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P98154

- IDD_MOUSE

UniProt

P98154 - IDD_MOUSE

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Protein

Integral membrane protein DGCR2/IDD

Gene
Dgcr2, Dgsc, Idd, Sez-12, Sez12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Alternative name(s):
Seizure-related membrane-bound adhesion protein
Gene namesi
Name:Dgcr2
Synonyms:Dgsc, Idd, Sez-12, Sez12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:892866. Dgcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 347323Extracellular Reviewed predictionAdd
BLAST
Transmembranei348 – 36619Helical; Reviewed predictionAdd
BLAST
Topological domaini367 – 548182Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 548524Integral membrane protein DGCR2/IDDPRO_0000021485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 44 By similarity
Disulfide bondi37 ↔ 57 By similarity
Disulfide bondi51 ↔ 66 By similarity
Disulfide bondi143 ↔ 263 By similarity
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi236 ↔ 255 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP98154.

PTM databases

PhosphoSiteiP98154.

Expressioni

Tissue specificityi

Ubiquitous in various organs with low abundance.

Gene expression databases

BgeeiP98154.
CleanExiMM_DGCR2.
GenevestigatoriP98154.

Structurei

3D structure databases

ProteinModelPortaliP98154.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6841LDL-receptor class AAdd
BLAST
Domaini113 – 239127C-type lectinAdd
BLAST
Domaini268 – 33164VWFCAdd
BLAST

Sequence similaritiesi

Contains 1 VWFC domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017655.
HOGENOMiHOG000112997.
HOVERGENiHBG006117.
OrthoDBiEOG7FXZXX.
PhylomeDBiP98154.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98154-1 [UniParc]FASTAAdd to Basket

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MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACHGG TIQCIPLPWQ    50
CDGWPTCEDK SDEADCPVTG EARPYGKETV DLRQGRARGG DPTHFHTVNV 100
AQPVRFSSFL GKCPSGWHHY EGTASCYRVY LSGENYWDAA QTCQRVNGSL 150
ATFSTDQELR FVLAQEWDQP ERSFGWKDQR KLWVGYQYVI TGRNHSLEGR 200
WEVAFKGSPE VFLPPDPIFA SAMSENDNVF CAQLQCFHFP TLRHHDLHSW 250
HAESCSEKSS FLCKRSQTCV DIKDNVVDEG FYFTPKGDDP CLSCTCHRGE 300
PEMCVAALCE RPQGCQQYRK DPKECCKFMC LDPDGSSLFD SMASGMRLVV 350
SCISSFLILS LLLFMVHRLA QRRRERIESL IGANLHHFNL GRRIPGFDYG 400
PDGFGTGLTP LHLSDDGEGG TFHFHDPPPP YTAYKYPDMD QPDDPPPPYE 450
ASINPDSVFY DPADDDAFEP VEASLPAPRD GGIEGALPRH LDQPLPPAET 500
SLADLEDSTD SSSALLVPPD PAQSGSTPAT EAPPGGGRLP RASLNTVV 548
Length:548
Mass (Da):60,697
Last modified:October 1, 1996 - v1
Checksum:i77AF5CA839F6B817
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671P → PE in BAA11460. 1 Publication
Sequence conflicti108 – 1114SFLG → R in BAA11460. 1 Publication
Sequence conflicti370 – 3701A → R in BAA11460. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95480 mRNA. Translation: CAA64749.1.
D78641 mRNA. Translation: BAA11460.1.
PIRiJC4798.
RefSeqiNP_001103220.1. NM_001109750.1.
UniGeneiMm.254515.

Genome annotation databases

EnsembliENSMUST00000117945; ENSMUSP00000112783; ENSMUSG00000003166.
GeneIDi13356.
KEGGimmu:13356.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

IDD

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95480 mRNA. Translation: CAA64749.1 .
D78641 mRNA. Translation: BAA11460.1 .
PIRi JC4798.
RefSeqi NP_001103220.1. NM_001109750.1.
UniGenei Mm.254515.

3D structure databases

ProteinModelPortali P98154.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P98154.

Proteomic databases

PRIDEi P98154.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117945 ; ENSMUSP00000112783 ; ENSMUSG00000003166 .
GeneIDi 13356.
KEGGi mmu:13356.

Organism-specific databases

CTDi 9993.
MGIi MGI:892866. Dgcr2.

Phylogenomic databases

GeneTreei ENSGT00390000017655.
HOGENOMi HOG000112997.
HOVERGENi HBG006117.
OrthoDBi EOG7FXZXX.
PhylomeDBi P98154.

Miscellaneous databases

ChiTaRSi DGCR2. mouse.
NextBioi 283684.
PROi P98154.
SOURCEi Search...

Gene expression databases

Bgeei P98154.
CleanExi MM_DGCR2.
Genevestigatori P98154.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and mapping of murine Dgcr2 and its homology to the Sez-12 seizure-related protein."
    Taylor C., Wadey R., O'Donnell H., Roberts C., Mattei M.-G., Kimber W.L., Wynshaw-Boris A., Scambler P.J.
    Mamm. Genome 8:371-375(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein."
    Kajiwara K., Nagasawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
    Biochem. Biophys. Res. Commun. 222:144-148(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain cortex.

Entry informationi

Entry nameiIDD_MOUSE
AccessioniPrimary (citable) accession number: P98154
Secondary accession number(s): Q61844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi