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Protein

Integral membrane protein DGCR2/IDD

Gene

DGCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: ProtInc
  • cell adhesion Source: UniProtKB-KW
  • cognition Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Gene namesi
Name:DGCR2
Synonyms:IDD, KIAA0163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000070413.18
HGNCiHGNC:2845 DGCR2
MIMi600594 gene
neXtProtiNX_P98153

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 349ExtracellularSequence analysisAdd BLAST329
Transmembranei350 – 368HelicalSequence analysisAdd BLAST19
Topological domaini369 – 550CytoplasmicSequence analysisAdd BLAST182

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9993
GeneReviewsiDGCR2
MalaCardsiDGCR2
OpenTargetsiENSG00000070413
PharmGKBiPA27307

Polymorphism and mutation databases

BioMutaiDGCR2
DMDMi1708396

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002148421 – 550Integral membrane protein DGCR2/IDDAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 44By similarity
Disulfide bondi37 ↔ 57By similarity
Disulfide bondi51 ↔ 66By similarity
Disulfide bondi145 ↔ 265By similarity
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 257By similarity
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP98153
PaxDbiP98153
PeptideAtlasiP98153
PRIDEiP98153
ProteomicsDBi57792
57793 [P98153-2]

PTM databases

iPTMnetiP98153
PhosphoSitePlusiP98153

Expressioni

Tissue specificityi

Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney.

Gene expression databases

BgeeiENSG00000070413
CleanExiHS_DGCR2
ExpressionAtlasiP98153 baseline and differential
GenevisibleiP98153 HS

Organism-specific databases

HPAiHPA000873
HPA075929

Interactioni

Protein-protein interaction databases

BioGridi115314, 10 interactors
IntActiP98153, 2 interactors
MINTiP98153
STRINGi9606.ENSP00000263196

Structurei

3D structure databases

ProteinModelPortaliP98153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 68LDL-receptor class APROSITE-ProRule annotationAdd BLAST41
Domaini115 – 241C-type lectinPROSITE-ProRule annotationAdd BLAST127
Domaini270 – 333VWFCAdd BLAST64

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT1 Eukaryota
ENOG4110Q97 LUCA
GeneTreeiENSGT00390000017655
HOGENOMiHOG000112997
HOVERGENiHBG006117
InParanoidiP98153
PhylomeDBiP98153
TreeFamiTF330997

Family and domain databases

CDDicd03599 CLECT_DGCR2_like, 1 hit
cd00112 LDLa, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR034010 DGCR2-like_CTLD
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00192 LDLa, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS01208 VWFC_1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P98153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ
60 70 80 90 100
CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV
110 120 130 140 150
NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG
160 170 180 190 200
SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE
210 220 230 240 250
GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH
260 270 280 290 300
SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG
310 320 330 340 350
GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL
360 370 380 390 400
VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD
410 420 430 440 450
YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP
460 470 480 490 500
YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA
510 520 530 540 550
GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV
Length:550
Mass (Da):60,811
Last modified:October 1, 1996 - v1
Checksum:i770204F2F36A8AAC
GO
Isoform 2 (identifier: P98153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):56,284
Checksum:i4594D654E309AAAD
GO
Isoform 3 (identifier: P98153-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-327: QGCQQYRKDPKEC → HGCSPLSCTARAT
     328-550: Missing.

Show »
Length:327
Mass (Da):36,713
Checksum:i59E483EBDD832BA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020046473V → A1 PublicationCorresponds to variant dbSNP:rs2072123Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04288626 – 66Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_057188315 – 327QGCQQ…DPKEC → HGCSPLSCTARAT in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_057189328 – 550Missing in isoform 3. 1 PublicationAdd BLAST223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84076 mRNA Translation: CAA58883.1
X83545 mRNA Translation: CAA58536.1
L46352 mRNA Translation: AAB59561.1
D79985 mRNA Translation: BAA11480.1
FJ032369 mRNA Translation: ACI00235.1
AK291670 mRNA Translation: BAF84359.1
AK304382 mRNA Translation: BAH14171.1
CR456433 mRNA Translation: CAG30319.1
AC000095 Genomic DNA No translation available.
AC004461 Genomic DNA No translation available.
AC004462 Genomic DNA No translation available.
AC004471 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03061.1
BC032430 mRNA Translation: AAH32430.1
CCDSiCCDS33598.1 [P98153-1]
CCDS54496.1 [P98153-2]
PIRiI37579
I84463
RefSeqiNP_001167004.1, NM_001173533.1 [P98153-2]
NP_001167005.1, NM_001173534.1
NP_005128.1, NM_005137.2 [P98153-1]
UniGeneiHs.517357

Genome annotation databases

EnsembliENST00000263196; ENSP00000263196; ENSG00000070413 [P98153-1]
ENST00000537045; ENSP00000440062; ENSG00000070413 [P98153-2]
GeneIDi9993
KEGGihsa:9993
UCSCiuc062bkk.1 human [P98153-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIDD_HUMAN
AccessioniPrimary (citable) accession number: P98153
Secondary accession number(s): A6NIB5
, A8K6K5, B5TY34, B7Z935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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