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Protein

Complement component C8 beta chain

Gene

C8B

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 beta chain
Alternative name(s):
Complement component 8 subunit beta
Gene namesi
Name:C8B
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Propeptidei33 – 5422Sequence analysisPRO_0000023595Add
BLAST
Chaini55 – 590536Complement component C8 beta chainPRO_0000023596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi65 ↔ 100By similarity
Glycosylationi70 – 701C-linked (Man)By similarity
Glycosylationi73 – 731C-linked (Man)By similarity
Disulfide bondi76 ↔ 79By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 116By similarity
Disulfide bondi122 ↔ 133By similarity
Disulfide bondi127 ↔ 146By similarity
Disulfide bondi140 ↔ 155By similarity
Disulfide bondi378 ↔ 403By similarity
Modified residuei418 – 4181PhosphothreonineBy similarity
Disulfide bondi503 ↔ 550By similarity
Disulfide bondi505 ↔ 521By similarity
Disulfide bondi508 ↔ 523By similarity
Disulfide bondi525 ↔ 534By similarity
Glycosylationi551 – 5511C-linked (Man)By similarity
Glycosylationi554 – 5541C-linked (Man)By similarity
Disulfide bondi557 ↔ 590By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP98137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 11754TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 15738LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini158 – 504347MACPFPROSITE-ProRule annotationAdd
BLAST
Domaini505 – 53531EGF-likeAdd
BLAST
Domaini545 – 58844TSP type-1 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG106489.
InParanoidiP98137.
KOiK03998.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50092. TSP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSWTWTWR VPAELLLLCA ALGCLCVPGS RSERPRSLEP TVVNRSLAKS
60 70 80 90 100
RHSRSVDATP MPIDCELSSW SSWTMCDPCQ KKRYRHAYLL RPSQFNGEPC
110 120 130 140 150
NFSDKEVEDC ATSRPCRSQV RCEGFVCAQT GRCVNRRLLC NGDNDCGDQS
160 170 180 190 200
DEANCRKIYK KCHHEMEQYW AIGSLASGIN LFTNSLEGPV LDHRYYAGGC
210 220 230 240 250
NPHYILDMRF RKPYNVESYT PQTQGKYKFA LAEYESYSDF ERNVMEKTYS
260 270 280 290 300
KSTFNLGFKI PSIFEFGINT ESDQLMNYIS RTKRFSHTKS KFLHARSALE
310 320 330 340 350
VAHYKLKPRN LMLHYDFLQR VQRVPLEYSY GEYRDLFRDF GHHFITEAVL
360 370 380 390 400
GGIYEYTLIM NKEAMERADY SLNDVQACAK NDFKLGAAIE EVYVSLGVST
410 420 430 440 450
SKCRGILNEI KDRNKRDTMV QDLVVLVRGG ASEHITALAY SDLPTADLMQ
460 470 480 490 500
EWGDAVQYNP AIIKIKVEPL YELVTATDVA YSSTVKQNMR QALEEFQGEV
510 520 530 540 550
SPCRCAPCQG NGVPVQKGSR CDCICPVGFQ GSACEITSRK NVPIDGRWSC
560 570 580 590
WSRWSSCSGG QKTRRRQCNN PAPQDGGSPC SGPASETLAC
Length:590
Mass (Da):66,858
Last modified:February 1, 1996 - v1
Checksum:i54ED81B15F2CCC2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26980 mRNA. Translation: AAA31192.1.
PIRiI46687.
RefSeqiNP_001076137.1. NM_001082668.1.
UniGeneiOcu.1991.

Genome annotation databases

GeneIDi100009385.
KEGGiocu:100009385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26980 mRNA. Translation: AAA31192.1.
PIRiI46687.
RefSeqiNP_001076137.1. NM_001082668.1.
UniGeneiOcu.1991.

3D structure databases

ProteinModelPortaliP98137.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009385.
KEGGiocu:100009385.

Organism-specific databases

CTDi732.

Phylogenomic databases

HOVERGENiHBG106489.
InParanoidiP98137.
KOiK03998.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50092. TSP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO8B_RABIT
AccessioniPrimary (citable) accession number: P98137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.