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P98133

- FBN1_BOVIN

UniProt

P98133 - FBN1_BOVIN

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Protein

Fibrillin-1

Gene

FBN1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix structural constituent Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_201925. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrillin-1
Alternative name(s):
MP340
Gene namesi
Name:FBN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 28712844Fibrillin-1PRO_0000007580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 94PROSITE-ProRule annotation
Disulfide bondi89 ↔ 100PROSITE-ProRule annotation
Disulfide bondi102 ↔ 111PROSITE-ProRule annotation
Disulfide bondi119 ↔ 129PROSITE-ProRule annotation
Disulfide bondi123 ↔ 134PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi150 ↔ 160PROSITE-ProRule annotation
Disulfide bondi154 ↔ 166PROSITE-ProRule annotation
Disulfide bondi168 ↔ 177PROSITE-ProRule annotation
Disulfide bondi250 ↔ 262PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Disulfide bondi273 ↔ 286PROSITE-ProRule annotation
Disulfide bondi292 ↔ 304PROSITE-ProRule annotation
Disulfide bondi299 ↔ 313PROSITE-ProRule annotation
Disulfide bondi315 ↔ 328PROSITE-ProRule annotation
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi453 ↔ 465PROSITE-ProRule annotation
Disulfide bondi460 ↔ 474PROSITE-ProRule annotation
Disulfide bondi476 ↔ 488PROSITE-ProRule annotation
Disulfide bondi494 ↔ 504PROSITE-ProRule annotation
Disulfide bondi499 ↔ 513PROSITE-ProRule annotation
Disulfide bondi515 ↔ 528PROSITE-ProRule annotation
Disulfide bondi534 ↔ 546PROSITE-ProRule annotation
Disulfide bondi541 ↔ 555PROSITE-ProRule annotation
Disulfide bondi557 ↔ 570PROSITE-ProRule annotation
Disulfide bondi576 ↔ 587PROSITE-ProRule annotation
Disulfide bondi582 ↔ 596PROSITE-ProRule annotation
Disulfide bondi598 ↔ 611PROSITE-ProRule annotation
Disulfide bondi617 ↔ 628PROSITE-ProRule annotation
Disulfide bondi623 ↔ 637PROSITE-ProRule annotation
Disulfide bondi639 ↔ 652PROSITE-ProRule annotation
Disulfide bondi727 ↔ 739PROSITE-ProRule annotation
Disulfide bondi734 ↔ 748PROSITE-ProRule annotation
Disulfide bondi750 ↔ 763PROSITE-ProRule annotation
Disulfide bondi769 ↔ 781PROSITE-ProRule annotation
Disulfide bondi776 ↔ 790PROSITE-ProRule annotation
Disulfide bondi792 ↔ 805PROSITE-ProRule annotation
Disulfide bondi811 ↔ 821PROSITE-ProRule annotation
Disulfide bondi816 ↔ 830PROSITE-ProRule annotation
Disulfide bondi832 ↔ 845PROSITE-ProRule annotation
Disulfide bondi853 ↔ 875PROSITE-ProRule annotation
Disulfide bondi862 ↔ 887PROSITE-ProRule annotation
Disulfide bondi876 ↔ 890PROSITE-ProRule annotation
Disulfide bondi896 ↔ 908PROSITE-ProRule annotation
Disulfide bondi914 ↔ 926PROSITE-ProRule annotation
Disulfide bondi921 ↔ 935PROSITE-ProRule annotation
Disulfide bondi937 ↔ 950PROSITE-ProRule annotation
Disulfide bondi1032 ↔ 1044PROSITE-ProRule annotation
Disulfide bondi1039 ↔ 1053PROSITE-ProRule annotation
Disulfide bondi1055 ↔ 1068PROSITE-ProRule annotation
Glycosylationi1067 – 10671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1074 ↔ 1086PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1095PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1111PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1129PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1138PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1153PROSITE-ProRule annotation
Glycosylationi1149 – 11491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1159 ↔ 1171PROSITE-ProRule annotation
Disulfide bondi1166 ↔ 1180PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1195PROSITE-ProRule annotation
Disulfide bondi1201 ↔ 1212PROSITE-ProRule annotation
Disulfide bondi1208 ↔ 1221PROSITE-ProRule annotation
Disulfide bondi1223 ↔ 1236PROSITE-ProRule annotation
Disulfide bondi1242 ↔ 1254PROSITE-ProRule annotation
Disulfide bondi1249 ↔ 1263PROSITE-ProRule annotation
Disulfide bondi1265 ↔ 1278PROSITE-ProRule annotation
Disulfide bondi1284 ↔ 1296PROSITE-ProRule annotation
Disulfide bondi1291 ↔ 1305PROSITE-ProRule annotation
Disulfide bondi1307 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1326 ↔ 1339PROSITE-ProRule annotation
Disulfide bondi1333 ↔ 1348PROSITE-ProRule annotation
Disulfide bondi1350 ↔ 1361PROSITE-ProRule annotation
Disulfide bondi1367 ↔ 1380PROSITE-ProRule annotation
Glycosylationi1369 – 13691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1374 ↔ 1389PROSITE-ProRule annotation
Disulfide bondi1391 ↔ 1402PROSITE-ProRule annotation
Disulfide bondi1408 ↔ 1420PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1429PROSITE-ProRule annotation
