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P98133

- FBN1_BOVIN

UniProt

P98133 - FBN1_BOVIN

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Protein

Fibrillin-1

Gene
FBN1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix structural constituent Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_201925. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrillin-1
Alternative name(s):
MP340
Gene namesi
Name:FBN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 28712844Fibrillin-1PRO_0000007580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 94 By similarity
Disulfide bondi89 ↔ 100 By similarity
Disulfide bondi102 ↔ 111 By similarity
Disulfide bondi119 ↔ 129 By similarity
Disulfide bondi123 ↔ 134 By similarity
Disulfide bondi136 ↔ 145 By similarity
Disulfide bondi150 ↔ 160 By similarity
Disulfide bondi154 ↔ 166 By similarity
Disulfide bondi168 ↔ 177 By similarity
Disulfide bondi250 ↔ 262 By similarity
Disulfide bondi257 ↔ 271 By similarity
Disulfide bondi273 ↔ 286 By similarity
Disulfide bondi292 ↔ 304 By similarity
Disulfide bondi299 ↔ 313 By similarity
Disulfide bondi315 ↔ 328 By similarity
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi453 ↔ 465 By similarity
Disulfide bondi460 ↔ 474 By similarity
Disulfide bondi476 ↔ 488 By similarity
Disulfide bondi494 ↔ 504 By similarity
Disulfide bondi499 ↔ 513 By similarity
Disulfide bondi515 ↔ 528 By similarity
Disulfide bondi534 ↔ 546 By similarity
Disulfide bondi541 ↔ 555 By similarity
Disulfide bondi557 ↔ 570 By similarity
Disulfide bondi576 ↔ 587 By similarity
Disulfide bondi582 ↔ 596 By similarity
Disulfide bondi598 ↔ 611 By similarity
Disulfide bondi617 ↔ 628 By similarity
Disulfide bondi623 ↔ 637 By similarity
Disulfide bondi639 ↔ 652 By similarity
Disulfide bondi727 ↔ 739 By similarity
Disulfide bondi734 ↔ 748 By similarity
Disulfide bondi750 ↔ 763 By similarity
Disulfide bondi769 ↔ 781 By similarity
Disulfide bondi776 ↔ 790 By similarity
Disulfide bondi792 ↔ 805 By similarity
Disulfide bondi811 ↔ 821 By similarity
Disulfide bondi816 ↔ 830 By similarity
Disulfide bondi832 ↔ 845 By similarity
Disulfide bondi853 ↔ 875 By similarity
Disulfide bondi862 ↔ 887 By similarity
Disulfide bondi876 ↔ 890 By similarity
Disulfide bondi896 ↔ 908 By similarity
Disulfide bondi914 ↔ 926 By similarity
Disulfide bondi921 ↔ 935 By similarity
Disulfide bondi937 ↔ 950 By similarity
Disulfide bondi1032 ↔ 1044 By similarity
Disulfide bondi1039 ↔ 1053 By similarity
Disulfide bondi1055 ↔ 1068 By similarity
Glycosylationi1067 – 10671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1074 ↔ 1086 By similarity
Disulfide bondi1081 ↔ 1095 By similarity
Disulfide bondi1097 ↔ 1111 By similarity
Disulfide bondi1117 ↔ 1129 By similarity
Disulfide bondi1124 ↔ 1138 By similarity
Disulfide bondi1140 ↔ 1153 By similarity
Glycosylationi1149 – 11491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1159 ↔ 1171 By similarity
Disulfide bondi1166 ↔ 1180 By similarity
Disulfide bondi1182 ↔ 1195 By similarity
Disulfide bondi1201 ↔ 1212 By similarity
Disulfide bondi1208 ↔ 1221 By similarity
Disulfide bondi1223 ↔ 1236 By similarity
Disulfide bondi1242 ↔ 1254 By similarity
Disulfide bondi1249 ↔ 1263 By similarity
Disulfide bondi1265 ↔ 1278 By similarity
Disulfide bondi1284 ↔ 1296 By similarity
Disulfide bondi1291 ↔ 1305 By similarity
Disulfide bondi1307 ↔ 1320 By similarity
Disulfide bondi1326 ↔ 1339 By similarity
Disulfide bondi1333 ↔ 1348 By similarity
Disulfide bondi1350 ↔ 1361 By similarity
Disulfide bondi1367 ↔ 1380 By similarity
Glycosylationi1369 – 13691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1374 ↔ 1389 By similarity
Disulfide bondi1391 ↔ 1402 By similarity
Disulfide bondi1408 ↔ 1420 By similarity
Disulfide bondi1415 ↔ 1429 By similarity
Disulfide bondi1431 ↔ 1444 By similarity
Disulfide bondi1450 ↔ 1461 By similarity
Disulfide bondi1456 ↔ 1470 By similarity
Disulfide bondi1472 ↔ 1485 By similarity
Glycosylationi1484 – 14841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1491 ↔ 1502 By similarity
Disulfide bondi1497 ↔ 1511 By similarity
Disulfide bondi1513 ↔ 1526 By similarity
Disulfide bondi1534 ↔ 1562 By similarity
Disulfide bondi1549 ↔ 1574 By similarity
Disulfide bondi1563 ↔ 1577 By similarity
Disulfide bondi1564 ↔ 1589 By similarity
Glycosylationi1581 – 15811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1610 ↔ 1622 By similarity
Disulfide bondi1617 ↔ 1631 By similarity
Disulfide bondi1633 ↔ 1646 By similarity
Disulfide bondi1652 ↔ 1663 By similarity
Disulfide bondi1658 ↔ 1672 By similarity
Glycosylationi1669 – 16691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1674 ↔ 1687 By similarity
Glycosylationi1703 – 17031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1713 – 17131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1770 ↔ 1782 By similarity
Disulfide bondi1777 ↔ 1791 By similarity
Disulfide bondi1793 ↔ 1806 By similarity
Disulfide bondi1812 ↔ 1824 By similarity
Disulfide bondi1818 ↔ 1833 By similarity
Disulfide bondi1835 ↔ 1847 By similarity
Disulfide bondi1853 ↔ 1865 By similarity
Disulfide bondi1860 ↔ 1874 By similarity
Disulfide bondi1876 ↔ 1889 By similarity
Disulfide bondi1895 ↔ 1905 By similarity
Disulfide bondi1900 ↔ 1914 By similarity
Glycosylationi1902 – 19021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1916 ↔ 1928 By similarity
Disulfide bondi1934 ↔ 1947 By similarity
Disulfide bondi1942 ↔ 1956 By similarity
Disulfide bondi1958 ↔ 1971 By similarity
Disulfide bondi1977 ↔ 1989 By similarity
Disulfide bondi1984 ↔ 1998 By similarity
Disulfide bondi2000 ↔ 2011 By similarity
Disulfide bondi2017 ↔ 2029 By similarity
Disulfide bondi2024 ↔ 2038 By similarity
Disulfide bondi2040 ↔ 2053 By similarity
Glycosylationi2077 – 20771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2131 ↔ 2142 By similarity
Disulfide bondi2137 ↔ 2151 By similarity
Disulfide bondi2153 ↔ 2164 By similarity
Disulfide bondi2170 ↔ 2181 By similarity
Disulfide bondi2176 ↔ 2190 By similarity
Glycosylationi2178 – 21781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2192 ↔ 2204 By similarity
Disulfide bondi2210 ↔ 2221 By similarity
Disulfide bondi2217 ↔ 2230 By similarity
Disulfide bondi2232 ↔ 2245 By similarity
Disulfide bondi2251 ↔ 2265 By similarity
Disulfide bondi2258 ↔ 2274 By similarity
Disulfide bondi2276 ↔ 2289 By similarity
Disulfide bondi2295 ↔ 2307 By similarity
Disulfide bondi2302 ↔ 2316 By similarity
Disulfide bondi2318 ↔ 2331 By similarity
Disulfide bondi2406 ↔ 2418 By similarity
Disulfide bondi2413 ↔ 2427 By similarity
Disulfide bondi2429 ↔ 2442 By similarity
Disulfide bondi2448 ↔ 2459 By similarity
Disulfide bondi2455 ↔ 2468 By similarity
Disulfide bondi2470 ↔ 2483 By similarity
Disulfide bondi2489 ↔ 2500 By similarity
Disulfide bondi2496 ↔ 2509 By similarity
Disulfide bondi2511 ↔ 2522 By similarity
Disulfide bondi2528 ↔ 2541 By similarity
Disulfide bondi2535 ↔ 2550 By similarity
Disulfide bondi2552 ↔ 2565 By similarity
Disulfide bondi2571 ↔ 2581 By similarity
Disulfide bondi2577 ↔ 2590 By similarity
Disulfide bondi2592 ↔ 2605 By similarity
Disulfide bondi2611 ↔ 2622 By similarity
Disulfide bondi2617 ↔ 2631 By similarity
Disulfide bondi2633 ↔ 2646 By similarity
Disulfide bondi2652 ↔ 2663 By similarity
Disulfide bondi2659 ↔ 2672 By similarity
Disulfide bondi2674 ↔ 2686 By similarity
Glycosylationi2734 – 27341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2750 – 27501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2767 – 27671N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98133.
PRIDEiP98133.

