UniProtKB - P98155 (VLDLR_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Very low-density lipoprotein receptor
Gene
VLDLR
Organism
Homo sapiens (Human)
Status
Functioni
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).By similarity
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- calcium-dependent protein binding Source: BHF-UCL
- calcium ion binding Source: InterPro
- glycoprotein transporter activity Source: BHF-UCL
- low-density lipoprotein particle receptor activity Source: ProtInc
- reelin receptor activity Source: BHF-UCL
- very-low-density lipoprotein particle binding Source: BHF-UCL
- very-low-density lipoprotein particle receptor activity Source: BHF-UCL
GO - Biological processi
- axon guidance Source: Reactome
- cholesterol metabolic process Source: UniProtKB-KW
- dendrite morphogenesis Source: Ensembl
- glycoprotein transport Source: BHF-UCL
- lipid transport Source: UniProtKB-KW
- low-density lipoprotein particle receptor catabolic process Source: Reactome
- memory Source: ProtInc
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- nervous system development Source: ProtInc
- positive regulation of dendrite development Source: BHF-UCL
- positive regulation of protein kinase activity Source: Ensembl
- receptor-mediated endocytosis Source: BHF-UCL
- reelin-mediated signaling pathway Source: BHF-UCL
- signal transduction Source: ProtInc
- ventral spinal cord development Source: Ensembl
- very-low-density lipoprotein particle clearance Source: BHF-UCL
Keywordsi
Molecular function | Receptor |
Biological process | Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Enzyme and pathway databases
Reactomei | R-HSA-8866376 Reelin signalling pathway R-HSA-8866427 VLDLR internalisation and degradation R-HSA-8964046 VLDL clearance |
SIGNORi | P98155 |
Names & Taxonomyi
Protein namesi | Recommended name: Very low-density lipoprotein receptorShort name: VLDL receptor Short name: VLDL-R |
Gene namesi | Name:VLDLR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147852.15 |
HGNCi | HGNC:12698 VLDLR |
MIMi | 192977 gene |
neXtProti | NX_P98155 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 797 | ExtracellularSequence analysisAdd BLAST | 770 | |
Transmembranei | 798 – 819 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 820 – 873 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Coated pit, Membrane, VLDLPathology & Biotechi
Involvement in diseasei
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures.
See also OMIM:224050Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 825 | K → R: Insensitive to MYLIP-triggered degradation; when associated with R-828 and R-839. 1 Publication | 1 | |
Mutagenesisi | 828 | K → R: Insensitive to MYLIP-triggered degradation; when associated with R-825 and R-839. 1 Publication | 1 | |
Mutagenesisi | 839 | K → R: Insensitive to MYLIP-triggered degradation. Insensitive to MYLIP-triggered degradation; when associated with R-825 and R-828. 1 Publication | 1 |
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 7436 |
GeneReviewsi | VLDLR |
MalaCardsi | VLDLR |
MIMi | 224050 phenotype |
OpenTargetsi | ENSG00000147852 |
Orphaneti | 1766 Dysequilibrium syndrome |
PharmGKBi | PA37317 |
Chemistry databases
DrugBanki | DB03017 Lauric Acid |
Polymorphism and mutation databases
BioMutai | VLDLR |
DMDMi | 1730111 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000017343 | 28 – 873 | Very low-density lipoprotein receptorAdd BLAST | 846 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 45 | By similarity | ||
Disulfide bondi | 40 ↔ 58 | By similarity | ||
Disulfide bondi | 52 ↔ 67 | By similarity | ||
Disulfide bondi | 72 ↔ 84 | By similarity | ||
Disulfide bondi | 79 ↔ 97 | By similarity | ||
Disulfide bondi | 91 ↔ 108 | By similarity | ||
Disulfide bondi | 113 ↔ 127 | |||
Disulfide bondi | 120 ↔ 140 | |||
Disulfide bondi | 134 ↔ 149 | |||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 154 ↔ 166 | By similarity | ||
Disulfide bondi | 161 ↔ 179 | By similarity | ||
Disulfide bondi | 173 ↔ 188 | By similarity | ||
Disulfide bondi | 193 ↔ 205 | By similarity | ||
Disulfide bondi | 200 ↔ 218 | By similarity | ||
Disulfide bondi | 212 ↔ 229 | By similarity | ||
