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P98154 (IDD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Integral membrane protein DGCR2/IDD
Alternative name(s):
Seizure-related membrane-bound adhesion protein
Gene names
Name:Dgcr2
Synonyms:Dgsc, Idd, Sez-12, Sez12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Ubiquitous in various organs with low abundance.

Sequence similarities

Contains 1 C-type lectin domain.

Contains 1 LDL-receptor class A domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandLectin
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

response to drug

Inferred from direct assay Ref.2. Source: MGI

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay Ref.2. Source: MGI

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 548524Integral membrane protein DGCR2/IDD
PRO_0000021485

Regions

Topological domain25 – 347323Extracellular Potential
Transmembrane348 – 36619Helical; Potential
Topological domain367 – 548182Cytoplasmic Potential
Domain28 – 6841LDL-receptor class A
Domain113 – 239127C-type lectin
Domain268 – 33164VWFC

Amino acid modifications

Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 44 By similarity
Disulfide bond37 ↔ 57 By similarity
Disulfide bond51 ↔ 66 By similarity
Disulfide bond143 ↔ 263 By similarity
Disulfide bond236 ↔ 255 By similarity

Experimental info

Sequence conflict671P → PE in BAA11460. Ref.2
Sequence conflict108 – 1114SFLG → R in BAA11460. Ref.2
Sequence conflict3701A → R in BAA11460. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P98154 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 77AF5CA839F6B817

FASTA54860,697
        10         20         30         40         50         60 
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACHGG TIQCIPLPWQ CDGWPTCEDK 

        70         80         90        100        110        120 
SDEADCPVTG EARPYGKETV DLRQGRARGG DPTHFHTVNV AQPVRFSSFL GKCPSGWHHY 

       130        140        150        160        170        180 
EGTASCYRVY LSGENYWDAA QTCQRVNGSL ATFSTDQELR FVLAQEWDQP ERSFGWKDQR 

       190        200        210        220        230        240 
KLWVGYQYVI TGRNHSLEGR WEVAFKGSPE VFLPPDPIFA SAMSENDNVF CAQLQCFHFP 

       250        260        270        280        290        300 
TLRHHDLHSW HAESCSEKSS FLCKRSQTCV DIKDNVVDEG FYFTPKGDDP CLSCTCHRGE 

       310        320        330        340        350        360 
PEMCVAALCE RPQGCQQYRK DPKECCKFMC LDPDGSSLFD SMASGMRLVV SCISSFLILS 

       370        380        390        400        410        420 
LLLFMVHRLA QRRRERIESL IGANLHHFNL GRRIPGFDYG PDGFGTGLTP LHLSDDGEGG 

       430        440        450        460        470        480 
TFHFHDPPPP YTAYKYPDMD QPDDPPPPYE ASINPDSVFY DPADDDAFEP VEASLPAPRD 

       490        500        510        520        530        540 
GGIEGALPRH LDQPLPPAET SLADLEDSTD SSSALLVPPD PAQSGSTPAT EAPPGGGRLP 


RASLNTVV

« Hide

References

[1]"Cloning and mapping of murine Dgcr2 and its homology to the Sez-12 seizure-related protein."
Taylor C., Wadey R., O'Donnell H., Roberts C., Mattei M.-G., Kimber W.L., Wynshaw-Boris A., Scambler P.J.
Mamm. Genome 8:371-375(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein."
Kajiwara K., Nagasawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
Biochem. Biophys. Res. Commun. 222:144-148(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95480 mRNA. Translation: CAA64749.1.
D78641 mRNA. Translation: BAA11460.1.
IPIIPI00762089.
PIRJC4798.
RefSeqNP_001103220.1. NM_001109750.1.
UniGeneMm.254515.

3D structure databases

ProteinModelPortalP98154.
SMRP98154. Positions 26-69.
ModBaseSearch...

PTM databases

PhosphoSiteP98154.

Proteomic databases

PRIDEP98154.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000117945; ENSMUSP00000112783; ENSMUSG00000003166.
GeneID13356.
KEGGmmu:13356.

Organism-specific databases

CTD9993.
MGIMGI:892866. Dgcr2.

Phylogenomic databases

GeneTreeENSGT00390000017655.
HOGENOMHOG000112997.
HOVERGENHBG006117.
OrthoDBEOG4FXR7C.

Gene expression databases

ArrayExpressP98154.
BgeeP98154.
CleanExMM_DGCR2.
GenevestigatorP98154.
GermOnlineENSMUSG00000003166. Mus musculus.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00057. Ldl_recept_a. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF56436. C-type_lectin_fold. 1 hit.
SSF57424. LDL_rcpt_classA_cys-rich. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDGCR2. mouse.
NextBio283684.
SOURCESearch...

Entry information

Entry nameIDD_MOUSE
AccessionPrimary (citable) accession number: P98154
Secondary accession number(s): Q61844
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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