Interactioni

Subunit structurei

Interacts with COL16A1. Interacts with ADAMTSL4 By similarity. Interacts with ADAMTS10; this interaction promotes microfibrils assembly By similarity. Interacts with THSD4; this interaction promotes fibril formation By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035493.

Structurei

3D structure databases

ProteinModelPortaliP98133.
SMRiP98133. Positions 1069-1154, 1486-1647, 2054-2205, 2455-2484.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 11232EGF-like 1Add
BLAST
Domaini115 – 14632EGF-like 2Add
BLAST
Domaini147 – 17832EGF-like 3Add
BLAST
Domaini184 – 23653TB 1Add
BLAST
Domaini246 – 28742EGF-like 4; calcium-bindingAdd
BLAST
Domaini288 – 32942EGF-like 5; calcium-bindingAdd
BLAST
Domaini334 – 38956TB 2Add
BLAST
Domaini449 – 48941EGF-like 6Add
BLAST
Domaini490 – 52940EGF-like 7; calcium-bindingAdd
BLAST
Domaini530 – 57142EGF-like 8; calcium-bindingAdd
BLAST
Domaini572 – 61241EGF-like 9; calcium-bindingAdd
BLAST
Domaini613 – 65341EGF-like 10; calcium-bindingAdd
BLAST
Domaini659 – 71153TB 3Add
BLAST
Domaini723 – 76442EGF-like 11; calcium-bindingAdd
BLAST
Domaini765 – 80642EGF-like 12; calcium-bindingAdd
BLAST
Domaini807 – 84640EGF-like 13; calcium-bindingAdd
BLAST
Domaini851 – 90252TB 4Add
BLAST
Domaini910 – 95142EGF-like 14; calcium-bindingAdd
BLAST
Domaini956 – 100853TB 5Add
BLAST
Domaini1028 – 106942EGF-like 15; calcium-bindingAdd
BLAST
Domaini1070 – 111243EGF-like 16; calcium-bindingAdd
BLAST
Domaini1113 – 115442EGF-like 17; calcium-bindingAdd
BLAST
Domaini1155 – 119642EGF-like 18; calcium-bindingAdd
BLAST
Domaini1197 – 123741EGF-like 19; calcium-bindingAdd
BLAST
Domaini1238 – 127942EGF-like 20; calcium-bindingAdd
BLAST
Domaini1280 – 132142EGF-like 21; calcium-bindingAdd
BLAST
Domaini1322 – 136241EGF-like 22; calcium-bindingAdd
BLAST
Domaini1363 – 140341EGF-like 23; calcium-bindingAdd
BLAST
Domaini1404 – 144542EGF-like 24; calcium-bindingAdd
BLAST
Domaini1446 – 148641EGF-like 25; calcium-bindingAdd
BLAST
Domaini1487 – 152741EGF-like 26; calcium-bindingAdd
BLAST
Domaini1532 – 158958TB 6Add
BLAST
Domaini1606 – 164742EGF-like 27; calcium-bindingAdd
BLAST
Domaini1648 – 168841EGF-like 28; calcium-bindingAdd
BLAST
Domaini1693 – 174856TB 7Add
BLAST
Domaini1766 – 180742EGF-like 29; calcium-bindingAdd
BLAST
Domaini1808 – 184841EGF-like 30; calcium-bindingAdd
BLAST
Domaini1849 – 189042EGF-like 31; calcium-bindingAdd
BLAST
Domaini1891 – 192939EGF-like 32; calcium-bindingAdd
BLAST
Domaini1930 – 197243EGF-like 33; calcium-bindingAdd
BLAST
Domaini1973 – 201240EGF-like 34; calcium-bindingAdd
BLAST
Domaini2013 – 205442EGF-like 35; calcium-bindingAdd
BLAST
Domaini2059 – 211153TB 8Add
BLAST
Domaini2127 – 216539EGF-like 36; calcium-bindingAdd
BLAST
Domaini2166 – 220540EGF-like 37; calcium-bindingAdd
BLAST
Domaini2206 – 224641EGF-like 38; calcium-bindingAdd
BLAST
Domaini2247 – 229044EGF-like 39; calcium-bindingAdd
BLAST
Domaini2291 – 233242EGF-like 40; calcium-bindingAdd
BLAST
Domaini2337 – 239054TB 9Add
BLAST
Domaini2402 – 244342EGF-like 41; calcium-bindingAdd
BLAST
Domaini2444 – 248441EGF-like 42; calcium-bindingAdd
BLAST
Domaini2485 – 252339EGF-like 43; calcium-bindingAdd
BLAST
Domaini2524 – 256643EGF-like 44; calcium-bindingAdd
BLAST
Domaini2567 – 260640EGF-like 45; calcium-bindingAdd
BLAST
Domaini2607 – 264741EGF-like 46; calcium-bindingAdd
BLAST
Domaini2648 – 268740EGF-like 47; calcium-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi392 – 44655Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the fibrillin family.
Contains 47 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231768.
HOVERGENiHBG005643.
KOiK06825.