Disulfide bondi1431 ↔ 1444PROSITE-ProRule annotation
Disulfide bondi1450 ↔ 1461PROSITE-ProRule annotation
Disulfide bondi1456 ↔ 1470PROSITE-ProRule annotation
Disulfide bondi1472 ↔ 1485PROSITE-ProRule annotation
Glycosylationi1484 – 14841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1491 ↔ 1502PROSITE-ProRule annotation
Disulfide bondi1497 ↔ 1511PROSITE-ProRule annotation
Disulfide bondi1513 ↔ 1526PROSITE-ProRule annotation
Disulfide bondi1534 ↔ 1562PROSITE-ProRule annotation
Disulfide bondi1549 ↔ 1574PROSITE-ProRule annotation
Disulfide bondi1563 ↔ 1577PROSITE-ProRule annotation
Disulfide bondi1564 ↔ 1589PROSITE-ProRule annotation
Glycosylationi1581 – 15811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1610 ↔ 1622PROSITE-ProRule annotation
Disulfide bondi1617 ↔ 1631PROSITE-ProRule annotation
Disulfide bondi1633 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1652 ↔ 1663PROSITE-ProRule annotation
Disulfide bondi1658 ↔ 1672PROSITE-ProRule annotation
Glycosylationi1669 – 16691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1674 ↔ 1687PROSITE-ProRule annotation
Glycosylationi1703 – 17031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1713 – 17131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1770 ↔ 1782PROSITE-ProRule annotation
Disulfide bondi1777 ↔ 1791PROSITE-ProRule annotation
Disulfide bondi1793 ↔ 1806PROSITE-ProRule annotation
Disulfide bondi1812 ↔ 1824PROSITE-ProRule annotation
Disulfide bondi1818 ↔ 1833PROSITE-ProRule annotation
Disulfide bondi1835 ↔ 1847PROSITE-ProRule annotation
Disulfide bondi1853 ↔ 1865PROSITE-ProRule annotation
Disulfide bondi1860 ↔ 1874PROSITE-ProRule annotation
Disulfide bondi1876 ↔ 1889PROSITE-ProRule annotation
Disulfide bondi1895 ↔ 1905PROSITE-ProRule annotation
Disulfide bondi1900 ↔ 1914PROSITE-ProRule annotation
Glycosylationi1902 – 19021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1916 ↔ 1928PROSITE-ProRule annotation
Disulfide bondi1934 ↔ 1947PROSITE-ProRule annotation
Disulfide bondi1942 ↔ 1956PROSITE-ProRule annotation
Disulfide bondi1958 ↔ 1971PROSITE-ProRule annotation
Disulfide bondi1977 ↔ 1989PROSITE-ProRule annotation
Disulfide bondi1984 ↔ 1998PROSITE-ProRule annotation
Disulfide bondi2000 ↔ 2011PROSITE-ProRule annotation
Disulfide bondi2017 ↔ 2029PROSITE-ProRule annotation
Disulfide bondi2024 ↔ 2038PROSITE-ProRule annotation
Disulfide bondi2040 ↔ 2053PROSITE-ProRule annotation
Glycosylationi2077 – 20771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2131 ↔ 2142PROSITE-ProRule annotation
Disulfide bondi2137 ↔ 2151PROSITE-ProRule annotation
Disulfide bondi2153 ↔ 2164PROSITE-ProRule annotation
Disulfide bondi2170 ↔ 2181PROSITE-ProRule annotation
Disulfide bondi2176 ↔ 2190PROSITE-ProRule annotation
Glycosylationi2178 – 21781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2192 ↔ 2204PROSITE-ProRule annotation
Disulfide bondi2210 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2217 ↔ 2230PROSITE-ProRule annotation
Disulfide bondi2232 ↔ 2245PROSITE-ProRule annotation
Disulfide bondi2251 ↔ 2265PROSITE-ProRule annotation
Disulfide bondi2258 ↔ 2274PROSITE-ProRule annotation
Disulfide bondi2276 ↔ 2289PROSITE-ProRule annotation
Disulfide bondi2295 ↔ 2307PROSITE-ProRule annotation
Disulfide bondi2302 ↔ 2316PROSITE-ProRule annotation
Disulfide bondi2318 ↔ 2331PROSITE-ProRule annotation
Disulfide bondi2406 ↔ 2418PROSITE-ProRule annotation
Disulfide bondi2413 ↔ 2427PROSITE-ProRule annotation
Disulfide bondi2429 ↔ 2442PROSITE-ProRule annotation
Disulfide bondi2448 ↔ 2459PROSITE-ProRule annotation
Disulfide bondi2455 ↔ 2468PROSITE-ProRule annotation
Disulfide bondi2470 ↔ 2483PROSITE-ProRule annotation
Disulfide bondi2489 ↔ 2500PROSITE-ProRule annotation
Disulfide bondi2496 ↔ 2509PROSITE-ProRule annotation
Disulfide bondi2511 ↔ 2522PROSITE-ProRule annotation
Disulfide bondi2528 ↔ 2541PROSITE-ProRule annotation
Disulfide bondi2535 ↔ 2550PROSITE-ProRule annotation
Disulfide bondi2552 ↔ 2565PROSITE-ProRule annotation
Disulfide bondi2571 ↔ 2581PROSITE-ProRule annotation
Disulfide bondi2577 ↔ 2590PROSITE-ProRule annotation
Disulfide bondi2592 ↔ 2605PROSITE-ProRule annotation
Disulfide bondi2611 ↔ 2622PROSITE-ProRule annotation
Disulfide bondi2617 ↔ 2631PROSITE-ProRule annotation
Disulfide bondi2633 ↔ 2646PROSITE-ProRule annotation
Disulfide bondi2652 ↔ 2663PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2672PROSITE-ProRule annotation
Disulfide bondi2674 ↔ 2686PROSITE-ProRule annotation
Glycosylationi2734 – 27341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2750 – 27501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2767 – 27671N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98133.
PRIDEiP98133.

Interactioni

Subunit structurei

Interacts with COL16A1. Interacts with ADAMTSL4 (By similarity). Interacts with ADAMTS10; this interaction promotes microfibrils assembly (By similarity). Interacts with THSD4; this interaction promotes fibril formation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035493.

Structurei

3D structure databases

ProteinModelPortaliP98133.
SMRiP98133. Positions 1069-1154, 1486-1647, 2054-2205, 2455-2484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 11232EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini115 – 14632EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 17832EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini184 – 23653TB 1Add
BLAST
Domaini246 – 28742EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini288 – 32942EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini334 – 38956TB 2Add
BLAST
Domaini449 – 48941EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini490 – 52940EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini530 – 57142EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini572 – 61241EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini613 – 65341EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini659 – 71153TB 3Add
BLAST
Domaini723 – 76442EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini765 – 80642EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini807 – 84640EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini851 – 90252TB 4Add
BLAST
Domaini910 – 95142EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini956 – 100853TB 5Add
BLAST
Domaini1028 – 106942EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1070 – 111243EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1113 – 115442EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1155 – 119642EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1197 – 123741EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1238 – 127942EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1280 – 132142EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1322 – 136241EGF-like 22; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1363 – 140341EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1404 – 144542EGF-like 24; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1446 – 148641EGF-like 25; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1487 – 152741EGF-like 26; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1532 – 158958TB 6Add
BLAST
Domaini1606 – 164742EGF-like 27; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1648 – 168841EGF-like 28; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1693 – 174856TB 7Add
BLAST
Domaini1766 – 180742EGF-like 29; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1808 – 184841EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1849 – 189042EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1891 – 192939EGF-like 32; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1930 – 197243EGF-like 33; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1973 – 201240EGF-like 34; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2013 – 205442EGF-like 35; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2059 – 211153TB 8Add
BLAST
Domaini2127 – 216539EGF-like 36; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2166 – 220540EGF-like 37; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2206 – 224641EGF-like 38; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2247 – 229044EGF-like 39; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2291 – 233242EGF-like 40; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2337 – 239054TB 9Add
BLAST
Domaini2402 – 244342EGF-like 41; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2444 – 248441EGF-like 42; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2485 – 252339EGF-like 43; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2524 – 256643EGF-like 44; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2567 – 260640EGF-like 45; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2607 – 264741EGF-like 46; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2648 – 268740EGF-like 47; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi392 – 44655Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the fibrillin family.Curated
Contains 47 EGF-like domains.PROSITE-ProRule annotation
Contains 9 TB (TGF-beta binding) domains.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231768.
HOVERGENiHBG005643.
InParanoidiP98133.
KOiK06825.

Family and domain databases

Gene3Di3.90.290.10. 10 hits.
InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN/EtMIC4.
IPR009030. Growth_fac_rcpt_N_dom.
IPR017878. TB_dom.
[Graphical view]
PANTHERiPTHR24039. PTHR24039. 1 hit.
PfamiPF12662. cEGF. 5 hits.
PF07645. EGF_CA. 33 hits.
PF00683. TB. 9 hits.
[Graphical view]
PIRSFiPIRSF036312. Fibrillin. 1 hit.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 42 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 10 hits.
SSF57581. SSF57581. 9 hits.
PROSITEiPS00010. ASX_HYDROXYL. 43 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 38 hits.
PS50026. EGF_3. 45 hits.
PS01187. EGF_CA. 43 hits.
PS51364. TB. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98133-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRRGGLLEVA LGFTVLLASY TSHGADTNLE AGNVKETRAN RAKRRGGGGH
60 70 80 90 100
NALKGPNVCG SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC
110 120 130 140 150
TCPSGQIAPS CGSRSIQHCN IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC
160 170 180 190 200
ESGCLNGGRC VAPNRCACTY GFTGPQCERD YRTGPCFTVI SNQMCQGQLS
210 220 230 240 250
GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR TGACQDVDEC
260 270 280 290 300
QAIPGLCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGICD
310 320 330 340 350
GGECTNTVSS YFCKCPPGFY TSPDGTRCID VRPGYCYTAL ANGRCSNQLP
360 370 380 390 400
QSITKMQCCC DAGRCWSPGV TVAPEMCPIR ATEDFNKLCS VPMVIPERPG
410 420 430 440 450
YPPPPLGPVP PVQPVPPGFP PGPQIMIPRP PVEYPYPSRE PPRVLPVNVT
460 470 480 490 500
DYCQLFRYLC QNGRCIPTPG SYRCECNKGF QLDLRGECID VDECEKNPCA
510 520 530 540 550
GGECINTQGS YTCQCRPGYQ STLTRTECRD IDECLQNGRI CNNGRCINTD
560 570 580 590 600
GSFHCVCNAG FHVTRDGKNC EDMDECSIRN MCLNGMCINE DGSFKCICKP
610 620 630 640 650
GFQLASDGRY CKDINECETL GICMNGRCVN TDGSYRCECF PGLAVGLDGR
660 670 680 690 700
VCVDTHMRST CYGGYKRGQC VKPLFGAVTK SECCCASTEY AFGEPCQPCP
710 720 730 740 750
SQNSAEYQAL CSSGPGITSA GSDINECALD PDICPNGICE NLRGTYKCIC
760 770 780 790 800
NSGYEVDSTG KNCVDINECV LNSLLCDNGQ CRNTPGSFVC TCPKGFIYKP
810 820 830 840 850
ELKTCEDIDE CESSPCINGV CKNSPGSFIC ECSSESTLDP TKTICIETIK
860 870 880 890 900
GTCWQTVIDG RCEININGAT LKSQCCSSLG AAWGSPCTPC QVDPICGKGY
910 920 930 940 950
SRIKGTQCED IDECEVFPGV CKNGLCVNSK GSFKCQCPSG MTLDATGRIC
960 970 980 990 1000
LDIRLETCFL RYEDEECTLP VAGRHRMDAC CCSVGAAWGT EECEECPVRN
1010 1020 1030 1040 1050
TPEYEELCPR GPGFATKEIT NGKRFFKDIN ECKMIPNLCT HGKCRNTIGS
1060 1070 1080 1090 1100
FKCRCDSGFA LDSEERNCTD IDECRISPDL CGRGQCVNTP GDFECKCDEG
1110 1120 1130 1140 1150
YESGFMMMKN CMDIDECQRD PLLCRGGVCL NTEGSYRCEC PPGHQLAPNI
1160 1170 1180 1190 1200
SACIDINECE LSAHLCPHGR CVNLIGKYQC ACNPGYHSTP DRLFCVDIDE
1210 1220 1230 1240 1250
CSIMNGGCET FCTNSEGSYE CSCQPGFALM PDQRSCTDID ECEDNPNICD
1260 1270 1280 1290 1300
GGQCTNIPGE YRCLCYDGFM ASEDMKTCVD VNECDLNPNI CLSGTCENTK
