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Protein

E-selectin

Gene

SELE

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:SELE
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 429ExtracellularSequence analysisAdd BLAST407
Transmembranei430 – 451HelicalSequence analysisAdd BLAST22
Topological domaini452 – 484CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001749423 – 484E-selectinAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 139By similarity
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 131By similarity
Disulfide bondi144 ↔ 155By similarity
Disulfide bondi149 ↔ 164By similarity
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 175By similarity
Disulfide bondi181 ↔ 222By similarity
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi208 ↔ 235By similarity
Disulfide bondi240 ↔ 285By similarity
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi271 ↔ 298By similarity
Disulfide bondi303 ↔ 348By similarity
Disulfide bondi334 ↔ 361By similarity
Disulfide bondi366 ↔ 407By similarity
Glycosylationi376N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi393 ↔ 420By similarity
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98110.
PRIDEiP98110.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006699.

Structurei

3D structure databases

ProteinModelPortaliP98110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 140C-type lectinPROSITE-ProRule annotationAdd BLAST118
Domaini141 – 176EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini179 – 237Sushi 1PROSITE-ProRule annotationAdd BLAST59
Domaini251 – 300Sushi 2PROSITE-ProRule annotationAdd BLAST50
Domaini301 – 363Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini364 – 422Sushi 4PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98110.
KOiK06494.

Family and domain databases

CDDicd00033. CCP. 4 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 4 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 4 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 4 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASQFLSAL PLVLLLLRES GAWSYSASTE TMTFDDASAY CQQRYTHLVA
60 70 80 90 100
IQNHAEIEYL NSTFNYSASY YWIGIRKING TWTWIGTKKA LTPEATNWAP
110 120 130 140 150
GEPNNKQSNE DCVEIYIKRD KDSGKWNDER CSKKKLALCY TAACTPTSCS
160 170 180 190 200
GHGECIETIN SSTCQCYPGF RGLQCEQVVE CDALENPVNG VVTCPQSLPW
210 220 230 240 250
NTTCAFECKE GFELIGPEHL QCTSSGSWDG KKPTCKAVTC DTVGHPQNGD
260 270 280 290 300
VSCNHSSIGE FAYKSTCHFT CAEGFGLQGP AQIECTAQGQ WTQQAPVCKA
310 320 330 340 350
VKCPAVSQPK NGLVKFTHSP TGEFTYKSSC AFSCEEGFEL RGSAQLACTS
360 370 380 390 400
QGQWTQEVPS CQVVQCSSLE VPREINMSCS GEPVFGAVCT FACPEGWMLN
410 420 430 440 450
GSVALTCGAT GHWSGMLPTC EAPAESKIPL AMGLAAGGVS FMTSASFLLW
460 470 480
LLKRLRKRAK KFVPSSSSEC LQPNGSYQMP SDLI
Length:484
Mass (Da):52,567
Last modified:February 1, 1996 - v1
Checksum:iAFF74FE25C1FD013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253C → Y in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti313L → F in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti321T → N in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti327K → N in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti363V → A in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti384V → M in AAA21541 (PubMed:7516159).Curated1
Sequence conflicti461 – 484KFVPS…PSDLI → NLFLPAAPNAFNPMDPTKCL LT in AAA21541 (PubMed:7516159).CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39076 mRNA. Translation: AAA61545.1.
U08350 mRNA. Translation: AAA21541.1.
RefSeqiNP_999433.1. NM_214268.1.
UniGeneiSsc.16297.

Genome annotation databases

GeneIDi397508.
KEGGissc:397508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39076 mRNA. Translation: AAA61545.1.
U08350 mRNA. Translation: AAA21541.1.
RefSeqiNP_999433.1. NM_214268.1.
UniGeneiSsc.16297.

3D structure databases

ProteinModelPortaliP98110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006699.

Proteomic databases

PaxDbiP98110.
PRIDEiP98110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397508.
KEGGissc:397508.

Organism-specific databases

CTDi6401.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98110.
KOiK06494.

Family and domain databases

CDDicd00033. CCP. 4 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 4 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 4 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 4 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM2_PIG
AccessioniPrimary (citable) accession number: P98110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Important in acute cellular allograft rejection and probably also in xenograft rejection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.