Family and domain databases

Gene3Di3.90.290.10. 10 hits.
InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN/EtMIC4.
IPR009030. Growth_fac_rcpt_N_dom.
IPR017878. TB_dom.
[Graphical view]
PANTHERiPTHR24039. PTHR24039. 1 hit.
PfamiPF12662. cEGF. 5 hits.
PF07645. EGF_CA. 33 hits.
PF00683. TB. 9 hits.
[Graphical view]
PIRSFiPIRSF036312. Fibrillin. 1 hit.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 42 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 10 hits.
SSF57581. SSF57581. 9 hits.
PROSITEiPS00010. ASX_HYDROXYL. 43 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 38 hits.
PS50026. EGF_3. 45 hits.
PS01187. EGF_CA. 43 hits.
PS51364. TB. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98133-1 [UniParc]FASTAAdd to Basket

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MRRGGLLEVA LGFTVLLASY TSHGADTNLE AGNVKETRAN RAKRRGGGGH     50
NALKGPNVCG SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC 100
TCPSGQIAPS CGSRSIQHCN IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC 150
ESGCLNGGRC VAPNRCACTY GFTGPQCERD YRTGPCFTVI SNQMCQGQLS 200
GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR TGACQDVDEC 250
QAIPGLCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGICD 300
GGECTNTVSS YFCKCPPGFY TSPDGTRCID VRPGYCYTAL ANGRCSNQLP 350
QSITKMQCCC DAGRCWSPGV TVAPEMCPIR ATEDFNKLCS VPMVIPERPG 400
YPPPPLGPVP PVQPVPPGFP PGPQIMIPRP PVEYPYPSRE PPRVLPVNVT 450
DYCQLFRYLC QNGRCIPTPG SYRCECNKGF QLDLRGECID VDECEKNPCA 500
GGECINTQGS YTCQCRPGYQ STLTRTECRD IDECLQNGRI CNNGRCINTD 550
GSFHCVCNAG FHVTRDGKNC EDMDECSIRN MCLNGMCINE DGSFKCICKP 600
GFQLASDGRY CKDINECETL GICMNGRCVN TDGSYRCECF PGLAVGLDGR 650
VCVDTHMRST CYGGYKRGQC VKPLFGAVTK SECCCASTEY AFGEPCQPCP 700
SQNSAEYQAL CSSGPGITSA GSDINECALD PDICPNGICE NLRGTYKCIC 750
NSGYEVDSTG KNCVDINECV LNSLLCDNGQ CRNTPGSFVC TCPKGFIYKP 800
ELKTCEDIDE CESSPCINGV CKNSPGSFIC ECSSESTLDP TKTICIETIK 850
GTCWQTVIDG RCEININGAT LKSQCCSSLG AAWGSPCTPC QVDPICGKGY 900
SRIKGTQCED IDECEVFPGV CKNGLCVNSK GSFKCQCPSG MTLDATGRIC 950
LDIRLETCFL RYEDEECTLP VAGRHRMDAC CCSVGAAWGT EECEECPVRN 1000
TPEYEELCPR GPGFATKEIT NGKRFFKDIN ECKMIPNLCT HGKCRNTIGS 1050
FKCRCDSGFA LDSEERNCTD IDECRISPDL CGRGQCVNTP GDFECKCDEG 1100
YESGFMMMKN CMDIDECQRD PLLCRGGVCL NTEGSYRCEC PPGHQLAPNI 1150
SACIDINECE LSAHLCPHGR CVNLIGKYQC ACNPGYHSTP DRLFCVDIDE 1200
CSIMNGGCET FCTNSEGSYE CSCQPGFALM PDQRSCTDID ECEDNPNICD 1250
GGQCTNIPGE YRCLCYDGFM ASEDMKTCVD VNECDLNPNI CLSGTCENTK 1300
GSFICHCDMG YSGKKGKTGC TDINECEIGA HNCDRHAVCT NTAGSFKCSC 1350
SPGWIGDGIK CTDLDECSNG THMCSQHADC KNTMGSYRCL CKEGYTGDGF 1400
TCTDLDECSE NLNLCGNGQC LNAPGGYRCE CDMGFVPSAD GKACEDIDEC 1450
SLPNICVFGT CHNLPGLFRC ECEIGYELDR SGGNCTDVNE CLDPTTCISG 1500
NCVNTPGSYT CDCPPDFELN PTRVGCVDTR SGNCYLDIRP RGDNGDTACS 1550
NEIGVGVSKA SCCCSLGKAW GTPCELCPPV NTSEYKILCP GGEGFRPNPI 1600
TVILEDIDEC QELPGLCQGG KCINTFGSFQ CRCPTGYYLN EDTRVCDDVN 1650
ECETPGICGP GTCYNTVGNY TCICPPDYMQ VNGGNNCMDM RRSLCYRNYY 1700
ADNQTCDGEL LFNMTKKMCC CSYNIGRAWN KPCEQCPIPS TDEFATLCGS 1750
QRPGFVIDIY TGLPVDIDEC REIPGVCENG VCINMVGSFR CECPVGFFYN 1800
DKLLVCEDID ECQNGPVCQR NAECINTAGS YRCDCKPGYR FTSTGQCNDR 1850
NECQEIPNIC SHGQCIDTVG SFYCLCHTGF KTNADQTMCL DINECERDAC 1900
GNGTCRNTIG SFNCRCNHGF ILSHNNDCID VDECATGNGN LCRNGQCINT 1950
VGSFQCQCNE GYEVAPDGRT CVDINECLLD PRKCAPGTCQ NLDGSYRCIC 2000
PPGYSLQNDK CEDIDECVEE PEICALGTCS NTEGSFKCLC PDGFSLSSTG 2050
RRCQDLRMSY CYAKFEGGKC SSPKSRNHSK QECCCALKGE GWGDPCELCP 2100
TEPDEAFRQI CPYGSGIIVG PDDSAVDMDE CKEPDVCKHG QCINTDGSYR 2150
CECPFGYILQ GNECVDTDEC SVGNPCGNGT CKNVIGGFEC TCEEGFEPGP 2200
MMTCEDINEC AQNPLLCAFR CVNTYGSYEC KCPAGYVLRE DRRMCKDEDE 2250
CEEGKHDCAE KQMECKNLIG TYLCICGPGY QRRPDGEGCV DENECQTKPG 2300
ICENGRCLNT RGSYTCECND GFTASPNQDE CLDNREGYCF TEVLQNMCQI 2350
GSSNRNPVTK SECCCDGGRG WGPHCEICPF QGTVAFKKLC PHGRGFMTNG 2400
ADIDECKVIH DVCRNGECVN DRGSYHCICK TGYTPDITGT ACVDLNECNQ 2450
APKPCNFICK NTEGSYQCSC PKGYILQEDG RSCKDLDECA TKQHNCQFLC 2500
VNTIGSFTCK CPPGFTQHHT ACIDNNECTS DINLCGSKGI CQNTPGSFTC 2550
ECQRGFSLDP TGASCEDVDE CEGNHRCQHG CQNIIGGYRC SCPQGYLQHY 2600
QWNQCVDENE CLSAHICGGA SCHNTLGSYK CMCPAGFQYE QFSGGCQDIN 2650
ECGSAQAPCS YGCSNTEGGY LCACPPGYFR IGQGHCVSGM GMGRGNPEPP 2700
ASGEMDDNSL SPEACYECKI NGYPKRGRKR RSANETDASN IEDQPEIEAN 2750
VSLASWDVEK TAVFAFNISH ISNKVRILEL LPALTTLTNH NRYLIESGNE 2800
NGFFKINQKE GISYLHFTKK KPVAGTYSLQ ISSTPLYKKK ELNQLEDKYD 2850
KDYLSGELGD NLKMKIQILL H 2871
Length:2,871
Mass (Da):312,250
Last modified:October 1, 1996 - v1
Checksum:iE77FD2A4F1451CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28748 mRNA. Translation: AAA74122.1.
PIRiA55567.
RefSeqiNP_776478.1. NM_174053.2.
UniGeneiBt.107024.

Genome annotation databases

GeneIDi281154.
KEGGibta:281154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28748 mRNA. Translation: AAA74122.1 .
PIRi A55567.
RefSeqi NP_776478.1. NM_174053.2.
UniGenei Bt.107024.

3D structure databases

ProteinModelPortali P98133.
SMRi P98133. Positions 1069-1154, 1486-1647, 2054-2205, 2455-2484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000035493.

Proteomic databases

PaxDbi P98133.
PRIDEi P98133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281154.
KEGGi bta:281154.

Organism-specific databases

CTDi 2200.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231768.
HOVERGENi HBG005643.
KOi K06825.

Enzyme and pathway databases

Reactomei REACT_201925. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi 20805217.

Family and domain databases

Gene3Di 3.90.290.10. 10 hits.
InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN/EtMIC4.
IPR009030. Growth_fac_rcpt_N_dom.
IPR017878. TB_dom.
[Graphical view ]
PANTHERi PTHR24039. PTHR24039. 1 hit.
Pfami PF12662. cEGF. 5 hits.
PF07645. EGF_CA. 33 hits.
PF00683. TB. 9 hits.
[Graphical view ]
PIRSFi PIRSF036312. Fibrillin. 1 hit.
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 42 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 10 hits.
SSF57581. SSF57581. 9 hits.
PROSITEi PS00010. ASX_HYDROXYL. 43 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 38 hits.
PS50026. EGF_3. 45 hits.
PS01187. EGF_CA. 43 hits.
PS51364. TB. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the coding region of the bovine fibrillin cDNA and localization to bovine chromosome 10."
    Tilstra D.J., Potter K.A., Byers P.H.
    Genomics 23:480-485(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)."
    Gibson M.A., Hatzinikolas G., Kumaratilake J.S., Sandberg L.B., Nicholl J.K., Sutherland G.R., Cleary E.G.
    J. Biol. Chem. 271:1096-1103(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiFBN1_BOVIN
AccessioniPrimary (citable) accession number: P98133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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