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P98153

- IDD_HUMAN

UniProt

P98153 - IDD_HUMAN

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Protein
Integral membrane protein DGCR2/IDD
Gene
DGCR2, IDD, KIAA0163
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cognition Source: UniProt
  3. organ morphogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Gene namesi
Name:DGCR2
Synonyms:IDD, KIAA0163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:2845. DGCR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 349329Extracellular Reviewed prediction
Add
BLAST
Transmembranei350 – 36819Helical; Reviewed prediction
Add
BLAST
Topological domaini369 – 550182Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 550530Integral membrane protein DGCR2/IDD
PRO_0000021484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 44 By similarity
Disulfide bondi37 ↔ 57 By similarity
Disulfide bondi51 ↔ 66 By similarity
Disulfide bondi145 ↔ 265 By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi233 ↔ 257 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP98153.
PaxDbiP98153.
PRIDEiP98153.

PTM databases

PhosphoSiteiP98153.

Expressioni

Tissue specificityi

Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney.

Gene expression databases

ArrayExpressiP98153.
BgeeiP98153.
CleanExiHS_DGCR2.
GenevestigatoriP98153.

Organism-specific databases

HPAiHPA000873.

Interactioni

Protein-protein interaction databases

BioGridi115314. 3 interactions.
IntActiP98153. 2 interactions.
MINTiMINT-1186622.
STRINGi9606.ENSP00000263196.

Structurei

3D structure databases

ProteinModelPortaliP98153.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6841LDL-receptor class A
Add
BLAST
Domaini115 – 241127C-type lectin
Add
BLAST
Domaini270 – 33364VWFC
Add
BLAST

Sequence similaritiesi

Contains 1 VWFC domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146589.
HOGENOMiHOG000112997.
HOVERGENiHBG006117.
InParanoidiP98153.
OMAiSWHAESC.
OrthoDBiEOG7FXZXX.
PhylomeDBiP98153.
TreeFamiTF330997.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P98153-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ    50
CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV 100
NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG 150
SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE 200
GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH 250
SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG 300
GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL 350
VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD 400
YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP 450
YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA 500
GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV 550
Length:550
Mass (Da):60,811
Last modified:October 1, 1996 - v1
Checksum:i770204F2F36A8AAC
GO
Isoform 2 (identifier: P98153-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Note: No experimental confirmation available.

Show »
Length:509
Mass (Da):56,284
Checksum:i4594D654E309AAAD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti473 – 4731V → A.1 Publication
Corresponds to variant rs2072123 [ dbSNP | Ensembl ].
VAR_020046

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 6641Missing in isoform 2.
VSP_042886Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84076 mRNA. Translation: CAA58883.1.
X83545 mRNA. Translation: CAA58536.1.
L46352 mRNA. Translation: AAB59561.1.
D79985 mRNA. Translation: BAA11480.1.
AK291670 mRNA. Translation: BAF84359.1.
AK304382 mRNA. Translation: BAH14171.1.
CR456433 mRNA. Translation: CAG30319.1.
AC000095 Genomic DNA. No translation available.
AC004461 Genomic DNA. No translation available.
AC004462 Genomic DNA. No translation available.
AC004471 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03061.1.
BC032430 mRNA. Translation: AAH32430.1.
CCDSiCCDS33598.1. [P98153-1]
CCDS54496.1. [P98153-2]
PIRiI37579.
I84463.
RefSeqiNP_001167004.1. NM_001173533.1. [P98153-2]
NP_001167005.1. NM_001173534.1.
NP_005128.1. NM_005137.2. [P98153-1]
UniGeneiHs.517357.

Genome annotation databases

EnsembliENST00000263196; ENSP00000263196; ENSG00000070413. [P98153-1]
ENST00000537045; ENSP00000440062; ENSG00000070413. [P98153-2]
GeneIDi9993.
KEGGihsa:9993.
UCSCiuc002zoq.1. human. [P98153-1]
uc021wky.1. human. [P98153-2]

Polymorphism databases

DMDMi1708396.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84076 mRNA. Translation: CAA58883.1 .
X83545 mRNA. Translation: CAA58536.1 .
L46352 mRNA. Translation: AAB59561.1 .
D79985 mRNA. Translation: BAA11480.1 .
AK291670 mRNA. Translation: BAF84359.1 .
AK304382 mRNA. Translation: BAH14171.1 .
CR456433 mRNA. Translation: CAG30319.1 .
AC000095 Genomic DNA. No translation available.
AC004461 Genomic DNA. No translation available.
AC004462 Genomic DNA. No translation available.
AC004471 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03061.1 .
BC032430 mRNA. Translation: AAH32430.1 .
CCDSi CCDS33598.1. [P98153-1 ]
CCDS54496.1. [P98153-2 ]
PIRi I37579.
I84463.
RefSeqi NP_001167004.1. NM_001173533.1. [P98153-2 ]
NP_001167005.1. NM_001173534.1.
NP_005128.1. NM_005137.2. [P98153-1 ]
UniGenei Hs.517357.

3D structure databases

ProteinModelPortali P98153.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115314. 3 interactions.
IntActi P98153. 2 interactions.
MINTi MINT-1186622.
STRINGi 9606.ENSP00000263196.

PTM databases

PhosphoSitei P98153.

Polymorphism databases

DMDMi 1708396.

Proteomic databases

MaxQBi P98153.
PaxDbi P98153.
PRIDEi P98153.

Protocols and materials databases

DNASUi 9993.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263196 ; ENSP00000263196 ; ENSG00000070413 . [P98153-1 ]
ENST00000537045 ; ENSP00000440062 ; ENSG00000070413 . [P98153-2 ]
GeneIDi 9993.
KEGGi hsa:9993.
UCSCi uc002zoq.1. human. [P98153-1 ]
uc021wky.1. human. [P98153-2 ]

Organism-specific databases

CTDi 9993.
GeneCardsi GC22M019023.
GeneReviewsi DGCR2.
HGNCi HGNC:2845. DGCR2.
HPAi HPA000873.
MIMi 600594. gene.
neXtProti NX_P98153.
PharmGKBi PA27307.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146589.
HOGENOMi HOG000112997.
HOVERGENi HBG006117.
InParanoidi P98153.
OMAi SWHAESC.
OrthoDBi EOG7FXZXX.
PhylomeDBi P98153.
TreeFami TF330997.

Miscellaneous databases

ChiTaRSi DGCR2. human.
GeneWikii DGCR2.
GenomeRNAii 9993.
NextBioi 37751.
PROi P98153.
SOURCEi Search...

Gene expression databases

ArrayExpressi P98153.
Bgeei P98153.
CleanExi HS_DGCR2.
Genevestigatori P98153.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a balanced translocation breakpoint in the DiGeorge syndrome critical region and isolation of a novel potential adhesion receptor gene in its vicinity."
    Demczuk S., Aledo R., Zucman J., Delattre O., Desmaze C., Dauphinot L., Jalbert P., Rouleau G.A., Thomas G., Aurias A.
    Hum. Mol. Genet. 4:551-558(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Isolation of a gene encoding an integral membrane protein from the vicinity of a balanced translocation breakpoint associated with DiGeorge syndrome."
    Wadey R., Daw S., Taylor C., Atif U., Kamath S., Halford S., O'Donnell H., Wilson D., Goodship J., Burn J., Scambler P.J.
    Hum. Mol. Genet. 4:1027-1033(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-473.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Trachea.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiIDD_HUMAN
AccessioniPrimary (citable) accession number: P98153
Secondary accession number(s): A6NIB5, A8K6K5, B7Z935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi