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Protein

Integral membrane protein DGCR2/IDD

Gene

DGCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: ProtInc
  • cell adhesion Source: UniProtKB-KW
  • cognition Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070413-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Gene namesi
Name:DGCR2
Synonyms:IDD, KIAA0163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2845. DGCR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 349ExtracellularSequence analysisAdd BLAST329
Transmembranei350 – 368HelicalSequence analysisAdd BLAST19
Topological domaini369 – 550CytoplasmicSequence analysisAdd BLAST182

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9993.
OpenTargetsiENSG00000070413.
PharmGKBiPA27307.

Polymorphism and mutation databases

BioMutaiDGCR2.
DMDMi1708396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002148421 – 550Integral membrane protein DGCR2/IDDAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 44By similarity
Disulfide bondi37 ↔ 57By similarity
Disulfide bondi51 ↔ 66By similarity
Disulfide bondi145 ↔ 265By similarity
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi233 ↔ 257By similarity
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP98153.
PaxDbiP98153.
PeptideAtlasiP98153.
PRIDEiP98153.

PTM databases

iPTMnetiP98153.
PhosphoSitePlusiP98153.

Expressioni

Tissue specificityi

Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney.

Gene expression databases

BgeeiENSG00000070413.
CleanExiHS_DGCR2.
ExpressionAtlasiP98153. baseline and differential.
GenevisibleiP98153. HS.

Organism-specific databases

HPAiHPA000873.

Interactioni

Protein-protein interaction databases

BioGridi115314. 9 interactors.
IntActiP98153. 2 interactors.
MINTiMINT-1186622.
STRINGi9606.ENSP00000263196.

Structurei

3D structure databases

ProteinModelPortaliP98153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 68LDL-receptor class APROSITE-ProRule annotationAdd BLAST41
Domaini115 – 241C-type lectinPROSITE-ProRule annotationAdd BLAST127
Domaini270 – 333VWFCAdd BLAST64

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT1. Eukaryota.
ENOG4110Q97. LUCA.
GeneTreeiENSGT00390000017655.
HOGENOMiHOG000112997.
HOVERGENiHBG006117.
InParanoidiP98153.
PhylomeDBiP98153.
TreeFamiTF330997.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P98153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ
60 70 80 90 100
CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV
110 120 130 140 150
NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG
160 170 180 190 200
SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE
210 220 230 240 250
GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH
260 270 280 290 300
SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG
310 320 330 340 350
GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL
360 370 380 390 400
VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD
410 420 430 440 450
YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP
460 470 480 490 500
YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA
510 520 530 540 550
GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV
Length:550
Mass (Da):60,811
Last modified:October 1, 1996 - v1
Checksum:i770204F2F36A8AAC
GO
Isoform 2 (identifier: P98153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):56,284
Checksum:i4594D654E309AAAD
GO
Isoform 3 (identifier: P98153-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-327: QGCQQYRKDPKEC → HGCSPLSCTARAT
     328-550: Missing.

Show »
Length:327
Mass (Da):36,713
Checksum:i59E483EBDD832BA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020046473V → A.1 PublicationCorresponds to variant rs2072123dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04288626 – 66Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_057188315 – 327QGCQQ…DPKEC → HGCSPLSCTARAT in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_057189328 – 550Missing in isoform 3. 1 PublicationAdd BLAST223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84076 mRNA. Translation: CAA58883.1.
X83545 mRNA. Translation: CAA58536.1.
L46352 mRNA. Translation: AAB59561.1.
D79985 mRNA. Translation: BAA11480.1.
FJ032369 mRNA. Translation: ACI00235.1.
AK291670 mRNA. Translation: BAF84359.1.
AK304382 mRNA. Translation: BAH14171.1.
CR456433 mRNA. Translation: CAG30319.1.
AC000095 Genomic DNA. No translation available.
AC004461 Genomic DNA. No translation available.
AC004462 Genomic DNA. No translation available.
AC004471 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03061.1.
BC032430 mRNA. Translation: AAH32430.1.
CCDSiCCDS33598.1. [P98153-1]
CCDS54496.1. [P98153-2]
PIRiI37579.
I84463.
RefSeqiNP_001167004.1. NM_001173533.1. [P98153-2]
NP_001167005.1. NM_001173534.1.
NP_005128.1. NM_005137.2. [P98153-1]
UniGeneiHs.517357.

Genome annotation databases

EnsembliENST00000263196; ENSP00000263196; ENSG00000070413. [P98153-1]
ENST00000537045; ENSP00000440062; ENSG00000070413. [P98153-2]
GeneIDi9993.
KEGGihsa:9993.
UCSCiuc062bkk.1. human. [P98153-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84076 mRNA. Translation: CAA58883.1.
X83545 mRNA. Translation: CAA58536.1.
L46352 mRNA. Translation: AAB59561.1.
D79985 mRNA. Translation: BAA11480.1.
FJ032369 mRNA. Translation: ACI00235.1.
AK291670 mRNA. Translation: BAF84359.1.
AK304382 mRNA. Translation: BAH14171.1.
CR456433 mRNA. Translation: CAG30319.1.
AC000095 Genomic DNA. No translation available.
AC004461 Genomic DNA. No translation available.
AC004462 Genomic DNA. No translation available.
AC004471 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03061.1.
BC032430 mRNA. Translation: AAH32430.1.
CCDSiCCDS33598.1. [P98153-1]
CCDS54496.1. [P98153-2]
PIRiI37579.
I84463.
RefSeqiNP_001167004.1. NM_001173533.1. [P98153-2]
NP_001167005.1. NM_001173534.1.
NP_005128.1. NM_005137.2. [P98153-1]
UniGeneiHs.517357.

3D structure databases

ProteinModelPortaliP98153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115314. 9 interactors.
IntActiP98153. 2 interactors.
MINTiMINT-1186622.
STRINGi9606.ENSP00000263196.

PTM databases

iPTMnetiP98153.
PhosphoSitePlusiP98153.

Polymorphism and mutation databases

BioMutaiDGCR2.
DMDMi1708396.

Proteomic databases

MaxQBiP98153.
PaxDbiP98153.
PeptideAtlasiP98153.
PRIDEiP98153.

Protocols and materials databases

DNASUi9993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263196; ENSP00000263196; ENSG00000070413. [P98153-1]
ENST00000537045; ENSP00000440062; ENSG00000070413. [P98153-2]
GeneIDi9993.
KEGGihsa:9993.
UCSCiuc062bkk.1. human. [P98153-1]

Organism-specific databases

CTDi9993.
DisGeNETi9993.
GeneCardsiDGCR2.
GeneReviewsiDGCR2.
HGNCiHGNC:2845. DGCR2.
HPAiHPA000873.
MIMi600594. gene.
neXtProtiNX_P98153.
OpenTargetsiENSG00000070413.
PharmGKBiPA27307.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPT1. Eukaryota.
ENOG4110Q97. LUCA.
GeneTreeiENSGT00390000017655.
HOGENOMiHOG000112997.
HOVERGENiHBG006117.
InParanoidiP98153.
PhylomeDBiP98153.
TreeFamiTF330997.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070413-MONOMER.

Miscellaneous databases

ChiTaRSiDGCR2. human.
GeneWikiiDGCR2.
GenomeRNAii9993.
PROiP98153.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070413.
CleanExiHS_DGCR2.
ExpressionAtlasiP98153. baseline and differential.
GenevisibleiP98153. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00192. LDLa. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS01208. VWFC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDD_HUMAN
AccessioniPrimary (citable) accession number: P98153
Secondary accession number(s): A6NIB5
, A8K6K5, B5TY34, B7Z935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.