UniProtKB - P98153 (IDD_HUMAN)
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Protein
Integral membrane protein DGCR2/IDD
Gene
DGCR2
Organism
Homo sapiens (Human)
Status
Functioni
Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.
Caution
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
GO - Biological processi
- animal organ morphogenesis Source: ProtInc
- cell adhesion Source: UniProtKB-KW
- cognition Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: Integral membrane protein DGCR2/IDD |
Gene namesi | Name:DGCR2 Synonyms:IDD, KIAA0163 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000070413.18 |
HGNCi | HGNC:2845 DGCR2 |
MIMi | 600594 gene |
neXtProti | NX_P98153 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 349 | ExtracellularSequence analysisAdd BLAST | 329 | |
Transmembranei | 350 – 368 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 369 – 550 | CytoplasmicSequence analysisAdd BLAST | 182 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9993 |
GeneReviewsi | DGCR2 |
OpenTargetsi | ENSG00000070413 |
PharmGKBi | PA27307 |
Polymorphism and mutation databases
BioMutai | DGCR2 |
DMDMi | 1708396 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000021484 | 21 – 550 | Integral membrane protein DGCR2/IDDAdd BLAST | 530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 44 | By similarity | ||
Disulfide bondi | 37 ↔ 57 | By similarity | ||
Disulfide bondi | 51 ↔ 66 | By similarity | ||
Disulfide bondi | 145 ↔ 265 | By similarity | ||
Glycosylationi | 149 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 233 ↔ 257 | By similarity | ||
Modified residuei | 381 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P98153 |
PaxDbi | P98153 |
PeptideAtlasi | P98153 |
PRIDEi | P98153 |
PTM databases
iPTMneti | P98153 |
PhosphoSitePlusi | P98153 |
Expressioni
Tissue specificityi
Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney.
Gene expression databases
Bgeei | ENSG00000070413 |
CleanExi | HS_DGCR2 |
ExpressionAtlasi | P98153 baseline and differential |
Genevisiblei | P98153 HS |
Organism-specific databases
HPAi | HPA000873 HPA075929 |
Interactioni
Protein-protein interaction databases
BioGridi | 11531410 interactors. |
IntActi | P98153 2 interactors. |
MINTi | P98153 |
STRINGi | 9606.ENSP00000263196 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 68 | LDL-receptor class APROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 115 – 241 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 127 | |
Domaini | 270 – 333 | VWFCAdd BLAST | 64 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IPT1 Eukaryota ENOG4110Q97 LUCA |
GeneTreei | ENSGT00390000017655 |
HOGENOMi | HOG000112997 |
HOVERGENi | HBG006117 |
InParanoidi | P98153 |
PhylomeDBi | P98153 |
TreeFami | TF330997 |
Family and domain databases
CDDi | cd03599 CLECT_DGCR2_like, 1 hit cd00112 LDLa, 1 hit |
Gene3Di | 3.10.100.101 hit |
InterProi | View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR034010 DGCR2-like_CTLD IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR001007 VWF_dom |
Pfami | View protein in Pfam PF00057 Ldl_recept_a, 1 hit PF00059 Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034 CLECT, 1 hit SM00192 LDLa, 1 hit SM00214 VWC, 1 hit |
SUPFAMi | SSF56436 SSF56436, 1 hit SSF57424 SSF57424, 1 hit |
PROSITEi | View protein in PROSITE PS50041 C_TYPE_LECTIN_2, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit PS01208 VWFC_1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P98153-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ
60 70 80 90 100
CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV
110 120 130 140 150
NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG
160 170 180 190 200
SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE
210 220 230 240 250
GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH
260 270 280 290 300
SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG
310 320 330 340 350
GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL
360 370 380 390 400
VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD
410 420 430 440 450
YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP
460 470 480 490 500
YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA
510 520 530 540 550
GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020046 | 473 | V → A1 PublicationCorresponds to variant dbSNP:rs2072123Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042886 | 26 – 66 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_057188 | 315 – 327 | QGCQQ…DPKEC → HGCSPLSCTARAT in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_057189 | 328 – 550 | Missing in isoform 3. 1 PublicationAdd BLAST | 223 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84076 mRNA Translation: CAA58883.1 X83545 mRNA Translation: CAA58536.1 L46352 mRNA Translation: AAB59561.1 D79985 mRNA Translation: BAA11480.1 FJ032369 mRNA Translation: ACI00235.1 AK291670 mRNA Translation: BAF84359.1 AK304382 mRNA Translation: BAH14171.1 CR456433 mRNA Translation: CAG30319.1 AC000095 Genomic DNA No translation available. AC004461 Genomic DNA No translation available. AC004462 Genomic DNA No translation available. AC004471 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03061.1 BC032430 mRNA Translation: AAH32430.1 |
CCDSi | CCDS33598.1 [P98153-1] CCDS54496.1 [P98153-2] |
PIRi | I37579 I84463 |
RefSeqi | NP_001167004.1, NM_001173533.1 [P98153-2] NP_001167005.1, NM_001173534.1 NP_005128.1, NM_005137.2 [P98153-1] |
UniGenei | Hs.517357 |
Genome annotation databases
Ensembli | ENST00000263196; ENSP00000263196; ENSG00000070413 [P98153-1] ENST00000537045; ENSP00000440062; ENSG00000070413 [P98153-2] |
GeneIDi | 9993 |
KEGGi | hsa:9993 |
UCSCi | uc062bkk.1 human [P98153-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | IDD_HUMAN | |
Accessioni | P98153Primary (citable) accession number: P98153 Secondary accession number(s): A6NIB5 B7Z935 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 25, 2018 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |