892.1. NM_001161420.1.
NP_038731.2. NM_013703.2.
XP_006526980.1. XM_006526917.1.
XP_006526981.1. XM_006526918.1.
UniGeneiMm.4141.

Genome annotation databases

EnsembliENSMUST00000167487; ENSMUSP00000127329; ENSMUSG00000024924.
GeneIDi22359.
KEGGimmu:22359.
UCSCiuc008hbt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33417 mRNA. Translation: AAC37668.1 .
U06670 mRNA. Translation: AAA59384.1 .
S73732 Genomic DNA. Translation: AAB32228.2 .
CCDSi CCDS29721.1.
PIRi I48952.
RefSeqi NP_001154892.1. NM_001161420.1.
NP_038731.2. NM_013703.2.
XP_006526980.1. XM_006526917.1.
XP_006526981.1. XM_006526918.1.
UniGenei Mm.4141.

3D structure databases

ProteinModelPortali P98156.
SMRi P98156. Positions 21-789.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204529. 3 interactions.
DIPi DIP-33283N.
IntActi P98156. 2 interactions.
MINTi MINT-4140012.

Proteomic databases

MaxQBi P98156.
PaxDbi P98156.
PRIDEi P98156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167487 ; ENSMUSP00000127329 ; ENSMUSG00000024924 .
GeneIDi 22359.
KEGGi mmu:22359.
UCSCi uc008hbt.2. mouse.

Organism-specific databases

CTDi 7436.
MGIi MGI:98935. Vldlr.

Phylogenomic databases

eggNOGi NOG255913.
GeneTreei ENSGT00740000114992.
HOGENOMi HOG000115656.
HOVERGENi HBG006250.
InParanoidi P98156.
OMAi MGTSARW.
PhylomeDBi P98156.
TreeFami TF351700.

Miscellaneous databases

NextBioi 302661.
PROi P98156.
SOURCEi Search...

Gene expression databases

ArrayExpressi P98156.
Bgeei P98156.
CleanExi MM_VLDLR.
Genevestigatori P98156.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 8 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor."
    Oka K., Ishimura-Oka K., Chu M.J., Sullivan M., Krushkal J., Li W.H., Chan L.
    Eur. J. Biochem. 224:975-982(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Heart.
  2. "Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19."
    Gafvels M.E., Paavola L.G., Boyd C.O., Nolan P.M., Wittmaack F., Chawla A., Lazar M.A., Bucan M., Angelin B.O., Strauss J.F.
    Endocrinology 135:387-394(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The mouse very low density lipoprotein receptor (Vldlr) gene maps to chromosome 19."
    Naggert J.K., Mu J.L.
    Mamm. Genome 5:453-455(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-262.
  4. "Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation."
    Hiesberger T., Trommsdorff M., Howell B.W., Goffinet A.M., Mumby M.C., Cooper J.A., Herz J.
    Neuron 24:481-489(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REELIN.
  5. "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor."
    Stockinger W., Sailler B., Strasser V., Recheis B., Fasching D., Kahr L., Schneider W.J., Nimpf J.
    EMBO J. 21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX17.
  6. "Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia."
    Jones C., Hammer R.E., Li W.-P., Cohen J.C., Hobbs H.H., Herz J.
    J. Biol. Chem. 278:29024-29030(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDLRAP1.
  7. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
    Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
    J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.

Entry informationi

Entry nameiVLDLR_MOUSE
AccessioniPrimary (citable) accession number: P98156
Secondary accession number(s): Q64022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in "reeler" and "scrambler" mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi