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P98154

- IDD_MOUSE

UniProt

P98154 - IDD_MOUSE

Protein

Integral membrane protein DGCR2/IDD

Gene

Dgcr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. response to drug Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integral membrane protein DGCR2/IDD
    Alternative name(s):
    Seizure-related membrane-bound adhesion protein
    Gene namesi
    Name:Dgcr2
    Synonyms:Dgsc, Idd, Sez-12, Sez12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:892866. Dgcr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 548524Integral membrane protein DGCR2/IDDPRO_0000021485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 44By similarity
    Disulfide bondi37 ↔ 57By similarity
    Disulfide bondi51 ↔ 66By similarity
    Disulfide bondi143 ↔ 263By similarity
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi236 ↔ 255By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP98154.

    PTM databases

    PhosphoSiteiP98154.

    Expressioni

    Tissue specificityi

    Ubiquitous in various organs with low abundance.

    Gene expression databases

    BgeeiP98154.
    CleanExiMM_DGCR2.
    GenevestigatoriP98154.

    Structurei

    3D structure databases

    ProteinModelPortaliP98154.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 347323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini367 – 548182CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei348 – 36619HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 6841LDL-receptor class APROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 239127C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 33164VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000017655.
    HOGENOMiHOG000112997.
    HOVERGENiHBG006117.
    OrthoDBiEOG7FXZXX.
    PhylomeDBiP98154.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    4.10.400.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00057. Ldl_recept_a. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    SM00192. LDLa. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57424. SSF57424. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01209. LDLRA_1. 1 hit.
    PS50068. LDLRA_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98154-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACHGG TIQCIPLPWQ    50
    CDGWPTCEDK SDEADCPVTG EARPYGKETV DLRQGRARGG DPTHFHTVNV 100
    AQPVRFSSFL GKCPSGWHHY EGTASCYRVY LSGENYWDAA QTCQRVNGSL 150
    ATFSTDQELR FVLAQEWDQP ERSFGWKDQR KLWVGYQYVI TGRNHSLEGR 200
    WEVAFKGSPE VFLPPDPIFA SAMSENDNVF CAQLQCFHFP TLRHHDLHSW 250
    HAESCSEKSS FLCKRSQTCV DIKDNVVDEG FYFTPKGDDP CLSCTCHRGE 300
    PEMCVAALCE RPQGCQQYRK DPKECCKFMC LDPDGSSLFD SMASGMRLVV 350
    SCISSFLILS LLLFMVHRLA QRRRERIESL IGANLHHFNL GRRIPGFDYG 400
    PDGFGTGLTP LHLSDDGEGG TFHFHDPPPP YTAYKYPDMD QPDDPPPPYE 450
    ASINPDSVFY DPADDDAFEP VEASLPAPRD GGIEGALPRH LDQPLPPAET 500
    SLADLEDSTD SSSALLVPPD PAQSGSTPAT EAPPGGGRLP RASLNTVV 548
    Length:548
    Mass (Da):60,697
    Last modified:October 1, 1996 - v1
    Checksum:i77AF5CA839F6B817
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671P → PE in BAA11460. (PubMed:8630060)Curated
    Sequence conflicti108 – 1114SFLG → R in BAA11460. (PubMed:8630060)Curated
    Sequence conflicti370 – 3701A → R in BAA11460. (PubMed:8630060)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95480 mRNA. Translation: CAA64749.1.
    D78641 mRNA. Translation: BAA11460.1.
    PIRiJC4798.
    RefSeqiNP_001103220.1. NM_001109750.1.
    UniGeneiMm.254515.

    Genome annotation databases

    EnsembliENSMUST00000117945; ENSMUSP00000112783; ENSMUSG00000003166.
    GeneIDi13356.
    KEGGimmu:13356.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    IDD

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95480 mRNA. Translation: CAA64749.1 .
    D78641 mRNA. Translation: BAA11460.1 .
    PIRi JC4798.
    RefSeqi NP_001103220.1. NM_001109750.1.
    UniGenei Mm.254515.

    3D structure databases

    ProteinModelPortali P98154.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P98154.

    Proteomic databases

    PRIDEi P98154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000117945 ; ENSMUSP00000112783 ; ENSMUSG00000003166 .
    GeneIDi 13356.
    KEGGi mmu:13356.

    Organism-specific databases

    CTDi 9993.
    MGIi MGI:892866. Dgcr2.

    Phylogenomic databases

    GeneTreei ENSGT00390000017655.
    HOGENOMi HOG000112997.
    HOVERGENi HBG006117.
    OrthoDBi EOG7FXZXX.
    PhylomeDBi P98154.

    Miscellaneous databases

    ChiTaRSi DGCR2. mouse.
    NextBioi 283684.
    PROi P98154.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98154.
    CleanExi MM_DGCR2.
    Genevestigatori P98154.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    4.10.400.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00057. Ldl_recept_a. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    SM00192. LDLa. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57424. SSF57424. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01209. LDLRA_1. 1 hit.
    PS50068. LDLRA_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and mapping of murine Dgcr2 and its homology to the Sez-12 seizure-related protein."
      Taylor C., Wadey R., O'Donnell H., Roberts C., Mattei M.-G., Kimber W.L., Wynshaw-Boris A., Scambler P.J.
      Mamm. Genome 8:371-375(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein."
      Kajiwara K., Nagasawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
      Biochem. Biophys. Res. Commun. 222:144-148(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiIDD_MOUSE
    AccessioniPrimary (citable) accession number: P98154
    Secondary accession number(s): Q61844
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3