1310 1320 1330 1340 1350
GSFICHCDMG YSGKKGKTGC TDINECEIGA HNCDRHAVCT NTAGSFKCSC
1360 1370 1380 1390 1400
SPGWIGDGIK CTDLDECSNG THMCSQHADC KNTMGSYRCL CKEGYTGDGF
1410 1420 1430 1440 1450
TCTDLDECSE NLNLCGNGQC LNAPGGYRCE CDMGFVPSAD GKACEDIDEC
1460 1470 1480 1490 1500
SLPNICVFGT CHNLPGLFRC ECEIGYELDR SGGNCTDVNE CLDPTTCISG
1510 1520 1530 1540 1550
NCVNTPGSYT CDCPPDFELN PTRVGCVDTR SGNCYLDIRP RGDNGDTACS
1560 1570 1580 1590 1600
NEIGVGVSKA SCCCSLGKAW GTPCELCPPV NTSEYKILCP GGEGFRPNPI
1610 1620 1630 1640 1650
TVILEDIDEC QELPGLCQGG KCINTFGSFQ CRCPTGYYLN EDTRVCDDVN
1660 1670 1680 1690 1700
ECETPGICGP GTCYNTVGNY TCICPPDYMQ VNGGNNCMDM RRSLCYRNYY
1710 1720 1730 1740 1750
ADNQTCDGEL LFNMTKKMCC CSYNIGRAWN KPCEQCPIPS TDEFATLCGS
1760 1770 1780 1790 1800
QRPGFVIDIY TGLPVDIDEC REIPGVCENG VCINMVGSFR CECPVGFFYN
1810 1820 1830 1840 1850
DKLLVCEDID ECQNGPVCQR NAECINTAGS YRCDCKPGYR FTSTGQCNDR
1860 1870 1880 1890 1900
NECQEIPNIC SHGQCIDTVG SFYCLCHTGF KTNADQTMCL DINECERDAC
1910 1920 1930 1940 1950
GNGTCRNTIG SFNCRCNHGF ILSHNNDCID VDECATGNGN LCRNGQCINT
1960 1970 1980 1990 2000
VGSFQCQCNE GYEVAPDGRT CVDINECLLD PRKCAPGTCQ NLDGSYRCIC
2010 2020 2030 2040 2050
PPGYSLQNDK CEDIDECVEE PEICALGTCS NTEGSFKCLC PDGFSLSSTG
2060 2070 2080 2090 2100
RRCQDLRMSY CYAKFEGGKC SSPKSRNHSK QECCCALKGE GWGDPCELCP
2110 2120 2130 2140 2150
TEPDEAFRQI CPYGSGIIVG PDDSAVDMDE CKEPDVCKHG QCINTDGSYR
2160 2170 2180 2190 2200
CECPFGYILQ GNECVDTDEC SVGNPCGNGT CKNVIGGFEC TCEEGFEPGP
2210 2220 2230 2240 2250
MMTCEDINEC AQNPLLCAFR CVNTYGSYEC KCPAGYVLRE DRRMCKDEDE
2260 2270 2280 2290 2300
CEEGKHDCAE KQMECKNLIG TYLCICGPGY QRRPDGEGCV DENECQTKPG
2310 2320 2330 2340 2350
ICENGRCLNT RGSYTCECND GFTASPNQDE CLDNREGYCF TEVLQNMCQI
2360 2370 2380 2390 2400
GSSNRNPVTK SECCCDGGRG WGPHCEICPF QGTVAFKKLC PHGRGFMTNG
2410 2420 2430 2440 2450
ADIDECKVIH DVCRNGECVN DRGSYHCICK TGYTPDITGT ACVDLNECNQ
2460 2470 2480 2490 2500
APKPCNFICK NTEGSYQCSC PKGYILQEDG RSCKDLDECA TKQHNCQFLC
2510 2520 2530 2540 2550
VNTIGSFTCK CPPGFTQHHT ACIDNNECTS DINLCGSKGI CQNTPGSFTC
2560 2570 2580 2590 2600
ECQRGFSLDP TGASCEDVDE CEGNHRCQHG CQNIIGGYRC SCPQGYLQHY
2610 2620 2630 2640 2650
QWNQCVDENE CLSAHICGGA SCHNTLGSYK CMCPAGFQYE QFSGGCQDIN
2660 2670 2680 2690 2700
ECGSAQAPCS YGCSNTEGGY LCACPPGYFR IGQGHCVSGM GMGRGNPEPP
2710 2720 2730 2740 2750
ASGEMDDNSL SPEACYECKI NGYPKRGRKR RSANETDASN IEDQPEIEAN
2760 2770 2780 2790 2800
VSLASWDVEK TAVFAFNISH ISNKVRILEL LPALTTLTNH NRYLIESGNE
2810 2820 2830 2840 2850
NGFFKINQKE GISYLHFTKK KPVAGTYSLQ ISSTPLYKKK ELNQLEDKYD
2860 2870
KDYLSGELGD NLKMKIQILL H
Length:2,871
Mass (Da):312,250
Last modified:October 1, 1996 - v1
Checksum:iE77FD2A4F1451CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28748 mRNA. Translation: AAA74122.1.
PIRiA55567.
RefSeqiNP_776478.1. NM_174053.2.
UniGeneiBt.107024.