Disulfide bondi | 239 ↔ 251 | By similarity | ||
Disulfide bondi | 246 ↔ 264 | By similarity | ||
Disulfide bondi | 258 ↔ 273 | By similarity | ||
Disulfide bondi | 278 ↔ 290 | By similarity | ||
Disulfide bondi | 285 ↔ 303 | By similarity | ||
Disulfide bondi | 297 ↔ 312 | By similarity | ||
Disulfide bondi | 318 ↔ 331 | By similarity | ||
Disulfide bondi | 326 ↔ 344 | By similarity | ||
Disulfide bondi | 338 ↔ 355 | By similarity | ||
Disulfide bondi | 360 ↔ 371 | By similarity | ||
Disulfide bondi | 367 ↔ 380 | By similarity | ||
Disulfide bondi | 382 ↔ 394 | By similarity | ||
Disulfide bondi | 400 ↔ 410 | By similarity | ||
Disulfide bondi | 406 ↔ 419 | By similarity | ||
Disulfide bondi | 421 ↔ 434 | By similarity | ||
Disulfide bondi | 706 ↔ 719 | By similarity | ||
Disulfide bondi | 715 ↔ 734 | By similarity | ||
Disulfide bondi | 736 ↔ 749 | By similarity | ||
Glycosylationi | 765 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 781 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 839 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Ubiquitinated at Lys-839 by MYLIP leading to degradation.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P98155 |
MaxQBi | P98155 |
PaxDbi | P98155 |
PeptideAtlasi | P98155 |
PRIDEi | P98155 |
PTM databases
iPTMneti | P98155 |
PhosphoSitePlusi | P98155 |
Expressioni
Tissue specificityi
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Gene expression databases
Bgeei | ENSG00000147852 |
CleanExi | HS_VLDLR |
ExpressionAtlasi | P98155 baseline and differential |
Genevisiblei | P98155 HS |
Organism-specific databases
HPAi | CAB032462 HPA051312 |
Interactioni
Subunit structurei
Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9.By similarity3 Publications
Binary interactionsi
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- calcium-dependent protein binding Source: BHF-UCL
- very-low-density lipoprotein particle binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 11327712 interactors. |
DIPi | DIP-40925N |
IntActi | P98155 5 interactors. |
STRINGi | 9606.ENSP00000371532 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Turni | 115 – 117 | Combined sources | 3 | |
Beta strandi | 121 – 125 | Combined sources | 5 | |
Beta strandi | 132 – 137 | Combined sources | 6 | |
Turni | 141 – 145 | Combined sources | 5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1V9U | X-ray | 3.60 | 5 | 111-151 | [»] | |
3DPR | X-ray | 3.50 | E | 113-151 | [»] | |
ProteinModelPortali | P98155 | |||||
SMRi | P98155 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P98155 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 69 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 70 – 110 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 111 – 151 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 152 – 190 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 191 – 231 | LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 237 – 275 | LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 276 – 314 | LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 316 – 355 | LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 356 – 395 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 396 – 435 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 439 – 480 | LDL-receptor class B 1Add BLAST | 42 | |
Repeati | 481 – 524 | LDL-receptor class B 2Add BLAST | 44 | |
Repeati | 525 – 567 | LDL-receptor class B 3Add BLAST | 43 | |
Repeati | 568 – 611 | LDL-receptor class B 4Add BLAST | 44 | |
Repeati | 612 – 654 | LDL-receptor class B 5Add BLAST | 43 | |
Repeati | 655 – 697 | LDL-receptor class B 6Add BLAST | 43 | |
Domaini | 702 – 750 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 751 – 790 | Clustered O-linked oligosaccharidesAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 832 – 837 | Endocytosis signalSequence analysis | 6 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IPT5 Eukaryota ENOG410YQ6J LUCA |
GeneTreei | ENSGT00760000118968 |
HOGENOMi | HOG000115656 |
HOVERGENi | HBG006250 |
InParanoidi | P98155 |
KOi | K20053 |
OMAi | HTKCPAS |
OrthoDBi | EOG091G01MX |
PhylomeDBi | P98155 |
TreeFami | TF351700 |
Family and domain databases
CDDi | cd00112 LDLa, 8 hits |
