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Protein

Complement component C8 alpha chain

Gene

C8A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 alpha chain
Alternative name(s):
Complement component 8 subunit alpha
Gene namesi
Name:C8A
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000002358921 – 30Sequence analysis10
ChainiPRO_000002359031 – 585Complement component C8 alpha chainAdd BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 74By similarity
Glycosylationi44C-linked (Man) tryptophanBy similarity1
Disulfide bondi50 ↔ 53By similarity
Disulfide bondi84 ↔ 90By similarity
Disulfide bondi96 ↔ 108By similarity
Disulfide bondi102 ↔ 121By similarity
Disulfide bondi115 ↔ 130By similarity
Disulfide bondi140 ↔ 177By similarity
Disulfide bondi194Interchain (with C-60 in C8-gamma chain)PROSITE-ProRule annotation
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543C-linked (Man) tryptophanBy similarity1
Glycosylationi546C-linked (Man) tryptophanBy similarity1
Glycosylationi549C-linked (Man) tryptophanBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP98136

Interactioni

Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Protein-protein interaction databases

CORUMiP98136
STRINGi9986.ENSOCUP00000014764

Structurei

3D structure databases

ProteinModelPortaliP98136
SMRiP98136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 91TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini94 – 132LDL-receptor class APROSITE-ProRule annotationAdd BLAST39
Domaini136 – 499MACPFPROSITE-ProRule annotationAdd BLAST364
Domaini499 – 530EGF-likeAdd BLAST32
Domaini540 – 584TSP type-1 2PROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG410IE8U Eukaryota
ENOG410Y5MF LUCA
HOGENOMiHOG000231146
HOVERGENiHBG005368
InParanoidiP98136
KOiK03997

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
InterProiView protein in InterPro
IPR037565 Complement_C8_alpha
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF385 PTHR19325:SF385, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00090 TSP_1, 2 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 2 hits
SUPFAMiSSF57424 SSF57424, 1 hit
SSF82895 SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50092 TSP1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAAFFTLF LVTCQPAVTA QEKVNQRVNR AATPRAFDCQ LSSWSEWTDC
60 70 80 90 100
FPCQDTKYRH RSLLQPNKFG GTICSGDIWD RASCYSPTAC LRPAQCGQDF
110 120 130 140 150
QCKETGRCLK RHLVCNGEND CLDGSDEDNC EDIRATESDC AQYDPIPGSE
160 170 180 190 200
KAALGYNILT QEEAQSVYDA RYYGGRCETV YNGEWRHVRY DPVCERLHHG
210 220 230 240 250
EDDKYFRKPY NFLKYHFEAR ADTGISFELY VDGNDLFSKV KNDKSHSAGV
260 270 280 290 300
TISAGLTGSP LLGTVGVSGS EDASFLNKLS QYNEKKYNFM RIFTKVQTAH
310 320 330 340 350
FKMRRDDIVL DEGMLQALVE LPEQYNYGMY SKFINDYGTH YITSGSMGGT
360 370 380 390 400
YEYILVLNTE KMESLGVTSE DISSCFGGFG EIQYEKGKIN AQGILSGKHC
410 420 430 440 450
KKSGSGDKEA DKMGQAVKDI ISRVRGGSSG WGGGLSQNGS ATTYRFWGRS
460 470 480 490 500
LKYNPVVIDF EMQPIHEVLL HTNLGHVEAK RQNLRRALDQ YLMEFNACRC
510 520 530 540 550
GPCFNNGKPI LEGTSCRCQC SLGLQGPACE QTEQQGAKAD GHWSCWGSWS
560 570 580
PCTAGTRERR RECNNPAPQN GGAPCPGWRV QTQAC
Length:585
Mass (Da):65,306
Last modified:February 1, 1996 - v1
Checksum:i2FFD3241B0310048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26981 mRNA Translation: AAA31191.1
PIRiI46686
RefSeqiNP_001075724.1, NM_001082255.1
UniGeneiOcu.1990

Genome annotation databases

GeneIDi100009076
KEGGiocu:100009076

Similar proteinsi

Entry informationi

Entry nameiCO8A_RABIT
AccessioniPrimary (citable) accession number: P98136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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