Genome annotation databases

GeneIDi281154.
KEGGibta:281154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28748 mRNA. Translation: AAA74122.1 .
PIRi A55567.
RefSeqi NP_776478.1. NM_174053.2.
UniGenei Bt.107024.

3D structure databases

ProteinModelPortali P98133.
SMRi P98133. Positions 1069-1154, 1486-1647, 2054-2205, 2455-2484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000035493.

Proteomic databases

PaxDbi P98133.
PRIDEi P98133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281154.
KEGGi bta:281154.

Organism-specific databases

CTDi 2200.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231768.
HOVERGENi HBG005643.
InParanoidi P98133.
KOi K06825.

Enzyme and pathway databases

Reactomei REACT_201925. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi 20805217.

Family and domain databases

Gene3Di 3.90.290.10. 10 hits.
InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN/EtMIC4.
IPR009030. Growth_fac_rcpt_N_dom.
IPR017878. TB_dom.
[Graphical view ]
PANTHERi PTHR24039. PTHR24039. 1 hit.
Pfami PF12662. cEGF. 5 hits.
PF07645. EGF_CA. 33 hits.
PF00683. TB. 9 hits.
[Graphical view ]
PIRSFi PIRSF036312. Fibrillin. 1 hit.
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 42 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 10 hits.
SSF57581. SSF57581. 9 hits.
PROSITEi PS00010. ASX_HYDROXYL. 43 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 38 hits.
PS50026. EGF_3. 45 hits.
PS01187. EGF_CA. 43 hits.
PS51364. TB. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the coding region of the bovine fibrillin cDNA and localization to bovine chromosome 10."
    Tilstra D.J., Potter K.A., Byers P.H.
    Genomics 23:480-485(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)."
    Gibson M.A., Hatzinikolas G., Kumaratilake J.S., Sandberg L.B., Nicholl J.K., Sutherland G.R., Cleary E.G.
    J. Biol. Chem. 271:1096-1103(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiFBN1_BOVIN
AccessioniPrimary (citable) accession number: P98133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3