Gene3Di | 2.120.10.301 hit |
InterProi | View protein in InterPro IPR011042 6-blade_b-propeller_TolB-like IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR000033 LDLR_classB_rpt IPR002172 LDrepeatLR_classA_rpt IPR032931 VLDLR |
PANTHERi | PTHR43966:SF6 PTHR43966:SF6, 1 hit |
Pfami | View protein in Pfam PF07645 EGF_CA, 1 hit PF00057 Ldl_recept_a, 8 hits PF00058 Ldl_recept_b, 5 hits |
PRINTSi | PR00261 LDLRECEPTOR |
SMARTi | View protein in SMART SM00181 EGF, 6 hits SM00179 EGF_CA, 2 hits SM00192 LDLa, 8 hits SM00135 LY, 5 hits |
SUPFAMi | SSF57424 SSF57424, 8 hits |
PROSITEi | View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS01186 EGF_2, 3 hits PS50026 EGF_3, 2 hits PS01187 EGF_CA, 1 hit PS01209 LDLRA_1, 8 hits PS50068 LDLRA_2, 8 hits PS51120 LDLRB, 5 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform Long (identifier: P98155-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGTSALWALW LLLALCWAPR ESGATGTGRK AKCEPSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCVD GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRIHEISC GAHSTQCIPV SWRCDGENDC DSGEDEENCG
160 170 180 190 200
NITCSPDEFT CSSGRCISRN FVCNGQDDCS DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP ASEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDISKVCNQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTADIQ
610 620 630 640 650
WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPSGY NVEENGRDCQ
760 770 780 790 800
STATTVTYSE TKDTNTTEIS ATSGLVPGGI NVTTAVSEVS VPPKGTSAAW
810 820 830 840 850
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG
860 870
RHSASVGHTY PAISVVSTDD DLA
Isoform Short (identifier: P98155-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
751-779: STATTVTYSETKDTNTTEISATSGLVPGG → R
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | L → V in AAA53684 (PubMed:8128315).Curated | 1 | |
Sequence conflicti | 13 | L → V in AAA61344 (PubMed:8020981).Curated | 1 | |
Sequence conflicti | 424 | G → A in AAA53684 (PubMed:8128315).Curated | 1 | |
Sequence conflicti | 678 | L → H in AAA53684 (PubMed:8128315).Curated | 1 | |
Sequence conflicti | 766 | T → S in AAA61344 (PubMed:8020981).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011865 | 59 | V → I2 PublicationsCorresponds to variant dbSNP:rs6149Ensembl. | 1 | |
Natural variantiVAR_025063 | 262 | P → H1 PublicationCorresponds to variant dbSNP:rs34761707Ensembl. | 1 | |
Natural variantiVAR_011866 | 379 | E → K1 PublicationCorresponds to variant dbSNP:rs6146Ensembl. | 1 | |
Natural variantiVAR_025064 | 464 | L → I1 PublicationCorresponds to variant dbSNP:rs34753566Ensembl. | 1 | |
Natural variantiVAR_025065 | 561 | I → V1 PublicationCorresponds to variant dbSNP:rs35724190Ensembl. | 1 | |
Natural variantiVAR_025066 | 613 | R → H1 PublicationCorresponds to variant dbSNP:rs35948251Ensembl. | 1 | |
Natural variantiVAR_025067 | 791 | V → I1 PublicationCorresponds to variant dbSNP:rs35334949Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004304 | 751 – 779 | STATT…LVPGG → R in isoform Short. CuratedAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20470 mRNA Translation: AAA53684.1 S73849 mRNA Translation: AAB31735.1 D16532 Genomic DNA Translation: BAA03969.1 D16493 mRNA Translation: BAA03945.1 D16494 mRNA Translation: BAA03946.1 L22431 mRNA Translation: AAA61344.1 DQ067198 Genomic DNA Translation: AAY46157.1 AL450467 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58805.1 CH471071 Genomic DNA Translation: EAW58806.1 BC136562 mRNA Translation: AAI36563.1 |
CCDSi | CCDS34979.1 [P98155-2] CCDS6446.1 [P98155-1] |
PIRi | A49729 |
RefSeqi | NP_001018066.1, NM_001018056.2 [P98155-2] NP_003374.3, NM_003383.4 [P98155-1] |
UniGenei | Hs.370422 |
Genome annotation databases
Ensembli | ENST00000382099; ENSP00000371531; ENSG00000147852 [P98155-2] ENST00000382100; ENSP00000371532; ENSG00000147852 [P98155-1] |
GeneIDi | 7436 |
KEGGi | hsa:7436 |
UCSCi | uc003zhk.2 human [P98155-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | VLDLR_HUMAN | |
Accessioni | P98155Primary (citable) accession number: P98155 Secondary accession number(s): B2RMZ7, D3DRH6, Q5VVF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 25, 2018 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |