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Protein

Integral membrane protein DGCR2/IDD

Gene

Dgcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cognition Source: MGI
  • response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Alternative name(s):
Seizure-related membrane-bound adhesion protein
Gene namesi
Name:Dgcr2
Synonyms:Dgsc, Idd, Sez-12, Sez12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:892866. Dgcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 347323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei348 – 36619HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 548182CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 548524Integral membrane protein DGCR2/IDDPRO_0000021485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 44By similarity
Disulfide bondi37 ↔ 57By similarity
Disulfide bondi51 ↔ 66By similarity
Disulfide bondi143 ↔ 263By similarity
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi236 ↔ 255By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP98154.
PRIDEiP98154.

PTM databases

PhosphoSiteiP98154.

Expressioni

Tissue specificityi

Ubiquitous in various organs with low abundance.

Gene expression databases

BgeeiP98154.
CleanExiMM_DGCR2.
ExpressionAtlasiP98154. baseline and differential.
GenevisibleiP98154. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012152.

Structurei

3D structure databases

ProteinModelPortaliP98154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6841LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini113 – 239127C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini268 – 33164VWFCAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000112997.
HOVERGENiHBG006117.
InParanoidiP98154.
OrthoDBiEOG7FXZXX.
PhylomeDBiP98154.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACHGG TIQCIPLPWQ
60 70 80 90 100
CDGWPTCEDK SDEADCPVTG EARPYGKETV DLRQGRARGG DPTHFHTVNV
110 120 130 140 150
AQPVRFSSFL GKCPSGWHHY EGTASCYRVY LSGENYWDAA QTCQRVNGSL
160 170 180 190 200
ATFSTDQELR FVLAQEWDQP ERSFGWKDQR KLWVGYQYVI TGRNHSLEGR
210 220 230 240 250
WEVAFKGSPE VFLPPDPIFA SAMSENDNVF CAQLQCFHFP TLRHHDLHSW
260 270 280 290 300
HAESCSEKSS FLCKRSQTCV DIKDNVVDEG FYFTPKGDDP CLSCTCHRGE
310 320 330 340 350
PEMCVAALCE RPQGCQQYRK DPKECCKFMC LDPDGSSLFD SMASGMRLVV
360 370 380 390 400
SCISSFLILS LLLFMVHRLA QRRRERIESL IGANLHHFNL GRRIPGFDYG
410 420 430 440 450
PDGFGTGLTP LHLSDDGEGG TFHFHDPPPP YTAYKYPDMD QPDDPPPPYE
460 470 480 490 500
ASINPDSVFY DPADDDAFEP VEASLPAPRD GGIEGALPRH LDQPLPPAET
510 520 530 540
SLADLEDSTD SSSALLVPPD PAQSGSTPAT EAPPGGGRLP RASLNTVV
Length:548
Mass (Da):60,697
Last modified:October 1, 1996 - v1
Checksum:i77AF5CA839F6B817
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671P → PE in BAA11460 (PubMed:8630060).Curated
Sequence conflicti108 – 1114SFLG → R in BAA11460 (PubMed:8630060).Curated
Sequence conflicti370 – 3701A → R in BAA11460 (PubMed:8630060).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95480 mRNA. Translation: CAA64749.1.
D78641 mRNA. Translation: BAA11460.1.
PIRiJC4798.
RefSeqiNP_001103220.1. NM_001109750.1.
UniGeneiMm.254515.

Genome annotation databases

GeneIDi13356.
KEGGimmu:13356.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

IDD

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95480 mRNA. Translation: CAA64749.1.
D78641 mRNA. Translation: BAA11460.1.
PIRiJC4798.
RefSeqiNP_001103220.1. NM_001109750.1.
UniGeneiMm.254515.

3D structure databases

ProteinModelPortaliP98154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012152.

PTM databases

PhosphoSiteiP98154.

Proteomic databases

MaxQBiP98154.
PRIDEiP98154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13356.
KEGGimmu:13356.

Organism-specific databases

CTDi9993.
MGIiMGI:892866. Dgcr2.

Phylogenomic databases

HOGENOMiHOG000112997.
HOVERGENiHBG006117.
InParanoidiP98154.
OrthoDBiEOG7FXZXX.
PhylomeDBiP98154.

Miscellaneous databases

ChiTaRSiDgcr2. mouse.
NextBioi283684.
PROiP98154.
SOURCEiSearch...

Gene expression databases

BgeeiP98154.
CleanExiMM_DGCR2.
ExpressionAtlasiP98154. baseline and differential.
GenevisibleiP98154. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and mapping of murine Dgcr2 and its homology to the Sez-12 seizure-related protein."
    Taylor C., Wadey R., O'Donnell H., Roberts C., Mattei M.-G., Kimber W.L., Wynshaw-Boris A., Scambler P.J.
    Mamm. Genome 8:371-375(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein."
    Kajiwara K., Nagasawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
    Biochem. Biophys. Res. Commun. 222:144-148(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain cortex.

Entry informationi

Entry nameiIDD_MOUSE
AccessioniPrimary (citable) accession number: P98154
Secondary accession number(s): Q61844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.